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1. 发明申请

WO2008079812A2 DERMAL AND TRANSDERMAL CRYOGENIC MICROPROBE SYSTEMS AND METHODS 审中-公开
标题翻译：真空和超低温微生物微生物系统及方法
公开(公告)号：WO2008079812A2
公开(公告)日：2008-07-03
申请号：PCT/US2007/087893
申请日：2007-12-18
申请人： MYOSCIENCE, INC. , BURGER, Keith , WILLIAMS, Ronald , ELKINS, Lisa
发明人： BURGER, Keith , WILLIAMS, Ronald , ELKINS, Lisa
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/00747 , A61B2018/00452 , A61B2018/0262 , A61B2018/0293
摘要： Medical devices, systems, and methods optionally treat dermatological and/or cosmetic defects, and/or a wide range of additional target tissues. Embodiments apply cooling with at least one small, tissue-penetrating probe, the probe often comprising a needle having a size suitable for inserting through an exposed surface of the skin of a patient without leaving a visible scar. Treatment may be applied along most or all of the insertable length of an elongate needle, optionally by introducing cryogenic cooling fluid into the needle lumen through a small, tightly-tolerated lumen of a fused silica fluid supply tube, with the supply tube lumen often metering the cooling fluid. Treatment temperature and/or time control may be enhanced using a simple pressure relief valve coupled to the needle lumen via a limited total exhaust volume space.
摘要翻译：医疗装置，系统和方法可任选地治疗皮肤病学和/或美容缺陷，和/或广泛的其它靶组织。实施例用至少一个小的组织穿透探针进行冷却，所述探针通常包括具有适合于穿过患者皮肤的暴露表面插入的尺寸的针而不留下可见的瘢痕。治疗可以沿着细长针的大部分或全部可插入长度施加，任选地通过将低温冷却流体通过熔融石英流体供应管的小的，容许容忍的内腔引入针管内腔，供应管内腔经常计量冷却液。可以通过经由有限的总排气量空间耦合到针内腔的简单的压力释放阀来增强治疗温度和/或时间控制。

2. 发明申请

WO2006074339A1 EQUALIZING FLAPPER FOR HIGH SLAM RATE APPLICATIONS 审中-公开
标题翻译：均匀化FLAPPER用于高SLAM速率应用
公开(公告)号：WO2006074339A1
公开(公告)日：2006-07-13
申请号：PCT/US2006/000413
申请日：2006-01-06
申请人： BAKER HUGHES INCORPORATED , WILLIAMS, Ronald , MCVICKER, Van , STRATTON, Scott , IVES, Jason
发明人： WILLIAMS, Ronald , MCVICKER, Van , STRATTON, Scott , IVES, Jason
IPC分类号： E21B34/10 , F16K39/02
CPC分类号： F16K39/024 , E21B34/101 , E21B2034/005 , F16K15/181
摘要： A flapper valve assembly is described having an equalizing port assembly (32) with a bleed valve member (64) that is moveable between an open position and a closed position. The equalizing port assembly features a structural support member in the form of a retainer key (80) that is secured to the flapper valve member both axially and radially. Additionally, a compressible spring (86) is located between the structural support member and provides biasing force upon the valve member to urge it toward a closed position. Additionally, the flapper valve member presents a pair of raised, substantially flat actuator contact portions (54) upon its downstream face to meet an actuating tube (34) in a mating contact arrangement and resist material deformation that could tend to clog or block the equalizing fluid flow port.
摘要翻译：描述了一种挡板阀组件，其具有带有放气阀构件（64）的均衡端口组件（32），该释放阀构件可在打开位置和关闭位置之间移动。平衡端口组件具有保持键（80）形式的结构支撑构件，其沿轴向和径向固定到挡板阀构件。此外，可压缩弹簧（86）位于结构支撑构件之间并且向阀构件提供偏压力以将其推向关闭位置。此外，挡板阀构件在其下游面上具有一对凸起的，基本上平坦的致动器接触部分（54），以在匹配的接触装置中与致动管（34）相遇并抵抗材料变形，这可能会阻塞或阻止均衡流体流通口。

3. 发明申请

WO2009065061A1 PAIN MANAGEMENT USING CRYOGENIC REMODELING 审中-公开
标题翻译：使用低温重塑的疼痛管理
公开(公告)号：WO2009065061A1
公开(公告)日：2009-05-22
申请号：PCT/US2008/083668
申请日：2008-11-14
申请人： MYOSCIENCE, INC. , BURGER, Keith , ELKINS, Lisa , WILLIAMS, Ronald
发明人： BURGER, Keith , ELKINS, Lisa , WILLIAMS, Ronald
IPC分类号： A61B18/02
CPC分类号： A61F7/12 , A61B18/0218 , A61B2018/00452 , A61B2018/0293 , A61F7/00 , A61F2007/0056 , A61F2007/0063 , A61F2007/0087 , A61F2007/0094 , A61F2007/0285 , A61F2007/126
摘要： Medical devices, systems, and methods for pain management and other applications may apply cooling with at least one probe inserted through an exposed skin surface of skin. The cooling may remodel one or more target tissues so as to effect a desired change in composition of the target tissue and/or a change in its behavior, often to interfere with transmission of pain signals along sensory nerves. Alternative embodiments may interfere with the function of motor nerves, the function of contractile muscles, and/or some other tissue included in the contractile function chain so as to inhibit muscle contraction and thereby alleviate associated pain. In some embodiments, other sources of pain such as components of the spine (optionally including herniated disks) may be treated.
摘要翻译：用于疼痛管理和其它应用的医疗装置，系统和方法可以使用至少一个穿过皮肤暴露的皮肤表面插入的探针进行冷却。冷却可以改变一个或多个靶组织，以便实现目标组织的组成所需的改变和/或其行为的变化，经常干扰沿着感觉神经传递疼痛信号。替代实施例可能干扰运动神经的功能，收缩肌肉的功能，和/或包含在收缩功能链中的一些其他组织，以便抑制肌肉收缩，从而减轻相关的疼痛。在一些实施例中，可以治疗其他疼痛源，例如脊柱的部件（可选地包括突出的椎间盘）。

4. 发明申请

WO2006127467A2 SUBDERMAL CRYOGENIC REMODELING OF MUSCLES, NERVES, CONNECTIVE TISSUE, AND/OR ADIPOSE TISSUE (FAT) 审中-公开
标题翻译：肌肉，神经，连接组织和/或ADIPOSE组织（FAT）的低温低温重建
公开(公告)号：WO2006127467A2
公开(公告)日：2006-11-30
申请号：PCT/US2006/019471
申请日：2006-05-18
申请人： MYOSCIENCE, INC. , ELKINS, Lisa , WILLIAMS, Ronald
发明人： ELKINS, Lisa , WILLIAMS, Ronald
IPC分类号： H01R4/24
CPC分类号： A61B18/02 , A61B18/14 , A61B2017/00747 , A61B2017/00792 , A61B2018/00023 , A61B2018/00041 , A61B2018/00452 , A61B2018/00464 , A61B2018/0262 , A61B2018/0293 , A61M5/44 , A61M37/0015 , A61M2037/0023 , A61M2037/003
摘要： Devices, systems, and methods treat cosmetic defects, and often apply cooling with at least one tissue-penetrating probe inserted through of the skin of a patient. The cooling may remodel one or more target tissue so as to effect a desired change in a composition of the target tissue and/or a change in its behavior. Exemplary embodiments of the cooling treatments will interfere with the nerve/muscle contractile function chain so as to mitigate wrinkles of the skin. Related treatments may be used therapeutically for treatment of back and other muscle spasms, chronic pain, and the like. Some embodiments may remodel subcutaneous adipose tissue so as to alter a shape or appearance of the skin surface.
摘要翻译：装置，系统和方法处理化妆品缺陷，并且经常使用插入穿过患者皮肤的至少一个组织穿透探针施加冷却。冷却可以改变一个或多个靶组织，以便实现靶组织的组合物的期望变化和/或其行为的改变。冷却处理的示例性实施方案将干扰神经/肌肉收缩功能链，以减轻皮肤的皱纹。相关治疗可用于治疗背部和其它肌肉痉挛，慢性疼痛等。一些实施方案可改变皮下脂肪组织以改变皮肤表面的形状或外观。

5. 发明申请

WO2016065069A1 WEIGHT STACK PUSHUP EXERCISE DEVICE 审中-公开
标题翻译：重量堆叠推动装置
公开(公告)号：WO2016065069A1
公开(公告)日：2016-04-28
申请号：PCT/US2015/056760
申请日：2015-10-21
申请人： WILLIAMS, Ronald
发明人： WILLIAMS, Ronald
IPC分类号： A63B23/12
CPC分类号： A63B23/1236 , A63B21/00065 , A63B21/0407 , A63B21/055 , A63B21/0552 , A63B21/0628 , A63B21/063 , A63B21/068 , A63B21/154 , A63B21/156 , A63B21/4034 , A63B21/4035 , A63B21/4045 , A63B22/0002 , A63B23/03533 , A63B23/03541 , A63B23/1245 , A63B23/1254 , A63B2071/009 , A63B2225/09
摘要： An exercise machine is provided for developing the chest muscles while maintaining correct biomechanical posture and joint movement for the user, thereby maximizing efficiency and safety. The exercise machine includes a track on which two platforms independently slide. The platforms are each interconnected to a weight stack unit or other vertical resistance unit that provide resistance to the inward movement of the platforms. Each platform may also be connected to a tension element or resistance band that is configured to provide gradual and progressively increased resistance as the platforms are moved inwardly towar15ds the center or center stop of the track.
摘要翻译：提供锻炼机器用于发展胸肌，同时为使用者保持正确的生物力学姿势和关节运动，从而最大限度地提高效率和安全性。健身器包括两个平台独立滑动的轨道。平台各自与重量堆叠单元或其他垂直阻力单元相互连接，从而提供抵抗平台向内运动的阻力。每个平台还可以连接到张力元件或电阻带，该张力元件或电阻带被配置为当平台向内移动时提供渐进和逐渐增加的阻力，从而使轨道的中心或中心停止。

6. 发明申请

WO2010075448A1 SKIN PROTECTION FOR SUBDERMAL CRYOGENIC REMODELING FOR COSMETIC AND OTHER TREATMENTS 审中-公开
标题翻译：皮肤保护用于化妆品和其他处理剂的低温低温重塑
公开(公告)号：WO2010075448A1
公开(公告)日：2010-07-01
申请号：PCT/US2009/069304
申请日：2009-12-22
申请人： MYOSCIENCE, INC. , FOURKAS, Michael , WILLIAMS, Ronald , GOVENJI, Punit , REYNOLDS, Byron , OLSEN, Phillip
发明人： FOURKAS, Michael , WILLIAMS, Ronald , GOVENJI, Punit , REYNOLDS, Byron , OLSEN, Phillip
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/00084 , A61B2018/00041 , A61B2018/00452 , A61B2018/0293
摘要： A systems and methods for controlling temperature in a cryogenic device includes providing a device having a probe and a heater element. A distal region of the probe is engaged with the target region. Measuring and recording current temperature of a proximal region of the probe and time of the measurement is used to determine slope of a temperature curve defined by two points. The first point is defined by the current temperature and time of measurement and a second point is defined by a previous measurement of proximal region temperature and time of measurement. When the slope is less than a slope threshold value a treatment flag is activated, treatment start time is recorded and the proximal region is heated with the heater element. Heating is discontinued and the treatment flag is deactivated after elapsed treatment time exceeds a duration threshold value.
摘要翻译：用于控制低温装置中的温度的系统和方法包括提供具有探针和加热器元件的装置。探针的远侧区域与目标区域接合。测量和记录探头近端区域的当前温度和测量时间用于确定由两点定义的温度曲线的斜率。第一点由当前的测量温度和时间定义，第二个点由先前测量的近端区域温度和测量时间定义。当斜率小于斜率阈值时，处理标志被激活，记录处理开始时间，并且用加热器元件加热近端区域。加热停止，经过治疗时间超过持续时间阈值后，治疗标志被禁用。

7. 发明申请

WO2010075438A1 INTEGRATED CRYOSURGICAL SYSTEM WITH REFRIGERANT AND ELECTRICAL POWER SOURCE 审中-公开
标题翻译：具有制冷和电力来源的综合性CRYOSURGICAL系统
公开(公告)号：WO2010075438A1
公开(公告)日：2010-07-01
申请号：PCT/US2009/069282
申请日：2009-12-22
申请人： MYOSCIENCE, INC. , FOURKAS, Michael , WILLIAMS, Ronald , GOVENJI, Punit , REYNOLDS, Byron
发明人： FOURKAS, Michael , WILLIAMS, Ronald , GOVENJI, Punit , REYNOLDS, Byron
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2018/00041 , A61B2018/0281 , A61B2018/0293 , A61F2007/0052 , A61F2007/0056
摘要： A system for treating tissue in a patient includes a body having a cooling fluid supply path and a tissue piercing probe in fluid communication with the cooling fluid supply path. The probe extends distally from the body and is insertable into the tissue through the patient's skin. A cooling fluid source is fluidly coupled with the probe such that when cooling is initiated, cooling fluid flows in the probe thereby cooling the probe and any adjacent tissue. A heater element is in thermal engagement with the cooling fluid source and a power source provides power to the heater element thereby heating the cooling fluid. The power source has sufficient power to heat the cooling fluid to at least a desired temperature but has insufficient power to heat the cooling fluid above a critical temperature which results in rupture of the cooling fluid source.
摘要翻译：用于治疗患者组织的系统包括具有冷却流体供应路径和与冷却流体供应路径流体连通的组织刺穿探针的主体。探头从身体向远端延伸，并通过病人的皮肤插入组织。冷却流体源与探针流体耦合，使得当冷却开始时，冷却流体在探针中流动，从而冷却探针和任何相邻组织。加热器元件与冷却流体源热接合，并且电源为加热器元件提供电力，从而加热冷却流体。电源具有足够的功率以将冷却流体加热到至少所需温度，但是具有不足以将冷却流体加热到高于导致冷却流体源破裂的临界温度以上的功率。

8. 发明申请

WO2013188572A2 EXERCISE DEVICE 审中-公开
标题翻译：锻炼装置
公开(公告)号：WO2013188572A2
公开(公告)日：2013-12-19
申请号：PCT/US2013/045480
申请日：2013-06-12
申请人： WILLIAMS, Ronald
发明人： WILLIAMS, Ronald
CPC分类号： A63B21/00178 , A63B21/00061 , A63B21/00065 , A63B21/02 , A63B21/0428 , A63B21/0552 , A63B21/15 , A63B21/151 , A63B21/153 , A63B21/4033 , A63B21/4035 , A63B21/4045 , A63B22/203 , A63B23/0211 , A63B23/03508 , A63B23/03525 , A63B23/03541 , A63B23/0488 , A63B23/1236 , A63B23/1281 , A63B2022/206 , A63B2071/027 , A63B2208/0204 , A63B2208/0219
摘要： [0082] The present invention provides an exercise machine for developing the chest muscles while maintaining correct biomechanical posture and joint movement for the user, thereby maximizing efficiency and safety. The present invention includes a track in which two handles independently slide. The handles are interconnected to either an end bridge or a middle bridge by one or more tensioning elements that are configured to provide gradual and progressively increased resistance as a distance between the interconnected components increases.
摘要翻译：本发明提供了一种用于在保持正确的生物力学姿势和关节运动的情况下用于胸部肌肉的锻炼机器，从而使效率和安全性最大化。本发明包括其中两个手柄独立滑动的轨道。手柄通过一个或多个张紧元件与端桥或中间桥互连，所述张紧元件构造为当互连部件之间的距离增加时提供逐渐增加的阻力。

9. 发明申请

WO2008101027A2 REPLACEABLE AND/OR EASILY REMOVABLE NEEDLE SYSTEMS FOR DERMAL AND TRANSDERMAL CRYOGENIC REMODELING 审中-公开
标题翻译：可更换和/或易用的可拆卸针头系统用于真空和超导低温重构
公开(公告)号：WO2008101027A2
公开(公告)日：2008-08-21
申请号：PCT/US2008/053876
申请日：2008-02-13
申请人： MYOSCIENCE, INC. , BURGER, Keith , ELKINS, Lisa , WILLIAMS, Ronald
发明人： BURGER, Keith , ELKINS, Lisa , WILLIAMS, Ronald
IPC分类号： A61B18/02 , A61M5/31
CPC分类号： A61B18/0218 , A61B18/02 , A61B2017/00747 , A61B2018/00023 , A61B2018/00458 , A61B2018/0262 , A61B2018/0293
摘要： The present invention generally provides improved medical devices, systems, and methods. Embodiments may be particularly well suited for the treatment of dermatological and/or cosmetic defects, and alternative embodiments may be configured for treatment of a wide range of target tissues. Some embodiments of the present invention apply cooling with at least one small, tissue-penetrating probe, the probe often comprising a needle having a size suitable for inserting through an exposed surface of the skin of a patient without leaving a visible scar. The cooling may remodel one or more target tissue so as to effect a desired change in a composition of the target tissue and/or a change in its behavior. Exemplary embodiments make use of replaceable needle probes supported by a probe body handle, with small needle probes often being replaced during treatment of a single patient. Unlike the large format cryogenic cooling systems of the past, small cryogenic cooling needle probes may dull or be damaged by insertion. Careful control over the control of cryogenic cooling fluid into a needle probe can allow the length of the active cooling to be controlled through depletion of liquid from an evaporating cryogenic cooling flow. Hence, even needles having similar external structures may provide differing lengths of an iceball along the needle axis. Surprisingly, small cryogenic cooling needles and/or other cryogenic cooling probes having a lubricious coating will allow safe removal of the probe from the treatment region while at a least a portion of the tissue remains frozen, significantly decreasing the overall time for a procedure involving many insertion/freeze/removal cycles.
摘要翻译：本发明通常提供改进的医疗装置，系统和方法。实施方案可以特别适用于治疗皮肤病和/或美容缺陷，并且替代实施方案可被配置用于治疗大范围的靶组织。本发明的一些实施方案用至少一个小的穿透组织的探针进行冷却，所述探针通常包括具有适合穿过患者皮肤暴露表面的尺寸的针而不留下可见的瘢痕。冷却可以改变一个或多个靶组织，以便实现靶组织的组合物的期望变化和/或其行为的改变。示例性实施例使用由探针主体手柄支撑的可替换的针探针，在单个患者的治疗期间经常更换小的针头探针。与过去的大型低温冷却系统不同，小型低温冷却针探针可能会沉没或被插入而损坏。将低温冷却液控制到针头探针中的仔细控制可以通过从蒸发的低温冷却流中消耗液体来控制主动冷却的长度。因此，即使具有相似外部结构的针也可以沿针轴提供不同长度的冰球。令人惊讶的是，具有光滑涂层的小型低温冷却针和/或其它低温冷却探针将允许从处理区域安全地移除探针，同时在组织的至少一部分保持冷冻，显着降低涉及许多方法的程序的总体时间插入/冻结/去除循环。

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