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1. 发明申请

WO2011083464A2 METHODS FOR USE OF A SPECIFIC ANTI-ANGIOGENIC ADENOVIRAL AGENT 审中-公开
标题翻译：使用特异性抗血管生成剂的方法
公开(公告)号：WO2011083464A2
公开(公告)日：2011-07-14
申请号：PCT/IL2011/000007
申请日：2011-01-05
申请人： VASCULAR BIOGENICS LTD. , COHEN, Yael , SHER, Naamit , FEIGE, Erez , BANGIO, Livnat , BREITBART, Eyal
发明人： COHEN, Yael , SHER, Naamit , FEIGE, Erez , BANGIO, Livnat , BREITBART, Eyal
IPC分类号： A61K48/00
CPC分类号： C12N15/86 , A61K38/177 , A61K48/005 , A61K48/0058 , A61K48/0083 , C07K14/70578 , C07K14/7151 , C07K2319/00 , C12N15/87 , C12N2799/022 , C12N2830/008 , C12N2830/85
摘要： Anti-angiogenic adenovirus vectors, and therapeutic use thereof are provided, and more particularly, but not exclusively, clinical protocols for treatment of solid tumors in patients with an Ad5-PPE-1-3X-fas-chimera adenovirus vector.
摘要翻译：本发明提供了抗血管生成腺病毒载体及其治疗用途，更具体地但非唯一地，用于在Ad5-PPE-1-3X-嵌合体腺病毒载体的患者中治疗实体瘤的临床方案。

2. 发明申请

WO2011083466A1 COMPOSITIONS AND METHODS FOR TREATING GLIOBLASTOMA GBM 审中-公开
标题翻译：用于治疗GLIOBLASTOMA GBM的组合物和方法
公开(公告)号：WO2011083466A1
公开(公告)日：2011-07-14
申请号：PCT/IL2011/000009
申请日：2011-01-05
申请人： VASCULAR BIOGENICS LTD. , COHEN, Yael , BANGIO, Livnat , BRENNER, Andrew J. , BREITBART, Eyal
发明人： COHEN, Yael , BANGIO, Livnat , BRENNER, Andrew J. , BREITBART, Eyal
IPC分类号： C12N15/00 , C07H21/02
CPC分类号： A61K38/177 , A61K38/162 , A61K39/39558 , A61K48/005 , A61K2039/5258 , A61N5/1001 , A61N5/1077 , A61N2005/1087 , C07K14/70578 , C12N2799/022 , Y02E60/36
摘要： Methods of treating a malignant glioma in a subject are disclosed. The methods comprise administering to the subject a therapeutically effective amount of a viral vector comprising: (i) a first polynucleotide sequence encoding a Fas-chimera (Fas-c), said first polynucleotide sequence comprising SEQ ID NOs: 2 and 3; and (ii) a second polynucleotide sequence encoding an endothelial cell-specific promoter or a periendothelial cell-specific promoter.
摘要翻译：公开了治疗受试者中恶性胶质瘤的方法。所述方法包括向受试者施用治疗有效量的病毒载体，其包含：（i）编码Fas嵌合体（Fas-c）的第一多核苷酸序列，所述第一多核苷酸序列包含SEQ ID NO：2和3; 和（ii）编码内皮细胞特异性启动子或周内皮细胞特异性启动子的第二多核苷酸序列。

3. 发明申请

WO2011083465A1 TREATMENT WITH VB-201 审中-公开
标题翻译：用VB-201处理
公开(公告)号：WO2011083465A1
公开(公告)日：2011-07-14
申请号：PCT/IL2011/000008
申请日：2011-01-05
申请人： VASCULAR BIOGENICS LTD. , COHEN, Yael , SHER, Naamit , MENDEL, Itzhak , YACOV, Niva , BREITBART, Eyal
发明人： COHEN, Yael , SHER, Naamit , MENDEL, Itzhak , YACOV, Niva , BREITBART, Eyal
IPC分类号： A01N57/00
CPC分类号： A61K31/685 , A61K31/198 , A61K31/366 , A61K31/40 , A61K31/505 , A61K31/683 , A61K38/02 , A61K45/06 , Y02A50/414
摘要： Unit dosage forms comprising between 1 mg and 100 mg VB-201 and a pharmaceutically acceptable carrier, and formulated for oral administration, are disclosed herein, as well as treatment regimens comprising oral administration of VB-201 once or twice daily for treating an inflammatory disease or disorder.
摘要翻译：本文公开了包含1mg至100mg的VB-201和药学上可接受的载体并且配制用于口服给药的单位剂量，以及包括每天一次或两次口服VB-201治疗炎性疾病的治疗方案或障碍。

4. 发明申请

WO2011083469A1 TREATMENT WITH VB-201 审中-公开
标题翻译：用VB-201处理
公开(公告)号：WO2011083469A1
公开(公告)日：2011-07-14
申请号：PCT/IL2011/000012
申请日：2011-01-05
申请人： VASCULAR BIOGENICS LTD. , MENDEL, Itzhak , YACOV, Niva , COHEN, Yael , FEIGE, Erez , BREITBART, Eyal
发明人： MENDEL, Itzhak , YACOV, Niva , COHEN, Yael , FEIGE, Erez , BREITBART, Eyal
IPC分类号： A61K45/00
CPC分类号： A61K31/685 , A61K31/198 , A61K31/366 , A61K31/40 , A61K31/505 , A61K31/683 , A61K38/02 , A61K45/06 , Y02A50/414
摘要： Novel unit dosage forms, methods and treatment regimens, utilizing VB-201 are disclosed. In particular, disclosed are unit dosage forms comprising less than 1 mg VB-201 and a pharmaceutically acceptable carrier, and formulated for oral administration, as well as treatment regimens comprising oral administration of VB-201 once per two or more days, for treating an inflammatory disease or disorder. Further disclosed are methods of treating metabolic syndrome, by administration of VB-201.
摘要翻译：公开了使用VB-201的新型单位剂量形式，方法和治疗方案。特别地，公开了包含小于1mg VB-201和药学上可接受的载体并且配制用于口服给药的单位剂型，以及包含每两天或更多天一次口服VB-201一次的治疗方案，用于治疗炎性疾病或病症。进一步公开的是通过施用VB-201治疗代谢综合征的方法。

5. 发明申请

WO2011083467A1 COMBINED TREATMENT UTILIZING VB-201 审中-公开
标题翻译：使用VB-201的组合治疗
公开(公告)号：WO2011083467A1
公开(公告)日：2011-07-14
申请号：PCT/IL2011/000010
申请日：2011-01-05
申请人： VASCULAR BIOGENICS LTD. , COHEN, Yael , YACOV, Niva , BREITBART, Eyal
发明人： COHEN, Yael , YACOV, Niva , BREITBART, Eyal
IPC分类号： A61K45/00
CPC分类号： A61K31/685 , A61K31/198 , A61K31/366 , A61K31/40 , A61K31/505 , A61K31/683 , A61K38/02 , A61K45/06 , Y02A50/414
摘要： Methods of treatment which utilize co-administration of the oxidized lipid VB-201 with an additional therapeutically active agent are described herein. Methods of treating a cardiovascular disease are described herein, comprising co-administration of VB-201 and a statin to a subject who is not fully responsive to the statin, as well as methods of treating an inflammatory disease or disorder, comprising co-administration of VB-201 and glatiramer acetate. A pharmaceutical composition comprising VB-201, identified for use in combination with glatiramer acetate, is also described herein. Methods of determining a therapeutically effective amount of VB-201 in a subject and of determining a therapeutically effective amount of VB-201 for co-administration with an additional therapeutically active agent are also described. Novel unit dosage forms of VB-201 and methods utilizing same are also disclosed.
摘要翻译：本文描述了利用氧化脂质VB-201与另外的治疗活性剂共同给药的治疗方法。本文描述了治疗心血管疾病的方法，包括将VB-201和他汀类药物共同给予对他汀类药物不完全反应的受试者以及治疗炎性疾病或病症的方法，包括共同给予 VB-201和醋酸格拉默。本文还描述了一种包含鉴定为与醋酸格拉默组合使用的VB-201的药物组合物。还描述了确定受试者中治疗有效量的VB-201和确定治疗有效量的用于与另外的治疗活性剂共同施用的VB-201的方法。还公开了VB-201的新型单位剂型及其利用方法。

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