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1. 发明申请

WO2014124532A1 OPTICAL STANDARD FOR CALIBRATION OF SPECTRAL MEASURING SYSTEMS 审中-公开
标题翻译：用于校准光谱测量系统的光学标准
公开(公告)号：WO2014124532A1
公开(公告)日：2014-08-21
申请号：PCT/CA2014/050094
申请日：2014-02-11
申请人： VERISANTE TECHNOLOGY, INC. , BRITISH COLUMBIA CANCER AGENCY BRANCH
发明人： ZENG, Haishan , WANG, Hequn , BRAUN, Thomas Andrew
IPC分类号： G01J3/02 , A61B6/00
CPC分类号： G01N21/278 , A61B5/0075 , A61B2560/0233 , G01N21/645 , G01N21/65 , G01N2021/6482
摘要： Examples of an optical standard and a calibration apparatus for calibrating or characterizing a spectroscopy system using such optical standard are disclosed. The optical standard can comprises a mixture of acetaminophen and barium sulfate, wherein a mass of the acetaminophen in the mixture is being less than a mass of the BaSO4. Such optical standard can be used in a calibration device for calibrating or characterizing a spectroscopy system. The calibration device can comprise a substrate base with a top surface and a bottom surface. The top surface can include a section for receiving the optical standard sample. The receiving section can be adhesive. The calibration device can further comprise a film that can be attached to the top surface of the substrate base to cover at least the section of the substrate where the optical standard is being placed. The calibration device can be disposed after the calibration measurements are completed. The optical standard and the calibration apparatus using the optical standard can be used as a wavelength calibration standard to calibrate a Raman system, a reflectance reference standard for a reflectance spectral measurement or for a reliability check in a fluorescence spectral system.
摘要翻译：公开了用于校准或表征使用这种光学标准的光谱系统的光学标准和校准装置的示例。光学标准可以包括对乙酰氨基酚和硫酸钡的混合物，其中混合物中对乙酰氨基酚的质量小于BaSO 4的质量。这种光学标准可用于校准或表征光谱系统的校准装置中。校准装置可以包括具有顶表面和底表面的基底基底。顶表面可以包括用于接收光学标准样品的部分。接收部分可以是粘合剂。校准装置还可以包括可以附着到基板基底的顶表面的膜，以至少覆盖放置光学标准的基板的至少部分。校准装置可以在校准测量结束后进行设置。使用光学标准的光学标准和校准装置可用作校准拉曼系统的波长校准标准，用于反射光谱测量的反射参考标准或荧光光谱系统中的可靠性检查。

2. 发明申请

WO2012135961A1 APPARATUS AND METHODS FOR MULTIPHOTON MICROSCOPY 审中-公开
标题翻译：多光子显微镜的装置和方法
公开(公告)号：WO2012135961A1
公开(公告)日：2012-10-11
申请号：PCT/CA2012/050223
申请日：2012-04-05
申请人： BRITISH COLUMBIA CANCER AGENCY BRANCH , ZENG, Haishan , LUI, Harvey , MCLEAN, David , LEE, Anthony , WANG, Hequn , TANG, Shuo
发明人： ZENG, Haishan , LUI, Harvey , MCLEAN, David , LEE, Anthony , WANG, Hequn , TANG, Shuo
IPC分类号： G01J3/443 , A61B5/103 , A61N5/06 , G02B21/06 , G01J3/10
CPC分类号： A61B5/0064 , A61B5/0071 , A61B5/0075 , A61B5/4836 , A61B5/6831 , A61B5/6832 , A61B18/18 , A61N5/06 , A61N5/0616 , G01J3/0218 , G01J3/027 , G01J3/44 , G02B21/0052 , G02B21/0076 , G02B21/06
摘要： A multiphoton microscope is provided. The microscope includes: an excitation source for providing an optical excitation beam at an excitation wavelength λ; a scanner for scanning the excitation beam on a sample; an objective for irradiating the sample with the excitation beam scanned by the scanner and for collecting an emission beam from the sample; a first detector for detecting a plurality of multiphoton signals; and an emission light path allowing transmission from the objective to the first detector a wavelength band limited to greater than or equal to λ/2 and less than λ, wherein the plurality of multiphoton signals have wavelengths within the wavelength band; wherein the plurality of multiphoton signals com- prises a first multiphoton signal and a second multiphoton signal of different types. Fast image capture rate multiphoton microscopes for in vivo imaging, as well as photothermolysis methods using the microscopes are also provided.
摘要翻译：提供多光子显微镜。显微镜包括：用于在激发波长λ处提供光学激发光束的激发源; 用于扫描样品上的激发光束的扫描器; 用扫描仪扫描的激发光束照射样品并收集来自样品的发射光束的目的; 用于检测多个多光子信号的第一检测器; 以及发射光路，其允许从所述物镜向所述第一检测器发送限制为大于或等于λ/ 2且小于λ的波长带，其中所述多个多光子信号具有所述波长带内的波长; 其中所述多个多光子信号包括不同类型的第一多光子信号和第二多光子信号。还提供用于体内成像的快速图像捕获率多光子显微镜以及使用显微镜的光热解方法。

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