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1. 发明申请

WO0212283A3 DISINTEGRIN HOMOLOGS, ZSNK10, ZSNK11, AND ZSNK12 审中-公开
标题翻译：灭菌HOMOLOGS，ZSNK10，ZSNK11和ZSNK12
公开(公告)号：WO0212283A3
公开(公告)日：2003-04-10
申请号：PCT/US0124536
申请日：2001-08-02
申请人： ZYMOGENETICS INC
发明人： FOX BRIAN A , SHEPPARD PAUL O
IPC分类号： A61K38/00 , C07K14/705 , C12N15/57 , A61K38/48 , A61K39/395 , C07K16/40 , C12N9/64
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention relates to polynucleotide and polypeptide molecules, and variants thereof, for ZSNK10, and ZSNK11, and ZSNK12, novel members of the Disintegrin Proteases. The polypeptides, and polynucleotides encoding them, are cell-cell interaction modulating and may be used for delivery and therapeutics. The present invention also includes antibodies to the ZSNK10, SZNK11, and ZSNK12 polypeptides.
摘要翻译：本发明涉及用于ZSNK10和ZSNK11的多核苷酸和多肽分子及其变体，以及ZSNK12，分解素蛋白酶的新成员。多肽和编码它们的多核苷酸是细胞 - 细胞相互作用调控，可用于递送和治疗。本发明还包括针对ZSNK10，SZNK11和ZSNK12多肽的抗体。

2. 发明申请

WO0146232A3 SOLUBLE INTERLEUKIN-20 RECEPTOR 审中-公开
标题翻译：可溶性INTERLEUKIN-20受体
公开(公告)号：WO0146232A3
公开(公告)日：2002-02-21
申请号：PCT/US0035307
申请日：2000-12-22
申请人： ZYMOGENETICS INC
发明人： FOSTER DONALD C , XU WENFENG , MADDEN KAREN L , KELLY JAMES D , SPRECHER CINDY A , BRANDT CAMERON S , RIXON MARK W , PRESNELL SCOTT R , FOX BRIAN A
IPC分类号： C12N15/09 , A61K38/00 , A61P17/06 , A61P29/00 , C07K14/54 , C07K14/705 , C07K16/00 , C07K14/715 , C12N15/62
CPC分类号： C07K14/7056 , A61K38/00 , C07K2319/00
摘要： A soluble receptor to IL-20 having two polypeptide subunits, IL-20RA (formerly called ZcytoR7) and IL-20RB (formerly called DIRS1). The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.
摘要翻译：具有两个多肽亚单位IL-20RA（以前称为ZcytoR7）和IL-20RB（以前称为DIRS1）的IL-20的可溶性受体。两个亚基优选连接在一起。在一个实施方案中，一个亚基与免疫球蛋白的轻链的恒定区融合，另一个亚基与免疫球蛋白的重链的恒定区融合。轻链和重链通过二硫键连接。

3. 发明申请

WO2005054290A3 PEPTIDE HORMONES ZALPHA48 AND ZSIG97 审中-公开
标题翻译： PEPTIDE HORMONES ZALPHA48和ZSIG97
公开(公告)号：WO2005054290A3
公开(公告)日：2005-09-01
申请号：PCT/US2004039908
申请日：2004-11-24
申请人： ZYMOGENETICS INC , SHEPPARD PAUL O , FOX BRIAN A
发明人： SHEPPARD PAUL O , FOX BRIAN A
IPC分类号： A61K38/00 , A61K38/22 , C07K14/435 , C07K14/47 , C07K14/575 , C07K16/26 , G01N33/574 , G01N33/74 , C12N15/16 , C12N15/62 , G01N33/50
CPC分类号： C07K14/47 , A61K38/00 , C07K14/575 , G01N33/57407 , G01N33/57434 , G01N33/74 , G01N2500/10
摘要： The present invention relates to polynucleotide and polypeptide molecules for zalpha48 and zsig97, two proteins that define a novel peptide hormone family. The DNA encoding the peptides and the encoded peptides are useful in treating disorders of the thyroid, prostate, neural dysfunction, immune dysfunction, diseases of the pancreas, adrenal gland, ovary, and pituitary. The present invention also includes methods for producing the protein, uses therefor and antibodies therefore.
摘要翻译：本发明涉及zalpha48和zsig97的多核苷酸和多肽分子，其定义了新的肽激素家族的两种蛋白质。编码肽和编码肽的DNA可用于治疗甲状腺，前列腺，神经功能障碍，免疫功能障碍，胰腺，肾上腺，卵巢和垂体疾病的病症。本发明还包括用于生产蛋白质的方法，其用途和抗体。

4. 发明申请

WO0202627A3 INTERFERON-LIKE PROTEIN ZCYTO21 审中-公开
标题翻译：类似蛋白质的ZCYTO21
公开(公告)号：WO0202627A3
公开(公告)日：2003-01-03
申请号：PCT/US0121087
申请日：2001-06-29
申请人： ZYMOGENETICS INC
发明人： SHEPPARD PAUL O , PRESNELL SCOTT R , FOX BRIAN A , GILBERT TERESA , HALDEMAN BETTY A , GRANT FRANCIS J
IPC分类号： G01N33/53 , C07H21/02 , C07H21/04 , C07K14/47 , C07K14/52 , C07K14/555 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N9/99 , C12N15/09 , C12N15/19 , C12N15/21 , C12N15/74 , C12P21/02 , C12P21/04 , C12P21/06 , C12Q1/68 , G01N33/566
CPC分类号： C07K14/47 , C07K14/52 , C07K2319/00
摘要： The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon- alpha at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.
摘要翻译：本发明涉及用于Zcyto21的多核苷酸和多肽分子，干扰素样蛋白与氨基酸序列水平上的干扰素-α最相关。本发明还包括对Zcyto21多肽的抗体，以及使用多核苷酸和多肽的方法。

5. 发明申请

WO0147958A3 KUNITZ DOMAIN POLYPEPTIDE ZKUN10 审中-公开
公开(公告)号：WO0147958A3
公开(公告)日：2002-01-03
申请号：PCT/US0035709
申请日：2000-12-28
申请人： ZYMOGENETICS INC
发明人： SHEPPARD PAUL O , FOX BRIAN A
IPC分类号： A61K38/00 , C07K14/755 , C07K14/81 , C12N9/64
CPC分类号： C07K14/8114 , A61K38/00 , C07K14/755 , C07K2319/00 , C12N2799/022
摘要： Proteinase inhibitors comprising a Kunitz domain are disclosed. The Kunitz domain comprises a motif of amino acid residues as shown in SEQ ID NO:4, and the sequence of the Kunitz domain is shown in residues 57 through 107 of SEQ ID NO:2. The polypeptide also includes an N-terminal collagen domain in which a von Willebrand domain resides, and is shown in SEQ ID NO:5. Also disclosed are methods for making the proteinase inhibitors, and expression vectors and cultured cells that are useful within the methods. The proteinase inhibitors may be used as components of cell culture media, in protein purification, and as inhibitors of protease degradation of plasma proteins.
摘要翻译：公开了包含Kunitz结构域的蛋白酶抑制剂。 Kunitz结构域包含如SEQ ID NO：4所示的氨基酸残基的基序，Kunitz结构域的序列显示于SEQ ID NO：2的残基57至107中。多肽还包括其中von Willebrand结构域所在的N-末端胶原结构域，并且显示在SEQ ID NO：5中。还公开了制备蛋白酶抑制剂，表达载体和在该方法中有用的培养细胞的方法。蛋白酶抑制剂可以用作细胞培养基的组分，蛋白质纯化，以及作为血浆蛋白质蛋白酶降解的抑制剂。

6. 发明申请

WO2008140565A3 USE OF TUMOR NECROSIS FACTOR RECEPTOR 14 ANTAGONISTS FOR TREATING PSORIASIS 审中-公开
标题翻译：肿瘤坏死因子受体的使用14治疗PSORIASIS的拮抗剂
公开(公告)号：WO2008140565A3
公开(公告)日：2009-06-11
申请号：PCT/US2007084140
申请日：2007-11-08
申请人： ZYMOGENETICS INC , FOX BRIAN A , HOLLOWAY JAMES L , SHEPPARD PAUL O , DILLON STACEY R
发明人： FOX BRIAN A , HOLLOWAY JAMES L , SHEPPARD PAUL O , DILLON STACEY R
IPC分类号： A61K39/395 , A61K38/17 , A61P1/00 , A61P17/06 , A61P37/00
CPC分类号： C07K16/2878 , A61K38/177 , A61K2039/505 , C07K2317/34 , C07K2317/70 , C07K2317/73 , C07K2319/30
摘要： Novel tumor necrosis factor receptor (TNFR) polypeptides, polynucleotides encoding the polypeptides, antibodies and related compositions and methods are disclosed. The polypeptides may be used for detecting ligand, as well as agonists and antagonists. The polypeptides, polynucleotides and antibodies may also be used in methods that modulate tumor growth, metastasis, and immunity such as separating resting from stimulated immune cells.
摘要翻译：公开了新型肿瘤坏死因子受体（TNFR）多肽，编码多肽的多核苷酸，抗体及相关组合物和方法。多肽可用于检测配体，以及激动剂和拮抗剂。多肽，多核苷酸和抗体也可以用于调节肿瘤生长，转移和免疫的方法，例如从刺激的免疫细胞分离休息。

7. 发明申请

WO2007030803A9 METHOD FOR PREPARING TRIMERIC PROTEINS 审中-公开
标题翻译：制备TRIMERIC蛋白的方法
公开(公告)号：WO2007030803A9
公开(公告)日：2008-05-29
申请号：PCT/US2006035225
申请日：2006-09-11
申请人： ZYMOGENETICS INC , MOORE MARGARET D , FOX BRIAN A
发明人： MOORE MARGARET D , FOX BRIAN A
IPC分类号： C12N15/63
CPC分类号： C12N15/62 , A61K38/00 , C07K14/005 , C07K14/705 , C07K2319/03 , C07K2319/81 , C12N2740/10022 , C12N2740/13022
摘要： The present invention relates to a method of preparing a trimeric protein comprising culturing a host cell transformed or transfected with an expression vector encoding a fusion protein comprising a ZymoZipper (ZZ) domain and a heterologous protein. In one embodiment, the heterologous protein is a membrane protein, the portion of the heterologous protein that included in the fusion protein is the extracellular domain of that protein, and the resulting fusion protein is soluble. In another embodiment of the present invention, the ZZ domain is derived from the transmembrane (TM) subunit of a virus envelope protein or another heptad repeat containing gene of a virus genome. The method can be used to produced homo- and hetero-trimeric proteins. The present invention also encompasses DNA molecules, expression vectors, and host cells used in the present method and fusion proteins produced by the present method.
摘要翻译：本发明涉及三聚蛋白的制备方法，其包括用编码包含ZymoZipper（ZZ）结构域和异源蛋白质的融合蛋白的表达载体转化或转染的宿主细胞。在一个实施方案中，异源蛋白质是膜蛋白，融合蛋白中包含的异源蛋白质的部分是该蛋白质的细胞外结构域，并且所得的融合蛋白质是可溶的。在本发明的另一个实施方案中，ZZ结构域衍生自病毒包膜蛋白的跨膜（TM）亚基或其它含有病毒基因组的七重复重复基因。该方法可用于产生同型和异三聚体蛋白质。本发明还包括本方法中使用的DNA分子，表达载体和宿主细胞以及通过本发明方法产生的融合蛋白。

8. 发明申请

WO0129224A3 GRANULOCYTE PEPTIDE HOMOLOG ZGPA1 审中-公开
公开(公告)号：WO0129224A3
公开(公告)日：2002-02-07
申请号：PCT/US0029177
申请日：2000-10-20
申请人： ZYMOGENETICS INC
发明人： CONKLIN DARRELL C , ADLER DAVID A , FOX BRIAN A
IPC分类号： C07K14/47 , C12N1/21 , C12N15/12 , C07K16/18 , C12N15/62 , C12Q1/68 , G01N33/68
CPC分类号： C07K14/47
摘要： Novel granulocyte peptide homolog zgpal polypeptides, materials and methods for making them, and method of use are disclosed. The polypeptides comprise at least nine contiguous amino acid residues of SEQ ID NO:5 OR SEQ ID NO:8, and may be prepared as polypeptide fusions that comprise heterologous sequences, such as chimeric polypeptides and affinity tags. The polypeptides and polynucleotides encoding them, and antibodies thereto may be used within a variety of therapeutic, diagnostic, and research applications.
摘要翻译：公开了新型粒细胞肽同系物多肽，其制备方法及其使用方法。多肽包含SEQ ID NO：5或SEQ ID NO：8的至少九个连续氨基酸残基，并且可以制备成包含异源序列的多肽融合体，例如嵌合多肽和亲和标签。编码它们的多肽和多核苷酸及其抗体可用于多种治疗，诊断和研究应用。

9. 发明申请

WO2009046407A3 B7 FAMILY MEMBER zB7H6 AND RELATED COMPOSITIONS AND METHODS 审中-公开
标题翻译： B7家族成员zB7H6及相关组合物和方法
公开(公告)号：WO2009046407A3
公开(公告)日：2011-05-19
申请号：PCT/US2008078911
申请日：2008-10-06
申请人： ZYMOGENETICS INC , BRANDT CAMERON S , KENNEDY JACOB J , XU WENFENG , YI EUGENE C , FOX BRIAN A , GAO ZEREN , SIVAKUMAR PALLAVUR V
发明人： BRANDT CAMERON S , KENNEDY JACOB J , XU WENFENG , YI EUGENE C , FOX BRIAN A , GAO ZEREN , SIVAKUMAR PALLAVUR V
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2827 , A61K47/6851 , A61K2039/505 , C07K14/70532 , C07K2317/21 , C07K2317/24 , C07K2317/30 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2319/30 , G01N33/5011 , G01N2333/705 , G01N2500/02
摘要： Disclosed is a newly identified B7 family member, zB7H6, which functions as a counter-receptor for the NK cell triggering receptor, NKp30. Methods and compositions for modulating NKp30-mediated NK cell activity based on the interaction of zB7H6 with NKp30, as well as related screening methods, are also disclosed. Further disclosed are anti-zB7H6 antibodies as well as antibody-drug conjugates comprising an anti-zB7H6 antibody conjugated to a therapeutic agent, including methods for using such antibodies and antibody-drug conjugates to exert therapeutic effects against zB7H6-expressing cells.
摘要翻译：公开了一种新鉴定的B7家族成员，zB7H6，其作为NK细胞触发受体NKp30的反受体。还公开了基于zB7H6与NKp30的相互作用调节NKp30介导的NK细胞活性的方法和组合物以及相关筛选方法。还公开了抗zB7H6抗体以及包含与治疗剂缀合的抗-zB7H6抗体的抗体 - 药物偶联物，包括使用这种抗体和抗体 - 药物偶联物对表达zB7H6的细胞施加治疗效果的方法。

10. 发明申请

WO2006074389A3 FOUR-HELICAL BUNDLE PROTEIN ZSIG99 审中-公开
标题翻译：四联蛋白ZSIG99
公开(公告)号：WO2006074389A3
公开(公告)日：2006-11-02
申请号：PCT/US2006000494
申请日：2006-01-06
申请人： ZYMOGENETICS INC , FOX BRIAN A , WEST JAMES W , TANNHEIMER STACEY
发明人： FOX BRIAN A , WEST JAMES W , TANNHEIMER STACEY
IPC分类号： C07K14/54 , C07K16/24 , C07K19/00 , C12N15/10 , G01N33/53
CPC分类号： C07K14/52 , C07K14/5415
摘要： A four helical bundle cytokine has been identified and designated zsig99. The polypeptide is 201 amino acids in length with the mature polypeptide starting at residue 43 as is shown in SEQ ID NO:2. When the zsig99 polynucleotide is co-expressed with a polynucleotide encoding for leukemia inhibitory factor (LIF), a heterodimer comprising zsig99 and LIF is secreted. Also disclosed are antibodies to zsig99, methods for producing the polypeptide using expression vectors and host cells. Diagnostic methods for identifying the presence of zsig99 polypeptide are also disclosed.
摘要翻译：已经鉴定了四种螺旋束细胞因子并命名为zsig99。该多肽长度为201个氨基酸，成熟多肽从残基43开始，如SEQ ID NO：2所示。当zsig99多核苷酸与编码白血病抑制因子（LIF）的多核苷酸共同表达时，分泌包含zsig99和LIF的异源二聚体。还公开了针对zsig99的抗体，使用表达载体和宿主细胞产生多肽的方法。还公开了用于鉴定zsig99多肽的存在的诊断方法。

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