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1. 发明申请

WO2008090196A1 METHOD FOR EVALUATING THE RESPONSE OF AN INDIVIDUAL TO A TREATMENT WITH A TYPE I INTERFERON (IFN) 审中-公开
标题翻译：用于评估个体对I型干扰素（IFN）的治疗反应的方法
公开(公告)号：WO2008090196A1
公开(公告)日：2008-07-31
申请号：PCT/EP2008/050807
申请日：2008-01-24
申请人： UNIVERSITE LIBRE DE BRUXELLES , STORDEUR, Patrick , VOKAER, Mathieu , OCMANT, Annick , GOLDMAN, Michel
发明人： STORDEUR, Patrick , VOKAER, Mathieu , OCMANT, Annick , GOLDMAN, Michel
IPC分类号： C12Q1/70
CPC分类号： C12Q1/707 , C12Q1/6883 , C12Q2600/106 , C12Q2600/158
摘要： The present invention relates to a method for evaluating the in vivopresence of a factor that prevents the biological effect of a type I (IFN) in an individual that is under treatment with said type I interferon. In particular, the present invention relates to a method for evaluating the in vivo presence of antibodies directed against a type I interferon (IFN) in an individual that is under treatment with said type I interferon. The method comprises incubating a blood sample of said individual in vitrowith a suitable amount of said type I interferon for a suitable period of time, and determining mRNA levels of a biological marker of IFN activity, preferably MxA, in said blood sample. The treatment mayinvolve a treatment of multiple sclerosis, HCV or HBV using a type I interferon.
摘要翻译：本发明涉及一种用于评估在所述I型干扰素治疗的个体中预防I型（IFN）的生物学作用的因素的活动性的方法。特别地，本发明涉及一种用于评估在用所述I型干扰素治疗的个体中针对I型干扰素（IFN）的体内存在的方法。该方法包括将玻璃体中所述个体的血液样品与合适量的所述I型干扰素孵育合适的时间，并测定所述血液样品中IFN活性生物学标志物，优选MxA的mRNA水平。该治疗可以使用I型干扰素治疗多发性硬化症，HCV或HBV。

2. 发明申请

WO2010108989A1 NEW MARKER FOR DIAGNOSIS OF ACTIVE MULTIPLE SCLEROSIS 审中-公开
标题翻译：用于诊断主动性多发性硬化症的新标记
公开(公告)号：WO2010108989A1
公开(公告)日：2010-09-30
申请号：PCT/EP2010/053944
申请日：2010-03-25
申请人： UNIVERSITÉ LIBRE DE BRUXELLES , STORDEUR, Patrick , VILLÉE, Françoise , VOKAER, Mathieu , OCMANT, Annick , GOLDMAN, Michel
发明人： STORDEUR, Patrick , VILLÉE, Françoise , VOKAER, Mathieu , OCMANT, Annick , GOLDMAN, Michel
IPC分类号： G01N33/50 , G01N33/564 , G01N33/68
CPC分类号： G01N33/6869 , G01N33/6896 , G01N2333/545 , G01N2800/285
摘要： The invention provides an improved method for monitoring the course of the MS disease and to predict, diagnose or prognosticate whether a subject is in an active or non-active period of MS. The method is based on determining the ratio of the expression levels of two cytokines, measured before and after stimulation of the subject by an immunomodulator.
摘要翻译：本发明提供了一种用于监测MS疾病进程并预测，诊断或预测受试者是否处于MS的活动期或非活动期的改进方法。该方法基于通过免疫调节剂测定受试者刺激之前和之后测量的两种细胞因子的表达水平的比例。

3. 发明申请

WO2011051402A1 NEW BIOMARKERS FOR DETERMINING ALLERGY STATUS 审中-公开
标题翻译：用于确定过敏状态的新生物标志物
公开(公告)号：WO2011051402A1
公开(公告)日：2011-05-05
申请号：PCT/EP2010/066398
申请日：2010-10-28
申请人： UNIVERSITE LIBRE DE BRUXELLES , HAMDI, Haïfa , STORDEUR, Patrick , OCMANT, Annick
发明人： HAMDI, Haïfa , STORDEUR, Patrick , OCMANT, Annick
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/158
摘要： The present invention provides new methods for diagnosing, predicting and/or prognosticating the allergic response of a subject to a certain allergen, based on the expression levels of 4 biomarkers identified in Basophils, after stimulation with a real allergen, and kits for carrying out said methods.
摘要翻译：本发明提供了用于基于在用真实过敏原刺激之后在嗜碱性粒细胞中鉴定的4种生物标志物的表达水平，以及用于实施所述抗原的试剂盒来诊断，预测和/或预测受试者对某些变应原的过敏反应的新方法方法。

4. 发明申请

WO2005005044A1 DEVICE, KIT AND METHOD FOR PULSING BIOLOGICAL SAMPLES WITH AN AGENT AND STABILISING THE SAMPLE SO PULSED 审中-公开
标题翻译：装置，套件和方法，用于使用药剂脉冲生物样品并稳定样品
公开(公告)号：WO2005005044A1
公开(公告)日：2005-01-20
申请号：PCT/EP2003/007453
申请日：2003-07-10
申请人： UNIVERSITE LIBRE DE BRUXELLES , STORDEUR, Patrick , GOLDMAN, Michel
发明人： STORDEUR, Patrick , GOLDMAN, Michel
IPC分类号： B01L3/00
CPC分类号： A61B5/411 , A61B5/15003 , A61B5/150221 , A61B5/150351 , A61B5/150755 , A61B5/413 , B01L3/502 , B01L3/5082 , B01L2200/16 , B01L2200/18 , B01L2300/042 , B01L2300/044 , B01L2300/048 , B01L2300/0672 , B01L2300/0832 , B01L2400/0478
摘要： The present invention is related to a device, kit and method for pulsing a biological sample with a pulsing agent and subsequently stabilizing the biological sample so pulsed. The invention has application in the fields of medical diagnostics, particularly relating to immunity. One embodiment of the present invention is a vessel suitable for accepting a liquid biological sample, exposing said sample to a first substance and subsequently a nucleic acid stabilising agent, said vessel comprising: a) a first substance present inside said vessel, b) a container in which said stabilising agent is present, c) a connection between the inside of said vessel and the inside of said container, d) a physical barrier that temporarily blocks said connection.
摘要翻译：本发明涉及用脉冲发生脉冲生物样品并随后稳定生物样品如此脉冲的装置，试剂盒和方法。本发明在医学诊断领域中的应用，特别是涉及免疫的领域。本发明的一个实施方案是适于接受液体生物样品的容器，将所述样品暴露于第一物质和随后的核酸稳定剂，所述容器包括：a）存在于所述容器内的第一物质，b）容器其中存在所述稳定剂，c）所述容器的内部和所述容器的内部之间的连接，d）暂时阻止所述连接的物理屏障。

5. 发明申请

WO2003060119A2 METHOD TO DETERMINE IN VIVO NUCLEIC ACID LEVELS 审中-公开
标题翻译：用于确定体内核酸水平的方法
公开(公告)号：WO2003060119A2
公开(公告)日：2003-07-24
申请号：PCT/EP2003/000493
申请日：2003-01-20
申请人： UNIVERSITE LIBRE DE BRUXELLES , STORDEUR, Patrick , GOLDMAN, Michel
发明人： STORDEUR, Patrick , GOLDMAN, Michel
IPC分类号： C12N15/10
CPC分类号： C12N15/1003 , C12Q1/6806
摘要： The invention in particular relates to a method for the quantification of in vivo RNA from a biological sample comprising the steps of: collecting said biological sample in a tube comprising a compound inhibiting RNA degradation and/or gene induction; forming a precipate comprising nucleic acids; separating said precipate from the supernatant; dissolving said precipitate using a buffer, forming a suspension; isolating nucleic acids from said suspension using an automated device; dispersing/distributing a reagent mix for RT-PCR using an automated device; dispersing/distributing the isolated nucleic acids within the dispersed reagent mix using an automated device, and determining the in vivo levels of transcripts using the nucleic acid/RT-PCR reagent mix in an automated setup. The present invention also relates to the quantitatification of DNA from a biological sample. The present invention further elucidates a kit for isolating quantifiable nucleic acids from a biological sample. Applications of the method according to present invention are aldo disclosed.
摘要翻译：本发明特别涉及一种用于从生物样品中定量体内RNA的方法，包括以下步骤：在包含抑制RNA降解和/或基因诱导的化合物的管中收集所述生物样品; 形成包含核酸的沉淀物; 将上述沉淀物与上清液分离; 用缓冲液溶解所述沉淀物，形成悬浮液; 使用自动化装置从所述悬浮液中分离核酸; 使用自动化装置分散/分配用于RT-PCR的试剂混合物; 使用自动化装置将分离的核酸分散/分散在分散的试剂混合物中，并且在自动设置中使用核酸/ RT-PCR试剂混合物确定转录物的体内水平。本发明还涉及来自生物样品的DNA的定量化。本发明进一步阐明了用于从生物样品中分离可量化核酸的试剂盒。根据本发明的方法的应用是公开的。

6. 发明申请

WO2010043271A1 DEVICE, KIT AND METHOD FOR PULSING BIOLOGICAL SAMPLES WITH AN AGENT AND STABILISING THE SAMPLE SO PULSED 审中-公开
标题翻译：装置，套件和方法，用于使用药剂脉冲生物样品并稳定样品
公开(公告)号：WO2010043271A1
公开(公告)日：2010-04-22
申请号：PCT/EP2008/064030
申请日：2008-10-17
申请人： UNIVERSITE LIBRE DE BRUXELLES , STORDEUR, Patrick , GOLDMAN, Michel , TUIJNDER, Marius
发明人： STORDEUR, Patrick , GOLDMAN, Michel , TUIJNDER, Marius
IPC分类号： B01L3/00 , B01L3/14 , C12N15/10
CPC分类号： B01L3/5082 , B01L3/563 , B01L2200/026 , B01L2300/042 , B01L2300/044 , B01L2300/047 , B01L2300/048 , B01L2300/0858 , B01L2400/0478 , B01L2400/0481 , B01L2400/0487
摘要： The present invention is related to a device and kitfor pulsing a biological sample with a pulsing agent, subsequently stabilizing the biological sample so pulsed, which device or kit provides a control reaction. The invention has application in the fields of medical diagnostics, particularly relating to immunity.
摘要翻译：本发明涉及用于用脉动剂脉冲生物样品的装置和试剂盒，随后稳定生物样品如此脉冲，该装置或试剂盒提供控制反应。本发明在医学诊断领域中的应用，特别是涉及免疫的领域。

7. 发明申请

WO2003060119A3 METHOD FOR THE QUANTIFICATION OF IN VIVO NUCLEIC ACID LEVELS 审中-公开
公开(公告)号：WO2003060119A3
公开(公告)日：2003-07-24
申请号：PCT/EP2003/000493
申请日：2003-01-20
申请人： UNIVERSITE LIBRE DE BRUXELLES , STORDEUR, Patrick , GOLDMAN, Michel
发明人： STORDEUR, Patrick , GOLDMAN, Michel
IPC分类号： C12N15/10
摘要： The invention in particular relates to a method for the quantification of in vivo RNA from a biological sample comprising the steps of: collecting said biological sample in a tube comprising a compound inhibiting RNA degradation and/or gene induction; forming a precipate comprising nucleic acids; separating said precipate from the supernatant; dissolving said precipitate using a buffer, forming a suspension; isolating nucleic acids from said suspension using an automated device; dispersing/distributing a reagent mix for RT-PCR using an automated device; dispersing/distributing the isolated nucleic acids within the dispersed reagent mix using an automated device, and determining the in vivo levels of transcripts using the nucleic acid/RT-PCR reagent mix in an automated setup. The present invention also relates to the quantitatification of DNA from a biological sample. The present invention further elucidates a kit for isolating quantifiable nucleic acids from a biological sample. Applications of the method according to present invention are aldo disclosed.

8. 发明申请

WO2007060647A2 A METHOD FOR DETECTING SEPSIS 审中-公开
标题翻译：一种检测SEPSIS的方法
公开(公告)号：WO2007060647A2
公开(公告)日：2007-05-31
申请号：PCT/IE2006/000133
申请日：2006-11-27
申请人： THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH, NEAR DUBLIN , RYAN, Thomas , KELLEHER, Dermot , MCMANUS, Owen, Ross , O'DWYER, Michael , STORDEUR, Patrick
发明人： RYAN, Thomas , KELLEHER, Dermot , MCMANUS, Owen, Ross , O'DWYER, Michael , STORDEUR, Patrick
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158
摘要： The present invention relates to a method for identifying patients who are likely to develop sepsis in response to infection, a method for monitoring the progress of sepsis in a patient and to an assay kit for identifying patients who are likely to develop sepsis and/or monitoring the progress of sepsis.
摘要翻译：本发明涉及一种用于鉴定可能发展为感染的败血症的患者的方法，用于监测患者败血症进展的方法以及用于鉴定可能发展为败血症和/或监测的患者的测定试剂盒败血症的进展。

9. 发明申请

WO2010064223A3 CYTOKINES AS PROGNOSTIC MARKERS OF RESPIRATORY-TRACT INFECTION FOLLOWING MAJOR SURGERY 审中-公开
公开(公告)号：WO2010064223A3
公开(公告)日：2010-06-10
申请号：PCT/IE2009/000085
申请日：2009-11-30
申请人： THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN , RYAN, Thomas , WHITE, Mary , McMANUS, Owen Ross , KELLEHER , Dermot , STORDEUR, Patrick , YOUNG, Vincent
发明人： RYAN, Thomas , WHITE, Mary , McMANUS, Owen Ross , KELLEHER , Dermot , STORDEUR, Patrick , YOUNG, Vincent
IPC分类号： C12Q1/68
摘要： The invention relates to the use of a certain subset of cytokine markers as prognostic variables of infection status in an individual, and especially as prognostic markers of a patients developing severe infection such as pneumonia, and respiratory tract infection following surgery. The subset of cytokine markers consists of the interleukin cytokines IL-2, IL-7, IL-23, IL-27, and IL-IO, and Interferon-γ (INFγ) and Tissue Necrosis Factor-α (TNFα). The markers may be employed as individual prognostic variables of infection status, or they may be used in pairs or other combinations. Generally, the abundance of the markers is correlated with infection status by means of an absolute pre-operative value of biomarker abundance, ratio's of pre-operative to post-operative biomarker abundance, or ratio values for pairs of certain biomarkers within the subset. Typically, cytokine abundance is expressed in terms of mRNA copy number wherein the copy numbers are ideally normalised to a house keeping gene and quantification of mRNA copy number is determined by RT-PCR containing reference serial dilutions of cytokine specific cDNA.

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