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1. 发明申请

WO2007070695A3 FLUX-ENABLING COMPOSITIONS AND METHODS FOR DERMAL DELIVERY OF DRUGS 审中-公开
标题翻译：助燃剂组合物和用于药物递送的方法
公开(公告)号：WO2007070695A3
公开(公告)日：2008-08-21
申请号：PCT/US2006048061
申请日：2006-12-14
申请人： ZARS INC , ZHANG JIE , WARNER KEVIN S , SHARMA SANJAY
发明人： ZHANG JIE , WARNER KEVIN S , SHARMA SANJAY
IPC分类号： A61K8/02 , A61F13/00
CPC分类号： A61K9/7015 , A61K9/0014 , A61K9/0017
摘要： The present invention is drawn to adhesive solidifying formulations, methods of drug delivery, and solidified layers for dermal delivery of a drug. The formulation can include a drug, a solvent vehicle, and a solidifying agent. The solvent vehicle can include a volatile solvent system comprising at least one volatile solvent, and a non-volatile solvent system comprising at least one non-volatile solvent, wherein at least one non-volatile solvent is a flux-enabling non-volatile solvent(s) capable of facilitating the delivery of the drug at therapeutically effective rates over a sustained period of time. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified layer after at least a portion of the volatile solvent system is evaporated.
摘要翻译：本发明涉及粘合剂凝固制剂，药物递送方法和用于药物真皮递送的固化层。制剂可以包括药物，溶剂载体和固化剂。溶剂载体可以包括包含至少一种挥发性溶剂的挥发性溶剂体系和包含至少一种非挥发性溶剂的非挥发性溶剂体系，其中至少一种非挥发性溶剂是助熔剂非挥发性溶剂（ s），其能够在持续的时间段内以治疗有效率促进药物的递送。在挥发性溶剂体系蒸发之前，配方可以具有适用于皮肤表面的粘度。当施用于皮肤时，在挥发性溶剂体系的至少一部分蒸发后，制剂可以形成固化层。

2. 发明申请

WO2007070694A3 SPRAY-ON FORMULATIONS AND METHODS FOR DERMAL DELIVERY OF DRUGS 审中-公开
公开(公告)号：WO2007070694A3
公开(公告)日：2007-06-21
申请号：PCT/US2006/048060
申请日：2006-12-14
申请人： ZARS, INC. , ZHANG, Jie , WARNER, Kevin, S. , SHARMA, Sanjay
发明人： ZHANG, Jie , WARNER, Kevin, S. , SHARMA, Sanjay
IPC分类号： A61K9/12
摘要： The present invention is drawn to sprayable formulations, methods of drug delivery, and resultant solidified layers for dermal delivery of a drug. The formulation can include a drug, a non-volatile solvent system, a solidifying agent, and a propellant. The formulation can have an initial viscosity suitable to be expelled out of a pressurized or manual pump container and applied onto a skin surface as a layer. When applied to the skin, the formulation can form a solidified layer after at least a portion of the propellant is evaporated.

3. 发明申请

WO2006053222A2 INSTANT PATCH FOR DERMAL DRUG DELIVERY 审中-公开
标题翻译：用于真菌药物递送的实际配对
公开(公告)号：WO2006053222A2
公开(公告)日：2006-05-18
申请号：PCT/US2005/040938
申请日：2005-11-11
申请人： ZARS, INC. , ZHANG, Jie , WARNER, Kevin, S.
发明人： ZHANG, Jie , WARNER, Kevin, S.
IPC分类号： A61F13/02 , A61L15/16
CPC分类号： A61K9/703 , A61K9/7084 , A61L15/16 , A61L15/44 , A61L15/60 , A61L2300/40 , A61L2300/602
摘要： The present invention is drawn toward systems, devices, and methods of dermal drug delivery. The system can comprise a gel-triggering agent and a drug-containing composition including a drug and a gelling agent, wherein the drug-containing composition forms a soft, coherent solid when contacted with the gell-triggering agent. A cavity patch (10) is also included having an open cavity (18) configured to be closed at least in part by a skin surface (44). The open cavity can be further configured to facilitate contact between the skin surface and the gel. The gel-triggering agent and the drug-containing composition can be positioned in the system such that they are kept isolated from one another until immediately before or during use.
摘要翻译：本发明涉及皮肤药物递送的系统，装置和方法。该系统可以包含凝胶引发剂和包含药物和胶凝剂的药物组合物，其中当与凝胶引发剂接触时，含药组合物形成柔软的粘连固体。还包括空腔贴片（10），其具有被构造为至少部分地由皮肤表面（44）封闭的开放空腔（18）。开放空腔可进一步构造成促进皮肤表面和凝胶之间的接触。凝胶引发剂和含药物的组合物可以定位在系统中，使得它们彼此隔离直到使用前或使用前。

4. 发明申请

WO2005041883A2 SYSTEMS AND METHODS FOR REDUCING UNITENDED USE OF ACTIVE INGREDIENTS IN DERMAL DELIVERY DEVICES 审中-公开
标题翻译：用于减少在送货设备中使用活性成分的系统和方法
公开(公告)号：WO2005041883A2
公开(公告)日：2005-05-12
申请号：PCT/US2004/036131
申请日：2004-10-28
申请人： ZARS, INC. , WARNER, Kevin, S. , ASHBURN, Michael, A. , NIU, Suyi
发明人： WARNER, Kevin, S. , ASHBURN, Michael, A. , NIU, Suyi
IPC分类号： A61K
CPC分类号： A61K9/7023 , B09B3/0075 , B09B2220/14
摘要： The present invention is drawn to systems and methods for reducing unintended use of an active ingredient, such as residual active ingredients present in spent dermal patches and peels. The system can include a dermal patch including an active ingredient and a destructive agent configured to chemically react with the active ingredient. The destructive agent can be present in a container or an absorber. In one embodiment, the absorber can be used within the container. The container can be configured to receive the dermal patch such that the active ingredient contacts the destructive agent within the container. The absorber can be configured to contact the dermal patch such that the active ingredient contacts the destructive agent of the absorber. Additionally, systems and methods for impeding the unintended use of an active ingredient, such as those present in dermal patches or peels, are also provided. The system includes a dermal patch having a first side configured to deliver an active ingredient to a skin or mucosal surface, wherein the first side also includes a dermal adhesive. The system also includes an adhesive-coated device. The adhesive-coated surface of the device can be configured to adhere to the first side, wherein upon use of the dermal patch followed by contacting the adhesive-coated surface with the first side, residual active ingredient is rendered substantially inaccessible.
摘要翻译：本发明涉及用于减少活性成分的非预期用途的系统和方法，所述活性成分例如存在于有效皮肤贴剂和皮肤中的残留活性成分。该系统可以包括皮肤贴片，其包括配置成与活性成分发生化学反应的活性成分和破坏剂。破坏剂可存在于容器或吸收器中。在一个实施例中，吸收器可以在容器内使用。容器可以被配置为接收皮肤贴片，使得活性成分与容器内的破坏剂接触。吸收器可以被配置为接触皮肤贴片，使得活性成分与吸收体的破坏剂接触。此外，还提供了用于阻止意图使用活性成分（例如存在于真皮贴剂或皮肤中的那些）的系统和方法。该系统包括皮肤贴片，其具有构造成将活性成分递送至皮肤或粘膜表面的第一侧，其中第一面还包括真皮粘合剂。该系统还包括涂有粘合剂的装置。装置的粘合剂涂覆的表面可以被配置为粘附到第一侧，其中在使用皮肤贴片然后使粘合剂涂覆的表面与第一面接触时，残留的活性成分基本上不可接近。

5. 发明申请

WO03024383B1 METHODS AND APPARATUS FOR IMPROVED ADMINISTRATION OF ANALGESICS 审中-公开
标题翻译：改进管理管理的方法和装置
公开(公告)号：WO03024383B1
公开(公告)日：2004-02-19
申请号：PCT/US0229533
申请日：2002-09-17
申请人： ZARS INC
发明人： ZHANG JIE , ZHANG HAO
IPC分类号： A61M37/00 , A61B17/00 , A61F7/02 , A61F7/03 , A61F13/00 , A61K9/00 , A61K9/70 , A61K31/4468 , A61K31/4535 , A61M31/00 , A61N1/30 , A61K7/00
CPC分类号： A61K9/7084 , A61B2017/00765 , A61F7/02 , A61F7/032 , A61F7/034 , A61F2013/00187 , A61F2013/00204 , A61F2013/00906 , A61F2013/0091 , A61K9/0009 , A61K9/0024 , A61K9/7023 , A61K31/4468 , A61K31/4535 , A61M31/002 , A61M37/00 , A61M2037/0007 , A61N1/30
摘要： Methods and apparatus for improving administration of drugs through the use of heat and other physical means. The present invention relates to the use of heat and other physical means in conjunction with specially designed dermal drug delivery systems., conventional commercial dermal drug delivery systems, or drugs delivered into a sub-skin depot site via injection and other methods to alter, mainly increase, the drug release rate from the dermal drug delivery systems or the depot sites to accommodate certain clinical needs.
摘要翻译：通过使用热等物理手段改善药物的给药方法和装置。本发明涉及热和其它物理方法与特别设计的真皮药物递送系统，常规商业皮肤药物递送系统或通过注射递送至皮下部位的药物以及其他方法改变主要用途的用途增加，从皮肤药物递送系统或药厂的药物释放速率，以适应某些临床需要。

6. 发明申请

WO2003024383A3 METHODS AND APPARATUS FOR IMPROVED ADMINISTRATION OF ANALGESICS 审中-公开
公开(公告)号：WO2003024383A3
公开(公告)日：2003-03-27
申请号：PCT/US2002/029533
申请日：2002-09-17
申请人： ZARS, INC.
发明人： ZHANG, Jie , ZHANG, Hao
IPC分类号： A61K9/70
摘要： Methods and apparatus for improving administration of drugs through the use of heat and other physical means. The present invention relates to the use of heat and other physical means in conjunction with specially designed dermal drug delivery systems., conventional commercial dermal drug delivery systems, or drugs delivered into a sub-skin depot site via injection and other methods to alter, mainly increase, the drug release rate from the dermal drug delivery systems or the depot sites to accommodate certain clinical needs.

7. 发明申请

WO03024383A2 METHODS AND APPARATUS FOR IMPROVED ADMINISTRATION OF ANALGESICS 审中-公开
标题翻译：改进管理管理的方法和装置
公开(公告)号：WO03024383A2
公开(公告)日：2003-03-27
申请号：PCT/US0229533
申请日：2002-09-17
申请人： ZARS INC
发明人： ZHANG JIE , ZHANG HAO
IPC分类号： A61M37/00 , A61B17/00 , A61F7/02 , A61F7/03 , A61F13/00 , A61K9/00 , A61K9/70 , A61K31/4468 , A61K31/4535 , A61M31/00 , A61N1/30 , A61J
CPC分类号： A61K9/7084 , A61B2017/00765 , A61F7/02 , A61F7/032 , A61F7/034 , A61F2013/00187 , A61F2013/00204 , A61F2013/00906 , A61F2013/0091 , A61K9/0009 , A61K9/0024 , A61K9/7023 , A61K31/4468 , A61K31/4535 , A61M31/002 , A61M37/00 , A61M2037/0007 , A61N1/30
摘要： Methods and apparatus for improving administration of drugs through the use of heat and other physical means. The present invention relates to the use of heat and other physical means in conjunction with specially designed dermal drug delivery systems., conventional commercial dermal drug delivery systems, or drugs delivered into a sub-skin depot site via injection and other methods to alter, mainly increase, the drug release rate from the dermal drug delivery systems or the depot sites to accommodate certain clinical needs.
摘要翻译：通过使用热等物理手段改善药物的给药方法和装置。本发明涉及热和其它物理方法与特别设计的真皮药物递送系统，常规商业皮肤药物递送系统或通过注射递送至皮下部位的药物以及其它方法改变主要用途的用途增加，从皮肤药物递送系统或药厂的药物释放速率，以适应某些临床需要。

8. 发明申请

WO2007070679A2 COMPOSITIONS AND METHODS FOR DERMALLY TREATING PAIN 审中-公开
标题翻译：用于牙痛治疗的组合物和方法
公开(公告)号：WO2007070679A2
公开(公告)日：2007-06-21
申请号：PCT/US2006/047926
申请日：2006-12-14
申请人： ZARS, INC. , ZHANG, Jie , WARNER, Kevin, S. , SHARMA, Sanjay
发明人： ZHANG, Jie , WARNER, Kevin, S. , SHARMA, Sanjay
IPC分类号： A61K9/12
CPC分类号： A61K9/0014 , A61K47/10 , A61K47/18
摘要： The present invention is drawn to solidifying formulations for dermal delivery of a drug for treating pain, such as musculoskeletal pain, inflammation, joint pain, or neuropathic pain. The formulation can include a drug selected from certain drug classes, a solvent vehicle, and a solidifying agent. The solvent vehicle can include a volatile solvent system comprising at least one volatile solvent, and a non-volatile solvent system comprising at least one non-volatile solvent, wherein the evaporation of at least some of the volatile solvent converts the formulation on the skin into a solidified layer and the non-volatile solvent system is capable of facilitating the topical delivery of the drug(s) at therapeutically effective rates over a sustained period of time.
摘要翻译：本发明涉及用于皮肤递送用于治疗疼痛的药物如肌肉骨骼疼痛，炎症，关节疼痛或神经性疼痛的固化制剂。制剂可以包括选自某些药物类别的药物，溶剂载体和固化剂。溶剂载体可以包括包含至少一种挥发性溶剂的挥发性溶剂体系和包含至少一种非挥发性溶剂的非挥发性溶剂体系，其中至少一些挥发性溶剂的蒸发将皮肤上的制剂转化成固化层和非挥发性溶剂体系能够在持续的时间内以治疗有效的速率促进药物的局部递送。

9. 发明申请

WO2007070643A2 COMPOSITIONS AND METHODS FOR TREATING DERMATOLOGICAL CONDITIONS 审中-公开
标题翻译：用于治疗皮肤病症的组合物和方法
公开(公告)号：WO2007070643A2
公开(公告)日：2007-06-21
申请号：PCT/US2006/047747
申请日：2006-12-14
申请人： ZARS, INC. , ZHANG, Jie , WARNER, Kevin, S. , SHARMA, Sanjay
发明人： ZHANG, Jie , WARNER, Kevin, S. , SHARMA, Sanjay
IPC分类号： A61K9/12
CPC分类号： A61K9/0014 , A61K9/7015
摘要： The present invention is drawn to solidifying adhesive formulations, methods of drug delivery, and solidified layers for dermal delivery of a drug which can treat various dermatological conditions, such as a bacterial infection, a virus infection, a fungal infection, alopecia, dermatitis, psoriasis, or photo damaged skin. The formulation can include a drug, a solvent vehicle, and a solidifying agent. The solvent vehicle can include a volatile solvent system including at least one volatile solvent, and a non-volatile solvent system including at least one non-volatile solvent. The non-volatile solvent system can facilitate the delivery of the drug at therapeutically effective rates for sustained period of time. The non-volatile solvent system can also act as a plasticizer for the solidifying agent. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified layer after at least a portion of the volatile solvent system is evaporated.
摘要翻译：本发明涉及固化粘合剂制剂，药物递送方法和用于皮肤递送药物的固化层，其可以治疗各种皮肤病学条件，例如细菌感染，病毒感染，真菌感染，脱发，皮炎，牛皮癣，或照片损伤的皮肤。制剂可以包括药物，溶剂载体和固化剂。溶剂载体可以包括包含至少一种挥发性溶剂的挥发性溶剂体系和包含至少一种非挥发性溶剂的非挥发性溶剂体系。非挥发性溶剂体系可以有助于以治疗有效率持续持续的时间递送药物。非挥发性溶剂体系也可以作为固化剂的增塑剂。在挥发性溶剂体系蒸发之前，配方可以具有适用于皮肤表面的粘度。当施用于皮肤时，在挥发性溶剂体系的至少一部分蒸发后，制剂可以形成固化层。

10. 发明申请

WO2005117905A3 SYSTEMS AND METHODS FOR TREATING PANIC ATTACKS 审中-公开
标题翻译：处理泛型攻击的系统和方法
公开(公告)号：WO2005117905A3
公开(公告)日：2006-06-01
申请号：PCT/US2005018555
申请日：2005-05-27
申请人： ZARS INC , ZHANG JIE , WARNER KEVIN S , ASHBURN MICHAEL A
发明人： ZHANG JIE , WARNER KEVIN S , ASHBURN MICHAEL A
IPC分类号： A61F13/00 , A61F7/02 , A61F7/03 , A61K9/00 , A61K9/70 , A61K31/4468 , A61K31/4535 , A61K31/66 , A61K47/10 , A61K47/14 , A61K47/22 , A61K47/32 , A61M31/00 , A61M37/00 , A61N1/30
CPC分类号： A61K9/0014 , A61F7/032 , A61F7/034 , A61F2007/0261 , A61F2013/00187 , A61F2013/00204 , A61F2013/00906 , A61F2013/0091 , A61K9/0009 , A61K9/0024 , A61K9/7053 , A61K9/7069 , A61K31/4468 , A61K31/4535 , A61K31/66 , A61K47/10 , A61K47/14 , A61K47/22 , A61K47/32 , A61M31/002 , A61M37/00 , A61M2037/0007 , A61N1/30
摘要： Systems and methods for attenuating a panic attack are provided. Such methods can comprise steps of delivering a drug to a subject such that the drug forms a depot (22) beneath a skin surface, wherein the drug is suitable for attenuating a panic attack if delivered in a pharmaceutically effective amount into systemic circulation of the subject; and applying heat (28) to the skin surface when the subject experiences an onset of the panic attack, thereby causing the pharmaceutically effective amount of the drug to rapidly enter systemic circulation from the depot.
摘要翻译：提供了用于减轻恐慌发作的系统和方法。这样的方法可以包括将药物递送到受试者的步骤，使得药物在皮肤表面下形成贮存库（22），其中该药物适于减少惊厥发作，如果以药学有效量递送到受试者的全身循环中 ; 以及当受试者经历恐慌发作的开始时将热量（28）施加到皮肤表面，从而使药物有效量的药物迅速地从贮库中进入系统循环。

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