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1. 发明申请

WO2015130722A1 METHODS AND ASSAYS FOR TREATING HANTAVIRUS INFECTIONS 审中-公开
标题翻译：治疗汉坦病毒感染的方法和测定
公开(公告)号：WO2015130722A1
公开(公告)日：2015-09-03
申请号：PCT/US2015/017410
申请日：2015-02-25
申请人： ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
发明人： CHANDRAN, Kartik , BRUMMELKAMP, Thijin, R. , JAE, Lucas, T. , JANGRA, Rohit, K.
IPC分类号： A61K39/395 , G01N33/68 , C12N15/113
CPC分类号： A61K39/12 , A61K31/7084 , A61K31/7105 , A61K2121/00 , G01N33/15 , G01N33/502 , G01N33/5023 , G01N33/53 , G01N2333/705 , G01N2500/00
摘要： Methods and assays are disclosed for treating a subject with a hantavirus infection using an agent that binds to protocadherin- 1 (PCDH1) or inhibits expression of protocadherin- 1 (PCDH1).
摘要翻译：公开了使用结合原螯合素-1（PCDH1）的药物或抑制原始儿茶素-1（PCDH1）的表达来治疗患有汉坦病毒感染的受试者的方法和测定法。

2. 发明申请

WO2015120362A1 METHODS OF GRADING CARCINOMAS 审中-公开
标题翻译：评价癌症的方法
公开(公告)号：WO2015120362A1
公开(公告)日：2015-08-13
申请号：PCT/US2015/014973
申请日：2015-02-09
申请人： ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
发明人： WU, Peng , ROUHANIFARD, Sara , ZHENG, Tianqing
IPC分类号： G01N33/53 , G01N33/574
CPC分类号： G01N33/57492 , A61K31/7004 , A61K35/15 , A61K35/51 , A61K38/45 , G01N33/5308 , G01N33/57415 , G01N33/57423 , G01N33/57438 , G01N33/57446 , G01N2400/00 , G01N2400/02 , G01N2800/56 , A61K2300/00
摘要： Methods for grading carcinomas are provided as well as kits therefor. A method is provided for grading a carcinoma, or suspected carcinoma, comprising obtaining a sample of the carcinoma or suspected carcinoma and contacting the sample with one or more reagents so as to identify LacNAc or Gal.beta.l,4GlcNAc expression on cell surfaces thereof, quantifying the identified LacNAc or Gal.beta.l,4GlcNAc expression, and comparing quantified LacNAc or Gal.beta.l,4GlcNAc expression to one or more predetermined control values, and assigning a grade to the suspected carcinoma based on the quantified LacNAc or Gal.beta.l,4GlcNAc expression being in excess of, or less than, the one or more predetermined control values. Also provided is a method for identifying a sample from a subject as a carcinoma sample. Also provided is a kit for grading carcinoma samples comprising a LacNAc-specific or Gal-l,4GlcNAc-specific glycosylation enzyme and a synthetically-labeled sugar molecule and written instructions for use thereof.
摘要翻译：提供了分级癌的方法及其工具。提供了一种用于分级癌或疑似癌的方法，包括获得癌症或疑似癌症的样品，并使样品与一种或多种试剂接触，以鉴定其细胞表面上的LacNAc或Gal.beta.I，4GlcNAc表达定量鉴定的LacNAc或Gal.beta.l，4GlcNAc表达，并将定量的LacNAc或Gal.beta.l，4GlcNAc表达与一个或多个预定对照值进行比较，并根据量化的LacNAc或 Gal1beta1，4GlcNAc表达超过或小于一个或多个预定对照值。还提供了从癌症样品中鉴定受试者的样品的方法。还提供了用于对包含LacNAc特异性或Gal-1，4GlcNAc特异性糖基化酶和合成标记的糖分子的癌症样品进行分级的试剂盒以及用于其的书面说明书。

3. 发明申请

WO2014176498A9 METHOD OF TREATING TUBERCULOSIS 审中-公开
公开(公告)号：WO2014176498A9
公开(公告)日：2014-10-30
申请号：PCT/US2014/035448
申请日：2014-04-25
申请人： ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
发明人： HARTMAN, Travis , BERNEY, Michael , JACOBS, Jr., William, R. , VILCHEZE, Catherine
IPC分类号： C12Q1/70 , C12N1/12 , C12N1/20
摘要： The present invention addresses a need for improved methods of treating M. tuberculosis infection using enhancers of respiration, and compositions for treating tuberculosis as well as assays for identifying novel agents for treating M. tuberculosis infection.

4. 发明申请

WO2014059065A1 SEROLOGIC TEST FOR THE RAPID DIAGNOSIS OF ACTIVE TUBERCULOSIS 审中-公开
标题翻译：主动管腔快速诊断的血清学检测
公开(公告)号：WO2014059065A1
公开(公告)日：2014-04-17
申请号：PCT/US2013/064203
申请日：2013-10-10
申请人： ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
发明人： ACHKAR, Jacqueline, Michele , CASADEVALL, Arturo , PRADOS-ROSALES, Rafael , ZIEGENBALG, Anke
IPC分类号： C12Q1/02
CPC分类号： G01N33/5695 , G01N33/6854 , G01N2333/35 , G01N2469/20
摘要： The present invention relates to methods and kits for detecting active tuberculosis infection in a subject using serological techniques and a first agent capable of binding an IgG, IgA and/or IgM directed to the first protein present in or on a Mycobacterium tuberculosis membrane vesicle or a Bacillus Calmette-Guerin (BCG) membrane vesicle. Also provided are methods of treating a subject with an active tuberculosis disease.
摘要翻译：本发明涉及使用血清学技术检测受试者中的活动性结核感染的方法和试剂盒，以及能够结合存在于结核分枝杆菌膜囊泡中或其上的第一种蛋白质的IgG，IgA和/或IgM的第一种试剂，或卡介苗（BCG）膜囊泡。还提供了治疗患有活动性结核病的受试者的方法。

5. 发明申请

WO2014052054A1 ENZYMATIC PLATFORM FOR THE SYNTHESIS OF ISOPRENOID PRECURSORS AND USES THEREOF 审中-公开
标题翻译：用于合成异丙烯酸前驱体的酶合成平台及其用途
公开(公告)号：WO2014052054A1
公开(公告)日：2014-04-03
申请号：PCT/US2013/059857
申请日：2013-09-16
申请人： ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
发明人： LEYH, Thomas, S.
IPC分类号： C12P5/02 , C12P5/00 , C12P7/04
CPC分类号： C12P9/00 , C12P5/007 , C12Y101/01088 , C12Y203/01009 , C12Y203/0301 , C12Y207/01036 , C12Y207/04002 , C12Y602/01001
摘要： Provided are method of synthesizing (R)-5-diphosphomevalonate (DPM), isopentenyl 5-pyrophosphase (IPP), dimethylallyl 5 -pyrophosphate (DMAPP) and isoprenoid using a one-pot synthesis.
摘要翻译：提供了使用一锅合成合成（R）-5-二磷酸戊糖醛酸（DPM），异戊烯基-5-焦磷酸（IPP），5-丙基二甲基烯丙基酯（DMAPP）和类异戊二烯的方法。

6. 发明申请

WO2013082105A1 STAT3 ACTIVATION AS A MARKER FOR CLASSIFICATION AND PROGNOSIS OF DLBCL PATIENTS 审中-公开
标题翻译： STAT3作为DLBCL患者分类和预防标志的激活
公开(公告)号：WO2013082105A1
公开(公告)日：2013-06-06
申请号：PCT/US2012/066782
申请日：2012-11-28
申请人： ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY , BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA , YE, Bihui, H. , CHAN, Wing (John) , FU, Kai
发明人： YE, Bihui, H. , CHAN, Wing (John) , FU, Kai
IPC分类号： G01N33/48 , G06F19/00
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158
摘要： Methods are disclosed for determining classification and prognosis of patients with diffuse large B-cell lymphoma (DLBCL) using activation of signal transducer and activator of transcription 3 (STAT3).
摘要翻译：公开了使用信号转导和转录激活因子3（STAT3）的激活来确定弥漫性大B细胞淋巴瘤（DLBCL）患者的分类和预后的方法。

7. 发明申请

WO2013070433A1 TARGETING AN AMPHIREGULIN-DERIVED CELL SURFACE NEO-EPITOPE 审中-公开
标题翻译：靶向AMPHIREGULIN衍生细胞表面NEO-EPITOPE
公开(公告)号：WO2013070433A1
公开(公告)日：2013-05-16
申请号：PCT/US2012/061629
申请日：2012-10-24
申请人： ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
发明人： KENNY, Paraic, Anthony , NAJARRO, Kelly, Susan, Levano , JUNG, Eric, Hoonee
IPC分类号： A61K39/00 , C12N5/07
CPC分类号： C07K16/22 , A61K35/15 , C07K2317/34
摘要： Antibodies to an amphiregulin neo-epitope, fragments thereof, and compositions comprising such are provided. Therapies for cancers in which cells thereof express amphiregulin are provided, as well as assays for identifying additional agents useful in such therapies.
摘要翻译：提供了对两性抗原表位的抗体，其片段和包含其的组合物。提供了其中表达双调蛋白的细胞的癌症的疗法，以及用于鉴定在这些疗法中有用的其它药剂的测定法。

8. 发明申请

WO2012161746A1 USE OF OXYTOCIN OR OXYTOCIN ANALOGUES TO TREAT OBESITY AND DIABETES 审中-公开
标题翻译：使用氧化蛋白或氧化蛋白类似物治疗肥胖和糖尿病
公开(公告)号：WO2012161746A1
公开(公告)日：2012-11-29
申请号：PCT/US2012/020404
申请日：2012-01-06
申请人： ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY , CAI, Dongsheng
发明人： CAI, Dongsheng
IPC分类号： A61K38/11
CPC分类号： A61K38/11 , A61K38/1709
摘要： Methods and compositions for treating obesity or an obesity comorbidity in a subject are provided, employing an inhibitor of synaptotagmin-4 or an amount of oxytocin or an analogue thereof. Methods and compositions for effecting weight gain in a subject are also provided employing synaptotagmin-4, or an analogue of synaptotagmin-4, or an oxytocin antagonist.
摘要翻译：提供了用于治疗受试者的肥胖症或肥胖症并发症的方法和组合物，其使用突触结合蛋白-4的抑制剂或催产素的量或其类似物。还提供了使用突触结合蛋白-4或突触结合蛋白-4的类似物或催产素拮抗剂来提供受试者体重增加的方法和组合物。

9. 发明申请

WO2012145568A1 ANTIBODIES TO HUMAN B7X FOR TREATMENT OF METASTATIC CANCER 审中-公开
标题翻译：人类B7X用于治疗分娩癌的抗体
公开(公告)号：WO2012145568A1
公开(公告)日：2012-10-26
申请号：PCT/US2012/034348
申请日：2012-04-20
申请人： ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY , SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH , ZANG, Xingxing , ALLISON, James, P.
发明人： ZANG, Xingxing , ALLISON, James, P.
IPC分类号： A61K39/395 , G01N33/53
CPC分类号： C07K16/30 , A61K9/0019 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K49/0008 , A61K2039/505 , C07K16/28 , C07K16/2827 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K16/3046 , C07K16/3053 , C07K16/3069 , C07K2317/34 , C07K2317/732 , C07K2317/76 , C07K2317/92 , G01N33/5011
摘要： Methods are provided for treating metastatic cancer in patients having metastatic cancer or for preventing metastasis in cancer patients at risk for metastasis comprising administering to the patient an antibody to B7x, or an active antibody fragment that binds B7x, in an amount effective to treat or prevent metastasis.
摘要翻译：提供了用于治疗患有转移性癌症的患者或用于预防转移风险的癌症患者转移的方法，其包括以有效治疗或预防的量向患者施用B7x抗体或结合B7x的活性抗体片段转移。

10. 发明申请

WO2012116248A1 ALTERNATIVELY SPLICED mRNA ISOFORMS AS PROGNOSTIC INDICATORS FOR METASTATIC CANCER 审中-公开
标题翻译：作为分泌癌的预后指标的异位mRNA表达
公开(公告)号：WO2012116248A1
公开(公告)日：2012-08-30
申请号：PCT/US2012/026424
申请日：2012-02-24
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY , MONTEFIORE MEDICAL CENTER , GERTLER, Frank, B. , BURGE, Christopher, Boyce , SHAPIRO, Irina, M. , CHENG, Wu, Albert , CONDEELIS, John, S. , OKTAY, Maja, H.
发明人： GERTLER, Frank, B. , BURGE, Christopher, Boyce , SHAPIRO, Irina, M. , CHENG, Wu, Albert , CONDEELIS, John, S. , OKTAY, Maja, H.
IPC分类号： G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/156 , G01N33/57415
摘要： The present invention provides a method for identifying a tumor as likely to metastasize, or likely to have metastasized, comprising obtaining a sample of the tumor and quantitating alternatively spliced mRNA isoforms of a cell motility gene, a cell adhesion gene and /or an actin cytoskeletal remodeling gene in the sample, or any specified genes or the level of RNA binding proteins compared to a predetermined non-metastasizing control.
摘要翻译：本发明提供了一种用于鉴定可能转移或可能转移的肿瘤的方法，包括获得肿瘤样品并定量细胞运动性基因，细胞粘附基因和/或肌动蛋白细胞骨架的可变剪接的mRNA同种型与预定的非转移对照相比，样品中的重塑基因，或任何指定的基因或RNA结合蛋白的水平。

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