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1. 发明申请

WO9964581A9 ELECTROFUSION CHAMBER 审中-公开
标题翻译：电磁室
公开(公告)号：WO9964581A9
公开(公告)日：2000-03-09
申请号：PCT/US9912872
申请日：1999-06-08
申请人： UNIV SOUTH FLORIDA , JAROSZESKI MARK J , GILBERT RICHARD A , HELLER RICHARD
发明人： JAROSZESKI MARK J , GILBERT RICHARD A , HELLER RICHARD
IPC分类号： C12M3/00 , C12N13/00 , C12N15/02 , C12M1/42
CPC分类号： C12N13/00 , C12M35/02
摘要： An apparatus is provided for producing cell electrofusion (20) wherein the cells to be fused are directed to and retained on one side of a substrate (34) and between the electrodes (30, 32). Thus, a significant portion of the cells are in close cell-to-cell contact so that dielectrophoresis is not needed before electrofusion. In a preferred embodiment, the substrate is porous (34) and the cells are held onto the porous substrate by means of a vacuum (38).
摘要翻译：提供了一种用于生产细胞电熔体（20）的装置，其中要熔化的细胞被引导并保持在基底（34）的一侧上并在电极（30,32）之间。因此，大部分细胞处于紧密的细胞间细胞接触，因此在电融合之前不需要介导电泳。在优选的实施方案中，基底是多孔的（34），并且通过真空将细胞保持在多孔基底上（38）。

2. 发明申请

WO2005123183A3 ELECTROPORATION DEVICE AND METHOD FOR DELIVERY TO OCULAR TISSUE 审中-公开
标题翻译：电动装置和用于输送至组织的方法
公开(公告)号：WO2005123183A3
公开(公告)日：2006-06-08
申请号：PCT/US2005020677
申请日：2005-06-13
申请人： UNIV SOUTH FLORIDA , HELLER RICHARD , JAROSZESKI MARK J , GILBERT RICHARD A , HAUSWIRTH WILLIAM H
发明人： HELLER RICHARD , JAROSZESKI MARK J , GILBERT RICHARD A , HAUSWIRTH WILLIAM H
IPC分类号： A61N1/30 , A61N1/05 , A61N1/32
CPC分类号： A61N1/0543 , A61N1/0412 , A61N1/0476 , A61N1/327
摘要： In accordance with the present invention is provided a device and method for delivering DNA for the purpose of gene therapy to specific regions within and around the eye.
摘要翻译：根据本发明提供了用于将基因治疗目的的DNA递送到眼睛内和眼睛周围的特定区域的装置和方法。

3. 发明申请

WO2005010161A3 DEVICE AND METHOD TO FACILITATE DIRECTED DELIVERY AND ELECTROPORATION 审中-公开
标题翻译：用于促进方向交付和电气化的装置和方法
公开(公告)号：WO2005010161A3
公开(公告)日：2007-02-08
申请号：PCT/US2004023052
申请日：2004-07-16
申请人： UNIV SOUTH FLORIDA , GILBERT RICHARD , JAROSZESKI MARK J , HELLER RICHARD
发明人： GILBERT RICHARD , JAROSZESKI MARK J , HELLER RICHARD
IPC分类号： C12M1/42 , A61N1/32 , C12M3/00 , C12N20060101 , C12N13/00 , C12N15/87
CPC分类号： A61N1/327 , A61N1/0416 , A61N1/0424 , A61N1/325 , C12M35/02 , C12N15/87
摘要： The present invention provides an apparatus and method that will accomplish molecular delivery and subsequent electroporation with a single apparatus without the need for separate molecule injection and placement of the electroporation applicators.
摘要翻译：本发明提供了一种将通过单个装置完成分子递送和随后的电穿孔而不需要单独的分子注入和放置电穿孔施用器的装置和方法。

4. 发明申请

WO02072781A3 ELECTROMANIPULATION DEVICE AND METHOD 审中-公开
标题翻译：电调装置和方法
公开(公告)号：WO02072781A3
公开(公告)日：2002-11-28
申请号：PCT/US0207637
申请日：2002-03-13
申请人： UNIV SOUTH FLORIDA , HOFF ANDREW , GILBERT RICHARD , JAROSZESKI MARK J , HELLER RICHARD
发明人： HOFF ANDREW , GILBERT RICHARD , JAROSZESKI MARK J , HELLER RICHARD
IPC分类号： A61N1/30 , A61N1/32 , C12N15/87
CPC分类号： A61N1/30 , A61N1/0424 , A61N1/325 , C12N15/87
摘要： The present invention is a device (10) for electromanipulation of chemical species in vivo relative to a target tissue (T) including a non-conductive, conformable array base (12) adapted to be placed coincident to the target tissue (T), a plurality of electrode elements (14,15) projecting from the array base towards the target tissue, the electrode elements (14,15) addressable individually, an electrical source (S) coupled to the plurality of electrodes (14,15), a control means (16) interposed between the electrical source (S) and the plurality of electrode elements (14,15) and in circuit communication therein, the control means (16) adapted to establish an electrical potential between at least two electrodes, and a delivery means (17) adapted to introduce chemical species to the target tissue (T).
摘要翻译：本发明是一种用于相对于目标组织（T）体内化学物质的电动操纵的装置（10），其包括适于放置成与目标组织（T）重合的不导电的适形阵列基座（12），从阵列基座向目标组织突出的多个电极元件（14,15），可单独寻址的电极元件（14,15），耦合到多个电极（14,15）的电源（S），控制器被置于电源（S）和多个电极元件（14,15）之间并且在其中进行电路通信的装置（16），控制装置（16）适于在至少两个电极之间建立电势，适于将化学物质引入目标组织（T）的装置（17）。

5. 发明申请

WO2007047951A2 MOLECULAR DELIVERY TO CELLS USING ASPIRIN-RELATED COMPOUNDS 审中-公开
标题翻译：使用与ASPIRIN相关的化合物分子细胞递送
公开(公告)号：WO2007047951A2
公开(公告)日：2007-04-26
申请号：PCT/US2006041085
申请日：2006-10-20
申请人： UNIV SOUTH FLORIDA , JAROSZESKI MARK J , LANGHAM JENNIFER , HELLER RICHARD , GILBERT RICHARD
发明人： JAROSZESKI MARK J , LANGHAM JENNIFER , HELLER RICHARD , GILBERT RICHARD
IPC分类号： C12N15/87
CPC分类号： C12N15/87 , A61K9/0009 , A61K47/12
摘要： The present invention provides for a system and method whereby aspirin and acetic acid help to permeabilize cell membranes to allow exogenous molecules to gain access to the cell interior. As such, the present invention provides a low cost drug and gene delivery tool that can be applied in combination with other molecular delivery methods.
摘要翻译：本发明提供了一种系统和方法，其中阿司匹林和乙酸有助于使细胞膜透化以允许外源性分子进入细胞内部。因此，本发明提供了可以与其他分子递送方法组合应用的低成本药物和基因递送工具。

6. 发明申请

WO2007021938A3 METHOD OF ENHANCING THERAPEUTIC EFFECT OF NUCLEIC ACIDS 审中-公开
标题翻译：增强核酸治疗效果的方法
公开(公告)号：WO2007021938A3
公开(公告)日：2008-01-17
申请号：PCT/US2006031385
申请日：2006-08-11
申请人： UNIV SOUTH FLORIDA , HELLER LOREE , GILBERT RICHARD , JAROSZESKI MARK J , HELLER RICHARD
发明人： HELLER LOREE , GILBERT RICHARD , JAROSZESKI MARK J , HELLER RICHARD
IPC分类号： A61K31/70 , A61N1/10
CPC分类号： A61K48/0083 , A61K41/00 , A61K48/00 , A61N1/0412 , A61N1/042 , A61N1/327
摘要： The present invention is a method of eliciting an antitumor effect in vivo comprising the steps of identifying a species representative of a treatment subject, identifying at least one non-coding nusleic acid sequence, introducing the at least one nucleic acid to at least one tumor in the treatment subject and applying an energy source to the at least one tumor. The energy source may comprise, but is not limited to, electrical, sonic, photonic, and microwave output.
摘要翻译：本发明是在体内引发抗肿瘤作用的方法，其包括以下步骤：鉴定治疗受试者的代表物种，鉴定至少一种非编码的胡萝卜酸序列，将至少一种核酸引入至少一种肿瘤所述治疗对象并向所述至少一个肿瘤施加能量源。能量源可以包括但不限于电子，声波，光子和微波输出。

7. 发明申请

WO2007117651A2 PASSIVE ELECTRIC FIELD FOCUS SYSTEM FOR IN VIVO AND IN VITRO APPLICATIONS 审中-公开
标题翻译：用于体内和体外应用的被动电场聚焦系统
公开(公告)号：WO2007117651A2
公开(公告)日：2007-10-18
申请号：PCT/US2007008662
申请日：2007-04-09
申请人： UNIV SOUTH FLORIDA , REY JOSE I , GILBERT RICHARD , JAROSZESKI MARK J , HELLER RICHARD
发明人： REY JOSE I , GILBERT RICHARD , JAROSZESKI MARK J , HELLER RICHARD
IPC分类号： C12M3/00
CPC分类号： A61N1/327 , A61N1/325 , C12M35/02
摘要： The present invention provides a system and method of directing, focusing, or concentrating electrical charges within a defined electric field so that these charges can be used to exert forces on cells and tissues in vivo and/or cell cultures in vitro. The present invention reduces and/or eliminates the damage at a target site that would normally be caused by an electrode that acts as a current source or sink to accomplish the same task.
摘要翻译：本发明提供了在限定的电场内引导，聚焦或集中电荷的系统和方法，使得这些电荷可以用于在体外对体内和/或细胞培养物上的细胞和组织施加力。本发明减少和/或消除了通常由用作电流源或吸收器来完成相同任务的电极引起的目标位置处的损伤。

8. 发明申请

WO2005123182A3 NERVOUS TISSUE ELECTRODE DEVICE 审中-公开
标题翻译：神经组织电极装置
公开(公告)号：WO2005123182A3
公开(公告)日：2007-04-19
申请号：PCT/US2005020670
申请日：2005-06-13
申请人： UNIV SOUTH FLORIDA , SANCHEZ-RAMOS JUAN , HELLER RICHARD , JAROSZESKI MARK J
发明人： SANCHEZ-RAMOS JUAN , HELLER RICHARD , JAROSZESKI MARK J
IPC分类号： A61N1/30 , A61N1/32
CPC分类号： A61N1/0534 , A61N1/0539 , A61N1/0551 , A61N1/327
摘要： In accordance with the present invention, a novel tri-pronged device that produces minimal damage to deep brain or spinal cord regions. The apparatus and associated method of the present invention provides for a single insertion of a novel probe effective for delivery of DNA and delivery of therapeutic electroporating current , thereby minimizing the potential damage to the nervous system The tri-pronged device is a combination of two electrode needles 20, which are spaced apart, and an injection needle 25, which is situated in between thereof.
摘要翻译：根据本发明，一种对深脑或脊髓区域产生最小伤害的新型三管齐射装置。本发明的装置和相关方法提供了一种有效用于递送DNA和传递治疗性电穿孔电流的新型探针的单次插入，从而最小化对神经系统的潜在损伤。三管装置是两个电极间隔开的针20和位于其间的注射针25。

9. 发明申请

WO2004013296A3 CELLULAR ELECTROMANIPULATION WAVEFORMS 审中-公开
标题翻译：细胞电磁波
公开(公告)号：WO2004013296A3
公开(公告)日：2004-05-27
申请号：PCT/US0324231
申请日：2003-08-01
申请人： UNIV SOUTH FLORIDA
发明人： HELLER RICHARD , GILBERT RICHARD , JAROSZESKI MARK J
IPC分类号： A61N1/32 , C12N15/87 , A61N1/18
CPC分类号： A61N1/325 , C12N15/87
摘要： The present invention is a method of electromanipulation for effecting substantially simultaneous electroporation and electromigration of molecules into cells by applying to a cellular target a preselected electrical waveform. The preselected electrical waveform may be formed of at least one curved or linear component either increasing or decreasing in amplitude as a function of time. In a preferred embodiment of the invention the at least one component has a duration no greater than five minutes and a maximum amplitude no greater than 10,000 V/cm. Alternatively, the waveform may also include a substantially constant amplitude component interposed between the increasing and decreasing components. The substantially constant amplitude component may also be applied prior or subsequent to the at least one component.
摘要翻译：本发明是一种电子操作的方法，通过将预先选择的电波形施加到细胞靶上，实现基本同时的电穿孔和电迁移到细胞中。预选的电波形可以由至少一个作为时间的函数的振幅增加或减小的弯曲或线性分量形成。在本发明的优选实施方案中，至少一种组分具有不大于5分钟的持续时间和不大于10,000V / cm的最大振幅。或者，波形还可以包括介于增减部件之间的基本恒定的振幅分量。基本恒定幅度分量也可以在至少一个分量之前或之后施加。

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