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1. 发明申请

WO2009006496A1 SYSTEM FOR AUTO-CONNECTING FLUID BAG TUBINGS TO A DISPOSABLE PUMP CASSETTE 审中-公开
标题翻译：将流体袋管自动连接到可拆卸泵套筒的系统
公开(公告)号：WO2009006496A1
公开(公告)日：2009-01-08
申请号：PCT/US2008/068959
申请日：2008-07-02
申请人： BAXTER INTERNATIONAL INC. , BAXTER HEALTHCARE S.A. , LEE, Patrick , BIEWER, John , CHILDERS, Robert , FOOHEY, Mark W. , GILBERT, Richard , KOPYCHEV, Andrey , MURPHEY, Randy , ORAND, Austin , REITZ, Douglas , ROGER, Roger , STECK, John
发明人： LEE, Patrick , BIEWER, John , CHILDERS, Robert , FOOHEY, Mark W. , GILBERT, Richard , KOPYCHEV, Andrey , MURPHEY, Randy , ORAND, Austin , REITZ, Douglas , ROGER, Roger , STECK, John
IPC分类号： A61M39/18 , A61M1/14 , A61M1/28
CPC分类号： A61M5/162 , A61M1/28 , A61M1/284 , A61M5/16813 , A61M39/18 , A61M2205/12 , A61M2205/58 , A61M2205/6054 , A61M2205/6072 , Y10T29/49826 , Y10T137/6116
摘要： A fluid dispensing machine, such as a peritoneal dialysis or hemodialysis machine, includes a dispenser or cassette (3) that pumps a medical fluid for dialysis or other treatments for patients. The machine includes and uses an autoconnect device (5) for connecting containers of liquid, such as bags of dialysis fluid or medication fluids, to the machine, while maintaining the sterility of the connection. The autoconnect device removes the cap from the fluid bag tubing and pierces the sealing membrane on the tubing. This makes it easier for patients to receive treatment, especially home treatment. Othe embodiments are useful for dispensing other liquids from other types of dispensing or pumping machines.
摘要翻译：流体分配机，例如腹膜透析或血液透析机，包括一个分配器或盒（3），该分配器或盒（3）泵送用于患者的透析或其它治疗的医用流体。该机器包括并使用自动连接装置（5），用于将诸如透析液或药液的液体容器连接到机器，同时保持连接的不连续性。自动连接装置从流体袋管道中取出盖子并刺穿管道上的密封膜。这使患者更容易接受治疗，特别是家庭治疗。这些实施例可用于从其他类型的分配或泵送机器分配其它液体。

2. 发明申请

WO2007096597A1 MOLECULAR DYE FOR SPECTROSCOPY 审中-公开
标题翻译：分光光度计
公开(公告)号：WO2007096597A1
公开(公告)日：2007-08-30
申请号：PCT/GB2007/000578
申请日：2007-02-20
申请人： E2V BIOSENSORS LIMITED , GILBERT, Richard
发明人： GILBERT, Richard
IPC分类号： C07F15/02 , G01N21/65
CPC分类号： G01N21/658 , C07D471/04 , C07D471/14 , C07D519/00 , C09B57/10
摘要： A method of detecting the presence, absence or quantity of a dye in a sample in a reaction region is provided, comprising the steps of providing a dye comprising a ligand ion complex, the ligand having a lowest unoccupied electron level and the ion having an excited electron level, the lowest unoccupied electron level of the ligand having an energy level such that an electron in the excited electron level of the ion may transfer non radiatively to the lowest unoccupied electron level of the ligand, the complex having a ground state electron level; illuminating the dye with a specified wavelength of radiation to detect the presence, absence or quantity of dye; detecting radiation from the illuminated dye; wherein the electron levels of the complex and the wavelength of the radiation are arranged such that electrons in the ground state are promoted to an excited state by photon absorption and it is energetically favourable for electrons to transfer to the lowest unoccupied electron level of the ligand from the excited electron level of the ion and undergo non-radiative relaxation via a thermally accessible electron level between the ground state electron level of the complex and the excited electron level of the ion to the ground state electron level.
摘要翻译：提供了一种检测反应区样品中染料存在，不存在或数量的方法，其包括以下步骤：提供包含配体离子络合物的染料，所述配体具有最低未占据的电子能级，所述离子具有激发态电子水平，具有能级的配体的最低未占有电子水平，使得离子的激发电子能级中的电子可以非辐射地转移到配体的最低未占空间的电子水平，该配体具有基态电子水平; 用特定波长的辐射照射染料以检测染料的存在，不存在或数量; 检测来自照射染料的辐射; 其中复合物的电子水平和辐射的波长被布置成使得处于基态的电子通过光子吸收促进为激发态，并且在能量上有利于电子转移到配体的最低未占有电子水平离子的激发的电子水平，并通过复合体的基态电子水平与离子的激发电子水平与基态电子能级之间的可热电子水平进行非辐射弛豫。

3. 发明申请

WO2006095181A2 BIOSENSOR LABELLING GROUPS 审中-公开
标题翻译：生物传感器标签组
公开(公告)号：WO2006095181A2
公开(公告)日：2006-09-14
申请号：PCT/GB2006/000849
申请日：2006-03-09
申请人： E2V BIOSENSORS LIMITED , GILBERT, Richard
发明人： GILBERT, Richard
IPC分类号： G01N33/58
CPC分类号： G01N33/583
摘要： A class of compounds specifically designed to act as resonance Raman spectroscopy labels, particularly surface-enhanced resonance Raman spectroscopy (SERRS) labels, for analytes such as proteins, peptides, nucleic acids, and related molecules is described. A resonance Raman spectroscopy label of the invention comprises a metallocene covalently attached to: a reactive group for covalent attachment of the label to an analyte; a SERRS surface binding group; and a halogen, wherein attachment of the halogen to the metallocene is such that the halogen causes a characteristic Raman peak to be produced when the label is subjected to resonance Raman spectroscopy. In a preferred aspect the label also has redox properties suitable for a second use as a label for electrochemical sensing.
摘要翻译：描述了一类专门用作共振拉曼光谱标记，特别是用于分析物如蛋白质，肽，核酸和相关分子的表面增强共振拉曼光谱（SERRS）标记的化合物。本发明的共振拉曼光谱标记包括茂金属共价连接到：将标记共价连接到分析物上的反应性基团; SERRS表面结合组; 和卤素，其中卤素与金属茂的连接使得当标签经受共振拉曼光谱法时，卤素引起产生特征拉曼峰。在优选的方面，该标签还具有适于第二次用作电化学感测标签的氧化还原性质。

4. 发明申请

WO2006043095A2 MONITORING ENZYME-SUBSTRATE REACTIONS 审中-公开
标题翻译：监测酶 - 底物反应
公开(公告)号：WO2006043095A2
公开(公告)日：2006-04-27
申请号：PCT/GB2005/004089
申请日：2005-10-21
申请人： E2V TECHNOLOGIES (UK) LIMITED , GILBERT, Richard
发明人： GILBERT, Richard
IPC分类号： C12Q1/37 , C12Q1/42 , C12Q1/48
CPC分类号： C12Q1/485 , C12Q1/37 , C12Q1/42
摘要： Methods of electrochemically monitoring enzyme-substrate reactions are described. The substrate is tagged with a redox-active group. Modification of the substrate by an enzyme can then be monitored electrochemically by means of the redox-active group. Such methods can be used in particular to monitor non-redox enzyme reactions, such as kinase, phosphatase, or protease reactions, although redox enzyme reactions can also be monitored by such methods. Screening assays to identify modulators of enzyme activity or new enzyme substrates are also described.
摘要翻译：描述了电化学监测酶底物反应的方法。底物标有氧化还原活性基团。然后可以借助氧化还原活性基团电化学监测通过酶修饰底物。这些方法可以特别用于监测非氧化还原酶反应，例如激酶，磷酸酶或蛋白酶反应，尽管还可以通过这些方法监测氧化还原酶反应。还描述了鉴定酶活性调节剂或新酶底物的筛选试验。

5. 发明申请

WO2005123183A2 ELECTROPORATION DEVICE AND METHOD FOR DELIVERY TO OCULAR TISSUE 审中-公开
标题翻译：电子装置和用于输送至组织的方法
公开(公告)号：WO2005123183A2
公开(公告)日：2005-12-29
申请号：PCT/US2005/020677
申请日：2005-06-13
申请人： UNIVERSITY OF SOUTH FLORIDA , HELLER, Richard , JAROSZESKI, Mark, J. , GILBERT, Richard, A. , HAUSWIRTH, William, H.
发明人： HELLER, Richard , JAROSZESKI, Mark, J. , GILBERT, Richard, A. , HAUSWIRTH, William, H.
IPC分类号： A61N1/30
CPC分类号： A61N1/0543 , A61N1/0412 , A61N1/0476 , A61N1/327
摘要： In accordance with the present invention is provided a device and method for delivering DNA for the purpose of gene therapy to specific regions within and around the eye.
摘要翻译：根据本发明提供了用于将基因治疗目的的DNA递送到眼睛内和眼睛周围的特定区域的装置和方法。

6. 发明申请

WO2005010161A2 DEVICE AND METHOD TO FACILITATE DIRECTED DELIVERY AND ELECTROPORATION 审中-公开
标题翻译：用于促进指导性交付和电气化的装置和方法
公开(公告)号：WO2005010161A2
公开(公告)日：2005-02-03
申请号：PCT/US2004/023052
申请日：2004-07-16
申请人： UNIVERSITY OF SOUTH FLORIDA , GILBERT, Richard , JAROSZESKI, Mark, J. , HELLER, Richard
发明人： GILBERT, Richard , JAROSZESKI, Mark, J. , HELLER, Richard
IPC分类号： C12N
CPC分类号： A61N1/327 , A61N1/0416 , A61N1/0424 , A61N1/325 , C12M35/02 , C12N15/87
摘要： The present invention provides an apparatus and method that will accomplish molecular delivery and subsequent electroporation with a single apparatus without the need for separate molecule injection and placement of the electroporation applicators.
摘要翻译：本发明提供了一种将单个装置完成分子递送和随后的电穿孔的装置和方法，而不需要单独的分子注射和放置电穿孔施用器。

7. 发明申请

WO2004097384A1 MOLECULAR DETECTOR ARRANGEMENT 审中-公开
标题翻译：分子检测器安排
公开(公告)号：WO2004097384A1
公开(公告)日：2004-11-11
申请号：PCT/GB2004/001788
申请日：2004-04-23
申请人： E2V TECHNOLOGIES LIMITED , ALLEN, Brian, Philip , ZHOU, Xiao-Feng , GILBERT, Richard
发明人： ALLEN, Brian, Philip , ZHOU, Xiao-Feng , GILBERT, Richard
IPC分类号： G01N21/65
CPC分类号： G01N21/658 , G01J3/44 , G01N21/03 , G01N2021/0346
摘要： An analyte carrier, such as a microtiter plate, microfluidic chip or other suitable arrangements for supporting an analyte has a conducting layer for receipt of an analyte having a non-random surface structure pattern designed to enhance the Raman scattering from molecules in an analysis region. The designed surface structure pattern has regions of high curvature, which increase the electromagnetic field provided from the surface, thereby enhancing the energy transfer from electrons in the metal surface to molecules in a region above the surface. This provides energy to electron bandgap levels in the molecules, thereby enhancing Raman scattering which can be detected by a separate detector.
摘要翻译：分析物载体，例如微量滴定板，微流体芯片或用于支持分析物的其它合适布置具有用于接收具有设计用于增强分析区域中的分子的拉曼散射的非随机表面结构图案的分析物的导电层。设计的表面结构图形具有高曲率的区域，这增加了从表面提供的电磁场，从而增强了从金属表面的电子到表面上方的分子的能量传递。这为分子中的电子带隙水平提供了能量，从而增强了可以通过单独的检测器检测的拉曼散射。

8. 发明申请

WO2003077892A3 4-(4-METHYLPIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3(4-PYRIDIN-3-YL)PYRIMIDIN-2-YL-AMINO)PHENYL]-BENZAMIDE FOR TREATING ANG II-MEDIATED DISEASES 审中-公开
公开(公告)号：WO2003077892A3
公开(公告)日：2003-09-25
申请号：PCT/EP2003/002709
申请日：2003-03-14
申请人： NOVARTIS AG , THE UNIVERSITY OF MELBOURNE , GILBERT, Richard, Ernest , KELLY, Darren, James , FELDMAN, David, Louis
发明人： GILBERT, Richard, Ernest , KELLY, Darren, James , FELDMAN, David, Louis
IPC分类号： A61K31/505
摘要： A PDGF receptor tyrosine kinase inhibitor, especially a 4-(4-methylpiperazin-l-ylmethyl)-N[4-methyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-benzamide of the formula I (I) or a pharmaceutically acceptable salt thereof can be used in the treatment of angiotensin IIinduced diseases and a combination which comprises (a) a PDGF receptor tyrosine kinase inhibitor preferably N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4(3-pyridyl)-2-pyrimidine-amine and (b) at least one compound selected from an anti hypertensive, an aldosterone antagonist, an aldosterone synthase inhibitor and/or an angiotensin receptor blocker agent and optionally at least one pharmaceutically acceptable carrier for simultaneous, separate or sequential use, in particular for the treatment of hypertension and hypertension-induced diseases.

9. 发明申请

WO03077892A2 4-(4-METHYLPIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3(4-PYRIDIN-3-YL)PYRIMIDIN-2-YL-AMINO)PHENYL]-BENZAMIDE FOR TREATING ANG II-MEDIATED DISEASES 审中-公开
标题翻译： 4-（4-甲基哌嗪-1-基甲基）-N- [4-甲基-3（4-吡啶-3-基）嘧啶-2-基]氨基]苯基] - 苯甲酰胺用于治疗IIG介导的疾病
公开(公告)号：WO03077892A2
公开(公告)日：2003-09-25
申请号：PCT/EP0302709
申请日：2003-03-14
申请人： NOVARTIS AG , UNIV MELBOURNE , GILBERT RICHARD ERNEST , KELLY DARREN JAMES , FELDMAN DAVID LOUIS
发明人： GILBERT RICHARD ERNEST , KELLY DARREN JAMES , FELDMAN DAVID LOUIS
IPC分类号： C07D401/04 , A61K31/00 , A61K31/41 , A61K31/505 , A61K31/506 , A61K31/549 , A61K45/06 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/00 , A61P13/12 , A61P43/00
CPC分类号： A61K45/06 , A61K31/00 , A61K31/41 , A61K31/505 , A61K31/549 , A61K2300/00
摘要： A PDGF receptor tyrosine kinase inhibitor, especially a 4-(4-methylpiperazin-l-ylmethyl)-N[4-methyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-benzamide of the formula I (I) or a pharmaceutically acceptable salt thereof can be used in the treatment of angiotensin IIinduced diseases and a combination which comprises (a) a PDGF receptor tyrosine kinase inhibitor preferably N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4(3-pyridyl)-2-pyrimidine-amine and (b) at least one compound selected from an anti hypertensive, an aldosterone antagonist, an aldosterone synthase inhibitor and/or an angiotensin receptor blocker agent and optionally at least one pharmaceutically acceptable carrier for simultaneous, separate or sequential use, in particular for the treatment of hypertension and hypertension-induced diseases.
摘要翻译： PDGF受体酪氨酸激酶抑制剂，特别是4-（4-甲基哌嗪-1-基甲基）-N [4-甲基-3-（4-吡啶-3-基）嘧啶-2-基氨基）苯基] - 苯甲酰胺式I（I）或其药学上可接受的盐可用于治疗血管紧张素II诱导的疾病和组合，其包含（a）PDGF受体酪氨酸激酶抑制剂，优选N- {5- [4-（4-甲基 - 哌嗪子基） - 甲基） - 苯甲酰氨基] -2-甲基苯基} -4-（3-吡啶基）-2-嘧啶胺和（b）至少一种选自抗高血压剂，醛固酮拮抗剂，醛固酮合酶抑制剂和/ 血管紧张素受体阻断剂和任选的至少一种用于同时，分开或顺序使用的药学上可接受的载体，特别是用于治疗高血压和高血压诱发的疾病。

10. 发明申请

WO0164200A3 USE OF PDGF RECEPTOR TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF DIABETIC NEPHROPATHY 审中-公开
标题翻译：使用PDGF受体酪氨酸激酶抑制剂治疗糖尿病性肾病
公开(公告)号：WO0164200A3
公开(公告)日：2002-01-17
申请号：PCT/EP0102340
申请日：2001-03-01
申请人： NOVARTIS AG , UNIV MELBOURNE , SOUTHERN HEALTH , ATKINS ROBERT CHARLES , CHADBAN STEVEN JAMES , COOPER MARK EMMANUEL , GILBERT RICHARD ERNEST , HILL PRUDENCE ANN , KELLY DARREN JAMES , NIKOLIC PATERSON DAVID JOHN
发明人： ATKINS ROBERT CHARLES , CHADBAN STEVEN JAMES , COOPER MARK EMMANUEL , GILBERT RICHARD ERNEST , HILL PRUDENCE ANN , KELLY DARREN JAMES , NIKOLIC-PATERSON DAVID JOHN
IPC分类号： C07D401/14 , A61K31/00 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K45/00 , A61P13/12 , A61P43/00
CPC分类号： A61K31/5377 , A61K31/00 , A61K31/505 , A61K31/506
摘要： The present invention relates to the use of PDGF receptor tyrosine kinase inhibitors, especially of N-phenyl-2-pyrimidine-amine derivatives of formula (I), in which the symbols and substituents have the meaning as defined herein in free form or in pharmaceutically acceptable salt form, in the manufacture of a pharmaceutical composition for the treatment of diabetic nephropathy; to a method of treatment of warm-blooded animals, including humans, suffering from diabetic nephropathy; and to the use of a PDGF receptor tyrosine kinase inhibitor of the formula (I), wherein R1, is pyridyl bonded at a carbon atom, R2, R3, R5, R6 and R8 are each hydrogen, R4 is lower alkyl, R7 a radical of formula (II):-N(R9)-C(=X)-(Y)n-R10, wherein R9 is hydrogen, X is oxo, n is 0 and R10 is 4-methyl-piperazinyl-methyl, or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for treating glomerulonephritis, chronic pyelonephritis or IgA nephropathy.
摘要翻译：本发明涉及PDGF受体酪氨酸激酶抑制剂，特别是式（I）的N-苯基-2-嘧啶 - 胺衍生物的用途，其中符号和取代基具有如本文定义的含义为游离形式或药学上在制备用于治疗糖尿病性肾病的药物组合物中的可接受的盐形式; 涉及一种治疗患有糖尿病肾病的温血动物（包括人）的方法; 以及使用式（I）的PDGF受体酪氨酸激酶抑制剂，其中R1是在碳原子上键合的吡啶基，R2，R3，R5，R6和R8各自为氢，R4为低级烷基，R7为自由基的式（II）：-N（R 9）-C（= X） - （Y）n -R 10，其中R 9是氢，X是氧代，n是0，R 10是4-甲基 - 哌嗪基 - 甲基，或其药学上可接受的盐用于制备用于治疗肾小球性肾炎，慢性肾盂肾炎或IgA肾病的药物。

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