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1. 发明申请

WO2008153945A3 NUTRACEUTICAL CO-CRYSTAL COMPOSITIONS 审中-公开
标题翻译：营养组合物
公开(公告)号：WO2008153945A3
公开(公告)日：2009-02-12
申请号：PCT/US2008007129
申请日：2008-06-06
申请人： UNIV SOUTH FLORIDA , ZAWOROTKO MICHAEL , CLARKE HEATHER , KAPILDEV ARORA , KAVURU PADMINI , SHYTLE ROLAND DOUGLAS , PUJARI TWARITA , MARSHALL LISSETTE , ONG TIEN TENG
发明人： ZAWOROTKO MICHAEL , CLARKE HEATHER , KAPILDEV ARORA , KAVURU PADMINI , SHYTLE ROLAND DOUGLAS , PUJARI TWARITA , MARSHALL LISSETTE , ONG TIEN TENG
IPC分类号： A61K9/14 , A23L1/09 , A61K31/205 , A61K31/551 , C07C233/00 , C07D223/18 , C07K14/18
CPC分类号： A61K31/55 , A23L33/10 , A61K31/197 , A61K31/20 , A61K31/375 , A61K31/455 , A61K31/522 , C07D401/14
摘要： Co-crystals comprising at least one nutraceutical compound and at least one co-crystal former with or without impurities. These co-crystals may be included in compositions (optionally also including other components such as pharmaceutically acceptable excipients, other nutritional supplements, etc.) having utility as pharmaceuticals, nutraceuticals, nutritional supplements, and foodstuffs.
摘要翻译：包含至少一种营养药物化合物和至少一种具有或不含杂质的共晶体形成体的共晶体。这些共晶体可以包含在作为药物，营养药物，营养补充剂和食品的作用的组合物（任选地还包括其它成分，例如药学上可接受的赋形剂，其它营养补充剂等）中。

2. 发明申请

WO2008109521A3 METHOD OF TREATMENT USING ATRANORIN 审中-公开
标题翻译：使用ATRANORIN治疗方法
公开(公告)号：WO2008109521A3
公开(公告)日：2008-12-24
申请号：PCT/US2008055655
申请日：2008-03-03
申请人： UNIV SOUTH FLORIDA , TAN JUN , SHYTLE ROLAND DOUGLAS , OBREGON DEMIAN
发明人： TAN JUN , SHYTLE ROLAND DOUGLAS , OBREGON DEMIAN
IPC分类号： C11B9/02
CPC分类号： A61K31/353 , A61K31/7048 , A61K36/09 , A61K2300/00
摘要： Disclosed herein is a method of treating a neurodegenerative disease, comprising the step of administering a therapeutically effective amount of Atranorin, or a closely related compound thereof. The neurodegenerative disease is Alzheimer's disease in one embodiment. The closely related compound is selected from the group consisting of chloroatranorin, evernic acid, barbatic acid, 4-O-demethyl-barbatic acid, lecanoric acid, diffratic acid and gyrophoric acid. Also disclosed is a method of treating a cellular proliferative disease, comprising the step of administering a therapeutically effective amount of Atranorin, or a closely related compound thereof. The cellular proliferative disease is cancer in one embodiment. The method of claim 1 wherein the closely related compound is selected from the group consisting of chloroatranorin, evernic acid, barbatic acid, 4-O-demethyl-barbatic acid, lecanoric acid, diffratic acid and gyrophoric acid
摘要翻译：本文公开了一种治疗神经退行性疾病的方法，其包括施用治疗有效量的阿特兰林或其紧密相关化合物的步骤。在一个实施方案中，神经变性疾病是阿尔茨海默氏病。密切相关的化合物选自氯丙酰胺，海藻酸，巴氏酸，4-O-去甲基 - 酸性酸，氨磺酸，异柠檬酸和旋花酸。还公开了一种治疗细胞增殖性疾病的方法，其包括施用治疗有效量的阿特兰林或其紧密相关的化合物的步骤。在一个实施方案中，细胞增殖性疾病是癌症。 2.根据权利要求1所述的方法，其中所述紧密相关的化合物选自氯化氨基葡萄糖苷，海藻酸，巴氏酸，4-O-去甲基 - 酸性酸，左旋肉碱酸，异柠檬酸和富马酸

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