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1. 发明申请

WO2017192792A1 METHOD AND APPARATUS FOR INJECTING A CHROMATOGRAPHIC SAMPLE 审中-公开
标题翻译：注射色谱样品的方法和设备
公开(公告)号：WO2017192792A1
公开(公告)日：2017-11-09
申请号：PCT/US2017/030950
申请日：2017-05-04
申请人： WATERS TECHNOLOGIES CORPORATION
发明人： GILAR, Martin , ANDREWS, Richard, W. , BEALS, Peyton, C. , MCDONALD, Thomas , FADGEN, Keith , KORNFELD, Jordan , GERHARDT, Geoff , CORMIER, Sylvain
IPC分类号： G01N30/20
摘要： A method for injecting a diluted sample in a chromatography system includes merging a flow of a sample and a flow of a diluent to form a flow of a diluted sample. A dilution ratio of the diluted sample equals a sum of the volumetric flow rates of the sample and the diluent divided by the volumetric flow rate of the sample. The diluted sample is stored in a holding element before injection into a chromatographic system flow. Sample dilution occurs under low pressure relative to the chromatographic flow thereby allowing lower pressure sample and diluent syringes to be used. Other benefits include reduced compressibility and a reduction in leaks due to the lower pressure operation. The method avoids problems associated with manual techniques which can introduce errors due, for example, to loss of sample, sample precipitation and adsorption of sample to vials.
摘要翻译：用于将稀释样品注入色谱系统的方法包括合并样品流和稀释剂流以形成稀释样品流。稀释样品的稀释比等于样品和稀释剂的体积流量之和除以样品的体积流量。稀释的样品在注入色谱系统流程之前储存在保持元件中。在相对于色谱流动的低压下进行样品稀释，从而允许使用较低压力的样品和稀释剂注射器。其他好处包括压缩性降低和由于较低压力操作导致的泄漏减少。该方法避免了由于例如样品损失，样品沉淀和样品吸附到样品瓶而可能引入误差的手动技术相关的问题。

2. 发明申请

WO2011091224A1 METHOD FOR DETERMINING EQUIVALENT THERMAL CONDITIONS BETWEEN LIQUID CHROMATOGRAPHY SYSTEMS 审中-公开
标题翻译：用于确定液相色谱系统之间等效热条件的方法
公开(公告)号：WO2011091224A1
公开(公告)日：2011-07-28
申请号：PCT/US2011/021999
申请日：2011-01-21
申请人： WATERS TECHNOLOGIES CORPORATION , ANDREWS, Richard, W. , BEALS, Peyton, C.
发明人： ANDREWS, Richard, W. , BEALS, Peyton, C.
IPC分类号： B01D15/10
CPC分类号： G01N30/04 , B01D15/424 , G01N30/8672 , G01N2030/047 , G01N2030/3007
摘要： Described is a method of transferring a chromatographic method between liquid chromatography (LC) systems. The method is based on a determination of an isoretention temperature at which two solutes co-elute. The method enables separations to be performed using different LC systems with reproducible and equivalent results. For example, the method allows for a chromatography method developed for HPLC to be more readily transferred to a UPLC system and for a chromatography method developed for a UPLC system to be more readily transferred to a HPLC system. The method addresses LC systems having column ovens of different design in which the internal column temperatures are not equal although the operating temperatures of the column ovens may be accurately controlled to equal values. The retention behavior and resolution of different LC systems is caused to be substantially the same so that equivalent separation results are obtained.
摘要翻译：描述了在液相色谱（LC）系统之间转移色谱方法的方法。该方法基于两个溶质共洗脱的等离子体停留温度的测定。该方法可以使用具有可重现性和等效结果的不同液相色谱系统进行分离。例如，该方法允许为HPLC开发的色谱方法更容易转移到UPLC系统中，并且为UPLC系统开发的色谱方法更容易转移到HPLC系统。该方法解决了具有不同设计的列炉的LC系统，其中内部柱温度不相等，尽管柱式炉的操作温度可以被精确地控制为相等的值。导致不同LC系统的保持行为和分辨率基本相同，从而获得等效的分离结果。

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