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1. 发明申请

WO2008156500A4 METHODS OF INDUCING OR INCREASING THE EXPRESSION OF PROTEOGLYCANS SUCH AS AGGRECAN IN CELLS 审中-公开
标题翻译：诱导或增加蛋白质表达的方法如细胞中的AGGRECAN
公开(公告)号：WO2008156500A4
公开(公告)日：2009-06-11
申请号：PCT/US2007084922
申请日：2007-11-16
申请人： WARSAW ORTHOPEDIC INC , YOON SANGWOOK T , UNIV EMORY , BODEN SCOTT D , MCKAY WILLIAM F
发明人： BODEN SCOTT D , MCKAY WILLIAM F
IPC分类号： C12N15/09
CPC分类号： A61K38/1841 , A61K38/1875 , A61K48/005 , A61K48/0075
摘要： Methods of inducing the expression of a proteoglycan such as aggrecan in a cell are described. A method is described which includes transfecting a cell with an isolated nucleic acid comprising a nucleotide sequence encoding a LIM mineralization protein operably linked to a promoter. The LIM mineralization protein can be rLMP, hLMP-1, hLMP-1s, or hLMP-3. Transfection maybe accomplishedex vivo or in vivo by direct injection of virus or naked DNA, or by a nonviral vector such as a plasmid. The method can be used to induce proteoglycan synthesis in osseous cells or to stimulate proteoglycan and/or collagen production in cells capable of producing proteoglycan and/or collagen (e.g., intervertebral disc cells including cells of the nucleus pulposus and annulus fibrosus).
摘要翻译：描述了在细胞中诱导蛋白聚糖如聚集蛋白聚糖表达的方法。描述了一种方法，其包括用包含与启动子可操作地连接的编码LIM矿化蛋白的核苷酸序列的分离的核酸转染细胞。 LIM矿化蛋白可以是rLMP，hLMP-1，hLMP-1或hLMP-3。转染可以通过直接注射病毒或裸DNA或通过非病毒载体如质粒在体内或体内完成。该方法可用于在骨细胞中诱导蛋白聚糖合成或刺激能够产生蛋白聚糖和/或胶原的细胞（例如包括髓核细胞和纤维环的椎间盘细胞）中的蛋白聚糖和/或胶原产生。

2. 发明申请

WO2008156500A2 METHODS OF INDUCING OR INCREASING THE EXPRESSION OF PROTEOGLYCANS SUCH AS AGGRECAN IN CELLS 审中-公开
标题翻译：诱导或增加蛋白质表达的方法如细胞中的AGGRECAN
公开(公告)号：WO2008156500A2
公开(公告)日：2008-12-24
申请号：PCT/US2007084922
申请日：2007-11-16
申请人： WARSAW ORTHOPEDIC INC , YOON SANGWOOK T , UNIV EMORY , BODEN SCOTT D , MCKAY WILLIAM F
发明人： BODEN SCOTT D , MCKAY WILLIAM F
IPC分类号： C12N15/09
CPC分类号： A61K38/1841 , A61K38/1875 , A61K48/005 , A61K48/0075
摘要： Methods of inducing the expression of a proteoglycan such as aggrecan in a cell are described. A method is described which includes transfecting a cell with an isolated nucleic acid comprising a nucleotide sequence encoding a LIM mineralization protein operably linked to a promoter. The LIM mineralization protein can be rLMP, hLMP-1, hLMP-1s, or hLMP-3. Transfection maybe accomplishedex vivo or in vivo by direct injection of virus or naked DNA, or by a nonviral vector such as a plasmid. The method can be used to induce proteoglycan synthesis in osseous cells or to stimulate proteoglycan and/or collagen production in cells capable of producing proteoglycan and/or collagen (e.g., intervertebral disc cells including cells of the nucleus pulposus and annulus fibrosus).
摘要翻译：描述了在细胞中诱导蛋白聚糖如聚集蛋白聚糖表达的方法。描述了一种方法，其包括用包含与启动子可操作地连接的编码LIM矿化蛋白的核苷酸序列的分离的核酸转染细胞。 LIM矿化蛋白可以是rLMP，hLMP-1，hLMP-1或hLMP-3。转染可以通过直接注射病毒或裸DNA或通过非病毒载体如质粒在体内或体内完成。该方法可用于在骨细胞中诱导蛋白聚糖合成或刺激能够产生蛋白聚糖和/或胶原的细胞（例如包括髓核细胞和纤维环的椎间盘细胞）中的蛋白聚糖和/或胶原产生。

3. 发明申请

WO2008156500A3 METHODS OF INDUCING OR INCREASING THE EXPRESSION OF PROTEOGLYCANS SUCH AS AGGRECAN IN CELLS 审中-公开
标题翻译：在细胞中诱导或增加蛋白聚糖如AGGREC的表达的方法
公开(公告)号：WO2008156500A3
公开(公告)日：2009-02-19
申请号：PCT/US2007084922
申请日：2007-11-16
申请人： WARSAW ORTHOPEDIC INC , YOON SANGWOOK T , UNIV EMORY , BODEN SCOTT D , MCKAY WILLIAM F
发明人： BODEN SCOTT D , MCKAY WILLIAM F
IPC分类号： C12N15/09
CPC分类号： A61K38/1841 , A61K38/1875 , A61K48/005 , A61K48/0075
摘要： Methods of inducing the expression of a proteoglycan such as aggrecan in a cell are described. A method is described which includes transfecting a cell with an isolated nucleic acid comprising a nucleotide sequence encoding a LIM mineralization protein operably linked to a promoter. The LIM mineralization protein can be rLMP, hLMP-1, hLMP-1s, or hLMP-3. Transfection maybe accomplishedex vivo or in vivo by direct injection of virus or naked DNA, or by a nonviral vector such as a plasmid. The method can be used to induce proteoglycan synthesis in osseous cells or to stimulate proteoglycan and/or collagen production in cells capable of producing proteoglycan and/or collagen (e.g., intervertebral disc cells including cells of the nucleus pulposus and annulus fibrosus).
摘要翻译：描述了在细胞中诱导蛋白聚糖如聚集蛋白聚糖表达的方法。描述了一种方法，其包括用分离的核酸转染细胞，所述分离的核酸包含可操作地连接至启动子的编码LIM矿化蛋白的核苷酸序列。 LIM矿化蛋白可以是rLMP，hLMP-1，hLMP-1s或hLMP-3。转染可能通过直接注射病毒或裸DNA或通过非病毒载体如质粒在体内或体内实现。该方法可用于在骨细胞中诱导蛋白多糖合成或在能够产生蛋白多糖和/或胶原蛋白的细胞（例如椎间盘细胞包括髓核细胞和纤维环纤维）中刺激蛋白多糖和/或胶原产生。

4. 发明申请

WO2007058878A2 MECHANISMS OF OSTEOINDUCTION BY LIM MINERALIZATION PROTEIN-1 (LMP-1) 审中-公开
标题翻译：由LIM矿化蛋白-1（LMP-1）引起的骨质疏松机制
公开(公告)号：WO2007058878A2
公开(公告)日：2007-05-24
申请号：PCT/US2006043610
申请日：2006-11-09
申请人： WARSAW ORTHOPEDIC INC , UNIV EMORY , MARX JEFFREY C , MCKAY WILLIAM F , BODEN SCOTT D , SANGADALA SREEDHARA
发明人： MARX JEFFREY C , MCKAY WILLIAM F , BODEN SCOTT D , SANGADALA SREEDHARA
IPC分类号： A61K38/17 , A61K38/00 , C12N5/077
CPC分类号： A61K45/06 , A61K38/1703 , A61K38/1875 , C12N5/0654 , C12N2501/155 , C12N2501/998 , C12Q1/26 , G01N33/6872 , G01N2333/51 , G01N2333/9015 , G01N2500/02 , A61K2300/00
摘要： The present invention relates to the methods and compositions for the treatment of subjects having compromised bone conditions. Specifically, the invention relates to Combinatorial therapeutic strategies including small molecules and peptide mimics of LIM mineralization proteins, particularly LMP-I, to overcome the dose-related translational barriers for BMP-2 therapeutics.
摘要翻译：本发明涉及用于治疗受损骨患者的方法和组合物。具体地，本发明涉及组合治疗策略，包括LIM矿化蛋白（特别是LMP-1）的小分子和肽模拟物，以克服BMP-2治疗剂的剂量相关翻译屏障。

5. 发明申请

WO03042368A3 METHODS OF EXPRESSING LIM MINERALIZATION PROTEIN IN NON-OSSEOUS CELLS 审中-公开
标题翻译：在非原生细胞中表达LIM矿化蛋白的方法
公开(公告)号：WO03042368A3
公开(公告)日：2003-10-16
申请号：PCT/US0236465
申请日：2002-11-14
申请人： MEDTRONIC SOFAMOR DANEK , MCKAY WILLIAM F , BODEN SCOTT D , YOON SANGWOOK T
发明人： MCKAY WILLIAM F , BODEN SCOTT D , YOON SANGWOOK T
IPC分类号： A61K35/12 , A61K48/00 , A61L27/38 , C07K14/47 , C07K14/78 , C07K16/18 , C12N5/08 , A01N43/04 , A01N63/00 , C07H21/02 , C07H21/04 , C12N5/00 , C12N15/00 , C12N15/63
CPC分类号： A61K48/005 , A61K35/12 , A61K35/13 , A61K48/00 , A61K2121/00 , A61L27/3804 , A61L27/3856 , C07K14/47 , C07K14/4702 , C07K14/78 , C07K16/18 , C12N2799/022
摘要： Methods of expressing LIM mineralization protein in non-osseous mammalian cells, such as stem cells or intervertebral disc cells (e.g., cells of the annulus fibrosus, or cells of the nucleus pulposus) are described. The methods involve transfecting the cells with an isolated nucleic acid comprising a nucleotide sequence encoding a LIM mineralization protein operably linked to a promoter. Transfection may be accomplished ex vivo or in vivo by direct injection of virus or naked DNA, or by a nonviral vector such as a plasmid. Expression of the LIM mineralization protein can stimulate proteoglycan and/or collagen production in cells capable of producing proteoglycyan and/or collagen. Methods for treating disc disease associated with trauma or disc degeneration are also described.
摘要翻译：描述了在非骨质哺乳动物细胞例如干细胞或椎间盘细胞（例如纤维环的细胞或髓核细胞）中表达LIM矿化蛋白的方法。所述方法涉及用包含编码LIM无机蛋白的核苷酸序列的分离的核酸转染细胞，所述核酸序列可操作地连接至启动子。可以通过直接注射病毒或裸DNA或通过非病毒载体如质粒体外或体内完成转染。 LIM矿化蛋白的表达可以刺激能够产生蛋白多糖和/或胶原蛋白的细胞中的蛋白多糖和/或胶原产生。还描述了用于治疗与创伤或椎间盘退变有关的椎间盘疾病的方法。

6. 发明申请

WO2008070273A2 METHODS OF EXPRESSING LIM MINERALIZATION PROTEIN 审中-公开
标题翻译：表达LIM矿化蛋白的方法
公开(公告)号：WO2008070273A2
公开(公告)日：2008-06-12
申请号：PCT/US2007080932
申请日：2007-10-10
申请人： WARSAW ORTHOPEDIC INC , BODEN SCOTT D , MCKAY WILLIAM F , TITUS FRANCIS L , SANGADALA SREEDHARA
发明人： BODEN SCOTT D , MCKAY WILLIAM F , TITUS FRANCIS L , SANGADALA SREEDHARA
IPC分类号： C12N5/00 , A61K35/12 , A61K48/00 , A61L27/38 , C07K14/47 , C07K14/78 , C07K16/18 , C12N5/08
CPC分类号： A61L27/3856 , A61K35/12 , A61K35/13 , A61K48/00 , A61K2121/00 , C07K14/47 , C07K14/78 , C07K16/18 , C12N2799/022
摘要： Methods of expressing LIM mineralization protein in mammalian cells are described. Methods of expressing LIM mineralization protein and assessing glycosylation of the LIM mineralization protein in prokaryotic and non-mammalian eukaryotic cells are also described. The methods involve transfecting the cells with an isolated nucleic acid comprising a nucleotide sequence encoding a LIM mineralization protein. Transfection may be accomplished in vitro, ex vivo or in vivo by direct injection of virus or naked DNA, or by a nonviral vector such as a plasmid.
摘要翻译：描述了在哺乳动物细胞中表达LIM矿化蛋白的方法。还描述了在原核和非哺乳动物真核细胞中表达LIM矿化蛋白和评估LIM矿化蛋白的糖基化的方法。该方法涉及用包含编码LIM矿化蛋白的核苷酸序列的分离的核酸转染细胞。转染可以通过体外，离体或体内通过直接注射病毒或裸DNA或通过非病毒载体如质粒完成。

7. 发明申请

WO2006102417A3 MECHANISMS OF OSTEOINDUCTION BY LIM MINERALIZATION PROTEIN-1 (LMP-1) 审中-公开
标题翻译：由LIM矿化蛋白-1（LMP-1）引起的骨质疏松机制
公开(公告)号：WO2006102417A3
公开(公告)日：2008-06-05
申请号：PCT/US2006010419
申请日：2006-03-22
申请人： WARSAW ORTHOPEDIC INC , MARX JEFFREY C , MCKAY WILLIAM F , BODEN SCOTT D
发明人： MARX JEFFREY C , MCKAY WILLIAM F , BODEN SCOTT D
IPC分类号： A61K38/00 , A61P19/08 , A61P19/10
CPC分类号： A61K38/1709 , A61K38/1875 , A61K2300/00
摘要： The present invention relates to the methods and compositions for the treatment of subjects having compromised bone conditions. Specifically, the invention relates to combinatorial therapeutic strategies including small molecules and peptide mimics of LIM mineralization proteins, particularly LMP-1, to overcome the dose-related translational barriers for BMP-2 therapeutics.
摘要翻译：本发明涉及用于治疗受损骨患者的方法和组合物。具体地，本发明涉及包括LIM矿化蛋白（特别是LMP-1）的小分子和肽模拟物的组合治疗策略，以克服BMP-2治疗剂的剂量相关翻译屏障。

8. 发明申请

WO2011094316A3 HIGHLY COMPRESSION RESISTANT MATRIX WITH POROUS SKELETON 审中-公开
标题翻译：高耐压矩阵与多孔的SKELETON
公开(公告)号：WO2011094316A3
公开(公告)日：2011-12-29
申请号：PCT/US2011022582
申请日：2011-01-26
申请人： WARSAW ORTHOPEDIC INC , MCKAY WILLIAM F
发明人： MCKAY WILLIAM F
IPC分类号： A61L27/40 , A61F2/28 , A61L27/10 , A61L27/12 , A61L27/14 , A61L27/24 , A61L27/42 , A61L27/54 , A61L27/56
CPC分类号： A61F2/4644 , A61F2002/4648 , A61K9/0024 , A61K9/19 , A61K9/70 , A61K9/7007 , A61L27/425 , A61L27/56
摘要： A highly compression resistant matrix is provided for implantation at or near a target tissue site beneath the skin. The matrix comprises a polymer and a ceramic skeleton. The compression resistance provides retention of a volume that facilitates bone regeneration.
摘要翻译：提供高抗压基质用于植入在皮肤下方的靶组织部位处或附近。该基质包括聚合物和陶瓷骨架。抗压性提供了保持促进骨再生的体积。

9. 发明申请

WO2011094735A3 SURGICAL RETRACTOR INSTRUMENT SYSTEMS AND METHODS OF USING THE SAME 审中-公开
标题翻译：手术回缩器仪器系统及其使用方法
公开(公告)号：WO2011094735A3
公开(公告)日：2011-12-08
申请号：PCT/US2011023318
申请日：2011-02-01
申请人： WARSAW ORTHOPEDIC INC , MCKAY WILLIAM F
发明人： MCKAY WILLIAM F
IPC分类号： A61B17/02 , A61B19/00 , G01L5/00
CPC分类号： A61B17/0206 , A61B2017/00017 , A61B2017/00115 , A61B2017/00128 , A61B2017/00398 , A61B2017/00539 , A61B2017/00544 , A61B2017/0212 , A61B2090/064 , A61B2090/065
摘要： A retractor system for percutaneous surgery in a patient includes first and second retractor portions positionable opposite one another in an incision of the patient. The system also includes at least one actuating member operable to provide an oscillating motion to at least one of the first and second retractor portions. The actuating member is in communication with a controller and is responsive to the controller to move and adjust at least one of the first and second retractor portions between a first position and a second position. The system also includes at least one pressure sensor and display and at least one timing circuit with display. In another form, a method is directed to retracting tissue for percutaneous access to a surgical site in a patient using the pressure sensors and display as will as the timing circuit and display to assure that the amount of pressure applied and the duration does not exceed pre-determined values.
摘要翻译：用于患者经皮手术的牵开器系统包括可在患者切口中彼此相对定位的第一和第二牵开器部分。该系统还包括至少一个致动构件，其可操作以向第一牵拉器部分和第二牵拉器部分中的至少一个提供摆动运动。致动构件与控制器连通并且响应于控制器在第一位置和第二位置之间移动和调节第一牵拉器部分和第二牵拉器部分中的至少一个。该系统还包括至少一个压力传感器和显示器以及至少一个具有显示器的定时电路。在另一种形式中，一种方法涉及使用压力传感器缩回用于经皮进入患者手术部位的组织，并且如同计时电路和显示器那样显示，以确保施加的压力量和持续时间不超过预先设定的时间 - 确定的值。

10. 发明申请

WO2011094626A3 NON-INVASIVE DEVICES AND METHODS TO DIAGNOSE PAIN GENERATORS 审中-公开
标题翻译：非侵入性装置和诊断疼痛发生器的方法
公开(公告)号：WO2011094626A3
公开(公告)日：2011-10-27
申请号：PCT/US2011023045
申请日：2011-01-28
申请人： WARSAW ORTHOPEDIC INC , MCKAY WILLIAM F
发明人： MCKAY WILLIAM F
IPC分类号： A61B5/00 , G01N29/24
CPC分类号： A61B8/00 , A61B5/06 , A61B5/441 , A61B5/4514 , A61B5/4528 , A61B5/4824 , A61B6/12 , A61B8/4245 , A61B8/4254
摘要： Devices and methods are provided that diagnose one or more pain generators at or near the spine in a patient suffering from pain. In one embodiment, a device is provided that includes: an external transducer probe having a proximal end, a distal end and a body therebetween wherein the probe is configured to be placed in contact with the skin of a patient near a pain generator or suspected pain generator; an energy source that supplies the probe with energy; and a conduit for engaging the energy source and the proximal end of the probe. The energy is transferred from the energy source to the distal end of the probe through the skin of the patient and has an intensity to deliver and produce a pain signal when at least the distal end of the probe is near the pain generator or suspected pain generator.
摘要翻译：提供了诊断患有疼痛的患者的脊柱处或附近的一个或多个疼痛发生器的装置和方法。在一个实施例中，提供了一种装置，其包括：外部换能器探头，其具有近端，远端以及其间的主体，其中，所述探头被配置为与疼痛发生器附近的患者皮肤接触或怀疑疼痛发电机; 为探针提供能量的能源; 以及用于接合能量源和探针的近端的导管。当探针的至少远端靠近疼痛发生器或疑似疼痛发生器时，能量从能量源传递到探针的远端并穿过患者的皮肤，并具有传递和产生疼痛信号的强度。

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