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1. 发明申请

WO2021055467A1 ORALLY ADMINISTRABLE NANO-MEDICINE FOR VIRAL DISEASES 审中-公开
公开(公告)号：WO2021055467A1
公开(公告)日：2021-03-25
申请号：PCT/US2020/051061
申请日：2020-09-16
申请人： UNIVERSITY OF MIAMI , DHAR, Shanta , SURNAR, Bapurao , JAYAWEERA, Dushyanth , DAUNERT, Sylvia , DEO, Sapna
发明人： DHAR, Shanta , SURNAR, Bapurao , JAYAWEERA, Dushyanth , DAUNERT, Sylvia , DEO, Sapna
IPC分类号： A61K47/00 , A61K47/68 , C07K17/02 , A61K9/52 , A61K47/10
摘要： This disclosure relates generally to orally administrable nanoparticle for treating and preventing viral infection, specifically ZIKA and coronavirus infections. Methods for using the orally administrable nanoparticle are also provided for treating and preventing viral disease.

2. 发明申请

WO2016106328A1 NANOPARTICLES FOR LIPID HOMEOSTASIS 审中-公开
标题翻译：用于脂肪家族成员的纳米脂
公开(公告)号：WO2016106328A1
公开(公告)日：2016-06-30
申请号：PCT/US2015/067403
申请日：2015-12-22
申请人： UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. , DHAR, Shanta , MARRACHE, Sean , WEN, Ru , BANIK, Bhabatosh
发明人： DHAR, Shanta , MARRACHE, Sean , WEN, Ru , BANIK, Bhabatosh
IPC分类号： A61K9/51 , A61K35/00
CPC分类号： A61K9/5153 , A61K9/1275 , A61K9/282 , A61K38/10 , A61K45/06 , A61K47/54 , A61K47/549 , A61K47/6927 , A61K47/6937 , A61K49/1824 , B82Y5/00
摘要： Nanoparticles include a polymeric core and a high density lipoprotein (HDL) component where the ratio by weight of the HDL component to the polymeric core is in a range from about 1:9 to about 9:1, such as about 75:25 or less or about 7:3 or less. The nanoparticles may also include a mitochondria targeting moiety. The nanoparticles may be used to treat or prevent atherosclerosis or to maintain lipid homeostasis.
摘要翻译：纳米颗粒包括聚合物芯和高密度脂蛋白（HDL）组分，其中HDL组分与聚合物芯的重量比在约1:9至约9:1的范围内，例如约75:25或更低或约7：3或更少。纳米颗粒还可以包括线粒体靶向部分。纳米颗粒可用于治疗或预防动脉粥样硬化或维持脂质体内平衡。

3. 发明申请

WO2011028847A1 POLYVALENT POLYNUCLEOTIDE NANOPARTICLE CONJUGATES AS DELIVERY VEHICLES FOR A CHEMOTHERAPEUTIC AGENT 审中-公开
标题翻译：多价多核苷酸纳米粒子作为化学药剂的交付车辆
公开(公告)号：WO2011028847A1
公开(公告)日：2011-03-10
申请号：PCT/US2010/047591
申请日：2010-09-01
申请人： NORTHWESTERN UNIVERSITY , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , MIRKIN, Chad, A. , GILJOHANN, David, A. , DANIEL, Weston, L. , LIPPARD, Stephen, J. , DHAR, Shanta
发明人： MIRKIN, Chad, A. , GILJOHANN, David, A. , DANIEL, Weston, L. , LIPPARD, Stephen, J. , DHAR, Shanta
IPC分类号： A61K48/00 , A61K9/14
CPC分类号： B82Y5/00 , A61K47/6923
摘要： The present invention is directed to compositions and methods of delivering a chemotherapeutic agent via a polynueleotide-functionalized nanoparticle (PN-NP).
摘要翻译：本发明涉及通过多核苷酸官能化的纳米颗粒（PN-NP）递送化学治疗剂的组合物和方法。

4. 发明申请

WO2010027428A1 PLATINUM ( IV) COMPLEXES FOR USE IN DUAL MODE PHARMACEUTICAL THERAPY 审中-公开
标题翻译：用于双模式药物治疗的白蛋白（IV）复合物
公开(公告)号：WO2010027428A1
公开(公告)日：2010-03-11
申请号：PCT/US2009/004846
申请日：2009-08-26
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , LIPPARD, Stephen, J. , DHAR, Shanta
发明人： LIPPARD, Stephen, J. , DHAR, Shanta
IPC分类号： A61K31/19 , A61K33/24 , A61K45/06 , A61P35/00
CPC分类号： A61K31/282 , A61K31/19 , A61K33/24 , A61K45/06 , A61K2300/00
摘要： The present invention provides compositions, preparations, formulations, kits, and methods useful for treating subjects in need of therapeutic protocol, including subjects having cancer or at risk of developing cancer. Some embodiments of the invention may comprise a composition comprising a first component comprising a precursor to a therapeutically active platinum agent and a precursor to a second therapeutically active agent. The therapeutically active platinum agent and the second therapeutically active agent may dissociate from each other, thereby forming a first therapeutically active platinum agent and a second therapeutically active agent. The second therapeutically active gent may affect a cellular pathway of a cancer cell and may be substantially inactive towards non-cancerous cells.
摘要翻译：本发明提供了可用于治疗需要治疗方案的受试者的组合物，制剂，制剂，试剂盒和方法，包括患有癌症或有发展癌症风险的受试者。本发明的一些实施方案可以包含包含第一组分的组合物，所述第一组分包含治疗活性铂剂的前体和第二治疗活性剂的前体。治疗活性的铂剂和第二治疗活性剂可以彼此离解，从而形成第一治疗活性的铂剂和第二治疗活性剂。第二治疗活性配偶可影响癌细胞的细胞途径，并且可能对非癌细胞基本上无活性。

5. 发明申请

WO2016022462A1 THERAPEUTIC NANOPARTICLES FOR ACCUMULATION IN THE BRAIN 审中-公开
标题翻译：用于在脑中积累的治疗性纳米颗粒
公开(公告)号：WO2016022462A1
公开(公告)日：2016-02-11
申请号：PCT/US2015/043398
申请日：2015-08-03
申请人： UNIVERSITY OF GEORGIA RESEARCH FOUNDATION INC. , DHAR, Shanta , WYATT, Emily, L. , MARRACHE, Sean , WEST, Franklin, D.
发明人： DHAR, Shanta , WYATT, Emily, L. , MARRACHE, Sean , WEST, Franklin, D.
IPC分类号： A61K35/30 , A61K38/43 , A61K31/573
CPC分类号： A61K9/5153 , A61K9/0019 , A61K31/122 , A61K31/573 , A61K47/02 , A61K47/48192 , A61K47/48953 , A61K47/59 , A61K47/6937 , A61K49/0067 , A61K2300/00
摘要： Nanoparticles containing a mitochondrial that are capable of crossing the blood-brain barrier and that have a targeting moiety, an antioxidant and an anti-inflammatory agent may be useful for treatment of traumatic brain injury.
摘要翻译：能够穿过血脑屏障并具有靶向部分的线粒体的纳米粒子，抗氧化剂和抗炎剂可用于治疗创伤性脑损伤。

6. 发明申请

WO2015134599A3 PLATINUM(IV) COMPOUNDS AND METHODS OF MAKING AND USING SAME 审中-公开
公开(公告)号：WO2015134599A3
公开(公告)日：2015-09-11
申请号：PCT/US2015/018720
申请日：2015-03-04
申请人： UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. , DHAR, Shanta , PATHAK, Rakesh, K. , POPIK, Vladimir, V. , MCNITT, Christopher, D.
发明人： DHAR, Shanta , PATHAK, Rakesh, K. , POPIK, Vladimir, V. , MCNITT, Christopher, D.
IPC分类号： A61K31/282 , C07D225/08 , C07D249/16
摘要： Reactions of 1,3-dipole-functional (e.g., azide-functional) platinum(IV) compounds with cyclic alkynes under conditions effective for a cycloaddition reaction to form a heterocyclic compound are disclosed herein. In certain embodiments, the conditions effective for the cycloaddition reaction to form the heterocyclic compound includes the substantial absence of added catalyst (e.g., copper catalyst).

7. 发明申请

WO2011084620A2 PARTICLES FOR MULTIPLE AGENT DELIVERY 审中-公开
标题翻译：用于多代理交付的粒子
公开(公告)号：WO2011084620A2
公开(公告)日：2011-07-14
申请号：PCT/US2010/060814
申请日：2010-12-16
申请人： BRIGHAM AND WOMEN'S HOSPITAL, INC. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , FAROKHZAD, Omid C. , KOLISHETTI, Nagesh , DHAR, Shanta , LIPPARD, Stephen J. , LANGER, Robert S.
发明人： FAROKHZAD, Omid C. , KOLISHETTI, Nagesh , DHAR, Shanta , LIPPARD, Stephen J. , LANGER, Robert S.
IPC分类号： A61K47/48 , A61K47/30 , A61K9/22 , A61K9/20 , A61P35/00 , A61P25/28
CPC分类号： A61K45/06 , A61K47/593 , A61K47/60 , A61K47/6937
摘要： Delivery compositions are provided that include two or more active agents, wherein at least one active agent is conjugated to a polymer. The delivery compositions allow for controlled release of multiple active agents, including active agents with varying solubility, charge, and/or molecular weight.
摘要翻译：提供递送组合物，其包含两种或更多种活性剂，其中至少一种活性剂与聚合物缀合。递送组合物允许控制释放多种活性剂，包括具有不同溶解度，电荷和/或分子量的活性剂。

8. 发明申请

WO2015138992A1 MITOCHONDRIAL DELIVERY OF 3-BROMOPYRUVATE 审中-公开
标题翻译： 3-BROMOPYRUVATE的MITOCHONDRIAL DELIVERY
公开(公告)号：WO2015138992A1
公开(公告)日：2015-09-17
申请号：PCT/US2015/020591
申请日：2015-03-13
申请人： UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. , DHAR, Shanta , MARRACHE, Sean
发明人： DHAR, Shanta , MARRACHE, Sean
IPC分类号： A61K31/66
CPC分类号： A61K31/19 , A61K31/194 , A61K31/416 , A61K31/7004 , A61K41/0042 , A61K41/0057 , A61K47/48084 , A61K47/48861 , A61K47/54 , A61K47/548 , A61K47/6907 , A61K47/6923 , A61N5/062 , A61N2005/067
摘要： A mitochondria targeted gold nanoparticle (T-3-BP-AuNP) decorated with 3- bromopyruvate (3 -BP) and delocalized lipophilic triphenylphosphonium (TPP) cations to target the mitochondrial membrane potential (Δ ψ m) was developed for delivery of 3 -BP to cancer cell mitochondria by taking advantage of higher Δ ψ m in cancer cell compared to normal cells. This construct showed remarkable anticancer activity in prostate cancer cells compared to non-targeted construct NT-3-BP-AuNP and free 3- BP. Anticancer activity of T-3-BP-AuNP was further enhanced upon laser irradiation by exciting the surface plasmon resonance band of AuNP and thereby utilizing a combination of 3 -BP chemotherapeutic and AuNP photothermal effects. T-3-BP- AuNPs showed markedly enhanced ability to alter cancer cell metabolism by inhibiting glycolysis and demolishing mitochondrial oxidative phosphorylation in prostate cancer cells. Our findings demonstrated that mitochondria targeted and concerted chemo-photothermal treatment of glycolytic cancer cells with a single NP may have promise as a new anticancer therapy.
摘要翻译：开发了用3-溴丙酮酸（3-BP）和离域亲脂性三苯基鏻（TPP）阳离子装饰的靶向线粒体膜电位（Δψm）的线粒体靶向金纳米颗粒（T-3-BP-AuNP），用于将3 -BP递送至与正常细胞相比，通过利用癌细胞中更高的Δψm来利用癌细胞线粒体。与非靶向构建体NT-3-BP-AuNP和游离3-BP相比，该构建体在前列腺癌细胞中显示出显着的抗癌活性。激光照射后，通过激发AuNP的表面等离子体共振带，从而利用3 -BP化学治疗和AuNP光热效应的组合，T-3-BP-AuNP的抗癌活性进一步提高。 T-3-BP-AuNPs通过抑制糖酵解和排除前列腺癌细胞中的线粒体氧化磷酸化显示出显着提高的癌细胞代谢能力。我们的研究结果表明线粒体靶向和一致的化学光热治疗糖酵解癌细胞与单一的NP可能有希望作为一种新的抗癌治疗。

9. 发明申请

WO2014169007A2 COMBINATION THERAPEUTIC NANOPARTICLES 审中-公开
标题翻译：组合治疗纳米颗粒
公开(公告)号：WO2014169007A2
公开(公告)日：2014-10-16
申请号：PCT/US2014/033431
申请日：2014-04-09
申请人： UNIVERSITY OF GEORGIA RESEARCH FOUNDATION INC. , DHAR, Shanta , PATHAK, Rakesh, Kumar
发明人： DHAR, Shanta , PATHAK, Rakesh, Kumar
CPC分类号： A61K9/50 , A61K9/5153 , A61K31/222 , A61K31/573 , A61K31/663 , A61K33/24 , A61K47/482 , A61K47/48246 , A61K47/55 , A61K47/593 , A61K47/64 , A61K47/6937 , C07C69/78 , C07J5/0053
摘要： Nanoparticles that include a chemotherapeutic agent and an anti-inflammatory are particularly cytotoxic to prostate cancer cells.
摘要翻译：包括化学治疗剂和抗炎剂的纳米颗粒对前列腺癌细胞特别是细胞毒性。

10. 发明申请

WO2010047765A8 NANOSTRUCTURES FOR DRUG DELIVERY 审中-公开
公开(公告)号：WO2010047765A8
公开(公告)日：2010-04-29
申请号：PCT/US2009/005687
申请日：2009-10-20
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , LIPPARD, Stephen, J. , DHAR, Shanta , FAROKHZAD, Omid, C. , KOLISHETTI, Nagesh , GU, Frank, X.
发明人： LIPPARD, Stephen, J. , DHAR, Shanta , FAROKHZAD, Omid, C. , KOLISHETTI, Nagesh , GU, Frank, X.
IPC分类号： A61K9/16 , A61K33/24 , A61P13/08
摘要： The present invention provides compositions, preparations, formulations, kits, and methods useful for treating subjects having cancer or at risk of developing cancer. Some embodiments of the invention may comprise a composition comprising a plurality of particles comprising a platinum(IV) therapeutically active precursor.

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