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1. 发明申请

WO2007070694A3 SPRAY-ON FORMULATIONS AND METHODS FOR DERMAL DELIVERY OF DRUGS 审中-公开
公开(公告)号：WO2007070694A3
公开(公告)日：2007-06-21
申请号：PCT/US2006/048060
申请日：2006-12-14
申请人： ZARS, INC. , ZHANG, Jie , WARNER, Kevin, S. , SHARMA, Sanjay
发明人： ZHANG, Jie , WARNER, Kevin, S. , SHARMA, Sanjay
IPC分类号： A61K9/12
摘要： The present invention is drawn to sprayable formulations, methods of drug delivery, and resultant solidified layers for dermal delivery of a drug. The formulation can include a drug, a non-volatile solvent system, a solidifying agent, and a propellant. The formulation can have an initial viscosity suitable to be expelled out of a pressurized or manual pump container and applied onto a skin surface as a layer. When applied to the skin, the formulation can form a solidified layer after at least a portion of the propellant is evaporated.

2. 发明申请

WO2006053222A2 INSTANT PATCH FOR DERMAL DRUG DELIVERY 审中-公开
标题翻译：用于真菌药物递送的实际配对
公开(公告)号：WO2006053222A2
公开(公告)日：2006-05-18
申请号：PCT/US2005/040938
申请日：2005-11-11
申请人： ZARS, INC. , ZHANG, Jie , WARNER, Kevin, S.
发明人： ZHANG, Jie , WARNER, Kevin, S.
IPC分类号： A61F13/02 , A61L15/16
CPC分类号： A61K9/703 , A61K9/7084 , A61L15/16 , A61L15/44 , A61L15/60 , A61L2300/40 , A61L2300/602
摘要： The present invention is drawn toward systems, devices, and methods of dermal drug delivery. The system can comprise a gel-triggering agent and a drug-containing composition including a drug and a gelling agent, wherein the drug-containing composition forms a soft, coherent solid when contacted with the gell-triggering agent. A cavity patch (10) is also included having an open cavity (18) configured to be closed at least in part by a skin surface (44). The open cavity can be further configured to facilitate contact between the skin surface and the gel. The gel-triggering agent and the drug-containing composition can be positioned in the system such that they are kept isolated from one another until immediately before or during use.
摘要翻译：本发明涉及皮肤药物递送的系统，装置和方法。该系统可以包含凝胶引发剂和包含药物和胶凝剂的药物组合物，其中当与凝胶引发剂接触时，含药组合物形成柔软的粘连固体。还包括空腔贴片（10），其具有被构造为至少部分地由皮肤表面（44）封闭的开放空腔（18）。开放空腔可进一步构造成促进皮肤表面和凝胶之间的接触。凝胶引发剂和含药物的组合物可以定位在系统中，使得它们彼此隔离直到使用前或使用前。

3. 发明申请

WO2007070679A2 COMPOSITIONS AND METHODS FOR DERMALLY TREATING PAIN 审中-公开
标题翻译：用于牙痛治疗的组合物和方法
公开(公告)号：WO2007070679A2
公开(公告)日：2007-06-21
申请号：PCT/US2006/047926
申请日：2006-12-14
申请人： ZARS, INC. , ZHANG, Jie , WARNER, Kevin, S. , SHARMA, Sanjay
发明人： ZHANG, Jie , WARNER, Kevin, S. , SHARMA, Sanjay
IPC分类号： A61K9/12
CPC分类号： A61K9/0014 , A61K47/10 , A61K47/18
摘要： The present invention is drawn to solidifying formulations for dermal delivery of a drug for treating pain, such as musculoskeletal pain, inflammation, joint pain, or neuropathic pain. The formulation can include a drug selected from certain drug classes, a solvent vehicle, and a solidifying agent. The solvent vehicle can include a volatile solvent system comprising at least one volatile solvent, and a non-volatile solvent system comprising at least one non-volatile solvent, wherein the evaporation of at least some of the volatile solvent converts the formulation on the skin into a solidified layer and the non-volatile solvent system is capable of facilitating the topical delivery of the drug(s) at therapeutically effective rates over a sustained period of time.
摘要翻译：本发明涉及用于皮肤递送用于治疗疼痛的药物如肌肉骨骼疼痛，炎症，关节疼痛或神经性疼痛的固化制剂。制剂可以包括选自某些药物类别的药物，溶剂载体和固化剂。溶剂载体可以包括包含至少一种挥发性溶剂的挥发性溶剂体系和包含至少一种非挥发性溶剂的非挥发性溶剂体系，其中至少一些挥发性溶剂的蒸发将皮肤上的制剂转化成固化层和非挥发性溶剂体系能够在持续的时间内以治疗有效的速率促进药物的局部递送。

4. 发明申请

WO2007070643A2 COMPOSITIONS AND METHODS FOR TREATING DERMATOLOGICAL CONDITIONS 审中-公开
标题翻译：用于治疗皮肤病症的组合物和方法
公开(公告)号：WO2007070643A2
公开(公告)日：2007-06-21
申请号：PCT/US2006/047747
申请日：2006-12-14
申请人： ZARS, INC. , ZHANG, Jie , WARNER, Kevin, S. , SHARMA, Sanjay
发明人： ZHANG, Jie , WARNER, Kevin, S. , SHARMA, Sanjay
IPC分类号： A61K9/12
CPC分类号： A61K9/0014 , A61K9/7015
摘要： The present invention is drawn to solidifying adhesive formulations, methods of drug delivery, and solidified layers for dermal delivery of a drug which can treat various dermatological conditions, such as a bacterial infection, a virus infection, a fungal infection, alopecia, dermatitis, psoriasis, or photo damaged skin. The formulation can include a drug, a solvent vehicle, and a solidifying agent. The solvent vehicle can include a volatile solvent system including at least one volatile solvent, and a non-volatile solvent system including at least one non-volatile solvent. The non-volatile solvent system can facilitate the delivery of the drug at therapeutically effective rates for sustained period of time. The non-volatile solvent system can also act as a plasticizer for the solidifying agent. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified layer after at least a portion of the volatile solvent system is evaporated.
摘要翻译：本发明涉及固化粘合剂制剂，药物递送方法和用于皮肤递送药物的固化层，其可以治疗各种皮肤病学条件，例如细菌感染，病毒感染，真菌感染，脱发，皮炎，牛皮癣，或照片损伤的皮肤。制剂可以包括药物，溶剂载体和固化剂。溶剂载体可以包括包含至少一种挥发性溶剂的挥发性溶剂体系和包含至少一种非挥发性溶剂的非挥发性溶剂体系。非挥发性溶剂体系可以有助于以治疗有效率持续持续的时间递送药物。非挥发性溶剂体系也可以作为固化剂的增塑剂。在挥发性溶剂体系蒸发之前，配方可以具有适用于皮肤表面的粘度。当施用于皮肤时，在挥发性溶剂体系的至少一部分蒸发后，制剂可以形成固化层。

5. 发明申请

WO2006053223A2 SYSTEMS AND METHODS FOR TREATING WARTS 审中-公开
标题翻译：用于处理警告的系统和方法
公开(公告)号：WO2006053223A2
公开(公告)日：2006-05-18
申请号：PCT/US2005/040939
申请日：2005-11-11
申请人： ZARS, INC. , ZHANG, Jie , WARNER, Kevin, S.
发明人： ZHANG, Jie , WARNER, Kevin, S.
IPC分类号： A61F13/02 , A61L15/16
CPC分类号： A61K9/703 , A61F13/063 , A61K9/7084 , A61L15/16 , A61L15/44 , A61L15/60 , A61L2300/40 , A61L2300/602
摘要： The present invention is drawn to systems and methods for treating warts. The system can comprise a wart treatment formulation comprising a substance for treating warts and a cavity patch (10) comprising an open cavity (18) being configured to become a closed cavity upon application and adherence to a skin surface (44). The closed cavity can be configured to contain the wart treatment formulation.
摘要翻译：本发明涉及用于治疗疣的系统和方法。该系统可以包括疣治疗制剂，该制剂包含用于治疗疣的物质和包含开放腔体（18）的空腔补片（10），该开放空腔被配置为在施加和粘附到皮肤表面（44）时变成封闭空腔。封闭的腔体可以配置成容纳疣处理制剂。

6. 发明申请

WO2005120473A2 ADHESIVE PEEL-FORMING FORMULATIONS FOR DERMAL DELIVERY OF DRUGS AND METHODS OF USING THE SAME 审中-公开
标题翻译：用于药物递送的胶粘剂成型制剂及其使用方法
公开(公告)号：WO2005120473A2
公开(公告)日：2005-12-22
申请号：PCT/US2005/020099
申请日：2005-06-07
申请人： ZARS, INC. , ZHANG, Jie , WARNER, Kevin, S. , ASHBURN, Michael, A. , RIGBY, Larry, D. , NIU, Suyi
发明人： ZHANG, Jie , WARNER, Kevin, S. , ASHBURN, Michael, A. , RIGBY, Larry, D. , NIU, Suyi
IPC分类号： A61K9/70
CPC分类号： A61K9/7015 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/445 , A61K31/573 , A61K47/10 , A61K47/32
摘要： The present invention is drawn to adhesive peel-forming formulations for dermal delivery of a drug. The formulation can include a drug, a solvent vehicle, and a peel-forming agent. The solvent vehicle can include a volatile solvent system having one or more volatile solvent, and a non-volatile solvent system having one or more non-volatile solvent, wherein the non-volatile solvent system has a solubility for the drug that is within a window of operable solubility for the drug such that the drug can be delivered at therapeutically effective rates over a sustained period of time. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified peelable layer after at least a portion of the volatile solvent system is evaporated.
摘要翻译：本发明涉及用于药物真皮递送的粘合剂剥离形成制剂。制剂可以包括药物，溶剂载体和剥离形成剂。溶剂载体可以包括具有一种或多种挥发性溶剂的挥发性溶剂体系和具有一种或多种非挥发性溶剂的非挥发性溶剂体系，其中所述非挥发性溶剂体系对于在窗口内的药物具有溶解性对药物具有可操作的溶解性，使得药物可以在持续的时间段内以治疗有效的速率递送。在挥发性溶剂体系蒸发之前，配方可以具有适用于皮肤表面的粘度。当施用于皮肤时，在挥发性溶剂体系的至少一部分蒸发之后，制剂可以形成固化的可剥离层。

7. 发明申请

WO2005117905A2 SYSTEMS AND METHODS FOR TREATING PANIC ATTACKS 审中-公开
标题翻译：处理泛型攻击的系统和方法
公开(公告)号：WO2005117905A2
公开(公告)日：2005-12-15
申请号：PCT/US2005/018555
申请日：2005-05-27
申请人： ZARS, INC. , ZHANG, Jie , WARNER, Kevin, S. , ASHBURN, Michael, A.
发明人： ZHANG, Jie , WARNER, Kevin, S. , ASHBURN, Michael, A.
IPC分类号： A61K31/66
CPC分类号： A61K9/0014 , A61F7/032 , A61F7/034 , A61F2007/0261 , A61F2013/00187 , A61F2013/00204 , A61F2013/00906 , A61F2013/0091 , A61K9/0009 , A61K9/0024 , A61K9/7053 , A61K9/7069 , A61K31/4468 , A61K31/4535 , A61K31/66 , A61K47/10 , A61K47/14 , A61K47/22 , A61K47/32 , A61M31/002 , A61M37/00 , A61M2037/0007 , A61N1/30
摘要： Systems and methods for attenuating a panic attack are provided. Such methods can comprise steps of delivering a drug to a subject such that the drug forms a depot (22) beneath a skin surface, wherein the drug is suitable for attenuating a panic attack if delivered in a pharmaceutically effective amount into systemic circulation of the subject; and applying heat (28) to the skin surface when the subject experiences an onset of the panic attack, thereby causing the pharmaceutically effective amount of the drug to rapidly enter systemic circulation from the depot.
摘要翻译：提供了用于衰减紧急袭击的系统和方法。这样的方法可以包括将药物递送到受试者的步骤，使得药物在皮肤表面下形成贮库（22），其中该药物适合于如果以药学有效量递送到受试者的全身循环中 ; 以及当受试者经历恐慌发作的开始时将热量（28）施加到皮肤表面，从而导致药物有效量的药物迅速地从贮库中进入系统循环。

8. 发明申请

WO2007100376A3 COMPOSITIONS AND METHODS FOR DERMAL DELIVERY OF DRUGS 审中-公开
公开(公告)号：WO2007100376A3
公开(公告)日：2007-09-07
申请号：PCT/US2006/048059
申请日：2006-12-14
申请人： ZARS, INC. , ZHANG, Jie , WARNER, Kevin, S. , SHARMA, Sanjay
发明人： ZHANG, Jie , WARNER, Kevin, S. , SHARMA, Sanjay
IPC分类号： A61F13/00
摘要： The present invention is drawn to adhesive formulations, methods of drug delivery, and solidified layers for dermal delivery of a drug. The formulation can include a drug, a solvent vehicle, and at least one solidifying agent. The solvent vehicle can have a volatile solvent system including at least one volatile solvent, and a non-volatile solvent system including at least one non-volatile solvent. The formulation can be formulated to contain at least two volatile solvents, at least two non-volatile solvents, or at least two solidifying agents. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified layer after at least a portion of the volatile solvent system is evaporated.

9. 发明申请

WO2007070695A2 FLUX-ENABLING COMPOSITIONS AND METHODS FOR DERMAL DELIVERY OF DRUGS 审中-公开
标题翻译：助燃剂组合物和用于药物递送的方法
公开(公告)号：WO2007070695A2
公开(公告)日：2007-06-21
申请号：PCT/US2006/048061
申请日：2006-12-14
申请人： ZARS, INC. , ZHANG, Jie , WARNER, Kevin, S. , SHARMA, Sanjay
发明人： ZHANG, Jie , WARNER, Kevin, S. , SHARMA, Sanjay
IPC分类号： A61K9/12
CPC分类号： A61K9/7015 , A61K9/0014 , A61K9/0017
摘要： The present invention is drawn to adhesive solidifying formulations, methods of drug delivery, and solidified layers for dermal delivery of a drug. The formulation can include a drug, a solvent vehicle, and a solidifying agent. The solvent vehicle can include a volatile solvent system comprising at least one volatile solvent, and a non-volatile solvent system comprising at least one non-volatile solvent, wherein at least one non-volatile solvent is a flux-enabling non-volatile solvent(s) capable of facilitating the delivery of the drug at therapeutically effective rates over a sustained period of time. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified layer after at least a portion of the volatile solvent system is evaporated.
摘要翻译：本发明涉及粘合剂凝固制剂，药物递送方法和用于药物真皮递送的固化层。制剂可以包括药物，溶剂载体和固化剂。溶剂载体可以包括包含至少一种挥发性溶剂的挥发性溶剂体系和包含至少一种非挥发性溶剂的非挥发性溶剂体系，其中至少一种非挥发性溶剂是助熔剂非挥发性溶剂（ s），其能够在持续的时间段内以治疗有效率促进药物的递送。在挥发性溶剂体系蒸发之前，配方可以具有适用于皮肤表面的粘度。当施用于皮肤时，在挥发性溶剂体系的至少一部分蒸发后，制剂可以形成固化层。

10. 发明申请

WO2008106220A1 TRANSDERMAL DRUG DELIVERY SYSTEMS FOR DELIVERY WITH CONTROLLED HEAT 审中-公开
标题翻译：用控制热量输送的超导药物输送系统
公开(公告)号：WO2008106220A1
公开(公告)日：2008-09-04
申请号：PCT/US2008/002700
申请日：2008-02-28
申请人： ZARS PHARMA, INC. , ZHANG, Jie , WARNER, Kevin, S. , NUI, Suyi , STRONG, Nathan , NELSON, Randal , VAWDRY, Alan , IVERSON, Matt , WESSMAN, Mike
发明人： ZHANG, Jie , WARNER, Kevin, S. , NUI, Suyi , STRONG, Nathan , NELSON, Randal , VAWDRY, Alan , IVERSON, Matt , WESSMAN, Mike
IPC分类号： A61K9/70 , A61F7/00
CPC分类号： A61K9/7061 , A61K9/0004 , A61K31/192
摘要： Systems and methods for transdermal drug delivery with controlled heat are provided Such systems can comprise a heating apparatus that includes an exothermic chemical composition, typically in the form of individual heating elements. The heating apparatus can be exposed to ambient oxygen through a cover.The cover can reduce the amount of ambient oxygen capable of contacting the chemical composition compared to when the cover is not present. The systems can further include a drug-containing layer that includes a drug.The drug-containing layer can have a surface area of about 50 cm2 to about 400 cm2.The systems of the present invention can deliver ketoprofen in an amount sufficient to produce a mean blood plasma concentration of ketoprofen in a human subject of at least 45 ng/ml within four hours after initial application of the system to a skin surface.
摘要翻译：提供具有受控热的透皮药物递送的系统和方法这样的系统可以包括加热装置，其包括通常以个体加热元件形式的放热化学组成。加热装置可以通过盖暴露于环境氧气。与不存在盖时相比，该盖可以减少能够接触化学成分的环境氧的量。该系统可以进一步包括含药物的层，药物含有层可以具有约50cm 2至约400cm 2的表面积。本发明的系统可以以足以产生在将该系统初次应用于皮肤表面后的四小时内，人受试者中酮洛芬的平均血药浓度至少为45ng / ml。

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