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1. 发明申请

WO2004038026A3 CALCINEURIN-LIKE HUMAN PHOSPHOESTERASE 审中-公开
标题翻译： CALCINEURIN-like人类磷酸酯酶
公开(公告)号：WO2004038026A3
公开(公告)日：2004-07-29
申请号：PCT/US0333703
申请日：2003-10-24
申请人： WYETH CORP , LIU WEI , WU LEEYING , FORD ROGER , BE XIAOBING
发明人： LIU WEI , WU LEEYING , FORD ROGER , BE XIAOBING
IPC分类号： C12N9/16 , C12N15/55 , A01K67/027 , A61K38/46 , C07K16/40 , C12N5/10 , C12N15/11 , C12Q1/44 , G01N33/573
CPC分类号： C12N9/16
摘要： This invention provides compositions, organisms and methodologies employing a novel human gene encoding a protein that has sequence homology to a consensus sequence of calcineurin-like phosphoesterase family are disclosed. The novel protein is encoded by a human gene comprising 4 exons. The human gene is localized in the 10p15 locus of human chromosome 10. The sequence similarities between the novel human protein and the consensus sequence of calcineurin-like phosphoesterases indicate that the novel human protein may function as a calcineurin-like protein phosphatase.
摘要翻译：本发明提供使用编码与钙调神经磷酸酯酶类家族的共有序列具有序列同源性的蛋白质的新型人基因的组合物，生物体和方法。该新蛋白由包含4个外显子的人基因编码。人类基因位于人类10号染色体10p15位点。新型人类蛋白质与钙调神经磷酸酯酶的共有序列之间的序列相似性表明新型人类蛋白质可作为钙调神经磷酸酶蛋白磷酸酶起作用。

2. 发明申请

WO2004033638A3 COMPOSITIONS, ORGANISMS AND METHODOLOGIES EMPLOYING A NOVEL HUMAN KINASE 审中-公开
标题翻译：使用新型人类激素的成分，组织和方法学
公开(公告)号：WO2004033638A3
公开(公告)日：2004-07-15
申请号：PCT/US0331591
申请日：2003-10-07
申请人： WYETH CORP , LIU WEI , WU LEEYING
发明人： LIU WEI , WU LEEYING
IPC分类号： C12N9/12 , C07H21/04 , A61K48/00 , C07K14/00 , C07K16/00 , C12N5/00 , C12N15/63 , G01N33/53
CPC分类号： C12N9/1205
摘要： This invention provides compositions, organisms and methodologies employing a novel human protein kinase, MCRK2. The novel human kinase has sequence homology to rat myotonic dystrophy kinase-related Cdc42 binding kinase (MRCK) alpha. The gene encoding the novel kinase is localized in locus 1q42 of human chromosome 1. The novel protein kinase comprises multiple functional/structural domains that include a kinase domain, a pkinase_C domain, a DAG-PE binding domain, and a CNH domain. The sequence and structure similarity between the novel human protein and rat MRCK alpha indicates that the novel human protein may function as a downstream effector of Cdc42 in cytoskeleton reorganization.
摘要翻译：本发明提供了使用新型人蛋白激酶MCRK2的组合物，生物体和方法。新型人类激酶与大鼠肌强直性营养不良激酶相关的Cdc42结合激酶（MRCK）α具有序列同源性。编码新型激酶的基因位于人染色体1的基因座1q42中。新型蛋白激酶包含多个功能/结构域，其包括激酶结构域，pkinase_C结构域，DAG-PE结合结构域和CNH结构域。新型人类蛋白质与大鼠MRCKα之间的序列和结构相似性表明新型人蛋白质可能在细胞骨架重组中起到Cdc42的下游作用。

3. 发明申请

WO2004087901A3 BRAIN-LOCALIZED PROTEIN KINASES HOMOLOGOUS TO HOMEODOMAIN-INTERACTING PROTEIN KINASES 审中-公开
标题翻译：脑定位蛋白激酶与家蚕相互作用的蛋白激酶
公开(公告)号：WO2004087901A3
公开(公告)日：2004-11-25
申请号：PCT/US2004009020
申请日：2004-03-25
申请人： WYETH CORP , LIU WEI , OZENBERGER BRADLEY A , WU LEEYING , LO CHING-HSIUNG FREDERICK , HANEY STEVEN A , SOOKDEO HEMCHAND , LEE JEE HYUNG
发明人： LIU WEI , OZENBERGER BRADLEY A , WU LEEYING , LO CHING-HSIUNG FREDERICK , HANEY STEVEN A , SOOKDEO HEMCHAND , LEE JEE HYUNG
IPC分类号： C12N9/12 , C12N15/55 , A01K67/027 , A61K31/713 , C07K16/40 , C12N9/16 , C12N15/11 , C12N15/54
CPC分类号： C12N9/1205
摘要： The invention provides isolated protein kinase polypeptides related to novel brain-localized protein kinases homologous to known homeodomain-interacting protein kinases (HIPKs), and the isolated nucleic acid molecules that encode these polypeptides. The novel polypeptides and nucleic acid molecules of the invention are termed HIPK4. The invention also provides genetically engineered expression vectors, host cells, and transgenic animals comprising the novel nucleic acid molecules of the invention. The invention additionally provides antisense and RNAi molecules to the nucleic acid molecules of the invention. The invention further provides inhibitors, activators, and antibodies capable of binding to the protein kinase polypeptides of the invention, and their use in the prevention and treatment of neurological disorders.
摘要翻译：本发明提供与与已知同源结构域相互作用的蛋白激酶（HIPK）同源的新型脑定位蛋白激酶相关的分离的蛋白激酶多肽以及编码这些多肽的分离的核酸分子。本发明的新型多肽和核酸分子称为HIPK4。本发明还提供了遗传工程改造的表达载体，宿主细胞和包含本发明的新型核酸分子的转基因动物。本发明还向本发明的核酸分子提供反义和RNAi分子。本发明还提供能够结合本发明的蛋白激酶多肽的抑制剂，活化剂和抗体及其在预防和治疗神经障碍中的用途。

4. 发明申请

WO2004087903A2 NOVEL PROTEINS HOMOLOGOUS TO KINASE SUPPRESSOR OF RAS 审中-公开
标题翻译：与蛋白酶同源的新蛋白质抑制RAS的抑制剂
公开(公告)号：WO2004087903A2
公开(公告)日：2004-10-14
申请号：PCT/US2004009487
申请日：2004-03-29
申请人： WYETH CORP , LIU WEI , WU LEEYING , CHANNAVAJHALA PADMA L , LIN LIH-LING , ZHANG YUHUA
发明人： LIU WEI , WU LEEYING , CHANNAVAJHALA PADMA L , LIN LIH-LING , ZHANG YUHUA
IPC分类号： C12N9/12
CPC分类号： C12N9/1205
摘要： The invention provides isolated protein kinase polypeptides homologous to Kinase Suppressor of Ras (KSR), and the isolated nucleic acid molecules that encode these polypeptides. The novel polypeptides and nucleic acid molecules of the invention are termed KSR-2. The invention also provides genetically engineered expression vectors, host cells, and transgenic animals comprising the novel nucleic acid molecules of the invention. The invention additionally provides antisense and RNAi molecules to the nucleic acid molecules of the invention. The invention further provides inhibitors, activators, and antibodies capable of binding to the protein kinase polypeptides of the invention. The invention also provides for the regulation of Cot/Tpl2-mediated cellular functions, such as ERK and NF-xB activation, as well as IL-8 production, through the use of the nucleic acid and protein kinase polypeptide molecules of the invention.
摘要翻译：本发明提供了与Ras的激酶抑制子（KSR）同源的分离的蛋白激酶多肽以及编码这些多肽的分离的核酸分子。本发明的新多肽和核酸分子被称为KSR-2。本发明还提供了包含本发明的新型核酸分子的基因工程表达载体，宿主细胞和转基因动物。本发明另外为本发明的核酸分子提供反义和RNAi分子。本发明进一步提供了能够结合本发明的蛋白激酶多肽的抑制剂，激活剂和抗体。本发明还提供了通过使用本发明的核酸和蛋白激酶多肽分子来调节Cot / Tpl2介导的细胞功能，例如ERK和NF-xB活化以及IL-8产生。

5. 发明申请

WO2004032877A3 COMPOSITIONS, ORGANISMS AND METHODOLOGIES EMPLOYING A NOVEL HUMAN KINASE 审中-公开
标题翻译：使用新型人类激素的成分，组织和方法学
公开(公告)号：WO2004032877A3
公开(公告)日：2005-10-06
申请号：PCT/US0332302
申请日：2003-10-10
申请人： WYETH CORP , LIU WEI , WU LEEYING
发明人： LIU WEI , WU LEEYING
IPC分类号： A01K67/027 , A61K20060101 , A61K6/00 , A61K31/7105 , A61K48/00 , C07H21/04 , C07K1/00 , C07K16/40 , C12N1/20 , C12N9/12 , C12N15/00 , C12N15/54 , C12Q1/48 , C12Q1/68 , G01N33/573
CPC分类号： C12Q1/485 , A01K2217/05 , A01K2217/075 , C12N9/1205 , G01N2500/04
摘要： This invention provides compositions, organisms and methodologies employing a novel human protein kinase, HPK3P23. The novel human kinase has sequence homology to the catalytic domains of several protein kinases. The gene encoding this novel protein kinase is localized in or near the 3p23 locus of the human chromosome 3.The sequence similarity between the novel human protein and the catalytic domain of protein kinases indicates that the novel human protein may function as a protein kinase.
摘要翻译：本发明提供了使用新型人蛋白激酶HPK3P23的组合物，生物体和方法。新型人类激酶与几种蛋白激酶的催化结构域具有序列同源性。编码这种新型蛋白激酶的基因位于人染色体3的3p23位点或其附近。新型人类蛋白质与蛋白激酶的催化结构域之间的序列相似性表明新型人蛋白质可能起蛋白激酶的作用。

6. 发明申请

WO2004032878A3 COMPOSITIONS, ORGANISMS AND METHODOLOGIES EMPLOYING A NOVEL HUMAN KINASE 审中-公开
标题翻译：使用新型人类激素的成分，组织和方法学
公开(公告)号：WO2004032878A3
公开(公告)日：2005-04-28
申请号：PCT/US0332305
申请日：2003-10-10
申请人： WYETH CORP , LIU WEI , WU LEEYING
发明人： LIU WEI , WU LEEYING
IPC分类号： A61K38/00 , C12N1/21 , C12N9/12 , C12Q1/48 , C12N15/54 , C12N5/10 , C12Q1/68
CPC分类号： C12N9/1205 , A01K2217/05 , A61K38/00 , C12Q1/485 , G01N2500/04
摘要： This invention provides compositions, organisms and methodologies employing a novel human protein kinase, NRHK1. The novel protein kinase is encoded by a human gene comprising 21 exons. The human gene is localized in or near the 9q34 locus of human chromosome 9. The sequence similarity between the novel human protein and the consensus sequence of NIMA-related kinase indicates that the novel human protein may function as an NIMA-related kinase.
摘要翻译：本发明提供了使用新型人蛋白激酶NRHK1的组合物，生物体和方法。新型蛋白激酶由包含21个外显子的人基因编码。人类基因定位在人染色体9的9q34位点或其附近。新型人类蛋白质与NIMA相关激酶的共有序列之间的序列相似性表明新型人类蛋白质可能作为NIMA相关激酶起作用。

7. 发明申请

WO2004050831A3 COMPOSITIONS, ORGANISMS AND METHODOLOGIES EMPLOYING A NOVEL HUMAN KINASE 审中-公开
标题翻译：使用新型人类激素的成分，组织和方法学
公开(公告)号：WO2004050831A3
公开(公告)日：2006-09-14
申请号：PCT/US0335609
申请日：2003-11-07
申请人： WYETH CORP , LIU WEI , WU LEEYING , CHEN HUIMIN
发明人： LIU WEI , WU LEEYING , CHEN HUIMIN
IPC分类号： C12N15/54 , C12N1/21 , C12N5/10 , C12N9/12
CPC分类号： C12N9/1205
摘要： This invention provides compositions, organisms and methodologies employing a novel human protein kinase, MCRKI . The novel human kinase has sequence homology to rat myotonic dystrophy kinase-related Cdc42 binding kinase (MRCK) alpha. The gene encoding the novel kinase is localized in locus 11 q13 of human chromosome 11. The novel protein kinase comprises multiple functional/structural domains that include a kinase domain, a pkinase_C domain, a DAG-PE binding domain, and a CNH domain. The sequence and structure similarity between the novel human protein and rat MRCK alpha indicates that the novel human protein may function as a downstream effector of Cdc42 in cytoskeleton reorganization.
摘要翻译：本发明提供使用新型人蛋白激酶MCRKI的组合物，生物体和方法。新型人类激酶与大鼠肌强直性营养不良激酶相关的Cdc42结合激酶（MRCK）α具有序列同源性。编码新型激酶的基因位于人染色体11的基因座11q13中。新型蛋白激酶包含多个功能/结构域，其包括激酶结构域，pkinase_C结构域，DAG-PE结合结构域和CNH结构域。新型人类蛋白质与大鼠MRCKα之间的序列和结构相似性表明新型人蛋白质可能在细胞骨架重组中起到Cdc42的下游作用。

8. 发明申请

WO2006119461A3 RAT AND MOUSE MEMBERS OF THE CRISP FAMILY OF GENES 审中-公开
标题翻译：基因家族的大鼠和小鼠成员
公开(公告)号：WO2006119461A3
公开(公告)日：2007-01-11
申请号：PCT/US2006017257
申请日：2006-05-03
申请人： WYETH CORP , NOLAN MICHAEL ALEXANDER , JOHNSTON DANIEL S , WU LEEYING , JELINSKY SCOTT ALAN
发明人： NOLAN MICHAEL ALEXANDER , JOHNSTON DANIEL S , WU LEEYING , JELINSKY SCOTT ALAN
IPC分类号： C07K14/435
CPC分类号： C07K16/18 , C07K14/47 , C12N9/6421 , G01N2500/00
摘要： Disclosed herein are nucleic acid and polypeptide sequences of the mouse and rat homologues of human cysteine-rich secretory protein-1. Also disclosed herein are methods related to the use of the aforementioned mouse and rat homologues.
摘要翻译：本文公开的是富含半胱氨酸的分泌蛋白-1的小鼠和大鼠同源物的核酸和多肽序列。本文还公开了与使用上述小鼠和大鼠同源物有关的方法。

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