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1. 发明申请

WO1997033626A1 NOVEL CHELATORS AND COMPOSITIONS PREPARED THEREWITH 审中-公开
标题翻译：新的勋章和组成
公开(公告)号：WO1997033626A1
公开(公告)日：1997-09-18
申请号：PCT/US1997004052
申请日：1997-03-12
申请人： UNIVERSITY OF MASSACHUSETTS , HNATOWICH, Donald, J. , RUSCKOWSKI, Mary , MARDIROSSIAN, George , WINNARD, Paul, Jr. , CHANG, Fengchun , QU, Tong
发明人： UNIVERSITY OF MASSACHUSETTS
IPC分类号： A61K51/00
CPC分类号： A61K51/088 , A61K2123/00 , C07K1/1077
摘要： Novel chelators and methods of synthesis and use thereof are disclosed. The compositions, methods and kits provided enable radionuclides for medical applications to be complexed to chelator-conjugates under mild conditions.
摘要翻译：公开了新型螯合剂及其合成和使用方法。提供的组合物，方法和试剂盒使得用于医疗应用的放射性核素在温和条件下与螯合剂缀合物络合。

2. 发明申请

WO1998021358A1 HUNTINGTIN-RELATED THERAPEUTICS AND BIOASSAY 审中-公开
标题翻译：与营养相关的治疗和生物学
公开(公告)号：WO1998021358A1
公开(公告)日：1998-05-22
申请号：PCT/US1997020745
申请日：1997-11-14
申请人： UNIVERSITY OF MASSACHUSETTS , THE GENERAL HOSPITAL CORPORATION
发明人： UNIVERSITY OF MASSACHUSETTS , THE GENERAL HOSPITAL CORPORATION , DilFIGLIA, Marian , ARONIN, Neil , VELIER, James
IPC分类号： C12Q01/00
CPC分类号： G01N33/5008 , G01N33/502 , G01N33/5044 , G01N33/5058 , G01N33/6896 , G01N2500/10
摘要： A method of identifying a compound useful in the treatment of a disease characterized by the presence of mutant huntingtin by: (a) providing a cell which expresses mutant huntingtin; (b) contacting the cell with a test compound; and (c) determining whether the level of clathrin-mediated endocytosis is increased in the presence of the test compound, compared to the level in the absence of the test compound. An increase in clathrin-mediated endocytosis is an indication that the test compound is useful in treating the disease.
摘要翻译：鉴定通过以下方法鉴定用于治疗特征在于存在突变型亨廷汀的疾病的化合物的方法：（a）提供表达突变型亨廷汀的细胞; （b）使细胞与测试化合物接触; 和（c）与不存在测试化合物的水平相比，确定在测试化合物存在下网格蛋白介导的内吞水平是否增加。网格蛋白介导的内吞作用的增加表明该试验化合物可用于治疗该疾病。

3. 发明申请

WO1998009913A1 REVERSIBLE COVALENT ATTACHMENT OF FULLERENES TO INSOLUBLE SUPPORTS 审中-公开
标题翻译：富裕人士对无力支持的反应可能
公开(公告)号：WO1998009913A1
公开(公告)日：1998-03-12
申请号：PCT/US1996014555
申请日：1996-09-06
申请人： UNIVERSITY OF MASSACHUSETTS , ROTELLO, Vincent
发明人： UNIVERSITY OF MASSACHUSETTS
IPC分类号： C01B31/02
CPC分类号： B82Y30/00 , B01J20/3204 , B01J20/3219 , B01J20/3248 , B01J20/3253 , B01J20/3255 , B82Y40/00 , C01B32/15 , C01B32/152
摘要： Methods of separating fullerenes from a mixture by covalent attachment to an insoluble support are disclosed. Compositions useful in the method, and methods of preparing the compositions, are also described.
摘要翻译：公开了通过共价连接到不溶性载体上将富勒烯与混合物分离的方法。还描述了可用于该方法的组合物和制备组合物的方法。

4. 发明申请

WO1998000068A1 FINGERTIP-MOUNTED MINIMALLY INVASIVE SURGICAL INSTRUMENTS AND METHODS OF USE 审中-公开
标题翻译：指尖安装的微型外科手术器械及使用方法
公开(公告)号：WO1998000068A1
公开(公告)日：1998-01-08
申请号：PCT/US1997011481
申请日：1997-06-30
申请人： UNIVERSITY OF MASSACHUSETTS , SMITH & NEPHEW, INC. , MEYERS, William, C. , EK, Steven , VERDURA, Javier , CARROLL, Maureen, E. , CHARLES, Kirk, W.
发明人： UNIVERSITY OF MASSACHUSETTS , SMITH & NEPHEW, INC.
IPC分类号： A61B17/32
CPC分类号： A61B17/3201 , A61B17/062 , A61B17/128 , A61B17/2812 , A61B17/2909 , A61B17/30 , A61B17/320016 , A61B17/3211 , A61B18/1442 , A61B90/30 , A61B90/361 , A61B2017/00265 , A61B2017/00367 , A61B2017/00438 , A61B2017/00464 , A61B2017/320044 , A61B2090/0817
摘要： The invention is a number of minimally invasive, miniature surgical instruments (10) that can be mounted directly on a surgeon's fingertips in a way that the surgeon can insert his or her hand into a patient through a minimal incision to perform surgical procedures, and also to use his or her fingers to manipulate tissues. The invention enables the surgeon to perform the procedures with all the benefits of minimally invasive surgery, but with much greater tactile sense, control, and ease of manipulation, than enabled by known minimally invasive surgical instruments.
摘要翻译：本发明是一些微创的微型手术器械（10），其可以直接安装在外科医生的指尖上，使得外科医生可以通过最小切口将他或她的手插入患者中以执行外科手术，并且还用他或她的手指操纵组织。本发明使得外科医生能够执行具有微创外科手术的所有益处的手术，但具有比已知的微创手术器械所能实现的更大的触觉，控制和易于操纵的手术。

5. 发明申请

WO1997044851A1 WAVEGUIDE-MICROSTRIP TRANSMISSION LINE TRANSITION STRUCTURE 审中-公开
标题翻译：波导 - 微波传输线转换结构
公开(公告)号：WO1997044851A1
公开(公告)日：1997-11-27
申请号：PCT/US1997007887
申请日：1997-05-07
申请人： UNIVERSITY OF MASSACHUSETTS
发明人： UNIVERSITY OF MASSACHUSETTS , POZAR, David, M.
IPC分类号： H01P05/107
CPC分类号： H01P5/107
摘要： A waveguide-microstrip transmission line transition structure (10) is provided with a microstrip transmission line structure (12) adapted for coupling to an open end of a waveguide (14). The microstrip transmission structure (12) includes a microstrip transmission line having a ground plane conductor (18) and an antenna (38) electrically coupled to the microstrip transmission line (30) through an aperture (22) in the ground plane conductor (18). The ground plane conductor (18) is adapted for mounting in a plane intersecting a longitudinal axis (24) of the waveguide (14). The antenna (38) provides impedance matching between microstrip transmission line (30) and waveguide (14). Thus, a relatively simpler manufacturing structure is provided for mounting to a standard waveguide flange (42) without special waveguide pieces. This arrangement provides a modular arrangement which allows for easy connection or disconnection of the microstrip transmission structure (12). Additionally, such a transition structure (10) requires no special openings, thus eliminating spurious radiation and provides a hermetic seal. The transition structure (10) is well suited for connecting waveguide feeds to planar antennas.
摘要翻译：波导 - 微带传输线过渡结构（10）设置有适于耦合到波导（14）的开口端的微带传输线结构（12）。微带传输结构（12）包括具有接地平面导体（18）的微带传输线和通过接地平面导体（18）中的孔（22）电耦合到微带传输线（30）的天线（38）。接地平面导体（18）适于安装在与波导（14）的纵向轴线（24）相交的平面中。天线（38）提供微带传输线（30）和波导（14）之间的阻抗匹配。因此，提供相对简单的制造结构用于安装到没有特殊波导片的标准波导法兰（42）。这种布置提供了一种模块化布置，其允许容易地连接或断开微带传输结构（12）。此外，这种过渡结构（10）不需要特殊的开口，从而消除杂散辐射并提供气密密封。过渡结构（10）非常适合于将波导馈线连接到平面天线。

6. 发明申请

WO1998018833A1 POLY(VINYL AMINE) ANALOGS 审中-公开
标题翻译： POLY（VINYL AMINE）ANALOGS
公开(公告)号：WO1998018833A1
公开(公告)日：1998-05-07
申请号：PCT/US1997019659
申请日：1997-10-27
申请人： UNIVERSITY OF MASSACHUSETTS
发明人： UNIVERSITY OF MASSACHUSETTS , NOVAK, Bruce, M. , CAFMEYER, Jeffrey, T.
IPC分类号： C08F26/00
CPC分类号： C08F26/00
摘要： In general, the invention features a polymer having formula (1), where R1 through R4, independently, are hydrogen; an alkyl, e.g., CaH2a+1, where a is 1 to 20 or higher; an aryl, e.g., phenyl or substituted phenyl, e.g., substituted with CH3, CF3, or OCH3; an acyl, e.g., COH, COCH3, or COCF3; or a halogen, e.g., F, Cl, Br, or I; R5 and R6, independently can be hydrogen; alkyl; aryl; acyl; alkoxycarbonyl, e.g., COOCH3, COOC(CH3)3, or COOCH2CH3; or silyl, e.g., Si(CH3)3, (CH3)2SiC(CH3)3 or Si(CH(CH3)2)3; and n is at least 2. n can be up to 100, 10,000, 1,000,000, or higher.
摘要翻译：通常，本发明的特征在于具有式（1）的聚合物，其中R 1至R 4独立地为氢; 烷基，例如CaH 2 a + 1，其中a为1至20或更高; 芳基，例如苯基或取代的苯基，例如被CH 3，CF 3或OCH 3取代; 酰基，例如COH，COCH 3或COCF 3; 或卤素，例如F，Cl，Br或I; R5和R6独立地可以是氢; 烷基; 芳基; 酰基; 烷氧基羰基，例如COOCH 3，COOC（CH 3）3或COOCH 2 CH 3; 或甲硅烷基，例如Si（CH 3）3，（CH 3）2 Si（CH 3）3或Si（CH（CH 3）2）3; n至少为2.n可以高达100，10,000，1,000,000或更高。

7. 发明申请

WO1998007841A1 EMBRYONIC OR STEM-LIKE CELL LINES PRODUCED BY CROSS SPECIES NUCLEAR TRANSPLANTATION 审中-公开
标题翻译：通过种类生产的胚胎或干细胞细胞核进行核移植
公开(公告)号：WO1998007841A1
公开(公告)日：1998-02-26
申请号：PCT/US1997012919
申请日：1997-07-28
申请人： UNIVERSITY OF MASSACHUSETTS
发明人： UNIVERSITY OF MASSACHUSETTS , ROBL, James , CIBELLI, Jose , STICE, Steven, L.
IPC分类号： C12N15/00
CPC分类号： C12N15/8776 , A61K35/12 , A61K38/00 , C12N15/87 , C12N2517/04
摘要： An improved method of nuclear transfer involving the transplantation of donor cell nuclei into enucleated oocytes of a species different from the donor cell is provided. The resultant nuclear transfer units are useful for the production of isogenic embryonic stem cells, in particular human isogenic embryonic or stem cells. These embryonic or stem-like cells are useful for producing desired differentiated cells and for introduction, removal or modification, of desired genes, e.g., at specific sites of the genome of such cells by homologous recombination. These cells, which may contain a heterologous gene, are especially useful in cell transplantation therapies and for in vitro study of cell differentiation.
摘要翻译：提供了涉及将供体细胞核移植到与供体细胞不同的物种的去核卵母细胞中的改进的核转移方法。所得到的核转移单位可用于生产等原胚胎干细胞，特别是人原代胚胎干细胞。这些胚胎或干细胞样细胞可用于产生所需的分化细胞并用于通过同源重组引入，去除或修饰所需基因，例如在这些细胞的基因组的特定位点。这些可能含有异源基因的细胞特别适用于细胞移植治疗和体外研究细胞分化。

8. 发明申请

WO1998000566A1 SEQUENCE-SPECIFIC METHYLATION OF RIBONUCLEIC ACID 审中-公开
标题翻译：抗坏血酸的序列特异性甲基化
公开(公告)号：WO1998000566A1
公开(公告)日：1998-01-08
申请号：PCT/US1997011251
申请日：1997-06-27
申请人： UNIVERSITY OF MASSACHUSETTS
发明人： UNIVERSITY OF MASSACHUSETTS , FOURNIER, Maurille, J. , NI, Jingwei
IPC分类号： C12Q01/68
CPC分类号： C12N15/113 , C07H21/00 , C12N15/1132 , C12N2310/111 , C12N2310/321 , C12P19/34 , C12N2310/3521
摘要： The invention features nucleic acid molecules and methods for use in site-specific methylation of ribonucleotides. The methods of the invention can be used to modulate RNA folding, RNA processing, RNA cleavage, and other processes involving sequence-specific recognition of RNA sequences, as well as for promoting RNA stability.
摘要翻译：本发明的核酸分子和用于核糖核苷酸的位点特异性甲基化的方法。本发明的方法可用于调节RNA折叠，RNA加工，RNA切割和涉及序列特异性识别RNA序列的其它过程，以及用于促进RNA稳定性。

9. 发明申请

WO1997046907A1 ALL-OPTICAL DEVICES 审中-公开
标题翻译：全光学设备
公开(公告)号：WO1997046907A1
公开(公告)日：1997-12-11
申请号：PCT/US1996012360
申请日：1996-07-26
申请人： UNIVERSITY OF MASSACHUSETTS , THE UNITED STATES OF AMERICA, represented by THE SECRETARY OF THE ARMY
发明人： UNIVERSITY OF MASSACHUSETTS , THE UNITED STATES OF AMERICA, represented by THE SECRETARY OF THE ARMY , RAO, Devulapalli, V., G., L., N. , ARANDA, Francisco, J. , RAO, Desai, Narayana , CHEN, Zongping , AKKARA, Joseph, A. , ROACH, Joseph, F.
IPC分类号： G02F01/03
CPC分类号： G02F1/0126 , G02F3/00
摘要： All-optical devices, e.g., optical switches and modulators (10), and logic gates (40) such as optical AND and OR gates, that include photochromic materials (20) having first and second stable states, such as bacteriorhodopsin, organic fulgides, azo and fluorescent dyes, phycobiliproteins, rhodopsins, and their analogs, irradiated in a four-wave mixing geometry, are described. These devices can be used in a wide variety of systems, such as, e.g., optical signal processors and optical computers.
摘要翻译：全光学装置，例如光开关和调制器（10）以及诸如光学AND和OR门的逻辑门（40），其包括具有第一和第二稳定状态的光致变色材料（20），例如细菌视紫红质，有机俘获物，描述了以四波混合几何形式照射的偶氮和荧光染料，藻胆蛋白，视紫质及其类似物。这些装置可用于各种系统，例如光信号处理器和光学计算机。

10. 发明申请

WO1997042494A1 RAPID SOIL NUTRIENT ANALYSIS 审中-公开
标题翻译：快速土壤营养分析
公开(公告)号：WO1997042494A1
公开(公告)日：1997-11-13
申请号：PCT/US1997007501
申请日：1997-05-02
申请人： UNIVERSITY OF MASSACHUSETTS
发明人： UNIVERSITY OF MASSACHUSETTS , CHOLLI, Ashok , BARRY, Eugene, F. , O'FLAHERTY, Brian , RAO, Nagarajan
IPC分类号： G01N27/26
CPC分类号： G01N33/24 , G01N27/447
摘要： A soil nutrient sensor comprising: a capillary (1), buffer source reservoir (15), buffer drain reservoir (6), high-voltage power source (10), electrical conductors (12, 14, 16), detector assembly (20), computer (60), microinfusion pump (40), injection loop (45), interface junction (30), soil probe (50), buffer reservoir (7), and samples of standard reference solutions (45).
摘要翻译：一种土壤营养传感器，包括：毛细管（1），缓冲源储存器（15），缓冲排放储存器（6），高压电源（10），电导体（12,14,16），检测器组件（20），计算机（60），微灌注泵（40），注射回路（45），界面结（30），土壤探针（50），缓冲液储存器（7）和标准参考溶液样品（45）。

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