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    • 1. 发明申请
    • METHODS AND KITS FOR DETECTING AN INFECTIOUS AGENT
    • 检测感染性药物的方法和试剂盒
    • WO2012002964A1
    • 2012-01-05
    • PCT/US2010/040649
    • 2010-06-30
    • ZHANG, AiguoOKUNIEFF, PaulZHANG, LurongZHANG, Lulu
    • ZHANG, AiguoOKUNIEFF, PaulZHANG, LurongZHANG, Lulu
    • C12Q1/68C12Q1/70
    • C12Q1/689C12Q1/682C12Q1/708C12Q2600/166Y02A50/54C12Q2525/313
    • The present invention provides methods and kits for determining the presence, absence, or level of an infectious agent in a sample. Specifically, the present invention provides methods and kits for detecting or quantifying certain target polynucleotides of the infectious agent. In certain embodiments, the present invention provides for such detection without the need for amplification (e.g., replication) of the target molecule and/or without the need for labor intensive purification procedures. In certain embodiments, the present invention provides positive control and housekeeping gene for normalization and quantatively detection of the copy numbers of infectious agent in a sample. In these or other embodiments, the invention allows for such detection with the desired sensitivity and/or specificity, even where the polynucleotide is present in the sample at low copy number.
    • 本发明提供了用于确定样品中感染因子的存在,不存在或水平的方法和试剂盒。 具体地,本发明提供了用于检测或定量感染因子的某些靶多核苷酸的方法和试剂盒。 在某些实施方案中,本发明提供了这种检测,而不需要靶分子的扩增(例如复制)和/或不需要劳动密集的纯化方法。 在某些实施方案中,本发明提供用于标准化和定量检测样品中感染因子的拷贝数的阳性对照和管家基因。 在这些或其它实施方案中,即使多核苷酸以低拷贝数存在于样品中,本发明允许具有期望的灵敏度和/或特异性的这种检测。