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1. 发明申请

WO2012141938A1 CHEMICALLY MODIFIED CELLULOSE FIBROUS MESHES FOR USE AS TISSUE ENGINEERING SCAFFOLDS 审中-公开
标题翻译：化学改性纤维素纤维素纤维网用作组织工程学
公开(公告)号：WO2012141938A1
公开(公告)日：2012-10-18
申请号：PCT/US2012/031935
申请日：2012-04-03
申请人： UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL , SONG, Jie , FILION POTTS, Tera, M. , KUTIKOV, Artem
发明人： SONG, Jie , FILION POTTS, Tera, M. , KUTIKOV, Artem
IPC分类号： C08J5/00 , D01F11/02 , D01F1/09 , D01F2/00 , D01F1/10 , D06M13/402
CPC分类号： A61K38/1841 , A61K9/0024 , A61K9/70 , A61K38/18 , A61K38/1825 , A61K38/1866 , A61K38/1875 , A61K38/191 , A61K38/30 , A61K47/38 , A61L31/04 , C08L1/12 , D01D5/003 , D01D10/02 , D01F2/28 , D01F11/02 , D06M13/262 , D06M13/342 , D06M13/368 , D06M13/372 , D06M2101/06
摘要： Cellulose and sulfated cellulose fibrous meshes exhibiting robust structural and mechanical integrity in water were fabricated using a combination of electrospinning, thermal- mechanical annealing and chemical modifications. The sulfated fibrous mesh exhibited higher retention capacity for human recombinant bone morphogenetic protein-2 than the cellulose mesh, and the retained proteins remained biologically active for at least 7 days. The sulfated fibrous mesh also more readily supported the attachment and osteogenic differentiation of rat bone marrow stromal cells in the absence of osteogenic growth factors. These properties combined make the sulfated cellulose fibrous mesh a promising bone tissue engineering scaffold.
摘要翻译：使用静电纺丝，热机械退火和化学修饰的组合制造了在水中显示出坚固的结构和机械完整性的纤维素和硫酸化纤维素纤维网。硫酸化纤维网对于人重组骨形态发生蛋白-2比纤维素网显示更高的保留能力，并且保留的蛋白质在生物活性上保持至少7天。在没有成骨生长因子的情况下，硫酸化纤维网也更容易地支持大鼠骨髓基质细胞的附着和成骨分化。这些性质联合使硫酸化纤维素纤维网成为有希望的骨组织工程支架。

2. 发明申请

WO2013044078A2 ELASTOMERIC AND DEGRADABLE HIGH-MINERAL CONTENT POLYMER COMPOSITES 审中-公开
标题翻译：弹性和可降解的高矿物含量聚合物复合材料
公开(公告)号：WO2013044078A2
公开(公告)日：2013-03-28
申请号：PCT/US2012/056641
申请日：2012-09-21
申请人： UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL , SONG, Jie , KUTIKOV, Artem
发明人： SONG, Jie , KUTIKOV, Artem
CPC分类号： C08K3/32 , A61L27/46 , A61L27/56 , A61L27/58 , A61L2400/16 , A61L2430/02 , A61L2430/06 , C08K2003/325 , C08K2201/018 , D01D5/0007 , D01F1/10 , D01F6/84 , D01F6/86 , C08L53/00 , C08L71/02
摘要： The invention provides novel compositions of hydroxyapatite and block copolymers, methods of their preparation, and uses thereof, wherein the co-polymers have degradable hydrophobic blocks and hydrophilic blocks for stable interfacing with hydroxyapatite, resulting in stable polymer-hydroxyapatite suspensions. The super- hydrophilicity, strengthened mechanical integrity, and retained structural integrity of the HA- PELA composite in aqueous environment represent major advantages over the HA-PLA composites for skeletal tissue engineering applications.
摘要翻译：本发明提供羟基磷灰石和嵌段共聚物的新组合物，其制备方法及其用途，其中共聚物具有可降解的疏水嵌段和用于与羟基磷灰石稳定接合的亲水嵌段，导致稳定的聚合物 - 羟基磷灰石悬浮液。 HA-PELA复合材料在水性环境中的超亲水性，增强的机械完整性和保留的结构完整性代表了骨架组织工程应用的HA-PLA复合材料的主要优点。

3. 发明申请

WO2012116250A1 MONOMERS AND POLYMERS FOR FUNCTIONAL POLYCARBONATES AND POLY (ESTER-CARBONATES) AND PEG-CO-POLYCARBONATE HYDROGELS 审中-公开
标题翻译：功能性聚碳酸酯和聚（酯 - 碳酸酯）和PEG-聚碳酸酯氢化物的单体和聚合物
公开(公告)号：WO2012116250A1
公开(公告)日：2012-08-30
申请号：PCT/US2012/026427
申请日：2012-02-24
申请人： UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL , SONG, Jie , XU, Jianwen
发明人： SONG, Jie , XU, Jianwen
IPC分类号： C07D319/12 , C08G63/08 , C08G63/64 , C08L67/04 , A61L27/52 , A61L27/38 , A61L33/06 , A61K47/34
CPC分类号： C07D405/14 , A61L27/18 , A61L27/52 , C07C247/04 , C07C247/10 , C07D319/06 , C07D405/06 , C08G64/0208 , C08G64/0241 , C08G64/0291 , C08G64/18 , C08G64/183 , C08L69/00
摘要： The invention generally relates to functional polymers and hydrogels. More particularly, the invention provides versatile monomers and polymers with well-defined functionalities, e.g ., polycarbonates and poly(ester-carbonates), compositions thereof, and methods for making and using the same. The invention also provides cytocompatible poly(ethylene glycol)-co-polycarobonate hydrogels ( e.g. , crosslinked by copper-free, strain- promoted "click" chemistry).
摘要翻译：本发明一般涉及功能聚合物和水凝胶。更具体地说，本发明提供通用单体和具有良好界定的官能团的聚合物，例如聚碳酸酯和聚（酯 - 碳酸酯），其组合物，以及制备和使用它们的方法。本发明还提供了细胞相容的聚（乙二醇） - 共 - 碳酸酯水凝胶（例如，通过无铜，应变促进的“点击”化学交联）。

4. 发明申请

WO2009020550A2 COMPOSITES FOR BIOMEDICAL APPLICATIONS 审中-公开
标题翻译：生物医学应用复合材料
公开(公告)号：WO2009020550A2
公开(公告)日：2009-02-12
申请号：PCT/US2008/009272
申请日：2008-07-31
申请人： UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL , SONG, Jie , AYERS, David, C. , LIAN, Jane, B. , LI, Xinning
发明人： SONG, Jie , AYERS, David, C. , LIAN, Jane, B. , LI, Xinning
IPC分类号： A61K48/00
CPC分类号： A61L27/46 , A61K38/1866 , A61K38/1875 , A61K48/00 , A61L27/38 , A61L27/3804 , A61L27/54 , A61L27/56 , A61L2300/258 , A61L2300/414 , A61L2430/02 , C08G77/045 , C08G77/38 , C08G77/445
摘要： The invention relates to composite materials that contain a polymer matrix and aggregates, and in some embodiments, methods of making, and methods of using these materials. Preferably, the aggregates are calcium phosphate aggregates. Preferably, the material is resistant to fracture. In further embodiments, the materials are used in surgical procedures of bone replacement. In further embodiments, the materials contain polyhedral silsesquioxanes and/or biodegradable segments. In further embodiments, the polymer matrix comprises biomolecules.
摘要翻译：本发明涉及包含聚合物基质和聚集体的复合材料，并且在一些实施方案中，涉及制造方法和使用这些材料的方法。优选地，聚集体是磷酸钙聚集体。优选地，该材料是抗断裂的。在进一步的实施例中，材料用于骨替换的外科手术中。在进一步的实施方式中，材料包含多面体倍半硅氧烷和/或可生物降解的片段。在进一步的实施方案中，聚合物基质包含生物分子。

5. 发明申请

WO2008130650A1 THERMAL RESPONSIVE POLYMER SILOXANES, COMPOSITIONS, AND METHODS AND APPLICATIONS RELATED THERETO 审中-公开
标题翻译：热应对聚合物硅氧烷，组合物及其相关方法及应用
公开(公告)号：WO2008130650A1
公开(公告)日：2008-10-30
申请号：PCT/US2008/005059
申请日：2008-04-18
申请人： UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL , SONG, Jie , XU, Jianwe
发明人： SONG, Jie , XU, Jianwe
IPC分类号： A61K31/695
CPC分类号： A61L27/18 , A61L27/50 , A61L31/06 , A61L2400/16 , C08G18/61 , C08G63/6952 , C08G77/045 , C08G77/38 , C08G77/445 , C08L83/04
摘要： The invention relates to materials comprising siloxanes, preferably the materials have thermal-responsive properties. In some embodiments, the invention relates to silsesquioxane groups functionalized with polymers. In another embodiment, silsequioxane-polymer conjugates comprise polylactone segments. The silsequioxane- polymer conjugates may be crosslinked together to form a material, and these materials may be functionalized with bioactive compounds so that the materials have desirable biocompatibility or bioactivity when used in medical devices. In further embodiments, the invention relates to composite materials that contain a polymer matrix and aggregates, and in some embodiments, methods of making, and methods of using these materials. Preferably, the aggregates are calcium phosphate aggregates. Preferably, the material is resistant to fracture. In further embodiments, the materials are used in surgical procedures of bone replacement. In further embodiments, the materials contain polyhedral silsesquioxanes and/or biodegradable segments.
摘要翻译：本发明涉及包含硅氧烷的材料，优选该材料具有热响应特性。在一些实施方案中，本发明涉及用聚合物官能化的倍半硅氧烷基团。在另一个实施方案中，硅二恶烷 - 聚合物共轭物包含聚内酯片段。硅氧烷 - 聚合物共轭物可以一起交联以形成材料，并且这些材料可以用生物活性化合物官能化，使得当用于医疗装置时，这些材料具有期望的生物相容性或生物活性。在另外的实施方案中，本发明涉及包含聚合物基质和聚集体的复合材料，并且在一些实施方案中涉及制备方法和使用这些材料的方法。优选地，聚集体是磷酸钙聚集体。优选地，该材料耐断裂。在另外的实施方案中，所述材料用于骨置换的外科手术中。在另外的实施方案中，材料含有多面体倍半硅氧烷和/或可生物降解的片段。

6. 发明申请

WO2009025719A1 POLYMER COMPOSITIONS FOR BIOMEDICAL AND MATERIAL APPLICATIONS 审中-公开
标题翻译：用于生物医药和材料应用的聚合物组合物
公开(公告)号：WO2009025719A1
公开(公告)日：2009-02-26
申请号：PCT/US2008/009253
申请日：2008-07-31
申请人： UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL , SONG, Jie , XU, Jianwe
发明人： SONG, Jie , XU, Jianwe
IPC分类号： C08F290/06
CPC分类号： A61L27/46 , A61K38/1866 , A61K38/1875 , A61K48/00 , A61L27/38 , A61L27/3804 , A61L27/54 , A61L27/56 , A61L2300/258 , A61L2300/414 , A61L2430/02 , C08G77/045 , C08G77/38 , C08G77/445
摘要： The invention relates to composite materials that contain a polymer matrix and aggregates, and in some embodiments, methods of making, and methods of using these materials. Preferably, the aggregates are calcium phosphate aggregates. Preferably, the material is resistant to fracture. In further embodiments, the materials are used in surgical procedures of bone replacement. In further embodiments, the materials contain polyhedral silsesquioxanes and/or biodegradable segments. In further embodiments, the polymer matrix comprises biomolecules.
摘要翻译：本发明涉及包含聚合物基质和聚集体的复合材料，并且在一些实施方案中涉及制备方法和使用这些材料的方法。优选地，聚集体是磷酸钙聚集体。优选地，该材料耐断裂。在另外的实施方案中，所述材料用于骨置换的外科手术中。在另外的实施方案中，材料含有多面体倍半硅氧烷和/或可生物降解的片段。在另外的实施方案中，聚合物基质包含生物分子。

7. 发明申请

WO2014099652A1 COMPOSITIONS AND METHODS FOR TEMPLATING THREE-DIMENSIONAL MINERALIZATION 审中-公开
标题翻译：用于三维矿化的组合物和方法
公开(公告)号：WO2014099652A1
公开(公告)日：2014-06-26
申请号：PCT/US2013/074950
申请日：2013-12-13
申请人： UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL
发明人： SONG, Jie , LIU, Pingsheng
IPC分类号： A61L27/44 , A61L27/38 , A61L27/58 , A61F2/08 , A61F2/28 , A61C13/00
CPC分类号： A61L27/46 , A61C8/0016 , A61L27/3821 , A61L27/427 , A61L27/58 , A61L2430/02 , A61L2430/06 , A61L2430/12 , C08L33/12
摘要： The invention provides novel compositions and methods for three-dimensional mineralization templated by synthetic scaffolds having zwitterionic mediators. The invention enables 3-D mineralization nucleation and growth of minerals in a well-controlled and defined manner. The composite materials prepared by the disclosed methods are cytocompatible and/or biodegradable and are suitable for use as medical implants in a variety of applications in skeletal tissue repair and regeneration. For example, cytocompatible zwitterionic sulfobetaine ligands are employed to facilitate 3-D mineralization of HA across covalently crosslinked hydrogels. The overall charge- neutral zwitterionic hydrogel effectively recruited oppositely charged precursor ions while overcame excessive swelling exhibited by anionic and cationic hydrogels under physiological conditions, resulting in denser and structurally well-integrated mineralized composite materials.
摘要翻译：本发明提供了由具有两性离子介体的合成支架模板化的三维矿化的新型组合物和方法。本发明能够以良好控制和限定的方式实现三维矿化成核和矿物生长。通过公开的方法制备的复合材料是细胞相容性和/或可生物降解的，并且适合用作骨骼组织修复和再生中各种应用中的医学植入物。例如，使用细胞相容的两性离子磺基甜菜碱配体来促进HA通过共价交联的水凝胶的3-D矿化。整个电荷 - 中性的两性离子水凝胶在生理条件下有效地招募了带相反电荷的前体离子，同时克服阴离子和阳离子水凝胶表现出的过度溶胀，导致更致密和结构完全一体化的矿化复合材料。

8. 发明申请

WO2015130877A1 AMPHIPHILIC DEGRADABLE POLYMERS FOR IMMOBILIZATION AND SUSTAINED DELIVERY OF BIOMOLECULES 审中-公开
标题翻译：用于固定和持续分送生物分子的聚合可降解聚合物
公开(公告)号：WO2015130877A1
公开(公告)日：2015-09-03
申请号：PCT/US2015/017640
申请日：2015-02-26
申请人： UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL
发明人： SONG, Jie , ZHANG, Jing
IPC分类号： A61K47/34 , C08G63/08 , A61F2/00
CPC分类号： A61L27/18 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/06 , A61L31/10 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2300/22 , A61L2300/414 , C08G63/664 , C08G63/823 , C08G2230/00 , C08L67/04
摘要： The invention provides a novel approach to controlled delivery of biomolecules (e.g., lipids and proteins) by employing novel amphiphilic polymers that are effective delivery vehicles. These unique amphiphilic polymers may be employed as controlled delivery vehicles or tissue engineering scaffolds wherein the delivery of lipophilic or amphiphilic bioactive molecules can be achieved. An amphiphilic biodegradable polymer platform is disclosed herein for the stable encapsulation and sustained release of biomolecules, such as SIP.
摘要翻译：本发明提供了一种通过使用作为有效递送载体的新型两亲性聚合物来控制传递生物分子（例如脂质和蛋白质）的新方法。这些独特的两亲性聚合物可以用作控制递送载体或组织工程支架，其中可以实现亲脂性或两亲生物活性分子的递送。本文公开了两亲生物可降解聚合物平台，用于稳定包封和持续释放生物分子，例如SIP。

9. 发明申请

WO2016007424A2 ZWITTERIONIC HYDROGELS FOR DELIVERY OF BIOMOLECULES 审中-公开
标题翻译：用于生物分子递送的ZWITTERICIC HYDROGEL
公开(公告)号：WO2016007424A2
公开(公告)日：2016-01-14
申请号：PCT/US2015/039227
申请日：2015-07-06
申请人： UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL
发明人： SONG, Jie , LIU, Pingsheng
IPC分类号： A61K47/32 , A61K38/18
CPC分类号： A61L27/58 , A61K38/18 , A61K38/1875 , A61K38/30 , A61L27/14 , A61L27/18 , A61L27/50 , A61L27/52 , A61L27/54 , A61L2300/414 , A61L2430/02
摘要： The invention provides a novel approach in which zwitterionic networks are used to sequester and deliver ionic biomolecules, such as proteins, without compromising their native conformation and bioactivity. Zwitterionic networks are designed to effectively retain and deliver ionic or polar biomolecules for guided tissue regeneration. The invention represents a conceptual advance and enables a novel strategy for the utilization of zwitterionic motifs as therapeutics delivery vehicles and tissue engineering scaffolds.
摘要翻译：本发明提供了一种新颖的方法，其中使用两性离子网络隔离和递送离子生物分子例如蛋白质，而不损害其天然构象和生物活性。两性离子网络被设计为有效地保留和传递用于引导组织再生的离子或极性生物分子。本发明代表了概念上的进步，并且使得能够利用两性离子基序作为治疗递送载体和组织工程支架的新策略。

10. 发明申请

WO2014204634A1 ELASTOMERIC AND DEGRADABLE POLYMER MINERAL COMPOSITE SCAFFOLDS 审中-公开
标题翻译：弹性和可降解的聚合物矿物复合材料
公开(公告)号：WO2014204634A1
公开(公告)日：2014-12-24
申请号：PCT/US2014/040194
申请日：2014-05-30
申请人： UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL
发明人： SONG, Jie , KUTIKOV, Artem
IPC分类号： A61F2/28
CPC分类号： A61L27/18 , A61F2/28 , A61F2/2846 , A61F2002/2817 , A61F2002/2835 , A61F2002/30293 , A61F2002/30915 , A61F2002/30971 , A61F2210/0004 , A61F2210/0014 , A61F2210/0061 , A61F2210/0085 , A61F2310/0097 , A61L27/3834 , A61L27/46 , A61L27/50 , A61L27/54 , A61L27/58 , A61L2400/16 , C08G63/912 , C08L71/02 , C08L67/04
摘要： This invention provides novel synthetic bone grafting materials or tissue engineering scaffolds with desired structural and biological properties ( e.g. , well-controlled macroporosities, spatially defined biological microenvironment, good handling characteristics, self-anchoring capabilities and shape memory properties) and methods of their applications in vivo .
摘要翻译：本发明提供具有所需结构和生物学特性（例如，良好控制的大孔隙度，空间定义的生物微环境，良好的处理特性，自锚定能力和形状记忆性质）的新型合成骨移植材料或组织工程支架及其应用的方法体内。

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