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1. 发明申请

WO2003094929A3 PREBLOCKING WITH NON-HA GAGS INCREASES EFFECTIVENESS OF HA CONJUGATED ANTICANCER AGENTS 审中-公开
公开(公告)号：WO2003094929A3
公开(公告)日：2003-11-20
申请号：PCT/US2003/014087
申请日：2003-05-06
申请人： UNIVERSITY OF UTAH RESEARCH FOUNDATION , PRESTWICH, Glenn, D. , ZHANG, Lurong
发明人： PRESTWICH, Glenn, D. , ZHANG, Lurong
IPC分类号： A61K31/74
摘要： A cell-targeted polymeric drug delivery system was designed based on the specific interaction between hyaluronic acid (HA) and its cell surface receptors over-expressed on cancer cell surface. Compounds composed of a carrier molecule, wherein the carrier molecule contains at least one residue of an anti-cancer agent and at least one residue of a hyaluronic acid, are described. Also described are methods comprising pre-administering a non-HA GAG blocking agent before administering the HA conjugate. Also described are methods of making and using the compounds thereof.

2. 发明申请

WO2003094929A2 PREBLOCKING WITH NON-HA GAGS INCREASES EFFECTIVENESS OF HA CONJUGATED ANTICANCER AGENTS 审中-公开
标题翻译：使用非HA GAGS进行预防可以提高HA联合抗体药剂的有效性
公开(公告)号：WO2003094929A2
公开(公告)日：2003-11-20
申请号：PCT/US2003/014087
申请日：2003-05-06
申请人： UNIVERSITY OF UTAH RESEARCH FOUNDATION , PRESTWICH, Glenn, D. , ZHANG, Lurong
发明人： PRESTWICH, Glenn, D. , ZHANG, Lurong
IPC分类号： A61K31/74
CPC分类号： A61K31/727 , A61K31/737 , A61K47/58 , A61K47/61 , A61K47/65 , A61K2300/00
摘要： A cell-targeted polymeric drug delivery system was designed based on the specific interaction between hyaluronic acid (HA) and its cell surface receptors over-expressed on cancer cell surface. Compounds composed of a carrier molecule, wherein the carrier molecule contains at least one residue of an anti-cancer agent and at least one residue of a hyaluronic acid, are described. Also described are methods comprising pre-administering a non-HA GAG blocking agent before administering the HA conjugate. Also described are methods of making and using the compounds thereof.
摘要翻译：基于透明质酸（HA）与其在癌细胞表面上过表达的细胞表面受体之间的特异性相互作用设计了细胞靶向聚合物药物递送系统。描述了由载体分子构成的化合物，其中载体分子含有至少一种抗癌剂残基和至少一种透明质酸残基。还描述了在施用HA缀合物之前预先施用非HA GAG封闭剂的方法。还描述了制备和使用其化合物的方法。

3. 发明申请

WO2012002964A1 METHODS AND KITS FOR DETECTING AN INFECTIOUS AGENT 审中-公开
标题翻译：检测感染性药物的方法和试剂盒
公开(公告)号：WO2012002964A1
公开(公告)日：2012-01-05
申请号：PCT/US2010/040649
申请日：2010-06-30
申请人： ZHANG, Aiguo , OKUNIEFF, Paul , ZHANG, Lurong , ZHANG, Lulu
发明人： ZHANG, Aiguo , OKUNIEFF, Paul , ZHANG, Lurong , ZHANG, Lulu
IPC分类号： C12Q1/68 , C12Q1/70
CPC分类号： C12Q1/689 , C12Q1/682 , C12Q1/708 , C12Q2600/166 , Y02A50/54 , C12Q2525/313
摘要： The present invention provides methods and kits for determining the presence, absence, or level of an infectious agent in a sample. Specifically, the present invention provides methods and kits for detecting or quantifying certain target polynucleotides of the infectious agent. In certain embodiments, the present invention provides for such detection without the need for amplification (e.g., replication) of the target molecule and/or without the need for labor intensive purification procedures. In certain embodiments, the present invention provides positive control and housekeeping gene for normalization and quantatively detection of the copy numbers of infectious agent in a sample. In these or other embodiments, the invention allows for such detection with the desired sensitivity and/or specificity, even where the polynucleotide is present in the sample at low copy number.
摘要翻译：本发明提供了用于确定样品中感染因子的存在，不存在或水平的方法和试剂盒。具体地，本发明提供了用于检测或定量感染因子的某些靶多核苷酸的方法和试剂盒。在某些实施方案中，本发明提供了这种检测，而不需要靶分子的扩增（例如复制）和/或不需要劳动密集的纯化方法。在某些实施方案中，本发明提供用于标准化和定量检测样品中感染因子的拷贝数的阳性对照和管家基因。在这些或其它实施方案中，即使多核苷酸以低拷贝数存在于样品中，本发明允许具有期望的灵敏度和/或特异性的这种检测。

4. 发明申请

WO2009023357A3 CURCUMIN DERIVATIVES AND THEIR USE AS RADIOPROTECTORS 审中-公开
公开(公告)号：WO2009023357A3
公开(公告)日：2009-02-19
申请号：PCT/US2008/064872
申请日：2008-05-27
申请人： UNIVERSITY OF ROCHESTER , OKUNIEFF, Paul , ZHANG, Lurong , LIU, Chaomei , SUN, Weimin , YANG, Shanmin , SWARTS, Steven
发明人： OKUNIEFF, Paul , ZHANG, Lurong , LIU, Chaomei , SUN, Weimin , YANG, Shanmin , SWARTS, Steven
IPC分类号： A01N43/20
摘要： Disclosed are compositions relating to analogues, derivatives, and metabolites of curcumin, methods of synthesis thereof, and methods for use of said compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

5. 发明申请

WO2006055875A3 METHODS AND COMPOSITIONS RELATED TO ESCULENTOSIDE A 审中-公开
公开(公告)号：WO2006055875A3
公开(公告)日：2006-05-26
申请号：PCT/US2005/042063
申请日：2005-11-18
申请人： UNIVERSITY OF ROCHESTER , OKUNIEFF, Paul , ZHANG, Lurong , XIAO, Zhenyu
发明人： OKUNIEFF, Paul , ZHANG, Lurong , XIAO, Zhenyu
IPC分类号： A01N43/04 , A61K31/70
摘要： Disclosed are compositions related to water soluble selective COX-2 inhibitors and methods of using the inhibitors (including Esculentoside A and derivatives thereof).

6. 发明申请

WO2021159076A1 USES OF GLYCYRRHETINIC ACID, GLYCYRRHIZIC ACID FOR TREATMENT OF PNEUMONITIS/PNEUMONIA/PULMONARY FIBROSIS 审中-公开
公开(公告)号：WO2021159076A1
公开(公告)日：2021-08-12
申请号：PCT/US2021/017084
申请日：2021-02-08
申请人： ZHANG, Lurong
发明人： ZHANG, Lurong
IPC分类号： A61K31/56 , A61K31/704 , A61P11/00
摘要： The present invention pertains to novel uses of glycyrrhetinic acid (GA), glycyrrhizic acid (GR) and related compounds for mitigation and/or treatment of pneumonitis/pneumonia/pulmonary fibrosis induced by various chemicals/bioagents and /or pathogens, such as anti-cancer therapies and /or virus. Also embodied are therapeutic uses of prodrugs, metabolites, derivatives ( e.g., acids, esters and ethers), and salts of glycyrrhetinic acid (GA) and glycyrrhizic acid (GR) in a form of drugs, health products, foods or food additives.

7. 发明申请

WO2012026928A1 USE OF GLYCYRRHETINIC ACID, GLYCYRRHIZIC ACID AND RELATED COMPOUNDS FOR PREVENTION AND/OR TREATMENT OF PULMONARY FIBROSIS 审中-公开
标题翻译：甘氨酸，甘油三酸的用途及相关化合物用于预防和/或治疗肺动脉高压
公开(公告)号：WO2012026928A1
公开(公告)日：2012-03-01
申请号：PCT/US2010/046600
申请日：2010-08-25
申请人： DIACARTA LLC , ZHANG, Lurong , ZHANG, Weijian , XU, Jianhua , YANG, Shanmin
发明人： ZHANG, Lurong , ZHANG, Weijian , XU, Jianhua , YANG, Shanmin
IPC分类号： A61K31/19 , A61K31/215 , A61K31/70 , A61P11/00
CPC分类号： A61K31/19 , A61K31/16 , A61K31/215 , A61K31/22 , A61K31/221 , A61K31/235 , A61K31/661 , A61K31/704
摘要： The present invention pertains to novel uses of glycyrrhetinic acid (GA), glycyrrhizic acid (GLA) and related compounds for prevention and/or treatment of pulmonary fibrosis, in particular, irradiation-induced pulmonary fibrosis. Also embodied are therapeutic uses of prodrugs, metabolites, derivatives (e.g., acids, esters and ethers), and salts of glycyrrhetinic acid (GA) and glycyrrhizic acid (GLA). The present invention also provides for therapeutic or pharmaceutical compositions comprising a compound of the invention in a form that can be combined with a pharmaceutically acceptable carrier.
摘要翻译：本发明涉及甘草次酸（GA），甘草酸（GLA）和相关化合物用于预防和/或治疗肺纤维化，特别是照射诱导的肺纤维化的新用途。还体现了前药，代谢物，衍生物（例如酸，酯和醚）和甘草次酸（GA）和甘草酸（GLA）的盐的治疗用途。本发明还提供包含可与药学上可接受的载体组合的形式的本发明化合物的治疗或药物组合物。

8. 发明申请

WO2009158238A2 FIBROBLAST GROWTH FACTOR (FGF) ANALOGS AND USES THEREOF 审中-公开
标题翻译： FIBROBLAST生长因子（FGF）模拟物及其用途
公开(公告)号：WO2009158238A2
公开(公告)日：2009-12-30
申请号：PCT/US2009/047498
申请日：2009-06-16
申请人： UNIVERSITY OF ROCHESTER , OKUNIEFF, Paul , ZHANG, Lurong
发明人： OKUNIEFF, Paul , ZHANG, Lurong
IPC分类号： A61K38/10
CPC分类号： A61K38/1825 , A61B17/1214 , A61B17/1215 , A61K38/196 , A61L27/227 , A61L27/54 , A61L29/048 , A61L29/16 , A61L31/047 , A61L31/16 , A61L2300/25 , C07K14/503 , A61K2300/00
摘要： The invention relates to novel peptide comprising FGF-P and methods of use thereof.
摘要翻译：本发明涉及包含FGF-P的新型肽及其使用方法。

9. 发明申请

WO2012040707A2 MATERIALS AND METHODS FOR IMPROVING GASTROINTESTINAL FUNCTION 审中-公开
标题翻译：用于改善胃肠功能的材料和方法
公开(公告)号：WO2012040707A2
公开(公告)日：2012-03-29
申请号：PCT/US2011/053265
申请日：2011-09-26
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. , VIDYASAGAR, Sadasivan , OKUNIEFF, Paul , ZHANG, Lurong
发明人： VIDYASAGAR, Sadasivan , OKUNIEFF, Paul , ZHANG, Lurong
IPC分类号： A61K31/198 , A61K31/195 , A61P1/04 , A61P1/00
CPC分类号： A61K31/405 , A61K9/0095 , A61K31/197 , A61K31/198 , A61K31/7004 , A61K31/7016 , A61K47/183 , A61K2300/00
摘要： The subject invention provides therapeutic compositions, and uses thereof for the treatment or amelioration of injury to small intestine mucosa. In preferred embodiments, the composition comprises one or more nutrients and/or electrolytes that acquire or retain considerable absorptive capacity.
摘要翻译：本发明提供治疗组合物及其用于治疗或改善对小肠粘膜损伤的用途。在优选的实施方案中，组合物包含获得或保持相当大的吸收能力的一种或多种营养物和/或电解质。

10. 发明申请

WO2010099127A2 FREE CIRCULATING DNA BIO-MARKERS AND THEIR APPLICATIONS 审中-公开
标题翻译：免费循环DNA生物标记及其应用
公开(公告)号：WO2010099127A2
公开(公告)日：2010-09-02
申请号：PCT/US2010/025114
申请日：2010-02-23
申请人： DIACARTA LLC , ZHANG, Lurong , OKUNIEFF, Paul , ZHANG, Lulu
发明人： ZHANG, Lurong , OKUNIEFF, Paul , ZHANG, Lulu
IPC分类号： C12Q1/68 , C12N15/11
CPC分类号： C12Q1/6876 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158
摘要： This invention relates generally to methods for detecting cell damage as a consequence of pathophysiological or traumatic insults such as in a nuclear accident, bioterror attack, tumorigenesis, infections or in individuals with cardiovascular disease.
摘要翻译：本发明一般涉及由于病理生理学或创伤性损伤如核事故，生物恐怖袭击，肿瘤发生，感染或心血管疾病的个体而检测细胞损伤的方法。

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