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1. 发明申请

WO2009023357A2 CURCUMIN DERIVATIVES AND THEIR USE AS RADIOPROTECTORS 审中-公开
标题翻译： CURCUMIN衍生物及其作为放射性物质的用途
公开(公告)号：WO2009023357A2
公开(公告)日：2009-02-19
申请号：PCT/US2008064872
申请日：2008-05-27
申请人： UNIV ROCHESTER , OKUNIEFF PAUL , ZHANG LURONG , LIU CHAOMEI , SUN WEIMIN , YANG SHANMIN , SWARTS STEVEN
发明人： OKUNIEFF PAUL , ZHANG LURONG , LIU CHAOMEI , SUN WEIMIN , YANG SHANMIN , SWARTS STEVEN
IPC分类号： A61K31/455
CPC分类号： C07D213/81 , C07C243/38 , C07C311/49 , C07D213/82 , C07D231/12 , C07D285/06 , C07D307/85 , C07D333/38 , C07D401/04 , C07D403/04 , C07D417/04 , C07D495/04
摘要： Disclosed are compositions relating to analogues, derivatives, and metabolites of curcumin, methods of synthesis thereof, and methods for use of said compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译：公开了与姜黄素的类似物，衍生物和代谢物相关的组合物，其合成方法和所述组合物的使用方法。该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。

2. 发明申请

WO2009017874A3 NOVEL CURCUMIN DERIVATIVES AND THEIR PHARMACEUTICAL USES THEREOF 审中-公开
标题翻译：新型CURCUMIN衍生物及其药物用途
公开(公告)号：WO2009017874A3
公开(公告)日：2009-05-22
申请号：PCT/US2008064877
申请日：2008-05-27
申请人： UNIV ROCHESTER , OKUNIEFF PAUL , LIU CHAOMEI , ZHANG LURONG
发明人： OKUNIEFF PAUL , LIU CHAOMEI , ZHANG LURONG
IPC分类号： A01N43/20 , A01N43/24 , A61K31/335
CPC分类号： A61K31/415
摘要： Disclosed are methods relating to analogues, derivatives, and metabolites of curcumin. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译：公开了与姜黄素的类似物，衍生物和代谢物相关的方法。该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。

3. 发明申请

WO2009017874A9 NOVEL CURCUMIN DERIVATIVES AND THEIR PHARMACEUTICAL USES THEREOF 审中-公开
标题翻译：新型姜黄素衍生物及其药物用途
公开(公告)号：WO2009017874A9
公开(公告)日：2009-03-19
申请号：PCT/US2008064877
申请日：2008-05-27
申请人： UNIV ROCHESTER , OKUNIEFF PAUL , LIU CHAOMEI , ZHANG LURONG
发明人： OKUNIEFF PAUL , LIU CHAOMEI , ZHANG LURONG
IPC分类号： A61K31/415
CPC分类号： A61K31/415
摘要： Disclosed are methods relating to analogues, derivatives, and metabolites of curcumin. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译：公开了涉及姜黄素的类似物，衍生物和代谢物的方法。该摘要旨在作为用于在特定领域中进行搜索的目的的扫描工具，并且不旨在限制本发明。

4. 发明申请

WO2009143475A1 METHODS AND COMPOSITIONS RELATED TO AGLYCOSIDIC ESCULENTOSIDE A 审中-公开
标题翻译：方法和组合物与淀粉酶A相关
公开(公告)号：WO2009143475A1
公开(公告)日：2009-11-26
申请号：PCT/US2009045056
申请日：2009-05-22
申请人： UNIV ROCHESTER , OKUNIEFF PAUL , LURONG ZHANG , SHANMIN YANG , MEI ZHANG , LIU CHAOMEI
发明人： OKUNIEFF PAUL , LURONG ZHANG , SHANMIN YANG , MEI ZHANG , LIU CHAOMEI
IPC分类号： A01N43/42
CPC分类号： A61K31/194
摘要： Disclosed are compositions related to water soluble selective COX-2 inhibitors and methods of using the inhibitors (including h-EsA and derivatives thereof.)
摘要翻译：公开了与水溶性选择性COX-2抑制剂相关的组合物和使用抑制剂的方法（包括h-EsA及其衍生物）。

5. 发明申请

WO0189447A8 ANTIFUNGAL SUBSTITUTED PROPYL TRIAZOLE COMPOUND, ITS SALT, AND PREPARATION METHODS THEREOF 审中-公开
标题翻译：反义替代丙三唑化合物及其盐及其制备方法
公开(公告)号：WO0189447A8
公开(公告)日：2002-05-23
申请号：PCT/CN0100862
申请日：2001-05-24
申请人： UNIV PLA 2ND MILITARY MEDICAL , LIU CHAOMEI , SUN QINGYAN
发明人： LIU CHAOMEI , SUN QINGYAN
IPC分类号： C07D249/08 , C07D521/00 , A61K31/495 , C07D249/12 , C07D401/12 , C07D403/12 , C07D403/14
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08
摘要： The substituted propyl triazole compounds of formula (I) and the salts thereof having the structure (II): (I), (II) wherein X is hydrogen or alkyl group; M is hydrogen, hydroxy or ester group; Ar is selected from phenyl, naphthyl, thienyl, furyl, pyridyl and pyrimidinyl substituted by halogen, nitro group, trifluoromethyl or trifluoromethoxy group; L is hydrochloric acid, hydrobromic acid, methyl sulfonic acid, nitric acid, sulfuric acid, phosphoric acid, acetic acid, oxalic acid, maleic acid, citric acid, fumaric acid, gluconic acid, lactic acid, succinic acid, tartaric acid, malic acid: Y is (a) wherein R1-8 is selected from hydrogen, alkyl, cyano or ester group; Z is selected from N or CH; R is selected from (1)formacyl;(2)alkyl group;(3) benzyl or substituted benzyl group;(4)phenyl or substituted phenyl group. The compounds of formula (I) and formula (II) have wide-spectrum potent activity against systemic fungal infections, as well as have low toxicity.
摘要翻译：式（I）的取代的丙基三唑化合物及其具有结构（II）的盐：（I），（II）其中X是氢或烷基; M是氢，羟基或酯基; Ar选自被卤素，硝基，三氟甲基或三氟甲氧基取代的苯基，萘基，噻吩基，呋喃基，吡啶基和嘧啶基; L是盐酸，氢溴酸，甲基磺酸，硝酸，硫酸，磷酸，乙酸，草酸，马来酸，柠檬酸，富马酸，葡萄糖酸，乳酸，琥珀酸，酒石酸，苹果酸：Y是（a）其中R1-8选自氢，烷基，氰基或酯基; Z选自N或CH; R选自（1）甲酰基;（2）烷基;（3）苄基或取代的苄基;（4）苯基或取代的苯基。式（I）和式（II）的化合物对全身真菌感染具有广谱的有效活性，并具有低毒性。

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