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1. 发明申请

WO2005010164A3 NUCLEIC ACID BIOMATERIALS AND METHODS OF FORMATION AND USE 审中-公开
标题翻译：核酸生物材料及其形成与使用方法
公开(公告)号：WO2005010164A3
公开(公告)日：2006-06-29
申请号：PCT/US2004023366
申请日：2004-07-22
申请人： MATERIALS EVOLUTION DEV USA IN , LYLES MARK B
发明人： LYLES MARK B
IPC分类号： A61K31/70 , A61K9/16 , A61K47/24 , A61L15/32 , A61L15/64 , A61L17/10 , A61L26/00 , A61L27/22 , A61L27/58
CPC分类号： A61K47/24 , A61K9/1611 , A61K9/167 , A61K31/70 , A61L15/32 , A61L15/64 , A61L17/10 , A61L26/0019 , A61L26/009 , A61L27/18 , A61L27/58 , C08L77/04
摘要： Polymers that are biocompatible are useful for various medical purposes such as tissue repair, reconstruction and wound healing. A method and composition for producing a biocompatible polymer formed from nucleic acids is disclosed. The nucleic acid polymer may be used to form a hybrid with an existing polymer to create a copolymer. The nucleic acids may be also be selected to encode particular proteins which may then be expressed in a biological tissue.
摘要翻译：生物相容的聚合物可用于各种医疗目的，如组织修复，重建和伤口愈合。公开了用于生产由核酸形成的生物相容性聚合物的方法和组合物。核酸聚合物可用于与现有聚合物形成杂化物以产生共聚物。也可以选择核酸来编码可以在生物组织中表达的特定蛋白质。

2. 发明申请

WO2005010083A2 CERAMIC AND METAL COMPOSITIONS 审中-公开
标题翻译：陶瓷和金属组合物
公开(公告)号：WO2005010083A2
公开(公告)日：2005-02-03
申请号：PCT/US2004/023611
申请日：2004-07-22
申请人： MATERIALS EVOLUTION DEVELOPMENT USA, INC. , LYLES, Mark B.
发明人： LYLES, Mark B.
IPC分类号： C08J
CPC分类号： C04B35/14 , A61K6/0235 , A61K6/046 , C04B35/18 , C04B35/626 , C04B35/80 , C04B38/0058 , C04B2235/3409 , C04B2235/3826 , C04B2235/386 , C04B2235/40 , C04B2235/5224 , C04B2235/5232 , C04B2235/5248 , C04B2235/75 , C04B2235/77 , C04B2235/80 , C23C18/1216 , C23C18/1245 , C23C18/127 , Y10T428/249953 , C04B35/00
摘要： A novel metal/ceramic hybrid material in which the void space of the ceramic is filled with metal. The metal may be bonded to the ceramic, for example by formation of a metal oxide. The metal may be introduced into the ceramic as small particles in a suspension then heated to melt the metal, allowing bonding to the ceramic or better filling of the void space. The hybrid material may be used in a variety of applications.
摘要翻译：一种新型金属/陶瓷混合材料，其中陶瓷的空隙空间填充有金属。例如通过形成金属氧化物，金属可以结合到陶瓷上。金属可以作为悬浮液中的小颗粒引入到陶瓷中，然后加热以熔化金属，允许与陶瓷结合或更好地填充空隙空间。混合材料可用于各种应用。

3. 发明申请

WO2004084828A2 KERATINOCYTE-FIBROCYTE CONCOMITANT GRAFTING FOR WOUND HEALING 审中-公开
标题翻译： KERATINOCYTE-FIBROCYTE CONCOMTIANT GRAFTING FOR WOUND HEALING
公开(公告)号：WO2004084828A2
公开(公告)日：2004-10-07
申请号：PCT/US2004/008622
申请日：2004-03-22
申请人： MATERIALS EVOLUTION AND DEVELOPMENT USA, INC. , LYLES, Mark, B.
发明人： LYLES, Mark, B.
IPC分类号： A61K
CPC分类号： A61M35/003 , A61K35/33 , A61K35/36 , A61K35/545 , A61K38/18 , A61K38/19 , A61K38/39 , A61K45/06 , A61L15/60 , A61L27/3804 , A61L27/3886 , C12N5/0698 , C12N2502/094 , C12N2502/1323 , A61K2300/00
摘要： A system and method for dispersing living cells onto an area of a subject lacking normal, healthy skin, such as an open wound surface, to form three dimensional epithelial tissue is provide. The cells are dispersed using an air-jet sprayer after being suspended in a soluble media such as dextran. The cells may be dispersed directly onto the area or onto a tissue scaffold or synthetic substance that promotes wound healing.
摘要翻译：提供了一种用于将活细胞分散到缺乏正常健康皮肤（例如开放伤口表面）的受试者的区域上以形成三维上皮组织的系统和方法。在悬浮在可溶性介质如葡聚糖中之后，使用喷气喷雾器将细胞分散。细胞可以直接分散到促进伤口愈合的组织支架或合成物质的区域上。

4. 发明申请

WO2005010083A3 CERAMIC AND METAL COMPOSITIONS 审中-公开
标题翻译：陶瓷和金属组合物
公开(公告)号：WO2005010083A3
公开(公告)日：2005-04-28
申请号：PCT/US2004023611
申请日：2004-07-22
申请人： MATERIALS EVOLUTION DEV USA IN , LYLES MARK B
发明人： LYLES MARK B
IPC分类号： A61K6/04 , A61K6/06 , B29C39/00 , B32B3/26 , C03C11/00 , C04B35/14 , C04B35/18 , C04B35/80 , C04B38/00 , C08J20060101
CPC分类号： C04B35/14 , A61K6/0235 , A61K6/046 , C04B35/18 , C04B35/626 , C04B35/80 , C04B38/0058 , C04B2235/3409 , C04B2235/3826 , C04B2235/386 , C04B2235/40 , C04B2235/5224 , C04B2235/5232 , C04B2235/5248 , C04B2235/75 , C04B2235/77 , C04B2235/80 , C23C18/1216 , C23C18/1245 , C23C18/127 , Y10T428/249953 , C04B35/00
摘要： A novel metal/ceramic hybrid material in which the void space of the ceramic is filled with metal. The metal may be bonded to the ceramic, for example by formation of a metal oxide. The metal may be introduced into the ceramic as small particles in a suspension then heated to melt the metal, allowing bonding to the ceramic or better filling of the void space. The hybrid material may be used in a variety of applications.
摘要翻译：一种新颖的金属/陶瓷混合材料，其中陶瓷的空隙被金属填充。金属可以结合到陶瓷上，例如通过形成金属氧化物。金属可以作为悬浮液中的小颗粒引入到陶瓷中，然后被加热以熔化金属，允许粘结到陶瓷或更好地填充空隙。混合材料可以用于各种应用中。

5. 发明申请

WO0173125A3 HIGH THROUGHPUT SCREENING ARRAY CONTAINING POROUS MATERIAL 审中-公开
标题翻译：包含多孔材料的高通量筛选阵列
公开(公告)号：WO0173125A3
公开(公告)日：2002-01-03
申请号：PCT/US0109430
申请日：2001-03-24
申请人： LYLES MARK B
发明人： LYLES MARK B
IPC分类号： C07B61/00 , C07H15/00 , C07H21/00 , C07K1/107 , C40B40/06 , C40B40/10 , C40B40/12 , G01N33/551 , B01J19/00 , C07K1/04 , C12Q1/68 , G01N33/50
CPC分类号： C07K1/1077 , B01J2219/00274 , B01J2219/00457 , B01J2219/00527 , B01J2219/00587 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00707 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , C07B2200/11 , C07H15/00 , C07H21/00 , C40B40/06 , C40B40/10 , C40B40/12 , G01N33/551
摘要： Two dimensional arrays of molecules on a porous material are disclosed. Combinatorial arrays of molecules may include peptides, oligosaccharides, proteins, oligonucleotides, RNA, DNA, antibodies, and small organic molecules. The arrays can be used in high throughput screening methods to identify targets, receptors, hybridizing sequences, antibody epitopes, and other chemical and biological molecule-molecule interactions. The porous material preferably comprises alumina and silica.
摘要翻译：公开了多孔材料上分子的二维阵列。组合分子阵列可以包括肽，寡糖，蛋白质，寡核苷酸，RNA，DNA，抗体和小有机分子。阵列可用于高通量筛选方法，以鉴定目标，受体，杂交序列，抗体表位和其他化学和生物分子 - 分子相互作用。多孔材料优选包含氧化铝和二氧化硅。

6. 发明申请

WO1996024631A1 CERAMIC FUSED FIBER ENHANCED DENTAL MATERIAL 审中-公开
标题翻译：陶瓷熔融纤维增强牙科材料
公开(公告)号：WO1996024631A1
公开(公告)日：1996-08-15
申请号：PCT/US1996001800
申请日：1996-02-08
申请人： MATERIALS EVOLUTION AND DEVELOPMENT USA, INC. , LYLES, Mark, B. , RITSCO, Ronald, G.
发明人： MATERIALS EVOLUTION AND DEVELOPMENT USA, INC.
IPC分类号： C08K03/38
CPC分类号： A61K6/027 , A61K6/0073 , A61K6/0088 , A61K6/0091 , A61K6/0205 , A61K6/04 , A61K6/05 , C08K3/01 , C08K3/38
摘要： The preferred embodiment of the present invention provides novel and unique filler compositions and ceramic enhanced dental materials. The preferred embodiment of the composition and the ceramic dental restorative materials made therefrom comprise a rigid three-dimensional network of fibers fused together at their points of contact wherein said network is greater than 60 % by volume void space, has mean pore diameters greater than 10 microns, or both.
摘要翻译：本发明的优选实施方案提供新颖且独特的填充剂组合物和陶瓷增强牙科材料。组合物和由其制成的陶瓷牙科修复材料的优选实施方案包括在其接触点处熔合在一起的纤维的刚性三维网络，其中所述网络大于60体积％的空隙空间，平均孔径大于10 微米或两者。

7. 发明申请

WO2004084828A3 KERATINOCYTE-FIBROCYTE CONCOMITANT GRAFTING FOR WOUND HEALING 审中-公开
标题翻译： KERATINOCYTE-FIBROCYTE CONCOMTIANT GRAFTING FOR WOUND HEALING
公开(公告)号：WO2004084828A3
公开(公告)日：2005-05-12
申请号：PCT/US2004008622
申请日：2004-03-22
申请人： MATERIALS EVOLUTION AND DEV US , LYLES MARK B
发明人： LYLES MARK B
IPC分类号： A61K20060101 , A61K35/12 , A61K35/36 , A61K35/48 , A61K38/19 , A61K45/00 , A61K45/06 , A61L15/60 , A61L27/38 , A61M35/00 , A61M37/00 , C12N5/00 , C12N5/071
CPC分类号： A61M35/003 , A61K35/33 , A61K35/36 , A61K35/545 , A61K38/18 , A61K38/19 , A61K38/39 , A61K45/06 , A61L15/60 , A61L27/3804 , A61L27/3886 , C12N5/0698 , C12N2502/094 , C12N2502/1323 , A61K2300/00
摘要： A system and method for dispersing living cells onto an area of a subject lacking normal, healthy skin, such as an open wound surface, to form three dimensional epithelial tissue is provide. The cells are dispersed using an air-jet sprayer after being suspended in a soluble media such as dextran. The cells may be dispersed directly onto the area or onto a tissue scaffold or synthetic substance that promotes wound healing.
摘要翻译：提供了一种用于将活细胞分散到缺乏正常健康皮肤（例如开放伤口表面）的受试者的区域上以形成三维上皮组织的系统和方法。在悬浮在可溶性介质如葡聚糖中之后，使用喷气喷雾器分散细胞。细胞可以直接分散到促进伤口愈合的组织支架或合成物质的区域上。

8. 发明申请

WO2005010164A2 NUCLEIC ACID BIOMATERIALS AND METHODS OF FORMATION AND USE 审中-公开
标题翻译：核酸生物材料及其形成与使用方法
公开(公告)号：WO2005010164A2
公开(公告)日：2005-02-03
申请号：PCT/US2004/023366
申请日：2004-07-22
申请人： MATERIALS EVOLUTION DEVELOPMENT USA, INC. , LYLES, Mark, B.
发明人： LYLES, Mark, B.
IPC分类号： C12N
CPC分类号： A61K47/24 , A61K9/1611 , A61K9/167 , A61K31/70 , A61L15/32 , A61L15/64 , A61L17/10 , A61L26/0019 , A61L26/009 , A61L27/18 , A61L27/58 , C08L77/04
摘要： Polymers that are biocompatible are useful for various medical purposes such as tissue repair, reconstruction and wound healing. A method and composition for producing a biocompatible polymer formed from nucleic acids is disclosed. The nucleic acid polymer may be used to form a hybrid with an existing polymer to create a copolymer. The nucleic acids may be also be selected to encode particular proteins which may then be expressed in a biological tissue.
摘要翻译：生物相容的聚合物可用于各种医疗目的，如组织修复，重建和伤口愈合。公开了用于生产由核酸形成的生物相容性聚合物的方法和组合物。核酸聚合物可用于与现有聚合物形成杂化物以产生共聚物。也可以选择核酸来编码可以在生物组织中表达的特定蛋白质。

9. 发明申请

WO0208237A2 MATERIALS AND METHODS FOR BINDING NUCLEIC ACIDS TO SURFACES 审中-公开
标题翻译：将核酸与表面结合的材料和方法
公开(公告)号：WO0208237A2
公开(公告)日：2002-01-31
申请号：PCT/US0123079
申请日：2001-07-20
申请人： LYLES MARK B
发明人： LYLES MARK B
IPC分类号： C07B61/00 , C07H21/00 , C07H
CPC分类号： C07H21/00 , C07B2200/11 , C40B40/00
摘要： Surfaces contaning high purity silica (silicon dioxide) exhibit high loading potential for nucleic acids. Formulations containing nucleic acids and materials which mask the electrostatic interactions between the nucleic acids and surfaces are disclosed. By masking the phosphate charges of the nucleic acids, undersired interactions may be minimized or eliminated, thereby allowing the covalent boding of the nucleic acids to the surface to proceed. The use of such formulations additionally minimizes nonspecific binding of the nucleic acids to the surface. Examples of materials to be included in such formulations include cations, xanthines, hexoses, purines, arginine, lysine, polyarginine, polylysine, and quaternary ammonium salts.
摘要翻译：表面高纯度二氧化硅（二氧化硅）表现出高的核酸负载潜力。公开了含有掩蔽核酸和表面之间的静电相互作用的核酸和材料的制剂。通过掩蔽核酸的磷酸盐电荷，可以将下面的相互作用最小化或消除，从而允许核酸对表面的共价引导进行。这种制剂的使用另外使核酸与表面的非特异性结合最小化。要包括在这种制剂中的材料的实例包括阳离子，黄嘌呤，己糖，嘌呤，精氨酸，赖氨酸，聚精氨酸，聚赖氨酸和季铵盐。

10. 发明申请

WO2005009582A3 NUCLEIC ACID BASED FILTERS 审中-公开
公开(公告)号：WO2005009582A3
公开(公告)日：2005-02-03
申请号：PCT/US2004/023496
申请日：2004-07-22
申请人： MATERIALS EVOLUTION DEVELOPMENT USA, INC. , LYLES, Mark, B.
发明人： LYLES, Mark, B.
IPC分类号： A24D03/06
摘要： The present invention provides a filter for removing carcinogens from a gas or liquid. The filter contains nucleic acids, for example DNA or apurinic acid, with which the carcinogens may react. In specific embodiments the filters are used for tobacco smoke or industrial pollutants.

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