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1. 发明申请

WO2008036916A3 PHYTASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译： PHYTASES，NUCLEIC ACID ENCODING THEM AND METHODS FOR MAKING AND USING THEM
公开(公告)号：WO2008036916A3
公开(公告)日：2008-11-27
申请号：PCT/US2007079187
申请日：2007-09-21
申请人： VERENIUM CORP , STEER BRIAN , DYCAICO MARK , KLINE KATIE , TREFZER AXEL , TODARO TOM , SOLBAK ARNE , EL-FARRAH FATIMA , ALVARADO ALBERTO , FREY GERHARD
发明人： STEER BRIAN , DYCAICO MARK , KLINE KATIE , TREFZER AXEL , TODARO TOM , SOLBAK ARNE , EL-FARRAH FATIMA , ALVARADO ALBERTO , FREY GERHARD
IPC分类号： C07H21/02 , A01N63/00 , A61K48/00 , C07H21/04 , C12N5/00 , C12N5/02
CPC分类号： C12N9/16 , A23K20/189 , A23L33/18 , A23V2002/00 , C12P7/10 , C12Y301/03008 , C12Y301/03026 , C12Y301/03072 , Y02E50/16 , Y02E50/17
摘要： This invention relates to phytases, polynucleotides encoding them, uses of the polynucleotides and polypeptides of the invention, as well as the production and isolation of such polynucleotides and polypeptides. In particular, the invention provides polypeptides having phytase activity under high temperature conditions, and phytases that retain activity after exposure to high temperatures. The phytases of the invention can be thermotolerant and/or thermostable at low temperatures, in addition to higher temperatures. The phytases of the invention can be used in foodstuffs to improve the feeding value of phytate rich ingredients. The phytases of the invention can be formulated as foods or feeds or supplements for either to, e.g., aid in the digestion of phytate. The foods or feeds of the invention can be in the form of pellets, liquids, powders and the like. In one aspect, phytases of the invention are stabile against thermal denaturation during pelleting; and this decreases the cost of the phytase product while maintaining in vivo efficacy and detection of activity in feed.
摘要翻译：本发明涉及植酸酶，编码它们的多核苷酸，本发明的多核苷酸和多肽的用途，以及这些多核苷酸和多肽的产生和分离。特别地，本发明提供了在高温条件下具有植酸酶活性的多肽，以及暴露于高温后保留活性的植酸酶。除了较高的温度之外，本发明的植酸酶还可以在低温下耐热和/或耐热。本发明的植酸酶可用于食品中以改善富含植酸盐的成分的摄食量。本发明的植酸酶可以配制成食品或饲料或补充剂，以便例如帮助消化植酸盐。本发明的食品或饲料可以是丸粒，液体，粉末等的形式。在一个方面，本发明的植酸酶在造粒期间对于热变性是稳定的; 并且这降低了植酸酶产品的成本，同时保持了体内功效并检测了饲料中的活性。

2. 发明申请

WO2013049227A3 HIGH EFFICIENCY, SMALL VOLUME NUCLEIC ACID SYNTHESIS 审中-公开
标题翻译：高效率，小体积的核酸合成
公开(公告)号：WO2013049227A3
公开(公告)日：2014-01-09
申请号：PCT/US2012057363
申请日：2012-09-26
申请人： GENEART AG , PETERSON TODD , TREFZER AXEL , POEHMERER THOMAS
发明人： PETERSON TODD , TREFZER AXEL , POEHMERER THOMAS
IPC分类号： B01J19/00 , C12N15/10 , C12N15/64 , C12P19/34
CPC分类号： C12N15/1093 , B01J19/0046 , B01J2219/00313 , B01J2219/00351 , B01J2219/00466 , B01J2219/005 , B01J2219/00596 , B01J2219/00648 , B01J2219/00653 , B01J2219/00655 , B01J2219/00659 , B01J2219/00713 , B01J2219/00722 , C12N15/10 , C12N15/1031 , C12N15/1068 , C12N15/64 , C12N15/66 , C12P19/34
摘要： The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e.g., large nucleic acid molecules such as genomes).
摘要翻译：本公开总体上涉及用于生产核酸分子的组合物和方法。在一些方面，本发明允许微量生成核酸分子，任选地随后将这些核酸分子组装成更大的分子。在一些方面，本发明允许有效生产核酸分子（例如大核酸分子，例如基因组）。

3. 发明申请

WO2005044979A3 GLYCOSYLATION ENZYMES AND SYSTEMS AND METHODS OF MAKING AND USING THEM 审中-公开
标题翻译：糖化酶和系统及其制备和使用方法
公开(公告)号：WO2005044979A3
公开(公告)日：2009-04-09
申请号：PCT/US2004025015
申请日：2004-08-04
申请人： DIVERSA CORP , TREFZER AXEL , GREEN BRIAN D , BIBB MERVYN , MASON DYLAN
发明人： TREFZER AXEL , GREEN BRIAN D , BIBB MERVYN , MASON DYLAN
IPC分类号： C12N1/20 , C07H21/04 , C12N20060101 , C12P19/26 , C12P21/00 , C12P21/02
CPC分类号： C12P21/005 , A01N43/90
摘要： The invention provides a novel technology for glycosylation of natural products using novel genetically engineered strains of bacteria. These in vivo glycosylation systems of the invention express a heterologous glycosyltransferase and deoxysugar pathway that are capable of glycosylating a suitable substrate, which can be added to a culture broth. The invention also provides novel compounds glycosylated by these novel genetically engineered strains (the in vivo glycosylation systems of the invention), including novel peptides, mixed polyketide-peptides, or polyketides, including novel macrolides, e.g., glycosylated spinosyn derivatives, glycosylated derivatives of antibiotics such as erythromycin, tetracycline, rifampicin, glycosylated derivatives of anti-tumor drugs such as daunorubicin, mithramycin, derivatives of immunosuppressants such as rapamycin, FK520, FK506, glycosylated derivatives of anti-fungals such as amphotericin, glycosylated derivatives of antibacterials such as tylosin, glycosylated derivatives of antiparasitics such as avermectin, glycosylated derivatives of insecticides such as spinosyn, and methods for making these compounds using the in vivoglycosylation systems of the invention.
摘要翻译：本发明提供了一种使用新型遗传工程菌株进行天然产物糖基化的新技术。本发明的这些体内糖基化体系表达能够糖基化合适底物的异源糖基转移酶和脱氧糖通路，其可加入到培养液中。本发明还提供了通过这些新型遗传工程菌株（本发明的体内糖基化体系）糖基化的新型化合物，包括新型肽，混合聚酮化合物肽或聚酮化合物，包括新型大环内酯类，例如糖基化多杀菌素衍生物，抗生素糖基化衍生物例如红霉素，四环素，利福平，抗肿瘤药物如柔红霉素，霉素霉素，免疫抑制剂如雷帕霉素的衍生物，FK520，FK506，抗真菌剂如两性霉素的糖基化衍生物，抗菌药的糖基化衍生物如泰乐菌素，抗寄生虫的糖基化衍生物，例如除虫菌素，杀虫剂的糖基化衍生物如多杀菌素，以及使用本发明的生物活性糖基化体系制备这些化合物的方法。

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