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1. 发明申请

WO2004087903A2 NOVEL PROTEINS HOMOLOGOUS TO KINASE SUPPRESSOR OF RAS 审中-公开
标题翻译：与蛋白酶同源的新蛋白质抑制RAS的抑制剂
公开(公告)号：WO2004087903A2
公开(公告)日：2004-10-14
申请号：PCT/US2004009487
申请日：2004-03-29
申请人： WYETH CORP , LIU WEI , WU LEEYING , CHANNAVAJHALA PADMA L , LIN LIH-LING , ZHANG YUHUA
发明人： LIU WEI , WU LEEYING , CHANNAVAJHALA PADMA L , LIN LIH-LING , ZHANG YUHUA
IPC分类号： C12N9/12
CPC分类号： C12N9/1205
摘要： The invention provides isolated protein kinase polypeptides homologous to Kinase Suppressor of Ras (KSR), and the isolated nucleic acid molecules that encode these polypeptides. The novel polypeptides and nucleic acid molecules of the invention are termed KSR-2. The invention also provides genetically engineered expression vectors, host cells, and transgenic animals comprising the novel nucleic acid molecules of the invention. The invention additionally provides antisense and RNAi molecules to the nucleic acid molecules of the invention. The invention further provides inhibitors, activators, and antibodies capable of binding to the protein kinase polypeptides of the invention. The invention also provides for the regulation of Cot/Tpl2-mediated cellular functions, such as ERK and NF-xB activation, as well as IL-8 production, through the use of the nucleic acid and protein kinase polypeptide molecules of the invention.
摘要翻译：本发明提供了与Ras的激酶抑制子（KSR）同源的分离的蛋白激酶多肽以及编码这些多肽的分离的核酸分子。本发明的新多肽和核酸分子被称为KSR-2。本发明还提供了包含本发明的新型核酸分子的基因工程表达载体，宿主细胞和转基因动物。本发明另外为本发明的核酸分子提供反义和RNAi分子。本发明进一步提供了能够结合本发明的蛋白激酶多肽的抑制剂，激活剂和抗体。本发明还提供了通过使用本发明的核酸和蛋白激酶多肽分子来调节Cot / Tpl2介导的细胞功能，例如ERK和NF-xB活化以及IL-8产生。

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