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1. 发明申请

WO2002061040A2 GENE DELIVERY FORMULATIONS AND METHODS FOR TREATMENT OF ISCHEMIC CONDITIONS 审中-公开
标题翻译：基因递送配方和治疗分离条件的方法
公开(公告)号：WO2002061040A2
公开(公告)日：2002-08-08
申请号：PCT/US2001/051307
申请日：2001-10-19
申请人： VALENTIS, INC. , COLEMAN, Michael, E. , MACLAUGHLIN, Fiona , WANG, Jijun , THIESSE, Mary, L. , YOUNG, Stewart , NORDSTROM, Jeffrey, L.
发明人： COLEMAN, Michael, E. , MACLAUGHLIN, Fiona , WANG, Jijun , THIESSE, Mary, L. , YOUNG, Stewart , NORDSTROM, Jeffrey, L.
IPC分类号： C12N
CPC分类号： C12N15/87 , A61K38/1866 , A61K48/00 , A61K48/0008 , A61K48/0075 , C07K14/475
摘要： The present inventors have developed a novel approach for efficient delivery of angiogenic factors to the cardiac and peripheral vasculature that avoids problems with toxicity inherent to existing delivery technologies. Vectors carrying coding sequences for Del-1 or VEGF, or both, can be formulated with poloxamers or other polymers for delivery into ischemic tissue and delivered to the heart by retrograde venous perfusion.
摘要翻译：本发明人已经开发出一种用于有效地将血管生成因子递送到心脏和外周脉管系统的方法，其避免了现有传递技术固有的毒性问题。携带Del-1或VEGF或两者的编码序列的载体可以用泊洛沙姆或其它聚合物配制，用于递送至缺血组织并通过逆行静脉灌注递送至心脏。

2. 发明申请

WO2009050676A1 PATHOLOGY-RELATED MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：病理相关磁共振成像
公开(公告)号：WO2009050676A1
公开(公告)日：2009-04-23
申请号：PCT/IB2008/054271
申请日：2008-10-17
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , BOERNERT, Peter , YOUNG, Stewart , BYSTROV, Daniel , NETSCH, Thomas , PEKAR, Vladimir , MUISWINKEL, Arianne van , COCOSCO, Christian, Adrian , DRIES, Sebastian, Peter, Michael , GIESEKE, Jürgen, Heinrich , HOLTHUIZEN, Ronaldus, Frederik, Johannes , SIMONETTI, Arjan, Willem
发明人： BOERNERT, Peter , YOUNG, Stewart , BYSTROV, Daniel , NETSCH, Thomas , PEKAR, Vladimir , MUISWINKEL, Arianne van , COCOSCO, Christian, Adrian , DRIES, Sebastian, Peter, Michael , GIESEKE, Jürgen, Heinrich , HOLTHUIZEN, Ronaldus, Frederik, Johannes , SIMONETTI, Arjan, Willem
IPC分类号： G01R33/54 , G06T7/00
CPC分类号： G01R33/54 , G01R33/4808 , G01R33/481 , G01R33/4812 , G01R33/543 , G01R33/546 , G01R33/5608 , G06F19/00 , G06F19/321 , G06F19/324 , G06T7/33 , G06T2207/10088 , G06T2207/10104 , G06T2207/30096
摘要： A magnetic resonance imaging method includes acquiring a first image (16, 20, 20') of a subject, electronically identifying information related to a suspected pathology based on the first image, electronically planning a magnetic resonance imaging session (40) relating to the suspected pathology based on the identified information relating to the suspected pathology, and executing a selected one of the magnetic resonance imaging sessions to acquire one or more magnetic resonance images of the subject probative of the suspected pathology. A suitable magnetic resonance imaging system may include a magnetic resonance scanner (10), a models database (34, 36) including pathology models (36) including information pertaining to pathologies derived from previously acquired magnetic resonance images of subjects having said pathologies, and a session planner (30) configured to construct a pathology- specific and subject- specific magnetic resonance imaging session plan (40) based on a magnetic resonance scout image (16) and the pathology models (36).
摘要翻译：一种磁共振成像方法包括获取对象的第一图像（16,20,20'），电子地识别与基于所述第一图像相关的疑似病理学的信息，电子地规划与所述疑似的磁共振成像会话（40）有关的信息基于与所述疑似病理学相关的所识别的信息的病理学，以及执行所述磁共振成像会话中的所选择的一个以获取所述疑似病理学的所述受试者的一个或多个磁共振图像。合适的磁共振成像系统可以包括磁共振扫描器（10），包括病理模型（36）的模型数据库（34,36），其包括关于从先前获得的具有所述病理学的受试者的磁共振图像导出的病理的信息，以及会话计划器（30）被配置为基于磁共振侦察图像（16）和病理模型（36）构建病理特异性和受试者特异性的磁共振成像计划（40）。

3. 发明申请

WO2008155718A2 DETECTING HAEMORRHAGIC STROKE IN CT IMAGE DATA 审中-公开
标题翻译：检测CT图像数据中的血流动力学
公开(公告)号：WO2008155718A2
公开(公告)日：2008-12-24
申请号：PCT/IB2008/052381
申请日：2008-06-17
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , MEETZ, Kirsten , BUELOW, Thomas , YOUNG, Stewart
发明人： MEETZ, Kirsten , BUELOW, Thomas , YOUNG, Stewart
IPC分类号： G06T7/00
CPC分类号： G06T7/0012 , A61B6/032 , A61B6/12 , A61B6/501 , A61B2576/026 , G06T7/44 , G06T2207/10081 , G06T2207/20156 , G06T2207/30016 , G06T2207/30096 , G06T2210/41
摘要： The invention relates to a system (100) arranged to delineate the acute intracerebral haematoma in non-contrasted CT images in two stages. The first stage, performed by the extraction unit (110), employs an analysis of gray values of the image data in order to extract the candidate region. The candidate region may comprise both an acute haematoma and other regions having similar gray values, e.g., regions resulting from partial volume effects at the interface of the bony structures of the skull and the brain. The novel second stage, performed by the classification unit (120), analyzes spatial features of the candidate region such as, for example, the size, shape, and connectedness to the skull bone of the candidate region. Using spatial features of the candidate region improves the correctness of classification of the candidate region as a true or false acute haematoma.
摘要翻译：本发明涉及一种系统（100），其被布置成在两个阶段中描绘非对照CT图像中的急性脑内血肿。由提取单元（110）执行的第一阶段对图像数据的灰度值进行分析，以提取候选区域。候选区域可以包括急性血肿和具有相似灰度值的其它区域，例如由头骨和脑的骨骼结构的界面处的部分体积效应产生的区域。由分类单元（120）执行的新颖的第二阶段分析候选区域的空间特征，例如与候选区域的颅骨的尺寸，形状和连接性。使用候选区域的空间特征将候选区域的分类的正确性提高为真的或假的急性血肿。

4. 发明申请

WO2006109269A1 A METHOD, A SYSTEM AND A COMPUTER PROGRAM FOR SEGMENTING A SURFACE IN A MULTI-DIMENSIONAL DATASET 审中-公开
标题翻译：一种用于在多维数据集中表征表面的方法，系统和计算机程序
公开(公告)号：WO2006109269A1
公开(公告)日：2006-10-19
申请号：PCT/IB2006/051145
申请日：2006-04-13
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , COCOSCO, Christian, A. , YOUNG, Stewart , NETSCH, Thomas , KAUS, Michael
发明人： COCOSCO, Christian, A. , YOUNG, Stewart , NETSCH, Thomas , KAUS, Michael
IPC分类号： G06T5/00
CPC分类号： G06T7/149 , G06T7/12 , G06T2207/10072 , G06T2207/30048
摘要： The method according to the invention is arranged to segment a surface in a multi-dimensional dataset comprising a plurality of images, which may be acquired using a suitable data-acquisition unit at a preparatory step 2. It is possible that data processing and data acquisition steps are temporally or geographically distanced, so that at step 4 the results of a suitable data segmentation step 6 are accessed, whereby said results comprise portions of the image which are subsequently used to segment the surface using the method of the invention. Next, at step 8 a suitable plurality of image features resembling possible spatial positions of the surface conceived to be segmented are selected and accessed. The features are subsequently matched for all image portions at step 10, whereby for each feature a matching error is assigned. At step 14 a pre-defined selectivity factor is accessed defining a maximum allowable variable fraction of the features having largest matching errors which can be discarded. The segmentation of the sought surface is performed at step 16, whereby the discarded features are not taken into account for evaluating the quality of fit of a candidate deformation of the. The resulting surface is being displayed on a suitable display means at step 18, whereby it is preferably overlaid on original, notably diagnostic data for user's analysis. In case when the user is satisfied with the result of the segmentation, the segmented surface is stored at step 18. Otherwise, the process is returned to step 14, where a further selectivity factor is accessed. It is possible that the further selectivity iactor is altered at step 11 by a user's input, or, alternatively it may be provided by a certain alteration algorithm 13. The invention further relates to a system, a computer program, a workstation, a viewing station, a computer program and a user interface.
摘要翻译：根据本发明的方法被布置为在包括多个图像的多维数据集中分割表面，所述多个图像可以在准备步骤2使用合适的数据采集单元获取。可能的是，数据处理和数据采集步骤在时间上或地理上是间距的，使得在步骤4中，访问合适的数据分割步骤6的结果，由此所述结果包括随后用于使用本发明的方法分割表面的图像的部分。接下来，在步骤8中，选择并访问类似于被分割的表面的可能的空间位置的合适的多个图像特征。随后在步骤10对所有图像部分匹配特征，由此为每个特征分配匹配误差。在步骤14，访问预定义的选择性因子，定义可以丢弃具有最大匹配误差的特征的最大允许可变分数。在步骤16执行所寻求的表面的分割，由此不考虑丢弃的特征来评估候选变形的拟合质量。在步骤18，所得到的表面被显示在合适的显示装置上，由此优选地覆盖在原始的，特别是用于用户分析的诊断数据上。在用户对分割结果满意的情况下，在步骤18存储分割曲面。否则，该过程返回到步骤14，其中进一步选择性因子被访问。在步骤11，用户的输入可以改变进一步的选择性因子，或者可以由某个改变算法13提供。本发明还涉及系统，计算机程序，工作站，观察站，计算机程序和用户界面。

5. 发明申请

WO2008120155A3 LEARNING ANATOMY DEPENDENT VIEWING PARAMETERS ON MEDICAL VIEWING WORKSTATIONS 审中-公开
公开(公告)号：WO2008120155A3
公开(公告)日：2008-10-09
申请号：PCT/IB2008/051166
申请日：2008-03-28
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , BYSTROV, Daniel , YOUNG, Stewart , PEKAR, Vladimir , COCOSCO, Christian, A.
发明人： BYSTROV, Daniel , YOUNG, Stewart , PEKAR, Vladimir , COCOSCO, Christian, A.
IPC分类号： G06T17/40
摘要： The invention relates to a data processing apparatus and a method for providing visualisation parameters controlling the display of a medical image (12). The data processing apparatus comprises a mapping component (16). The mapping component (16) is arranged to receive a current dataset (15) corresponding to the medical image and comprising a content description thereof,to compare the content description of the current dataset (15) witha content description ofa pluralityofstored datasets, to select at least one further dataset out of the plurality of stored datasets, to retrieve stored visualisation parameters corresponding to the at least one further dataset, and to prepare the retrieved visualisation parameters as the visualisation parameters controlling the display of the medical image (12).

6. 发明申请

WO2008007281A2 A METHOD, AN APPARATUS, A SYSTEM AND A COMPUTER PROGRAM FOR TRANSFERRING SCAN GEOMETRY BETWEEN SUBSEQUENT SCANS 审中-公开
标题翻译：一种方法，装置，系统和计算机程序，用于在后续扫描之间传输扫描几何
公开(公告)号：WO2008007281A2
公开(公告)日：2008-01-17
申请号：PCT/IB2007/052505
申请日：2007-06-28
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , BYSTROV, Daniel , PEKAR, Vladimir , YOUNG, Stewart , BERGMANS, Cornelis, J., F., M. , VAN MUISWINKEL, Arianne
发明人： BYSTROV, Daniel , PEKAR, Vladimir , YOUNG, Stewart , BERGMANS, Cornelis, J., F., M. , VAN MUISWINKEL, Arianne
CPC分类号： G01R33/54 , G01R33/543 , G06T7/74 , G06T2207/30004 , G06T2207/30244
摘要： The invention relates to a method, an apparatus and a computer program for transferring scan geometry between a first region and a second region, similar to the first region. In the method according to the invention the first region and the second region are being identified (4), preferably in the overview image, followed by determination (6) of the first scan geometry corresponding to the first region. Then, the first scan geometry is being transferred into the second scan geometry corresponding to the second region, whereby information on geometrical correspondence between the first region and the second region is used. Preferably, the step of transferring comprises establishing corresponding mappings between similar regions and their respective scan geometries.
摘要翻译：本发明涉及一种用于在第一区域和第二区域之间传送扫描几何形状的方法，装置和计算机程序，类似于第一区域。在根据本发明的方法中，优选地在概述图像中识别第一区域和第二区域（4），随后确定对应于第一区域的第一扫描几何形状（6）。然后，第一扫描几何被转移到对应于第二区域的第二扫描几何中，由此使用关于第一区域和第二区域之间的几何对应关系的信息。优选地，传送步骤包括在相似区域和它们各自的扫描几何之间建立对应的映射。

7. 发明申请

WO2005062259A1 METHOD FOR THE COMPUTER-ASSISTED VISUALIZATION OF DIAGNOSTIC IMAGE DATA 审中-公开
标题翻译：用于计算机辅助可视化诊断图像数据的方法
公开(公告)号：WO2005062259A1
公开(公告)日：2005-07-07
申请号：PCT/IB2004/052731
申请日：2004-12-09
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N. V. , NETSCH, Thomas , YOUNG, Stewart
发明人： NETSCH, Thomas , YOUNG, Stewart
IPC分类号： G06T17/40
CPC分类号： G06T19/00 , G06T2210/41
摘要： The invention relates to a method for the computer-assisted visualization of a three-dimensional anatomical object, wherein firstly two or more diagnostic image data records (1, 3, 4, 5) of the object are recorded. Thereafter, an imaging specification is defined for imaging the image data (1, 3, 4, 5) onto a two-dimensional display plane (8), wherein in order to define the imaging specification anatomical features (2) of the object are identified in at least one of the image data records (1). Finally, a combined two-dimensional representation is calculated by imaging the two or more image data records (1, 3, 4, 5) according to the previously defined imaging specification onto a common display plane (8).
摘要翻译：本发明涉及一种用于计算机辅助可视化三维解剖学对象的方法，其中首先记录对象的两个或多个诊断图像数据记录（1,3,4,5）。此后，定义成像规范用于将图像数据（1,3,4,5）成像到二维显示平面（8）上，其中为了限定成像规范，识别对象的解剖特征（2）被识别在图像数据记录（1）中的至少一个中。最后，通过将根据先前定义的成像规范的两个或多个图像数据记录（1,3,4,5）成像到公共显示平面（8）上来计算组合的二维表示。

8. 发明申请

WO2009115935A1 PERFUSION IMAGING 审中-公开
标题翻译：灌注成像
公开(公告)号：WO2009115935A1
公开(公告)日：2009-09-24
申请号：PCT/IB2009/050757
申请日：2009-02-25
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , MEETZ, Kirsten , CARLSEN, Ingwer , SCHULZ, Heinrich , WIEMKER, Rafael , YOUNG, Stewart
发明人： MEETZ, Kirsten , CARLSEN, Ingwer , SCHULZ, Heinrich , WIEMKER, Rafael , YOUNG, Stewart
IPC分类号： G06F19/00
CPC分类号： G06F19/321 , A61B6/481 , A61B6/504 , A61B6/507 , G06F19/00 , G06T7/0012 , G06T2207/10072 , G06T2207/30016 , G06T2207/30101 , G16H40/63 , G16H50/20 , G16H50/50
摘要： A perfusion analysis system includes a perfusion modeller (120) and a user interface (122). The perfusion modeller (120) generates a patient specific perfusion model based on medical imaging perfusion data for the patient, a general perfusion model, and a quantification of one or more identified pathologies of the patient that affect perfusion in the patient. The user interface (122) accepts an input indicative of a modification to the quantification of the one or more identified pathologies. In response, the perfusion modeller (120) updates the patient specific perfusion model based on the medical imaging perfusion data for the patient, the general perfusion model, and the quantification of the one or more identified pathologies of the patient, including the modification thereto.
摘要翻译：灌注分析系统包括灌注建模器（120）和用户界面（122）。灌注建模器（120）基于患者的医学成像灌注数据，一般灌注模型和影响患者灌注的患者的一个或多个鉴定的病理学的定量产生患者特异性灌注模型。用户界面（122）接受指示对一个或多个所识别的病理学的量化的修改的输入。作为响应，灌注建模器（120）基于患者的医学成像灌注数据，一般灌注模型和患者的一个或多个鉴定的病理学的定量（包括其修改）来更新患者特异性灌注模型。

9. 发明申请

WO2006119255A2 DEVICE FOR INTERCONNECTING COMPONENTS IN SPINAL INSTRUMENTATION 审中-公开
标题翻译：用于互连螺旋仪器组件的装置
公开(公告)号：WO2006119255A2
公开(公告)日：2006-11-09
申请号：PCT/US2006/016747
申请日：2006-05-01
申请人： SDGI HOLDINGS, INC. , TAYLOR, Harold , YOUNG, Stewart
发明人： TAYLOR, Harold , YOUNG, Stewart
IPC分类号： A61B17/70
CPC分类号： A61B17/705 , A61B17/7049
摘要： A device (20) for connection to a component (R) used in association with spinal instrumentation, including a connector body (22), at least one clamp element (24), and at least one fixation element (26). The connector body (22) defines a receptacle (30) extending therethrough and opening onto an outer surface thereof. The connector body (22) also defines a passage (50) in transverse communication with the receptacle (30). The clamp element (24) includes at least two arm portions (72a, 72b) defining a space (S) therebetween having an open end (94). The clamp element (24) is positioned within the passage (50) in the connector body (22) with the space (S) between the arm portions (72a, 72b) generally aligned with the receptacle (30) and with the component (R) received through the open end (94) and retained within the space (S). The fixation element (26) interacts with the clamp element (24) to displace the clamp element (24) relative to the connector body (22) to position at least a portion of the component (R) within the receptacle (30).
摘要翻译：一种用于连接到与脊髓仪器相关联的部件（R）的装置（20），包括连接器主体（22），至少一个夹紧元件（24）和至少一个固定元件（26）。连接器主体（22）限定了延伸穿过其并在其外表面上开口的容器（30）。连接器主体（22）还限定与插座（30）横向连通的通道（50）。夹紧元件（24）包括至少两个在其间具有开口端（94）的间隔（S）的臂部分（72a，72b）。夹紧元件（24）位于连接器主体（22）内的通道（50）内，其中臂部分（72a，72b）之间的空间（S）与插座（30）大致对准，并且部件（R ）通过开口端（94）接收并保持在空间（S）内。固定元件（26）与夹紧元件（24）相互作用，以相对于连接器主体（22）移动夹紧元件（24），以使部件（R）的至少一部分位于容器（30）内。

10. 发明申请

WO2006079933A1 USER INTERFACE FOR MOTION ANALYSIS IN KINEMATIC MR STUDIES 审中-公开
标题翻译：动力学研究运动分析的用户界面
公开(公告)号：WO2006079933A1
公开(公告)日：2006-08-03
申请号：PCT/IB2006/050042
申请日：2006-01-05
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , U.S. PHILIPS CORPORATION , BYSTROV, Daniel , PEKAR, Vladimir , MEETZ, Kirsten , NETSCH, Thomas , YOUNG, Stewart
发明人： BYSTROV, Daniel , PEKAR, Vladimir , MEETZ, Kirsten , NETSCH, Thomas , YOUNG, Stewart
IPC分类号： G06T17/00 , G06T15/70
CPC分类号： G06T13/20 , G06T7/246 , G06T2207/10076 , G06T2207/10088 , G06T2207/30048
摘要： In a diagnostic imaging system (10), a user interface (82) facilitates viewing of 4D kinematic data sets. A set of reference points is selected in a first 3D image to designate an anatomical component. An algorithm (104) calculates a propagation of the selected reference points from the first 3D image into other 3D images. Transforms which describe the propagation of the reference points between 3D images are defined. An aligning algorithm (112) applies inverse of the transforms to the 3D images to define a series of frames for the video processor (120) to display, in which frames the designated anatomical component defined by the reference points in each of the 3D images remains fixed while the other portions of the anatomical region of interest move relative to the fixed designated anatomical component.
摘要翻译：在诊断成像系统（10）中，用户界面（82）便于观看4D运动数据集。在第一3D图像中选择一组参考点以指定解剖组件。算法（104）计算所选择的参考点从第一3D图像到其他3D图像的传播。定义描述3D图像之间参考点传播的变换。对准算法（112）将变换的逆向应用于3D图像以定义用于视频处理器（120）显示的一系列帧，其中由每个3D图像中的参考点定义的指定解剖组件保留固定，而感兴趣的解剖区域的其他部分相对于固定的指定解剖部件移动。

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