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1. 发明申请

WO02078614A3 LPS-RESPONSIVE CHS1/BEIGE-LIKE ANCHOR GENE AND THERAPEUTIC APPLICATIONS THEREOF 审中-公开
标题翻译： LPS-RESPONSIVE CHS1 / BEIGE-like锚定基因及其治疗应用
公开(公告)号：WO02078614A3
公开(公告)日：2003-03-20
申请号：PCT/US0210350
申请日：2002-04-02
申请人： UNIV SOUTH FLORIDA , KERR WILLIAM G , WANG JIA-WANG
发明人： KERR WILLIAM G , WANG JIA-WANG
IPC分类号： A61P35/00 , C07K14/47 , C12N15/12 , C12Q1/68 , A01N43/04 , A61K31/07 , C07H21/04
CPC分类号： C07K14/47
摘要： The present invention relates to a novel LPS-responsive and Beige-like Anchor gene (lrba), variants of the lrba gene, fragments of the lrba gene, and polypeptides encoded thereby. The subject invention also pertains to lrba interfering RNA, and uses thereof. In another aspect, the present invention also includes methods of inhibiting tumor growth in a patient by suppressing lrba function.
摘要翻译：本发明涉及一种新的LPS-响应和米色样锚定基因（lrba），lrba基因的变体，lrba基因的片段，以及由此编码的多肽。本发明还涉及lrba干扰RNA及其用途。另一方面，本发明还包括通过抑制lba蛋白功能来抑制患者肿瘤生长的方法。

2. 发明申请

WO2009042910A2 SHIP INHIBITION TO DIRECT HEMATOPOIETIC STEM CELLS AND INDUCE EXTRAMEDULLARY HEMATOPOIESIS 审中-公开
标题翻译：直接导致HEMATOPOIETIC干细胞的SHIP抑制和诱导异常HEMATOPOIESISIS
公开(公告)号：WO2009042910A2
公开(公告)日：2009-04-02
申请号：PCT/US2008077940
申请日：2008-09-26
申请人： UNIV SOUTH FLORIDA , KERR WILLIAM G , HAZEN AMY
发明人： KERR WILLIAM G , HAZEN AMY
IPC分类号： A61K48/00 , C07H21/04 , C07K14/47 , C12N15/113
CPC分类号： C12N15/1137 , A61K38/1816 , A61K38/193 , C12N2310/14 , A61K2300/00
摘要： The present invention concerns inhibition of SHIP expression and/or function in mammalian subjects to direct HSC from the bone marrow to other sites in the body (such as the spleen and/or liver), where they then re-establish blood cell production. The method of the invention can be employed, for example, to rescue or enhance blood cell recovery during bone marrow impairment due to bone-seeking radioisotope exposure, chemotherapy, radiotherapy, infection, or genetic or congenital defects. Preferably, inhibition of SHIP expression and/or function is achieved by administering an effective amount of one or more SHIP inhibitors to the subject. In one embodiment, the subject is suffering from, or at risk of developing, bone marrow failure (such as an aplastic bone marrow failure syndrome). In another embodiment, the subject is suffering from, or at risk of, exposure to a bone-seeking radioisotope. In another embodiment, the subject is suffering from, or at risk of developing, flbrotic or damaged bone marrow due to chemotherapy and/or radiation therapy for cancer.
摘要翻译：本发明涉及对哺乳动物受试者中SHIP表达和/或功能的抑制以将HSC从骨髓引导至体内其他部位（例如脾脏和/或肝脏），然后再重新建立血细胞生产。本发明的方法可用于例如由于寻骨放射性同位素暴露，化学疗法，放射治疗，感染或遗传或先天性缺陷引起的骨髓损伤期间的拯救或增强血细胞恢复。优选地，通过向受试者施用有效量的一种或多种SHIP抑制剂来实现SHIP表达和/或功能的抑制。在一个实施方案中，受试者患有或有发生骨髓衰竭的风险（例如再发性骨髓衰竭综合征）。在另一个实施方案中，受试者遭受暴露于寻骨放射性同位素的风险或处于暴露于骨吸收放射性同位素的风险中。在另一个实施方案中，由于癌症的化学疗法和/或放射治疗，受试者患有或有风险发展为炎症或受损的骨髓。

3. 发明申请

WO2010045199A3 METHOD OF MODULATING SHIP ACTIVITY 审中-公开
标题翻译：调节船舶活动的方法
公开(公告)号：WO2010045199A3
公开(公告)日：2010-08-12
申请号：PCT/US2009060457
申请日：2009-10-13
申请人： UNIV SOUTH FLORIDA , KERR WILLIAM G
发明人： KERR WILLIAM G
IPC分类号： A61K31/575 , A61K48/00 , A61P3/04 , A61P35/00 , A61P37/00 , C12N15/12
CPC分类号： A61K31/575
摘要： A method of treating or preventing an immune disorder, such as graft versus host disease, in a subject. The method includes the administering a SHIP1 inhibitor, such as 3a-aminocholestane, to a subject in need of treatment. Thus, SHIP1 inhibitors taught herein represent a novel class of small molecules that have the potential to enhance allogeneic transplantation, boost innate immunity and improve the treatment of hematologic malignancies.
摘要翻译：在受试者中治疗或预防免疫病症如移植物抗宿主病的方法。该方法包括向需要治疗的受试者施用SHIP1抑制剂，例如3α-氨基胆甾烷。因此，本文教导的SHIP1抑制剂代表一类新型小分子，其具有增强异基因移植，增强先天免疫力和改善血液恶性肿瘤治疗的潜力。

4. 发明申请

WO0224233A3 CONTROL OF NK CELL FUNCTION AND SURVIVAL BY MODULATION OF SHIP ACTIVITY 审中-公开
标题翻译： NK细胞功能的控制和通过调节船舶活动生存
公开(公告)号：WO0224233A3
公开(公告)日：2003-03-13
申请号：PCT/US0129158
申请日：2001-09-19
申请人： UNIV SOUTH FLORIDA , KERR WILLIAM G
发明人： KERR WILLIAM G
IPC分类号： A61K38/00 , A61K38/11 , A61K48/00 , A61P37/06 , C12N9/14 , C12N15/85 , A01K67/027 , A61K31/7088 , A61K38/17 , G01N33/50
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/025 , A01K2267/0325 , A61K38/00 , A61K48/00 , C12N9/14 , C12N15/8509 , C12N2800/30 , G01N2333/916
摘要： Suppression of hematopoietic-specific SH2-containing inositol polyphosphatase (SHIP) activity by genetic and pharmaceutical means is taught for suppression of rejection of, and prevention of graft-versus-host disease in, solid organ allografts or xenotransplants, and histo-incompatible marrow grafts. Also disclosed are methods for the screening of substances and genetic constructs that inhibit SHIP function in mammalian cells, and cell lines and transgenic animals that have the SHIP phenotype.
摘要翻译：教导了通过遗传和药物手段抑制造血特异性SH2的肌醇多磷酸酶（SHIP）活性，以抑制实体器官同种异体移植物或异种移植物中的移植物抗宿主病，以及组织不相容的骨髓移植物。还公开了用于筛选抑制哺乳动物细胞中的SHIP功能的物质和遗传构建体的方法，以及具有SHIP 表型的细胞系和转基因动物。

5. 发明申请

WO2011127465A3 SHIP INHIBITORS AND USES THEREOF 审中-公开
标题翻译：船舶抑制剂及其用途
公开(公告)号：WO2011127465A3
公开(公告)日：2012-03-15
申请号：PCT/US2011031930
申请日：2011-04-11
申请人： UNIV NEW YORK STATE RES FOUND , SYRACUSE UNIVERSITY TECHNOLOGY TRANSFER AND IND DEV OFFICE , KERR WILLIAM G , CHISHOLM JOHN D
发明人： KERR WILLIAM G , CHISHOLM JOHN D
IPC分类号： C07C401/00 , A61K31/56 , A61K31/565 , A61K31/575 , A61P35/00
CPC分类号： C07J41/0005 , A61K31/56 , A61K31/565 , A61K31/575 , C07J1/0007 , C07J1/0011 , C07J9/00 , C07J31/003 , C07J31/006 , C07J41/0011 , C07J41/0027 , C07J41/005 , C07J41/0055
摘要： The present invention relates to SHIP inhibitor compounds and methods for using these compounds. In particular, the present invention discloses the following methods: (i) a method of treating graft versus host disease in a subject; (ii) a method of inhibiting a SHIP1 protein in a cell; (iii) a method of selectively inhibiting a SHIP1 protein in a cell; (iv) a method for treating or preventing graft-versus-host disease (GVHD) in a recipient of an organ or tissue transplant; (v) a method of modulating SHIP activity in a cell expressing SHIP1 or SHIP2; (vi) a method of ex vivo or in vitro treatment of transplants; (vii) a method of inhibiting tumor growth and metastasis in a subject; (viii) a method of treating a hematologic malignancy in a subject; (ix) a method of inducing apoptosis of multiple myeloma cells; (x) a method of treating multiple myeloma in a subject; (xi) a method of inhibiting the proliferation of a human breast cancer cell; and (xii) a method of treating breast cancer in a subject.
摘要翻译：本发明涉及SHIP抑制剂化合物和使用这些化合物的方法。特别地，本发明公开了以下方法：（i）在受试者中治疗移植物抗宿主病的方法; （ii）抑制细胞中SHIP1蛋白的方法; （iii）选择性抑制细胞中SHIP1蛋白的方法; （iv）在器官或组织移植受者中治疗或预防移植物抗宿主病（GVHD）的方法; （v）调节表达SHIP1或SHIP2的细胞中SHIP活性的方法; （vi）移植物的离体或体外治疗方法; （vii）抑制受试者的肿瘤生长和转移的方法; （viii）治疗受试者血液恶性肿瘤的方法; （ix）诱导多发性骨髓瘤细胞凋亡的方法; （x）治疗受试者中多发性骨髓瘤的方法; （i）抑制人乳腺癌细胞增殖的方法; 和（xii）治疗受试者乳腺癌的方法。

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