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1. 发明申请

WO2007096882A2 PROMOTERS EXHIBITING ENDOTHELIAL CELL SPECIFICITY AND METHODS OF USING SAME FOR REGULATION OF ANGIOGENESIS 审中-公开
标题翻译：展示内皮细胞特异性及其使用方法用于调节血管生成
公开(公告)号：WO2007096882A2
公开(公告)日：2007-08-30
申请号：PCT/IL2007/000242
申请日：2007-02-22
申请人： VASCULAR BIOGENICS LTD. , HARATS, Dror , GREENBERGER, Shoshana , BREITBART, Eyal , BANGIO, Livnat , PELED, Michael
发明人： HARATS, Dror , GREENBERGER, Shoshana , BREITBART, Eyal , BANGIO, Livnat , PELED, Michael
IPC分类号： A61K48/00 , C12N15/861 , A61K31/573 , A61K31/198
CPC分类号： A61K38/1858 , A01K2267/0331 , A01K2267/0393 , A61K31/198 , A61K31/573 , A61K38/1866 , A61K48/00 , A61K48/0058 , A61K48/0066 , C12N15/85 , C12N15/86 , C12N2710/10343 , C12N2830/002 , C12N2830/008 , C12N2840/203
摘要： Isolated polynucleotide sequences exhibiting endothelial cell specific promoter activity, novel cis regulatory elements and methods of use thereof enabling treatment of diseases characterized by aberrant neovascularization or cell growth are disclosed.
摘要翻译：公开了显示内皮细胞特异性启动子活性的分离的多核苷酸序列，新的顺式调节元件及其使用方法，其能够治疗以异常新生血管形成或细胞生长为特征的疾病。

2. 发明申请

WO2008132729A2 PROMOTERS EXHIBITING ENDOTHELIAL CELL SPECIFICITY AND METHODS OF USING SAME FOR REGULATION OF ANGIOGENESIS 审中-公开
标题翻译：展示内皮细胞特异性及其使用方法用于调节血管生成
公开(公告)号：WO2008132729A2
公开(公告)日：2008-11-06
申请号：PCT/IL2008/000543
申请日：2008-04-27
申请人： VASCULAR BIOGENICS LTD. , HARATS, Dror , GREENBERGER, Shoshana , BREITBART, Eyal , BANGIO, Livnat
发明人： HARATS, Dror , GREENBERGER, Shoshana , BREITBART, Eyal , BANGIO, Livnat
IPC分类号： A61K48/00 , A61P17/06 , A61P25/02 , A61P35/00 , A61P9/10 , C12N15/00 , C12N5/10
CPC分类号： C12N15/86 , A61K48/00 , C12N15/85 , C12N2710/10343 , C12N2830/008
摘要： Isolated polynucleotide sequences exhibiting endothelial cell specific promoter activity, novel cis regulatory elements and methods of use thereof enabling treatment of diseases characterized by aberrant neovascularization or cell growth are disclosed.
摘要翻译：公开了显示内皮细胞特异性启动子活性的分离的多核苷酸序列，新的顺式调节元件及其使用方法，其能够治疗以异常新生血管形成或细胞生长为特征的疾病。

3. 发明申请

WO2011086509A1 METHODS OF PRODUCING ADENOVIRUS VECTORS AND VIRAL PREPARATIONS GENERATED THEREBY 审中-公开
标题翻译：产生腺病毒载体的方法和生成的病毒制剂
公开(公告)号：WO2011086509A1
公开(公告)日：2011-07-21
申请号：PCT/IB2011/050137
申请日：2011-01-12
申请人： VASCULAR BIOGENICS LTD. , BANGIO, Livnat , SHER, Naamit , BREITBART, Eyal
发明人： BANGIO, Livnat , SHER, Naamit , BREITBART, Eyal
IPC分类号： A61K39/00 , C07K14/475 , C12N7/02 , C12N15/861
CPC分类号： C12N15/87 , C07K2319/00 , C12N7/00 , C12N2710/10343 , C12N2710/10352 , C12N2830/008
摘要： The present invention, in some embodiments thereof, relates to methods of producing adenoviruses such as pro- and anti-angiogenic adenovirus vectors and preparations generated thereby. Particularly, in some embodiments, the viral vectors comprise a heterologous pro- or anti-angiogenic gene under the transcriptional control of the murine pre-proendothelin promoter (e.g. PPE-1-3X), for targeted expression of in angiogenic endothelium.
摘要翻译：本发明在其一些实施方案中涉及产生腺病毒的方法，例如促血管生成腺病毒载体和抗血管生成腺病毒载体以及由此产生的制剂。特别地，在一些实施方案中，病毒载体在鼠前期内皮素启动子（例如PPE-1-3X）的转录控制下包含用于靶向表达血管生成内皮的异源原或抗血管生成基因。

4. 发明申请

WO2008015675A3 POLYPEPTIDES AND POLYNUCLEOTIDES ENCODING SAME AND USE THEREOF IN THE TREATMENT OF MEDICAL CONDITIONS ASSOCIATED WITH ISCHEMIA 审中-公开
公开(公告)号：WO2008015675A3
公开(公告)日：2008-02-07
申请号：PCT/IL2007/000959
申请日：2007-07-31
申请人： VASCULAR BIOGENICS LTD. , BREITBART, Eyal , BANGIO, Livnat , TAL, Reshef
发明人： BREITBART, Eyal , BANGIO, Livnat , TAL, Reshef
IPC分类号： C07H21/04 , C07K14/47 , C12N15/63 , C12N5/10 , A61K48/00 , A61K38/17
摘要： An isolated polynucleotide is disclosed comprising a nucleic acid sequence encoding a polypeptide having an amino acid sequence of HIF-1alpha, the polypeptide being stably expressed and constitutively active. Isolated polypeptides encoded by same are also disclosed and uses thereof.

5. 发明申请

WO2012052878A1 ISOLATED POLYNUCLEOTIDES AND NUCLEIC ACID CONSTRUCTS FOR DIRECTING EXPRESSION OF A GENE-OF-INTEREST IN CELLS 审中-公开
标题翻译：用于指导细胞中基因表达的分离的多核苷酸和核酸构建体
公开(公告)号：WO2012052878A1
公开(公告)日：2012-04-26
申请号：PCT/IB2011/054493
申请日：2011-10-12
申请人： VASCULAR BIOGENICS LTD. , FEIGE, Erez , GERSHGOREN, Tal , BANGIO, Livnat , BREITBART, Eyal
发明人： FEIGE, Erez , GERSHGOREN, Tal , BANGIO, Livnat , BREITBART, Eyal
IPC分类号： C07K14/575
CPC分类号： C07K14/57536 , C07K2319/00 , C07K2319/02
摘要： Isolated polynucleotides comprising at least 14 nucleotides of SEQ ID NO:6 of a pre-proendothelin promoter which comprise at least 2 consecutive sequences being positioned next to at least one nucleotide position selected from the group consisting of at least one nucleotide of SEQ ID NO:46, 47, 52, 49, 50, 53 and 54, which is mutated as compared to SEQ ID NO:6 such that when the isolated polynucleotide is integrated into the PPE-1 promoter and placed upstream of a luciferase coding sequence the expression level of the luciferase coding sequence is upregulated or downregulated as compared to when SEQ ID NO:6 is similarly integrated into the PPE-1 promoter and placed upstream of the luciferase coding sequence. Also provided are nucleic acid constructs comprising same, methods of using same and pharmaceutical compositions comprising same for increasing or decreasing expression of a polynucleotide of interest in endothelial and non-endothelial cells.
摘要翻译：包含前内皮素启动子的SEQ ID NO：6至少14个核苷酸的分离的多核苷酸，其包含至少两个连续序列，位于选自SEQ ID NO：6的至少一个核苷酸的至少一个核苷酸位置旁边。 46,47,52,49,50,53和54，其与SEQ ID NO：6相比突变，使得当分离的多核苷酸整合到PPE-1启动子中并置于萤光素酶编码序列的上游时，其表达水平与SEQ ID NO：6类似地整合到PPE-1启动子中并置于荧光素酶编码序列上游的荧光素酶编码序列的上调或下调。还提供了包含其的核酸构建体，使用它们的方法和包含其的药物组合物，用于增加或减少内皮和非内皮细胞中感兴趣的多核苷酸的表达。

6. 发明申请

WO2011083466A1 COMPOSITIONS AND METHODS FOR TREATING GLIOBLASTOMA GBM 审中-公开
标题翻译：用于治疗GLIOBLASTOMA GBM的组合物和方法
公开(公告)号：WO2011083466A1
公开(公告)日：2011-07-14
申请号：PCT/IL2011/000009
申请日：2011-01-05
申请人： VASCULAR BIOGENICS LTD. , COHEN, Yael , BANGIO, Livnat , BRENNER, Andrew J. , BREITBART, Eyal
发明人： COHEN, Yael , BANGIO, Livnat , BRENNER, Andrew J. , BREITBART, Eyal
IPC分类号： C12N15/00 , C07H21/02
CPC分类号： A61K38/177 , A61K38/162 , A61K39/39558 , A61K48/005 , A61K2039/5258 , A61N5/1001 , A61N5/1077 , A61N2005/1087 , C07K14/70578 , C12N2799/022 , Y02E60/36
摘要： Methods of treating a malignant glioma in a subject are disclosed. The methods comprise administering to the subject a therapeutically effective amount of a viral vector comprising: (i) a first polynucleotide sequence encoding a Fas-chimera (Fas-c), said first polynucleotide sequence comprising SEQ ID NOs: 2 and 3; and (ii) a second polynucleotide sequence encoding an endothelial cell-specific promoter or a periendothelial cell-specific promoter.
摘要翻译：公开了治疗受试者中恶性胶质瘤的方法。所述方法包括向受试者施用治疗有效量的病毒载体，其包含：（i）编码Fas嵌合体（Fas-c）的第一多核苷酸序列，所述第一多核苷酸序列包含SEQ ID NO：2和3; 和（ii）编码内皮细胞特异性启动子或周内皮细胞特异性启动子的第二多核苷酸序列。

7. 发明申请

WO2011083464A2 METHODS FOR USE OF A SPECIFIC ANTI-ANGIOGENIC ADENOVIRAL AGENT 审中-公开
标题翻译：使用特异性抗血管生成剂的方法
公开(公告)号：WO2011083464A2
公开(公告)日：2011-07-14
申请号：PCT/IL2011/000007
申请日：2011-01-05
申请人： VASCULAR BIOGENICS LTD. , COHEN, Yael , SHER, Naamit , FEIGE, Erez , BANGIO, Livnat , BREITBART, Eyal
发明人： COHEN, Yael , SHER, Naamit , FEIGE, Erez , BANGIO, Livnat , BREITBART, Eyal
IPC分类号： A61K48/00
CPC分类号： C12N15/86 , A61K38/177 , A61K48/005 , A61K48/0058 , A61K48/0083 , C07K14/70578 , C07K14/7151 , C07K2319/00 , C12N15/87 , C12N2799/022 , C12N2830/008 , C12N2830/85
摘要： Anti-angiogenic adenovirus vectors, and therapeutic use thereof are provided, and more particularly, but not exclusively, clinical protocols for treatment of solid tumors in patients with an Ad5-PPE-1-3X-fas-chimera adenovirus vector.
摘要翻译：本发明提供了抗血管生成腺病毒载体及其治疗用途，更具体地但非唯一地，用于在Ad5-PPE-1-3X-嵌合体腺病毒载体的患者中治疗实体瘤的临床方案。

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