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1. 发明申请

WO2017185074A1 DETERMINING TISSUE OXYGEN SATURATION WITH MELANIN CORRECTION 审中-公开
标题翻译：用梅兰宁校正法测定组织氧饱和度
公开(公告)号：WO2017185074A1
公开(公告)日：2017-10-26
申请号：PCT/US2017/029014
申请日：2017-04-21
申请人： VIOPTIX, INC.
发明人： BECHTEL, Kate LeeAnn , SHULTZ, Kimberly Merritt , MARGIOTT, Alex Michael , KECHTER, George Edward
IPC分类号： A61B5/145 , A61B5/1455 , A61B5/1477
摘要： An oximeter probe that takes into account tissue color (e.g., skin color or melanin content) to improve accuracy when determining oxygen saturation of tissue. Light is transmitted from a light source into tissue having melanin (e.g., eumelanin or pheomelanin). Light reflected from the tissue is received by a detector. A compensation factor is determined to account for absorption due to the melanin. The oximeter uses this compensation factor and determines a melanin-corrected oxygen saturation value.
摘要翻译：在确定组织的氧饱和度时考虑组织的颜色（例如，肤色或黑色素含量）以提高准确度的血氧计探针。光从光源传输到具有黑色素的组织（例如，真黑素或黑素素）。检测器接收从组织反射的光。确定补偿因子以解释由于黑色素引起的吸收。血氧计使用此补偿因子并确定黑色素校正的氧饱和度值。

2. 发明申请

WO2017184907A1 SLEEVE FOR A HANDHELD OXIMETRY PROBE 审中-公开
标题翻译：一只手持氧化测试探针
公开(公告)号：WO2017184907A1
公开(公告)日：2017-10-26
申请号：PCT/US2017/028700
申请日：2017-04-20
申请人： VIOPTIX, INC.
发明人： LONSINGER, Mark , COLERIDGE, Scott , BECHTEL, Kate LeeAnn , WELCH, William
IPC分类号： A61B5/00 , A61B5/1455 , A61F13/00
摘要： A sleeve includes a body having a top opening. The body covers a handheld oximeter probe or a portion of the probe. The sleeve has a shape that approximately matches the oximeter probe or portion of the probe, which is covered by the sleeve. The sleeve has a top opening that allows a user to slide the oximeter probe into the sleeve. The sleeve is transparent to radiation emitted and collected by the oximeter probe. The sleeve is formed of a material that prevents patient tissue, fluid, viruses, bacteria, and fungus from contacting the covered portions of the oximeter probe. The sleeve leaves the probe relatively sterile after use so that little or no clearing of the probe is required for a subsequent use, such as when the probe is covered with a new, unused sleeve.
摘要翻译：套筒包括具有顶部开口的主体。身体覆盖手持式血氧探头或探头的一部分。套管的形状大致与套管覆盖的血氧计探针或探针部分相匹配。套管有一个顶部开口，允许使用者将血氧计探头滑入套管。套管对由血氧计探头发射和收集的辐射是透明的。套筒由防止患者组织，流体，病毒，细菌和真菌接触血氧计探头的被覆盖部分的材料形成。套管在使用后离开探头相对无菌，以便随后的使用很少或不需要清除探头，例如当探头覆盖有新的未使用的套管时。

3. 发明申请

WO2017184906A1 OXIMETRY PROBE WITH ELECTRONICALLY SELECTABLE TISSUE DEPTH ANALYSIS 审中-公开
标题翻译：氧化电位探针与电子选择性组织深度分析
公开(公告)号：WO2017184906A1
公开(公告)日：2017-10-26
申请号：PCT/US2017/028699
申请日：2017-04-20
申请人： VIOPTIX, INC.
发明人： BECHTEL, Kate LeeAnn , KEATING, Jennifer Elizabeth , COLERIDGE, Scott
IPC分类号： A61B5/1455
摘要： An oximeter probe includes a probe unit or a base unit and a probe tip where the probe tip has a number of sources and detectors that can be accessed individually or in differing combinations for measuring tissue oxygen saturation at different tissue depth in tissue. A processor of the oximeter probe controls a multiplexer that is coupled to the detectors for selectively collecting measurement information from the detectors via the multiplexer. The oximeter probe is user programmable via one or more input devices on the oximeter probe for selecting the particular sources and detectors to collect measurement information from by the processor.
摘要翻译：血氧计探头包括探头单元或基座单元以及探头尖端，其中探头尖端具有多个源和检测器，其可以单独地或以不同的组合进入以测量不同的组织氧饱和度组织深度。血氧计探头的处理器控制与检测器耦合的多路复用器，用于通过多路复用器选择性地收集来自检测器的测量信息。血氧计探头可由用户通过血氧计探头上的一个或多个输入设备进行编程，用于选择特定的信号源和检测器以从处理器收集测量信息。

4. 发明申请

WO2017185104A1 DETERMINING ABSOLUTE AND RELATIVE TISSUE OXYGEN SATURATION 审中-公开
标题翻译：确定绝对和相对的组织氧饱和度
公开(公告)号：WO2017185104A1
公开(公告)日：2017-10-26
申请号：PCT/US2017/029221
申请日：2017-04-24
申请人： VIOPTIX, INC.
发明人： BECHTEL, Kate LeeAnn , LOHMAN, Robert , DJOHAN, Risal , COLERIDGE, Scott
IPC分类号： A61B5/145 , A61B5/1477 , A61B5/1455
摘要： An oximeter probe is user configurable for being in an absolute reporting mode and a relative reporting mode for measured values. The measured values for the absolute and relative modes include absolute oxygen saturation, relative oxygen saturation, absolute hemoglobin content, relative hemoglobin content, absolute blood volume, relative blood volume. The relative modes and absolute modes for determining and reporting relative or absolute hemoglobin content or relative or absolute blood volume for individual patients are beneficial when determining the efficacy of administered medications, such as epinephrine, that effect blood flow, but not oxygen saturation, in tissue, such as skin. The oximeter probe in these relative modes displays the efficacy of the administered medication as reported values for relative hemoglobin content or relative blood volume fall or rise.
摘要翻译：
血氧计探头可以用户配置为处于绝对报告模式，相对报告模式用于测量值。绝对和相对模式的测量值包括绝对氧饱和度，相对氧饱和度，绝对血红蛋白含量，相对血红蛋白含量，绝对血量，相对血容量。确定和报告相对或绝对血红蛋白含量或个体患者的相对或绝对血容量的相对模式和绝对模式在确定在组织中影响血流但不影响氧饱和度的施用药物（例如肾上腺素）的功效时是有益的，如皮肤。这些相对模式中的血氧计探头显示了相关血红蛋白含量或相对血容量下降或升高的报道值，所给药的药物的功效。

5. 发明申请

WO2013166465A1 TISSUE OXIMETRY PROBE WITH TISSUE MARKING FEATURE 审中-公开
标题翻译：组织标记探针组织特征
公开(公告)号：WO2013166465A1
公开(公告)日：2013-11-07
申请号：PCT/US2013/039581
申请日：2013-05-03
申请人： VIOPTIX, INC.
发明人： BECHTEL, Kate LeeAnn , HEANUE, Joseph Anthony , LLOYD, Lester John
IPC分类号： A61B5/1455
CPC分类号： A61B5/14551 , A61B5/0059 , A61B5/0075 , A61B5/14546 , A61B5/1455 , A61B5/14552 , A61B5/1459 , A61B5/1495 , A61B5/72 , A61B5/7246 , A61B5/7282 , A61B5/74 , A61B5/7405 , A61B5/742 , A61B5/7475 , A61B90/11 , A61B90/39 , A61B2090/065 , A61B2090/306 , A61B2090/395 , A61B2560/0431 , A61B2560/0475 , A61B2562/0271 , A61B2562/166 , A61M35/003
摘要： An intraoperative tissue oximetry device includes a tissue marker that includes one or more pens or one or more similar ink sources, such that the tissue marker can mark tissue according to oxygen saturation measurements made by the tissue oximetry device, thereby visually delineating regions of potentially viable tissue from regions of potentially nonviable tissue.
摘要翻译：术中组织血氧定量装置包括组织标记物，其包括一个或多个笔或一个或多个类似的墨源，使得组织标记物可以根据由组织血氧饱和度测量装置进行的氧饱和度测量来标记组织，从而可视地描绘潜在可行的区域组织来自潜在的非营养组织的区域。

6. 发明申请

WO2018017501A1 OXIMETRY DEVICE WITH LAPAROSCOPIC EXTENSION 审中-公开
标题翻译：带有腹腔镜扩张的OXIMETRY装置
公开(公告)号：WO2018017501A1
公开(公告)日：2018-01-25
申请号：PCT/US2017/042458
申请日：2017-07-17
申请人： VIOPTIX, INC.
发明人： BECHTEL, Kate LeeAnn , HARRIS, Todd Louis , SOLOMON, Edward Gerald , SUN, Winston , BALDWIN, Alan , COLERIDGE, Scott , LONSINGER, Mark
IPC分类号： A61B5/1455 , A61B5/1459 , A61B5/00
摘要： A laparoscopic medical device includes an oximeter sensor at its tip, which allows the making of oxygen saturation measurements laparoscopically. The device can be a unitary design, wherein a laparoscopic element includes electronics for the oximeter sensor at a distal end (e.g., opposite the tip). The device can be a multiple piece design (e.g., two-piece design), where some electronics is in a separate housing from the laparoscopic element, and the pieces (or portions) are removably connected together. The laparoscopic element can be removed and disposed of; so, the electronics can be reused multiple times with replacement laparoscopic elements. The electronics can include a processing unit for control, computation, or display, or any combination of these. However, in an implementation, the electronics can connect wirelessly to other electronics (e.g., another processing unit) for further control, computation, or display, or any combination of these.
摘要翻译：腹腔镜医疗装置在其尖端包括血氧计传感器，其允许腹腔镜地进行氧饱和度测量。该装置可以是整体式设计，其中腹腔镜元件包括远端（例如，与尖端相对）的血氧计传感器的电子器件。该装置可以是多件式设计（例如，两件式设计），其中一些电子器件位于与腹腔镜元件分离的外壳中，并且这些片（或部分）可拆卸地连接在一起。腹腔镜元件可以被移除和丢弃; 因此，电子设备可以在更换腹腔镜元件的情况下多次重复使用。电子设备可以包括用于控制，计算或显示的处理单元，或这些的任意组合。然而，在一个实施方式中，电子设备可以无线连接到其他电子设备（例如，另一个处理单元）以用于进一步的控制，计算或显示，或者这些的任意组合。

7. 发明申请

WO2017185096A1 ERGONOMIC HANDHELD OXIMETER DEVICE 审中-公开
标题翻译：符合人体工程学的手持式血压计装置
公开(公告)号：WO2017185096A1
公开(公告)日：2017-10-26
申请号：PCT/US2017/029196
申请日：2017-04-24
申请人： VIOPTIX, INC.
发明人： BECHTEL, Kate LeeAnn , BERGER, Sophia Elizabeth , STEEVER, Audrey
IPC分类号： A61B5/00 , A61B5/1455
摘要： An oximeter device has an ergonomically shaped enclosure that allows a user to comfortably grip and use the device during handheld operation. A sensor tip can be easily placed evenly on the tissue surface, so that all sources and detectors are directly on the tissue with even pressure. This allows for more consistent and accurate results. The user can easily move the device from one position to another and take numerous measurements. The user will have a wide, unobstructed view of the tissue because of the tips small size, angle of display, and the grip and fingers are positioned away from the tip. Components housed by the enclosure are arranged to give the device a balanced weighting while in the hand. The device can be used for long periods at a time without fatigue.
摘要翻译：血氧计装置具有符合人体工程学形状的外壳，其允许用户在手持操作期间舒适地抓握和使用该装置。传感器尖端可以很容易地均匀地放置在组织表面上，以便所有的源和检测器均匀地直接压在组织上。这允许更一致和准确的结果。用户可以轻松将设备从一个位置移动到另一个位置，并进行大量测量。由于尖端尺寸小，显示角度大，并且把手和手指远离尖端，使用者将具有宽阔且无阻碍的组织视野。由外壳安置的部件布置为在手中时使设备具有均衡的重量。该设备可以长时间使用而不会感到疲劳。

8. 发明申请

WO2013166463A1 MONTE CARLO AND ITERATIVE METHODS FOR DETERMINATION OF TISSUE OXYGEN SATURATION 审中-公开
标题翻译： MONTE CARLO和用于确定组织氧化饱和度的迭代方法
公开(公告)号：WO2013166463A1
公开(公告)日：2013-11-07
申请号：PCT/US2013/039578
申请日：2013-05-03
申请人： VIOPTIX, INC.
发明人： BECHTEL, Kate LeeAnn , NISHIHARA, H. Keith
IPC分类号： A61B5/1455
CPC分类号： A61B5/14551 , A61B5/0059 , A61B5/0075 , A61B5/14546 , A61B5/1455 , A61B5/14552 , A61B5/1459 , A61B5/1495 , A61B5/72 , A61B5/7246 , A61B5/7282 , A61B5/74 , A61B5/7405 , A61B5/742 , A61B5/7475 , A61B90/11 , A61B90/39 , A61B2090/065 , A61B2090/306 , A61B2090/395 , A61B2560/0431 , A61B2560/0475 , A61B2562/0271 , A61B2562/166 , A61M35/003
摘要： A method for determining oxygen saturation includes emitting light from sources into tissue; detecting the light by detectors subsequent to reflection; and generating reflectance data based on detecting the light. The method includes determining a first subset of simulated reflectance curves from a set of simulated reflectance curves stored in a tissue oximetry device for a coarse grid; and fitting the reflectance data points to the first subset of simulated reflectance curves to determine a closest fitting one of the simulated reflectance curves. The method includes determining a second subset of simulated reflectance curves for a fine grid based on the closest fitting one of the simulated reflectance curves; determining a peak of absorption and reflection coefficients from the fine grid; and determining an absorption and a reflectance coefficient for the reflectance data points by performing a weighted average of the absorption coefficients and reflection coefficients from the peak.
摘要翻译：确定氧饱和度的方法包括将来自源的光发射到组织中; 通过检测器在反射之后检测光; 以及基于检测光产生反射率数据。该方法包括从存储在用于粗网格的组织测温装置中的一组模拟反射曲线确定模拟反射曲线的第一子集; 并将反射率数据点拟合到模拟反射曲线的第一子集，以确定最接近的拟合反射曲线之一。该方法包括基于模拟反射曲线中最接近的拟合曲线确定精细网格的模拟反射率曲线的第二子集; 确定细网格的吸收和反射系数的峰值; 以及通过从峰值执行吸收系数和反射系数的加权平均值来确定反射率数据点的吸收和反射系数。

9. 发明申请

WO2021142466A1 PROBE TIP FOR MEDICAL DEVICE 审中-公开
公开(公告)号：WO2021142466A1
公开(公告)日：2021-07-15
申请号：PCT/US2021/013000
申请日：2021-01-11
申请人： VIOPTIX, INC.
发明人： BECHTEL, Kate LeeAnn , MARGIOTT, Alex Michael , KEATING, Jennifer Elizabeth , SHULTZ, Kimberly Merritt
IPC分类号： A61B5/1455 , A61B5/145 , G02B6/24 , A61B5/00 , G02B6/38 , A61B2503/10 , A61B2503/40 , A61B2560/0214 , A61B2560/0418 , A61B2562/0219 , A61B2562/0271 , A61B2562/166 , A61B2562/18 , A61B5/14552
摘要： A probe tip of an oximeter device includes first and second printed circuit boards (PCBs) that are coupled to the ends of optical fibers that transmit light between the PCBs and into patient tissue that is to be measured by the oximeter device. The PCBs are oriented at an angle between zero and ninety degrees so that the fibers have a curved shape between the locations at which the fibers are coupled to the first and second PCBs. The angular orientation of the PCBs and curved shape of the fibers allows the fibers to have a longer length than if the fibers were straight and allows for light transmitted through the fibers to have a uniform distribution across a cross-section of the fibers as the light is emitted from the fibers into patient tissue. The uniform distribution of light transmitted into patient tissue allows for reliable oximetry measurements.

10. 发明申请

WO2017185103A1 DETERMINING TISSUE OXYGEN SATURATION WITH QUALITY REPORTING 审中-公开
标题翻译：用质量报告确定组织氧饱和度
公开(公告)号：WO2017185103A1
公开(公告)日：2017-10-26
申请号：PCT/US2017/029220
申请日：2017-04-24
申请人： VIOPTIX, INC.
发明人： BECHTEL, Kate LeeAnn , MARGIOTT, Alex Michael , KEATING, Jennifer Elizabeth , SHULTZ, Kimberly Merritt , COLERIDGE, Scott , HEANUE, Joseph
IPC分类号： A61B5/145 , A61B5/1455
摘要： An oximeter probe determines an oxygen saturation for the tissue and determines a quality value for the oxygen saturation and associated measurements of the tissue. The quality value is calculated from reflectance data received at the detectors of the oximeter probe. The oximeter probe then displays a value for the oxygen saturation with the error value to indicate a quality level for the oxygen saturation and associated values used to calculate oxygen saturation.
摘要翻译：
一种血氧计探针确定用于组织中的氧饱和度，并确定的氧饱和度和组织的相关联的测量的质量值。质量值由血氧计探头检测器处接收的反射数据计算得出。然后，血氧计探头显示氧饱和度的值和误差值，以指示氧饱和度的质量水平以及用于计算氧饱和度的相关值。

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