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1. 发明申请

WO2018089399A1 CELL ENCAPSULATION DEVICES CONTAINING STRUCTURAL SPACERS 审中-公开
标题翻译：含有结构空间的细胞封装装置
公开(公告)号：WO2018089399A1
公开(公告)日：2018-05-17
申请号：PCT/US2017/060497
申请日：2017-11-08
申请人： W. L. GORE & ASSOCIATES, INC. , W. L. GORE & ASSOCIATES GMBH
发明人： CULLY, Edward, H. , ZAMBOTTI, Lauren , PARSONS, Bernadette , DRUMHELLER, Paul, D.
IPC分类号： A61L27/16 , A61L27/36 , A61F2/02 , A61M5/00 , A61M31/00 , A61M37/00 , C12N5/00
摘要： An implantable containment apparatus for receiving and retaining a plurality of cells for insertion into a patient, such as into a tissue bed, is disclosed. The device includes a chamber having structural spacers therein to maintain an average distance between the first interior surface and the second interior surface of the chamber and to define at least one reservoir space for the placement of cells within the chamber.
摘要翻译：公开了一种用于接收和保持多个细胞以插入患者体内的可植入容器装置，例如组织床。该装置包括其中具有结构间隔物的腔室，以维持腔室的第一内表面和第二内表面之间的平均距离并限定用于将细胞放置在腔室内的至少一个储存空间。

2. 发明申请

WO2015168627A1 PUSH AND PULL MEDICAL DEVICE DELIVERY SYSTEM 审中-公开
标题翻译：推送和推送医疗设备传送系统
公开(公告)号：WO2015168627A1
公开(公告)日：2015-11-05
申请号：PCT/US2015/028903
申请日：2015-05-01
申请人： W. L. GORE & ASSOCIATES, INC.
发明人： CULLY, Edward, H. , KARINIEMI, Ryan, D. , WILLIAMS, David, M.
IPC分类号： A61F2/95 , A61F2/24 , A61F2/962 , A61F2/966 , A61F2/97 , A61B17/00 , A61B17/34 , A61F2/07 , A61F2/954
CPC分类号： A61F2/962 , A61B17/00234 , A61B17/3415 , A61B17/3468 , A61F2/07 , A61F2/2436 , A61F2/92 , A61F2/95 , A61F2/954 , A61F2/966 , A61F2/97 , A61F2002/823 , A61F2002/9522 , A61F2220/0033 , A61F2220/0075 , A61F2250/0019 , A61F2250/0029
摘要： A system for delivery of a medical device includes a delivery member (206) and a medical device (500), which is mounted to the delivery member and releasably retained in a delivery configuration for endoluminal delivery of the medical device toward a treatment site in a human vessel. The delivery member includes an elongated first portion (205) configured to extend outside of the body from a first percutaneous access site (102) and an elongated second portion (207) configured to extend outside the body from a second percutaneous access site (104) to allow positioning of the medical device at the treatment site by manipulation of the first portion and second portion from outside of the body.
摘要翻译：一种用于医疗装置的输送系统包括一个输送部件（206）和一个医疗装置（500），该装置安装在输送部件上并可释放地保持在用于医疗装置的内腔输送朝向治疗部位人类血管递送构件包括细长的第一部分（205），其被配置为从第一经皮进入部位（102）延伸到身体外部，并且细长的第二部分（207）被配置为从第二经皮进入部位（104）延伸到身体外部，以允许通过从身体的外部操纵第一部分和第二部分来将医疗装置定位在治疗部位。

3. 发明申请

WO2016061186A1 BLOW MOLDED COMPOSITE DEVICES AND METHODS 审中-公开
标题翻译：吹塑复合材料和方法
公开(公告)号：WO2016061186A1
公开(公告)日：2016-04-21
申请号：PCT/US2015/055469
申请日：2015-10-14
申请人： W. L. GORE & ASSOCIATES, INC.
发明人： BROYLES, Michael, R. , CULLY, Edward, H. , HEICKSEN, Peter , KOENIG, Joseph, B. , MAULDING, Matthew, E. , MAZZARESE, Kenneth
IPC分类号： A61L29/12 , A61L29/14 , A61L29/04 , A61L29/08
CPC分类号： A61M25/1029 , A61L29/041 , A61L29/06 , A61L29/085 , A61L29/126 , A61L29/146 , A61L29/16 , A61M25/1002 , A61M2025/1031 , B29C49/20 , B29C2049/2047 , B29K2101/12 , B29K2627/18 , B29L2031/7543 , C08L27/18
摘要： The present disclosure is directed toward a composite balloon comprising a layer of material having a porous microstructure (e.g., ePTFE or expanded polyethylene) and a thermoplastic polymeric layer useful for medical applications. The layers of the composite balloons become adhered through a stretch blow-molding process. Methods of making and using such composite balloons are also described amongst others.
摘要翻译：本公开涉及包括具有多孔微结构（例如，ePTFE或膨胀聚乙烯）的材料层和可用于医疗应用的热塑性聚合物层的复合球囊。复合气囊的层通过拉伸吹塑法粘附。还描述了制造和使用这种复合气囊的方法。

4. 发明申请

WO2014158579A1 DECONSTRUCTABLE ENDOLUMINAL DEVICES AND RELATED SYSTEMS AND METHODS 审中-公开
标题翻译：可解构的内镜装置及相关系统和方法
公开(公告)号：WO2014158579A1
公开(公告)日：2014-10-02
申请号：PCT/US2014/018437
申请日：2014-02-25
申请人： W. L. GORE & ASSOCIATES, INC.
发明人： CULLY, Edward, H. , DUNCAN, Jeffrey, B. , MARTONIK, Brian, C.
IPC分类号： A61M25/00
CPC分类号： A61M25/005 , A61M25/0045 , A61M25/0662 , A61M25/0668
摘要： An endoluminal device comprises a tubular member and a reinforcement member that is separable from, or together with, a wall of the tubular member, and removable in-situ.
摘要翻译：腔内装置包括管状构件和加强构件，其可与管状构件的壁分离或与管壁构件的壁一起，并且可原位移除。

5. 发明申请

WO2013158342A1 SINGLE ACCESS FLOW-REVERSAL CATHETER DEVICES AND METHODS 审中-公开
标题翻译：单通道逆向导管装置和方法
公开(公告)号：WO2013158342A1
公开(公告)日：2013-10-24
申请号：PCT/US2013/033798
申请日：2013-03-26
申请人： W. L. GORE & ASSOCIATES, INC.
发明人： CULLY, Edward, H. , TRAPP, Benjamin, M. , VONESH, Michael, J.
IPC分类号： A61B17/12 , A61M25/10
CPC分类号： A61B17/12118 , A61B17/12036 , A61B17/12045 , A61B17/12109 , A61B17/12113 , A61B17/12136 , A61B17/12168 , A61B17/22 , A61B2017/00986 , A61B2017/22054 , A61B2017/22079 , A61B2217/005 , A61F2/01 , A61F2/013 , A61F2002/011 , A61M1/34 , A61M1/3403 , A61M1/3621 , A61M25/1011 , A61M2025/1015
摘要： Embodiments herein include devices and methods directed toward creating reverse flow within a vessel and thereby providing protection against embolic debris. Embodiments comprise a catheter and a plurality of occluders that are expandable and adjustable within a lumen to create low-pressure areas that reroute blood flow and embolic debris therein.
摘要翻译：本文的实施方案包括用于在容器内产生反向流动并由此提供防止栓塞碎片的装置和方法。实施例包括导管和多个封堵器，其可在腔内可扩张和调节，以产生将血液流动和栓塞碎屑重新路由的低压区域。

6. 发明申请

WO2019209260A1 MEDICAL DELIVERY DEVICES WITH INHIBITED OXYGEN PERMEATION 审中-公开
公开(公告)号：WO2019209260A1
公开(公告)日：2019-10-31
申请号：PCT/US2018/029019
申请日：2018-04-24
申请人： W. L. GORE & ASSOCIATES, INC.
发明人： CULLY, Edward, H. , GUNZEL, Edward, C. , SCOTTI, Christine, M.
IPC分类号： A61M5/315 , A61M5/31
摘要： The present disclosure relates to medical devices such as syringes, auto- injectors, and pens that inhibit oxygen permeation into the fluid chamber. The medical device includes a lubricant-free ( e.g. , silicone) or a siliconized barrel having an interior surface defining a fluid chamber, an elastomeric stopper, and a plunger rod. In one embodiment, at least a portion of the interior surface of the barrel is reduced to increase the interference fit between the stopper and the barrel. In another embodiment, the stopper may include a plurality of ribs and a valley between each pair of ribs may include a ring member provided in each of the valleys. The ring member includes an oxygen-absorbing, an oxygen-adsorbing material, or both, to bind any oxygen that permeates into the syringe, auto-injector, or pen. In yet another embodiment, the stopper may include a barrier coating including an oxygen barrier material to inhibit or prevent oxygen permeation.

7. 发明申请

WO2016054537A1 REMOVABLE COVERS FOR DRUG ELUTING MEDICAL DEVICES 审中-公开
标题翻译：用于药物治疗医疗器械的可拆卸盖子
公开(公告)号：WO2016054537A1
公开(公告)日：2016-04-07
申请号：PCT/US2015/053770
申请日：2015-10-02
申请人： W. L. GORE & ASSOCIATES, INC.
发明人： CULLY, Edward, H. , DUNCAN, Jeffrey, B. , HEICKSEN, Peter , KOENIG, Joseph, B. , KUSTUSCH, Jeffrey, J.
IPC分类号： A61F2/97 , A61M25/06 , A61M25/10 , A61L29/08 , A61F2/958
CPC分类号： A61M25/10184 , A61F2/95 , A61F2/958 , A61F2/97 , A61F2002/9583 , A61L29/041 , A61L29/085 , A61M25/1011 , A61M2025/105 , A61M2025/1081 , C08L27/18
摘要： The present disclosure includes an expandable medical device (104) and outer sheath (120) combination. The outer sheath is capable of being split to form multiple sheath sections (230, 232) that may be peeled back to expose a portion or all of the expandable medical device. The medical device, as well as the outer sheath, may include one or more therapeutic agents for delivery to a treatment area within a patient.
摘要翻译：本公开包括可扩张医疗装置（104）和外护套（120）的组合。外护套能够被分开以形成多个护套部分（230,232），其可被剥离以暴露可扩张医疗装置的一部分或全部。医疗装置以及外护套可以包括用于递送到患者内的治疗区域的一种或多种治疗剂。

8. 发明申请

WO2015084993A1 ANASTOMOTIC CONNECTORS 审中-公开
标题翻译：分析连接器
公开(公告)号：WO2015084993A1
公开(公告)日：2015-06-11
申请号：PCT/US2014/068425
申请日：2014-12-03
申请人： W. L. GORE & ASSOCIATES, INC.
发明人： CULLY, Edward, H. , DUNCAN, Jeffrey, B. , GOEPFRICH, James, L.
IPC分类号： A61B17/11 , A61F2/06
CPC分类号： A61B17/11 , A61B2017/00004 , A61B2017/1107 , A61B2017/1132 , A61B2017/1135 , A61B2017/1139 , A61F2/06 , A61F2/064 , A61F2210/0004 , A61F2250/0039
摘要： An anastomotic connector includes a tubular shell and a porous biocompatible liner configured to connect two or more natural and/or artificial lumens, such as blood vessels and/or grafts. The tubular shell may be bioabsorbable, ultimately dissolving in the body, while the biocompatible liner can remain in the body and connected to the lumens.
摘要翻译：吻合连接器包括管状壳体和被构造成连接两个或更多个天然和/或人造腔（例如血管和/或移植物）的多孔生物相容性衬里。管状壳可以是生物可吸收的，最终溶解在体内，同时生物相容的衬垫可以保留在体内并连接到腔。

9. 发明申请

WO2020068366A1 CELL ENCAPSULATION DEVICES WITH CONTROLLED CELL BED THICKNESS 审中-公开
公开(公告)号：WO2020068366A1
公开(公告)日：2020-04-02
申请号：PCT/US2019/049007
申请日：2019-08-30
申请人： W. L. GORE & ASSOCIATES, INC.
发明人： RUSCH, Greg , CULLY, Edward, H.
IPC分类号： A61F2/02
摘要： An implantable containment apparatus for receiving and retaining a biological moiety, including a plurality of cells, for insertion into a patient, such as into a tissue bed, is disclosed. The device includes a cell encapsulating pouch that forms and interior volume having a reservoir space for receiving cells, where the reservoir space includes first and second interior surfaces, and a tensioning member to maintain an average distance between the first interior surface and the second interior surface.

10. 发明申请

WO2015116045A1 ELASTIC STENT GRAFT 审中-公开
标题翻译：弹性棒
公开(公告)号：WO2015116045A1
公开(公告)日：2015-08-06
申请号：PCT/US2014/013496
申请日：2014-01-29
申请人： W. L. GORE & ASSOCIATES, INC.
发明人： CULLY, Edward, H. , DUNCAN, Jeffrey, B. , KARINIEMI, Ryan, D. , KARINIEMI, Thomas, E. , KUSTUSCH, Jeffrey, J. , NELSON, Jares, S.
IPC分类号： A61L31/10 , A61L31/14
CPC分类号： A61L31/10 , A61L31/14 , A61L31/146 , C08L27/12 , C08L27/18
摘要： A stent graft including (1 ) a stent having a wall having at least one opening, an outer surface, and an inner surface and (2) a covering of a composite material having a least one expanded fluoropolymer membrane and an elastomer is provided. The cover can be used to cover the outer and/or the inner surface of the stent. The expanded fluoropolymer membrane contains serpentine fibrils. In exemplary embodiments, the fluoropolymer is polytetrafluoroethylene. The composite material may be axially and/or circumferentially wrapped around the stent. The composite material is fold-free throughout its operating diameter range and exhibits a sharp increase in stiffness at a predetermined diameter. The stent graft can be designed to have a stop point in either a radial or axial direction. The stent graft can advantageously be implanted undersized with respect to a nominal diameter without having material infolding.
摘要翻译：一种覆膜支架，其包括（1）具有至少一个开口的壁的支架，外表面和内表面，以及（2）具有至少一个膨胀的含氟聚合物膜和弹性体的复合材料的覆盖物。盖可用于覆盖支架的外表面和/或内表面。膨胀的含氟聚合物膜含有蛇纹石原纤维。在示例性实施方案中，含氟聚合物是聚四氟乙烯。复合材料可以围绕支架轴向和/或周向缠绕。复合材料在其整个工作直径范围内是无折叠的，并且在预定直径处表现出刚度的急剧增加。支架移植物可以设计成在径向或轴向方向上具有停止点。支架移植物可以有利地相对于标称直径而不是材料折叠地被植入到尺寸不足的地方。

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