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1. 发明申请

WO2005041883A3 REDUCTION OF UNINTENDED USE OF TRANSDERMAL DEVICES 审中-公开
标题翻译：减少意外使用变形设备
公开(公告)号：WO2005041883A3
公开(公告)日：2005-11-17
申请号：PCT/US2004036131
申请日：2004-10-28
申请人： ZARS INC , WARNER KEVIN S , ASHBURN MICHAEL A , NIU SUYI
发明人： WARNER KEVIN S , ASHBURN MICHAEL A , NIU SUYI
IPC分类号： A61F13/00 , A61K20060101 , A61K9/70 , A61K49/00
CPC分类号： A61K9/7023 , B09B3/0075 , B09B2220/14
摘要： The present invention is drawn to systems and methods for reducing unintended use of an active ingredient, such as residual active ingredients present in spent dermal patches and peels. The system can include a dermal patch including an active ingredient and a destructive agent configured to chemically react with the active ingredient. The destructive agent can be present in a container or an absorber. In one embodiment, the absorber can be used within the container. The container can be configured to receive the dermal patch such that the active ingredient contacts the destructive agent within the container. The absorber can be configured to contact the dermal patch such that the active ingredient contacts the destructive agent of the absorber. Additionally, systems and methods for impeding the unintended use of an active ingredient, such as those present in dermal patches or peels, are also provided. The system includes a dermal patch having a first side configured to deliver an active ingredient to a skin or mucosal surface, wherein the first side also includes a dermal adhesive. The system also includes an adhesive-coated device. The adhesive-coated surface of the device can be configured to adhere to the first side, wherein upon use of the dermal patch followed by contacting the adhesive-coated surface with the first side, residual active ingredient is rendered substantially inaccessible.
摘要翻译：本发明涉及用于减少活性成分的非预期用途的系统和方法，所述活性成分例如存在于有效皮肤贴剂和皮肤中的残留活性成分。该系统可以包括皮肤贴片，其包括配置成与活性成分发生化学反应的活性成分和破坏剂。破坏剂可存在于容器或吸收器中。在一个实施例中，吸收器可以在容器内使用。容器可以被配置为接收皮肤贴片，使得活性成分与容器内的破坏剂接触。吸收器可以被配置为接触皮肤贴片，使得活性成分与吸收体的破坏剂接触。此外，还提供了用于阻止意图使用活性成分（例如存在于真皮贴剂或皮肤中的那些）的系统和方法。该系统包括皮肤贴片，其具有构造成将活性成分递送至皮肤或粘膜表面的第一侧，其中第一面还包括真皮粘合剂。该系统还包括涂有粘合剂的装置。装置的粘合剂涂覆的表面可以被配置为粘附到第一侧，其中在使用皮肤贴片然后使粘合剂涂覆的表面与第一面接触时，残留的活性成分基本上不可接近。

2. 发明申请

WO2005120473A3 DERMAL PEEL-FORMING FORMULATION 审中-公开
标题翻译： DERMAL PEEL-FORMING制剂
公开(公告)号：WO2005120473A3
公开(公告)日：2006-05-11
申请号：PCT/US2005020099
申请日：2005-06-07
申请人： ZARS INC , ZHANG JIE , WARNER KEVIN S , ASHBURN MICHAEL A , RIGBY LARRY D , NIU SUYI
发明人： ZHANG JIE , WARNER KEVIN S , ASHBURN MICHAEL A , RIGBY LARRY D , NIU SUYI
IPC分类号： A61F13/00 , A61K9/70
CPC分类号： A61K9/7015 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/445 , A61K31/573 , A61K47/10 , A61K47/32
摘要： The present invention is drawn to adhesive peel-forming formulations for dermal delivery of a drug. The formulation can include a drug, a solvent vehicle, and a peel-forming agent. The solvent vehicle can include a volatile solvent system having one or more volatile solvent, and a non-volatile solvent system having one or more non-volatile solvent, wherein the non-volatile solvent system has a solubility for the drug that is within a window of operable solubility for the drug such that the drug can be delivered at therapeutically effective rates over a sustained period of time. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified peelable layer after at least a portion of the volatile solvent system is evaporated.
摘要翻译：本发明涉及用于药物真皮递送的粘合剂剥离形成制剂。制剂可以包括药物，溶剂载体和剥离形成剂。溶剂载体可以包括具有一种或多种挥发性溶剂的挥发性溶剂体系和具有一种或多种非挥发性溶剂的非挥发性溶剂体系，其中所述非挥发性溶剂体系对于在窗口内的药物具有溶解性对于药物具有可操作的溶解性，使得药物可以在持续的时间段内以治疗有效的速率递送。在挥发性溶剂体系蒸发之前，配方可以具有适用于皮肤表面的粘度。当施用于皮肤时，在挥发性溶剂系统的至少一部分蒸发之后，制剂可以形成固化的可剥离层。

3. 发明申请

WO2005117905A3 SYSTEMS AND METHODS FOR TREATING PANIC ATTACKS 审中-公开
标题翻译：处理泛型攻击的系统和方法
公开(公告)号：WO2005117905A3
公开(公告)日：2006-06-01
申请号：PCT/US2005018555
申请日：2005-05-27
申请人： ZARS INC , ZHANG JIE , WARNER KEVIN S , ASHBURN MICHAEL A
发明人： ZHANG JIE , WARNER KEVIN S , ASHBURN MICHAEL A
IPC分类号： A61F13/00 , A61F7/02 , A61F7/03 , A61K9/00 , A61K9/70 , A61K31/4468 , A61K31/4535 , A61K31/66 , A61K47/10 , A61K47/14 , A61K47/22 , A61K47/32 , A61M31/00 , A61M37/00 , A61N1/30
CPC分类号： A61K9/0014 , A61F7/032 , A61F7/034 , A61F2007/0261 , A61F2013/00187 , A61F2013/00204 , A61F2013/00906 , A61F2013/0091 , A61K9/0009 , A61K9/0024 , A61K9/7053 , A61K9/7069 , A61K31/4468 , A61K31/4535 , A61K31/66 , A61K47/10 , A61K47/14 , A61K47/22 , A61K47/32 , A61M31/002 , A61M37/00 , A61M2037/0007 , A61N1/30
摘要： Systems and methods for attenuating a panic attack are provided. Such methods can comprise steps of delivering a drug to a subject such that the drug forms a depot (22) beneath a skin surface, wherein the drug is suitable for attenuating a panic attack if delivered in a pharmaceutically effective amount into systemic circulation of the subject; and applying heat (28) to the skin surface when the subject experiences an onset of the panic attack, thereby causing the pharmaceutically effective amount of the drug to rapidly enter systemic circulation from the depot.
摘要翻译：提供了用于减轻恐慌发作的系统和方法。这样的方法可以包括将药物递送到受试者的步骤，使得药物在皮肤表面下形成贮存库（22），其中该药物适于减少惊厥发作，如果以药学有效量递送到受试者的全身循环中 ; 以及当受试者经历恐慌发作的开始时将热量（28）施加到皮肤表面，从而使药物有效量的药物迅速地从贮库中进入系统循环。

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