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1. 发明申请

WO2008106193A1 WEIGHT MEASUREMENTS OF LIQUIDS IN FLEXIBLE CONTAINERS 审中-公开
标题翻译：液体在柔性容器中的重量测量
公开(公告)号：WO2008106193A1
公开(公告)日：2008-09-04
申请号：PCT/US2008/002639
申请日：2008-02-28
申请人： XCELLEREX, INC. , MITCHELL, Peter, A. , FISHER, Michael
发明人： MITCHELL, Peter, A. , FISHER, Michael
IPC分类号： G01F23/14 , C12M1/00
CPC分类号： G01F23/14 , G01F23/18 , G01F23/20 , G01G17/04
摘要： Articles and methods for measuring weight of a liquid in a disposable bag bioreactor are presented. In certain embodiments, bioreactor systems described herein include a supported container (e.g., a flexible bag in a reusable housing) for containing a liquid, and at least two pressure indicating sensors operatively associated with the container. A first pressure indicating sensor can be placed near the bottom of the container to measure the total downward force within the container, including the liquid head in the container and the gas pressure above the liquid. The second pressure indicating sensor can be placed near the top of the container to measure only the pressure at the top of or above the liquid. Signals from the pressure indicating sensors can be directed to a control system that receives the signals and calculates a difference between the signals. This difference can be used to determine a volume or a weight of the liquid in the container. Advantageously, real-time weight measurements can be obtained while the system is in operation and continuous flow processes can be monitored. Moreover, in some embodiments, the pressure indicating sensors are isolated from contact with any fluid (e.g., liquid) in the container and, therefore, do not require cleaning after processing of each batch of reactants. Contamination of the process fluid by contact with the pressure indicating sensors can also be avoided.
摘要翻译：提出了一次性袋式生物反应器中液体重量测量的物品和方法。在某些实施方案中，本文所述的生物反应器系统包括用于容纳液体的支撑容器（例如，可重复使用的壳体中的柔性袋）和与容器可操作地相关联的至少两个压力指示传感器。第一压力指示传感器可以放置在容器的底部附近，以测量容器内的总的向下的力，包括容器中的液体头和液体上方的气体压力。第二压力指示传感器可以放置在容器顶部附近，以仅测量液体顶部或上方的压力。来自压力指示传感器的信号可以被引导到接收信号并计算信号之间的差异的控制系统。该差异可用于确定容器中液体的体积或重量。有利的是，可以在系统运行时获得实时重量测量，并且可以监视连续的流程。此外，在一些实施例中，压力指示传感器与容器中的任何流体（例如液体）接触隔离，因此在处理每批反应物之后不需要清洁。也可以避免通过与压力指示传感器的接触对工艺流体的污染。

2. 发明申请

WO2011041508A1 DISPOSABLE BIOREACTOR CONDENSER BAG AND FILTER HEATER 审中-公开
标题翻译：可处理的生物反应器冷凝器袋和过滤器加热器
公开(公告)号：WO2011041508A1
公开(公告)日：2011-04-07
申请号：PCT/US2010/050859
申请日：2010-09-30
申请人： XCELLEREX, INC. , DAMREN, Richard , TOUHEY, Colin , ERDENBERGER, Thomas , FISHER, Michael , HODGE, Geoffrey, L. , GUERTIN, Patrick , GALLIHER, Parrish, M.
发明人： DAMREN, Richard , TOUHEY, Colin , ERDENBERGER, Thomas , FISHER, Michael , HODGE, Geoffrey, L. , GUERTIN, Patrick , GALLIHER, Parrish, M.
IPC分类号： F25D17/00
CPC分类号： C12M29/26 , B01D5/0042 , B01D5/0093 , B01D46/4263 , B01D53/265 , C12M23/28 , C12M29/04 , C12M41/12
摘要： Disclosed herein is a system and method for condensing moisture in a moist gas stream entering a bioreactor or leaving a bioreactor, the system comprising: a condenser container capable of holding a fluid, the condenser container comprising: an outer wall surface and an inner wall surface, the inner wall surface defining an interior chamber for holding the fluid; and a first fitment attached to the outer wall surface of the condenser container, the first fitment forming a first port configured to allow the moist gas stream to flow through the first port and into the interior chamber; a second fitment attached to the outer wall surface of the condenser container, the second fitment forming a second port configured to allow a dried gas to flow from the interior chamber and out of the second port; and a cooling device in contact with at least one portion of the outer wall surface of the condenser container and arranged to cool the at least one portion of the outer wall surface of the condenser container, thereby to condense moisture in the moist gas stream and forming a dry gas stream for entering or leaving the bioreactor.
摘要翻译：本文公开了一种用于冷凝进入生物反应器或离开生物反应器的湿气流中的水分的系统和方法，所述系统包括：能够保持流体的冷凝器容器，所述冷凝器容器包括：外壁表面和内壁表面所述内壁表面限定用于保持流体的内部腔室; 以及附接到所述冷凝器容器的外壁表面的第一配件，所述第一配件形成第一端口，所述第一端口被配置为允许所述湿气流流过所述第一端口并进入所述内部室; 附接到冷凝器容器的外壁表面的第二配件，所述第二配件形成第二端口，所述第二端口被配置为允许干燥的气体从所述内部室流出并且从所述第二端口流出; 以及与所述冷凝器容器的所述外壁表面的至少一部分接触并且布置成冷却所述冷凝器容器的所述外壁表面的所述至少一部分的冷却装置，从而冷凝所述湿气流中的水分并形成用于进入或离开生物反应器的干燥气流。

3. 发明申请

WO2010115185A1 TISSUE AND ORGAN GRAFT BIOREACTOR AND METHOD OF OPERATION 审中-公开
标题翻译：组织和组织GRAFT生物反应器和操作方法
公开(公告)号：WO2010115185A1
公开(公告)日：2010-10-07
申请号：PCT/US2010/029942
申请日：2010-04-05
申请人： XCELLEREX, INC. , HUMACYTE, INC. , GUERTIN, Patrick, M. , GALLIHER, Parrish, M. , FISHER, Michael , CROWELL, Joseph, D. , TUOHEY, Colin, R. , NIKLASON, Laura, E. , TENTE, William, E. , DAHL, Shannon, M. , BLUM, Juliana , STRADER, Justin
发明人： GUERTIN, Patrick, M. , GALLIHER, Parrish, M. , FISHER, Michael , CROWELL, Joseph, D. , TUOHEY, Colin, R. , NIKLASON, Laura, E. , TENTE, William, E. , DAHL, Shannon, M. , BLUM, Juliana , STRADER, Justin
IPC分类号： C12N5/00
CPC分类号： C12M27/00 , C12M21/08 , C12M23/14 , C12M23/28 , C12M25/14 , C12M29/06
摘要： A single-use, single or multiple tissue, organ, and graft bioreactor and environmental control system is designed to replicate the necessary conditions for growth of tissues, organs, or grafts, while addressing problems in scaling up the tissue growth; adaptation to a single-use or disposable format; and operation as a stand-alone unit that provides full environmental control of cell culture conditions.
摘要翻译：单次使用，单次或多次组织，器官和移植物生物反应器和环境控制系统被设计为复制组织，器官或移植物生长所必需的条件，同时解决扩大组织生长的问题; 适应一次性或一次性格式; 作为提供细胞培养条件的全面环境控制的独立单元的操作。

4. 发明申请

WO2009093995A1 BAG WRINKEL REMOVER, LEAK DETECTION SYSTEMS, AND ELECTROMAGNETIC AGITATION FOR LIQUID CONTAINMENT SYSTEMS 审中-公开
标题翻译： BAG WRINKEL REMOVER，LEAK DETECTION SYSTEMS，和ELECTROMAGNETIC AGITATION FOR LIQUIC CONTAINATION SYSTEMS
公开(公告)号：WO2009093995A1
公开(公告)日：2009-07-30
申请号：PCT/US2008/001005
申请日：2008-01-25
申请人： XCELLEREX, INC. , GALLIHER, Parrish, M. , FISHER, Michael , DAMREN, Richard, L. , HODGE, Geoffrey
发明人： GALLIHER, Parrish, M. , FISHER, Michael , DAMREN, Richard, L. , HODGE, Geoffrey
IPC分类号： C12M1/00 , C12M1/06 , G01M3/18
CPC分类号： C12M27/02 , C12M23/14 , G01M3/187
摘要： Systems and methods for containing and manipulating fluids, such as those involving collapsible bags and rigid containers that may be used as mixing systems, and as reactors for performing chemical, biochemical and/or biological reactions, are provided. A series of improvements and features for fluid containment systems such as containers including bag wrinkle removing systems, leak detection systems, and electromagnetic agitation systems are described.
摘要翻译：提供了用于容纳和操纵流体的系统和方法，例如涉及可以用作混合系统的可折叠袋和刚性容器的流体，以及用于进行化学，生化和/或生物反应的反应器。描述了流体容纳系统的一系列改进和特征，例如包括袋除皱系统，泄漏检测系统和电磁搅拌系统的容器。

5. 发明申请

WO2012051517A2 LARGE VOLUME DISPOSABLE ULTRAFILTRATION SYSTEMS AND METHODS 审中-公开
标题翻译：大容量一次性超滤系统和方法
公开(公告)号：WO2012051517A2
公开(公告)日：2012-04-19
申请号：PCT/US2011/056333
申请日：2011-10-14
申请人： XCELLEREX, INC. , MANGIACOTTI, Scott, A. , GALLIHER, Parrish, M. , ARDUINO, Joseph, J. , FISHER, Michael , VICALVI, John, J. Jr. , MAKOWIECKI, Joseph
发明人： MANGIACOTTI, Scott, A. , GALLIHER, Parrish, M. , ARDUINO, Joseph, J. , FISHER, Michael , VICALVI, John, J. Jr. , MAKOWIECKI, Joseph
IPC分类号： B01D27/04
CPC分类号： B01D61/22 , B01D61/145 , B01D2311/08 , B01D2311/25 , B01D2313/18 , B01D2313/20 , B01D2313/243 , B01D2313/58 , B01D2315/16 , B01D2317/08 , B01D2319/06 , C02F1/444 , C02F2209/005 , C02F2209/02 , C02F2209/03 , C02F2209/05 , C02F2209/11 , C02F2209/40 , B01D2311/04
摘要： A disposable filtration system can include a disposable filter housing having an ultrafiltration filter contained therein. The disposable filtration system can further include a feed inlet and retentate outlet in fluid communication on one side of the filter and a permeate conduit on the other side of the filter for withdrawing permeate that passes through the filter. The system can include at least one disposable pressure control valve in fluid communication with either the retentate outlet or the permeate conduit and configured to regulate the pressure within the housing.
摘要翻译：一次性过滤系统可以包括其中包含超滤过滤器的一次性过滤器壳体。一次性过滤系统还可以包括在过滤器的一侧流体连通的供给入口和滞留物出口以及在过滤器的另一侧的渗透物导管，用于抽出穿过过滤器的渗透物。该系统可以包括至少一个一次性压力控制阀，该一次性压力控制阀与渗余物出口或渗透物导管流体连通，并被配置成调节壳体内的压力。

6. 发明申请

WO2011025890A1 CONTINUOUS RECOVERY HARVEST BAG 审中-公开
标题翻译：连续收回收获袋
公开(公告)号：WO2011025890A1
公开(公告)日：2011-03-03
申请号：PCT/US2010/046841
申请日：2010-08-26
申请人： XCELLEREX, INC. , TOUHEY, Colin , ERDENBERGER, Thomas , DAMREN, Richard , FISHER, Michael , SWIBES, John
发明人： TOUHEY, Colin , ERDENBERGER, Thomas , DAMREN, Richard , FISHER, Michael , SWIBES, John
IPC分类号： C12N1/02
CPC分类号： C12M23/26 , C12M23/14 , C12M23/28 , C12M23/34 , C12M25/16 , C12M29/04 , C12M47/02 , C12M47/10
摘要： A nonporous vessel capable of holding a fluid comprises an outer wall surface and an inner wall surface, the inner wall surface defining an interior chamber for holding the fluid; a filter having a perimeter, a first surface and a second surface, and fixedly attached around its entire perimeter to a portion of the inner wall surface of the nonporous vessel, thereby forming an integrated interior bag within the nonporous vessel; and a fitment attached to the outer wall of the nonporous vessel at a portion of the outer wall that is adjacent to the first surface of the integrated interior bag, the fitment forming a port configured to allow fluid to flow from the interior chamber through the integrated interior bag, through the filter, and out of the port.
摘要翻译：能够保持流体的无孔容器包括外壁表面和内壁表面，内壁表面限定用于保持流体的内部腔室; 具有周边，第一表面和第二表面的过滤器，并且围绕其整个周边固定地附接到无孔容器的内壁表面的一部分，从而在无孔容器内形成一体的内部袋; 以及在所述外壁的与所述一体式内袋的第一表面相邻的部分处附接到所述无孔容器的外壁的配件，所述配件形成端口，所述端口被配置为允许流体从所述内部室流过所述集成内部袋，通过过滤器，并从出口。

7. 发明申请

WO2008088379A2 ENVIRONMENTAL CONTAINMENT SYSTEMS 审中-公开
标题翻译：环境容纳系统
公开(公告)号：WO2008088379A2
公开(公告)日：2008-07-24
申请号：PCT/US2007/015954
申请日：2007-07-13
申请人： XCELLEREX, INC. , GALLIHER, Parrish, M. , HODGE, Geoffrey, L. , FISHER, Michael
发明人： GALLIHER, Parrish, M. , HODGE, Geoffrey, L. , FISHER, Michael
IPC分类号： C12M1/00 , B01L1/04 , F24F3/16
CPC分类号： C12M41/14 , B08B15/02 , C12M23/52 , C12M37/02 , C12M41/00 , C12M41/40 , Y10S55/18
摘要： Environmental containment systems, and in certain embodiments, systems and methods involving vessels and unit operations or components of cell culture, cell containment, bioreactor, chemical manufacturing, or pharmaceutical manufacturing systems provided with environmental containment are provided. Certain vessels, unit operations, devices, and components may be used to perform all or part of biological, chemical, and/or pharmaceutical manufacturing processes therein. In some embodiments, an environmental containment system includes a multi-level containment apparatus. For instance, a first substantially closed environmental containment enclosure may be contained within a second substantially closed environmental containment enclosure; the first and second enclosures may be contained in a third substantially closed environmental containment enclosure, etc. Each of the environments within the substantially closed environmental containment enclosures may be controlled independently, and leakage of any materials from an inner system may be contained by an outer system.
摘要翻译：提供环境容纳系统，并且在某些实施方案中，提供了涉及容器和单元操作的系统和方法或细胞培养物，细胞容纳物，生物反应器，化学制造或具有环境容纳物的药物制造系统。某些容器，单元操作，装置和部件可用于执行其中的生物，化学和/或药物制造过程的全部或部分。在一些实施例中，环境容纳系统包括多级容纳装置。例如，第一基本封闭的环境容纳外壳可以包含在第二基本封闭的环境容纳外壳内; 第一和第二外壳可以包含在第三基本封闭的环境容纳外壳等中。基本封闭的环境容纳外壳内的每个环境可以被独立地控制，并且任何材料从内部系统的泄漏可以被外部系统。

8. 发明申请

WO2008088371A3 GAS DELIVERY CONFIGURATIONS, FOAM CONTROL SYSTEMS, AND BAG MOLDING METHODS AND ARTICLES FOR COLLAPSIBLE BAG VESSELS AND BIOREACTORS 审中-公开
公开(公告)号：WO2008088371A3
公开(公告)日：2008-07-24
申请号：PCT/US2007/014050
申请日：2007-06-15
申请人： XCELLEREX, INC. , GALLIHER, Parrish, M. , HODGE, Geoffrey, L. , FISHER, Michael
发明人： GALLIHER, Parrish, M. , HODGE, Geoffrey, L. , FISHER, Michael
IPC分类号： C12M1/04
摘要： Systems for containing and manipulating fluids including systems and methods involving supported collapsible bags that may be used as reactors for performing chemical, biochemical and/or biological reactions contained therein are provided. Generally, a series of improvements and features for fluid containment systems such as gas delivery configurations, foam control systems and bag molding methods and articles for supported collapsible bag vessels and bioreactors are provided. For instance, in one aspect, fluids contained in a vessel can be sparged, e.g., such that a fluid is directed into a container of the vessel, and in some cases, the sparging can be controlled by rapidly activating or altering the degree of sparging as needed. Multiple spargers may be used in some cases. In another aspect, the vessel includes a seamless collapsible bag. In some cases, the collapsible bag may be injected, blown, or spin cast molded. In yet another aspect, the vessel includes a device which can reduce the foam produced or contained within the vessel. Sensors and/or controllers may optionally be used to monitor and/or control foaming.

9. 发明申请

WO2013040161A1 SINGLE-USE MIXING AND BIOREACTOR SYSTEMS 审中-公开
标题翻译：单一混合和生物反应器系统
公开(公告)号：WO2013040161A1
公开(公告)日：2013-03-21
申请号：PCT/US2012/055081
申请日：2012-09-13
申请人： XCELLEREX, INC. , ERDENBERGER, Thomas , DAMREN, Richard L. , TUOHEY, Colin R. , FISHER, Michael , GALLIHER, Parrish M. , KENNEY, Jonathan A.
发明人： ERDENBERGER, Thomas , DAMREN, Richard L. , TUOHEY, Colin R. , FISHER, Michael , GALLIHER, Parrish M. , KENNEY, Jonathan A.
IPC分类号： B01F13/08
CPC分类号： B01F13/0818 , B01F3/04106 , B01F3/04531 , B01F7/0025 , B01F7/00633 , B01F7/162 , B01F13/0872 , B01F15/00714 , B01F15/0085 , B01F2003/04673 , B01F2015/0011 , B01F2215/0073 , C12M23/14 , C12M23/26 , C12M27/02
摘要： Disclosed are magnetic agitation mixing systems for use with flexible container reaction vessels. In one aspect of the invention, the orientation of magnetic coupling between the impeller magnets and the external driver magnets is modified such that the coupling is neither strictly axial nor strictly radial. Also disclosed are "receiver-less" retainer configurations whereby the single-use container need not have a rigid base that defines a cup or post to engage of rotatable agitator.
摘要翻译：公开了用于柔性容器反应容器的磁力搅拌混合系统。在本发明的一个方面中，叶轮磁体和外部驱动磁体之间的磁耦合的取向被改变，使得联接器既不是严格的轴向也不是严格的径向。还公开了“无接收器”保持器构造，由此一次性容器不需要具有限定杯或柱以接合可旋转搅拌器的刚性基座。

10. 发明申请

WO2012097079A2 LINEARLY SCALABLE SINGLE USE BIOREACTOR SYSTEM 审中-公开
标题翻译：线性可扩展单一使用生物反应器系统
公开(公告)号：WO2012097079A2
公开(公告)日：2012-07-19
申请号：PCT/US2012/020963
申请日：2012-01-11
申请人： XCELLEREX, INC. , TUOHEY, Colin , DELOGGIO, Ted , ERDENBERGER, Thomas , CLAPP, Kenneth, P. , DAMREN, Richard , GALLIHER, Parrish, M. , GUERTIN, Patrick , LEE, Jiyoung , FISHER, Michael
发明人： TUOHEY, Colin , DELOGGIO, Ted , ERDENBERGER, Thomas , CLAPP, Kenneth, P. , DAMREN, Richard , GALLIHER, Parrish, M. , GUERTIN, Patrick , LEE, Jiyoung , FISHER, Michael
IPC分类号： C12M1/02
CPC分类号： C12M23/28 , C12M23/02 , C12M23/14 , C12M23/26 , C12M27/02
摘要： Disclosed is a single-use bioreactor bag design providing substantially equivalent maximum shear rate at the impeller tip and average or bulk shear rate over a range of power per unit working volume and rpm needed for bioculture processing. The uniformity in shear profile of the bag design providing a unique advantage when used as a scale-down or scale-up platform. Also disclosed is a linearly scalable, single- use, bioreactor system for use in carrying out a scalable biomanu factoring process, the system comprising two single-use bioreactor bags of different volumes, wherein the ratio H/D of the height of the working volume H to the diameter D of the tank, or of the bag is equal to about 1.5, and the bulk shear in each of the bags is substantially constant. The disclosed small scale system models larger scale systems from both a shear/scalability/performance basis and also from a validation and regulatory basis. In summary, the 10L bioreactor system disclosed provides for "linear scalability" by using the same or substantially simulating the same vessel geometry, gas sparging system, impeller shape and type, polymer composition of the flexible bag/components, process control system, and shear rates as larger 50- 5000L systems.
摘要翻译：公开了一种一次性生物反应器袋设计，其在叶轮尖端处提供基本上等效的最大剪切速率，并且在每单位工作体积和生物培养处理所需的rpm的功率范围内的平均或体积剪切速率。袋子设计的剪切轮廓的均匀性在用作缩小或放大平台时提供了独特的优势。还公开了一种线性可伸缩的单次使用的生物反应器系统，用于执行可伸缩的生物反应因子分解过程，该系统包括两个不同体积的单次使用的生物反应器袋，其中工作体积的高度比H / D H至罐的直径D或袋的直径D等于约1.5，并且每个袋中的体积剪切基本上恒定。所披露的小规模系统从剪切/可扩展性/性能基础以及从验证和监管的角度来模拟更大规模的系统。总之，所公开的10L生物反应器系统通过使用相同或基本上模拟相同的容器几何形状，气体喷射系统，叶轮形状和类型，柔性袋/部件的聚合物组成，过程控制系统和剪切来提供“线性可伸缩性” 价格为更大的50- 5000L系统。

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