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1. 发明申请

WO2015114347A1 SYSTEM FOR A BRAIN-COMPUTER INTERFACE 审中-公开
标题翻译：脑电脑界面系统
公开(公告)号：WO2015114347A1
公开(公告)日：2015-08-06
申请号：PCT/GB2015/050217
申请日：2015-01-29
申请人： UNIVERSITY OF LEICESTER , UNIVERSITY OF NEWCASTLE UPON TYNE , IMPERIAL INNOVATIONS LIMITED
发明人： JACKSON, Andrew , CONSTANDINOU, Tim , EFTEKHAR, Amir , QUIROGA, Rodrigo Quian , AHUMADA, Joaquin Navajas
IPC分类号： G06F3/01
CPC分类号： A61B5/04 , A61B5/4064 , G06F3/015
摘要： The invention provides a two-step approach to providing a BCI system. In a first step the invention provides a low-power implantable platform for amplifying and filtering the extracellular recording, performing analogue to digital conversion (ADC) and detecting action potentials in real-time, which is connected to a remote device capable of performing the processor-intensive tasks of feature extraction and spike classification, thus generating a plurality of predetermined templates for each neuron to be used in a second processing step. In the second step the low-power implantable platform amplifies and filters the extracellular recording, performs ADC and detects action potentials, which can be matched on-chip to the predetermined templates generated by the external receiver in the first step. This two-step approach exploits the advantages of both offline and online processing, providing an effective and safe method for performing multiple recordings of single-neuron activity, for research or monitoring applications or for control of a remote device.
摘要翻译：本发明提供了一种提供BCI系统的两步法。在第一步中，本发明提供了一种用于放大和过滤细胞外记录，执行模数转换（ADC）和实时检测动作电位的低功率可植入平台，其连接到能够执行处理器的远程设备特征提取和尖峰分类的重点任务，从而为在第二处理步骤中使用的每个神经元生成多个预定模板。在第二步中，低功率可植入平台对细胞外记录进行放大和滤波，执行ADC并检测动作电位，该动作电位可以在片内匹配到第一步中由外部接收器生成的预定模板。这种两步法利用了离线和在线处理的优点，为进行单神经元活动的多个记录，研究或监控应用程序或远程设备的控制提供了有效和安全的方法。

2. 发明申请

WO2017199052A2 IMPLANTABLE NEURAL INTERFACE 审中-公开
标题翻译：可植入的神经接口
公开(公告)号：WO2017199052A2
公开(公告)日：2017-11-23
申请号：PCT/GB2017/051417
申请日：2017-05-19
申请人： IMPERIAL INNOVATIONS LIMITED , UNIVERSITY OF NEWCASTLE UPON TYNE
发明人： CONSTANDINOU, Timothy , JACKSON, Andrew
IPC分类号： A61N1/372
CPC分类号： A61N1/37229 , A61B5/04001 , A61B5/6868 , A61B2560/0219
摘要： A neural interface arrangement comprising: a plurality of probes for subdural implantation into or onto a human brain, each probe including at least one sensing electrode, a coil for receiving power via inductive coupling, signal processing circuitry coupled to the sensing electrode(s), and means for wirelessly transmitting data-carrying signals arising from the sensing electrode(s); an array of coils for implantation above the dura, beneath the skull, the array of coils being for inductively coupling with the coil of each of the plurality of probes, for transmitting power to the probes; and a primary (e.g. subcutaneous) coil connected to the array of coils, the primary coil being for inductively coupling with an external transmitter device, for receiving power from the external transmitter device; wherein, in use, the primary coil is operable to receive power from the external transmitter device by inductive coupling and to cause the array of coils to transmit power to the plurality of probes by inductive coupling; and wherein, in use, the plurality of probes are operable to wirelessly transmit data-carrying signals arising from the sensing electrodes.
摘要翻译：一种神经接口布置，包括：多个用于硬膜下植入人脑中或其上的探针，每个探针包括至少一个感测电极，用于经由感应耦合接收功率的线圈，耦合到所述人体大脑的信号处理电路，（一个或多个）感测电极和用于无线发射从感测电极产生的数据承载信号的装置; 用于植入硬膜上方的线圈阵列，位于颅骨下方，线圈阵列用于与多个探针中的每一个的线圈感应耦合，用于将功率传输至探针; 和连接到所述线圈阵列的主（例如皮下）线圈，所述主线圈用于与外部发射器装置感应耦合，用于从所述外部发射器装置接收功率; 其中，在使用中，所述初级线圈可操作以通过电感耦合从所述外部发射器装置接收电力，并使所述线圈阵列通过电感耦合将电力传输到所述多个探针; 并且其中在使用中，所述多个探针可操作以无线地发送从所述感测电极产生的携带数据的信号。

3. 发明申请

WO2017199052A3 IMPLANTABLE NEURAL INTERFACE 审中-公开
公开(公告)号：WO2017199052A3
公开(公告)日：2017-11-23
申请号：PCT/GB2017/051417
申请日：2017-05-19
申请人： IMPERIAL INNOVATIONS LIMITED , UNIVERSITY OF NEWCASTLE UPON TYNE
发明人： CONSTANDINOU, Timothy , JACKSON, Andrew
IPC分类号： A61N1/372 , A61B5/00 , A61B5/04
摘要： A neural interface arrangement comprising: a plurality of probes for subdural implantation into or onto a human brain, each probe including at least one sensing electrode, a coil for receiving power via inductive coupling, signal processing circuitry coupled to the sensing electrode(s), and means for wirelessly transmitting data-carrying signals arising from the sensing electrode(s); an array of coils for implantation above the dura, beneath the skull, the array of coils being for inductively coupling with the coil of each of the plurality of probes, for transmitting power to the probes; and a primary (e.g. subcutaneous) coil connected to the array of coils, the primary coil being for inductively coupling with an external transmitter device, for receiving power from the external transmitter device; wherein, in use, the primary coil is operable to receive power from the external transmitter device by inductive coupling and to cause the array of coils to transmit power to the plurality of probes by inductive coupling; and wherein, in use, the plurality of probes are operable to wirelessly transmit data-carrying signals arising from the sensing electrodes.

4. 发明申请

WO2010035036A2 ELECTRODE 审中-公开
标题翻译：电极
公开(公告)号：WO2010035036A2
公开(公告)日：2010-04-01
申请号：PCT/GB2009/051247
申请日：2009-09-24
申请人： UNIVERSITY OF NEWCASTLE UPON TYNE , BAKER, Stuart , BURDESS, James , HARRIS, Alun , JACKSON, Richard , JACKSON, Andrew
发明人： BAKER, Stuart , BURDESS, James , HARRIS, Alun , JACKSON, Richard , JACKSON, Andrew
IPC分类号： A61B5/04 , A61N1/05
CPC分类号： A61B5/04001 , A61B5/4041 , A61B10/0045 , A61B2562/187 , A61N1/0531 , A61N1/0539
摘要： An electrode (1) suitable for implantation in a body, for recording electrical signals from nervous tissues in the body and for electrically exciting nervous tissues in the body, is disclosed. The electrode (1) comprises a communication channel (11) for communicating signals to and /or from the body, and a support (3) for supporting the or each communication channel (11), such that the length of the communication channel (11) is greater than the distance between the its ends. The communication channel (11) may be flexible such that changes in the distance between the ends of the communication channel (11) can be accommodated. An anchor portion (9) anchors at least a portion of the electrode (11) to surrounding material when implanted in the body.
摘要翻译：公开了一种适合于植入体内的电极（1），用于记录来自身体中神经组织的电信号并用于电刺激身体中的神经组织。电极（1）包括用于向身体和/或从身体传递信号的通信信道（11）以及用于支撑该或每个通信信道（11）的支撑件（3），使得通信信道（11 ）大于其两端之间的距离。通信信道（11）可以是灵活的，使得可以适应通信信道（11）的端部之间的距离的变化。当植入体内时，锚定部分（9）将电极（11）的至少一部分锚定到周围的材料。

5. 发明申请

WO2018020002A1 OPTOGENETIC SYSTEM AND METHOD 审中-公开
标题翻译： OPTOGENETIC系统和方法
公开(公告)号：WO2018020002A1
公开(公告)日：2018-02-01
申请号：PCT/EP2017/069176
申请日：2017-07-28
申请人： UNIVERSITY OF NEWCASTLE UPON TYNE
发明人： JACKSON, Andrew , CUNNINGHAM, Mark , BAKER, Stuart , DEGENAAR, Patrick
IPC分类号： A61N5/06 , A61B5/00
摘要： An optogenetic system and method for preventing or halting seizures. The system and method use a sensor for monitoring the activity of a neural network containing a group of target neurons, and generating an input signal indicative of said activity, the target neurons being excitatory neurons. Excitatory stimulation is delivered in the form of an optical signal by an optical stimulator to the target neurons, the optical signal being determined based on the input signal, to reduce the overall activity of the target neurons.
摘要翻译：用于预防或停止癫痫发作的光遗传学系统和方法
该系统和方法使用传感器来监测包含一组目标神经元的神经网络的活动，并且生成指示所述活动的输入信号，目标神经元是兴奋性神经元。兴奋性刺激通过光学刺激器以光学信号的形式传递到目标神经元，该光学信号基于输入信号来确定，以减少目标神经元的整体活动。

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