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1. 发明申请

WO2016160012A1 IRON PLATINUM PARTICLES FOR ADHERENCE OF BIOLOGICS ON MEDICAL IMPLANTS 审中-公开
标题翻译：用于医疗植入物生物学附加的铁白蛋白颗粒
公开(公告)号：WO2016160012A1
公开(公告)日：2016-10-06
申请号：PCT/US2015/023880
申请日：2015-04-01
申请人： YALE UNIVERSITY , MAGNUS FLOW LIMITED , UNIVERSITY COLLEGE LONDON , QUEEN MARY UNIVERSITY OF LONDON
发明人： FAHMY, Tarek , SINUSAS, Albert , LEE, Jung, Seok , KIM, Dongin , MATHUR, Anthony , MARTIN, John
IPC分类号： A61N2/06 , A61N2/00
CPC分类号： A61K41/0052 , A61F2/82 , A61F2210/0076 , A61F2210/009 , A61K35/44 , A61K35/545 , A61L27/025 , A61L27/042 , A61L27/047 , A61L27/06 , A61L27/18 , A61L27/306 , A61L27/34 , A61L27/58 , A61L31/022 , A61L31/028 , A61L31/06 , A61L31/088 , A61L31/10 , A61L31/148 , A61L2400/18 , A61L2420/02 , A61L2420/06 , A61L2420/08 , A61L2430/20 , A61N2/002 , A61N2/06
摘要： It has been discovered that iron-platinum ferromagnetic particles can be dispersed in a polymer and coated into or onto, or directly linked to or embedded on to, medical devices and magnetized. The magnetized devices are used to attract, capture, and/or retain magnetically labeled cells on the surface of the device in vivo. The magnetic particles have an iron/platinum core. Annealing the Fe/Pt particle is very important for introducing a Ll0 interior crystalline phase. The Fe:Pt molar ratio for creation of the crystal phase is important and a molar range of 1.2-3.0 Fe to Pt (molar precursors, i.e. starting compounds) is desired for magnetization. The magnetic force as a whole can be measured with a "Super Conducting Quantum Interference Device", which is a sensitive magnetometer. The overall magnetic force is in the range from 0.1 to 2.0 Tesla.
摘要翻译：已经发现，铁 - 铂铁磁性颗粒可以分散在聚合物中并涂覆在医疗装置中或直接连接或嵌入到医疗装置上并被磁化。磁化装置用于在体内吸引，捕获和/或保留装置表面上的磁性标记细胞。磁性颗粒具有铁/铂核。退火Fe / Pt颗粒对于引入L10内部结晶相非常重要。用于产生结晶相的Fe：Pt摩尔比是重要的，并且对于磁化需要1.2-3.0Fe对Pt（摩尔前体，即起始化合物）的摩尔范围。磁力作为一个整体可以用“超导电量子干涉仪”测量，它是一个敏感的磁力计。总磁力在0.1至2.0特斯拉的范围内。

2. 发明申请

WO2015175597A1 COMPOSITIONS FOR NANOCONFINEMENT INDUCED CONTRAST ENHANCEMENT AND METHODS OF MAKING AND USING THEREOF 审中-公开
标题翻译： NANOCONFINEMENT诱导对比增强的组合物及其制备和使用方法
公开(公告)号：WO2015175597A1
公开(公告)日：2015-11-19
申请号：PCT/US2015/030468
申请日：2015-05-13
申请人： YALE UNIVERSITY
发明人： FAHMY, Tarek , SINUSAS, Albert , KIM, Dongin
IPC分类号： C08J3/12 , A61K49/04 , A61K49/18 , C08K9/10
CPC分类号： A61K49/0485 , A61K49/0423 , A61K49/0438 , A61K49/0442 , A61K49/1887 , C08J3/124 , C08K3/16 , C08K9/10
摘要： Multivalent CT or MR contrast agents and methods of making and using thereof are described herein. The agents contain a moiety, such as a polymer, that provides multivalent attachment of CT or MR contrast agents. Examples include, but are not limited to, multivalent linear polymers, branched polymers, or hyperbranched polymers, such as dendrimers, and combinations thereof. The dendrimer is functionalized with one or more high Z-elements, such as iodine. The high Z-elements can be covalently or non-covalently bound to the dendrimer. The dendrimers are confined in order to enhance CT contrast. In some embodiments, the moiety is confined by encapsulating the dendrimers in a material to form particles, such as nanoparticles. In other embodiments, the dendrimer is confined by conjugating the moiety to a material, such as a polymer, which forms a gel upon contact with bodily fluids.
摘要翻译：本文描述了多价CT或MR造影剂及其制备和使用方法。这些试剂含有提供CT或MR造影剂多价连接的部分，如聚合物。实例包括但不限于多价线性聚合物，支化聚合物或超支化聚合物，例如树枝状聚合物及其组合。树枝状聚合物用一种或多种高Z元素如碘官能化。高Z元素可以与树枝状聚合物共价或非共价结合。树枝状大分子被限制以增强CT对比度。在一些实施方案中，该部分通过将树状聚合物包封在材料中以形成颗粒例如纳米颗粒而被限制。在其它实施方案中，树枝状聚合物通过将该部分与该物质（例如聚合物）结合来限制，该聚合物在与体液接触时形成凝胶。

3. 发明申请

WO2022261502A1 NON-INVASIVE IMAGING METHODS OF DIAGNOSING PERIPHERAL ARTERIAL DISEASE 审中-公开
公开(公告)号：WO2022261502A1
公开(公告)日：2022-12-15
申请号：PCT/US2022/033110
申请日：2022-06-10
申请人： JUBILANT DRAXIMAGE INC. , YALE UNIVERSITY
发明人： SINUSAS, Albert , LAFRANCE, Norman
IPC分类号： A61B5/00 , A61M5/14 , A61K33/14 , G06T7/00 , G05B19/04 , A61P9/10
摘要： The present invention provides a method of determining whether a subject is suffering or at a risk of developing a peripheral arterial disease via Positron Emitting Tomography (PET) imaging technology. The method comprises administering a PET radionuclide into the subject via automated generation and/or infusion system, performing PET scan of the region of interest, automated assessment of the PET images, performing assessment and suggesting the most appropriate therapeutic and/or management options for the patients based on the severity score. The patient can be concurrently suffering from one or more disease like diabetes mellitus.

4. 发明申请

WO2016161148A1 FERROMAGNETIC PARTICLES BOUND TO POLYMERIC IMPLANTS 审中-公开
标题翻译：聚对苯二甲酸丁二醇酯
公开(公告)号：WO2016161148A1
公开(公告)日：2016-10-06
申请号：PCT/US2016/025328
申请日：2016-03-31
申请人： YALE UNIVERSITY
发明人： FAHMY, Tarek , SINUSAS, Albert , LEE, Jung, Seok , KIM, Dongin
IPC分类号： A61L27/04 , A61L27/06 , A61L27/52 , A61L27/54 , A61L31/02 , A61L31/16 , A61L24/02 , A61L27/44 , A61L31/12 , A61L24/00 , C08L67/04
CPC分类号： A61L31/022 , A61K49/126 , A61L24/0073 , A61L24/02 , A61L27/04 , A61L27/042 , A61L27/06 , A61L27/18 , A61L27/20 , A61L27/306 , A61L27/34 , A61L27/44 , A61L27/446 , A61L27/52 , A61L27/54 , A61L27/58 , A61L31/028 , A61L31/042 , A61L31/06 , A61L31/088 , A61L31/10 , A61L31/125 , A61L31/128 , A61L31/145 , A61L31/148 , A61L31/16 , A61L2400/12 , A61L2420/02
摘要： It has been discovered that iron-platinum magnetic particles can be dispersed in a polymer and coated into or onto, or directly linked to, polymeric materials, especially hydrogels, and magnetized. The magnetized materials are used to attract, capture, and/or retain magnetically labeled cells in the material in vivo. The magnetic particles have an iron/platinum core. Annealing the Fe:Pt is very important for introducing a crystal structure LIO interior crystalline phase. The Fe:Pt molar ratio for creation of the crystal phase is important and a molar range of 1.2-3.0 Fe to Pt (molar precursors, i.e starting compounds) is desired for magnetization. The magnetic force as a whole can be measured with a "Super Conducting Quantum Interference Scaffold", which is a sensitive magnetometer. The overall magnetic force is in the range from 0.1 to 2.0 Tesla.
摘要翻译：已经发现，铁 - 铂磁性颗粒可以分散在聚合物中并且涂覆在聚合材料中，或者直接连接到聚合材料，特别是水凝胶上并被磁化。磁化材料用于在体内吸引，捕获和/或保留材料中的磁性标记细胞。磁性颗粒具有铁/铂核。退火Fe：Pt对于引入晶体结构LIO内部结晶相非常重要。用于产生结晶相的Fe：Pt摩尔比是重要的，并且对于磁化需要1.2-3.0Fe对Pt（摩尔前体，即起始化合物）的摩尔范围。磁力作为一个整体可以用“超导电量子干涉支架”来测量，这是一个敏感的磁力计。总磁力在0.1至2.0特斯拉的范围内。

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