专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2012050646A2 BIOMIMETIC CHEMICAL SENSORS USING NANOELECTRONIC READOUT OF OLFACTORY RECEPTORS 审中-公开
标题翻译：使用纳米电子阅读器的生物化学传感器
公开(公告)号：WO2012050646A2
公开(公告)日：2012-04-19
申请号：PCT/US2011042290
申请日：2011-06-29
申请人： UNIV PENNSYLVANIA , UNIV ILLINOIS , JOHNSON ALAN T JR , GOLDSMITH BRETT R , MITALA JOSEPH J JR , DISCHER BOHDANA , SLIGAR STEPHEN G , BAYBURT TIMOTHY H
发明人： JOHNSON ALAN T JR , GOLDSMITH BRETT R , MITALA JOSEPH J JR , DISCHER BOHDANA , SLIGAR STEPHEN G , BAYBURT TIMOTHY H
IPC分类号： G01N33/53
CPC分类号： G01N33/6842 , G01N33/5432 , G01N33/54353 , G01N33/5438 , G01N33/554 , G01N33/6872 , G01N2333/726 , G06F19/28
摘要： The present invention provides biomimetic sensor devices that utilize proteins - such as G-protein coupled receptors - and are useful in high-sensitivity analysis of analyte-containing samples. These sensors may be used to determine the presence or concentration of one or more analytes in a sample. The invention also includes methods of fabricating the devices and methods of using the devices to assay samples.
摘要翻译：本发明提供利用蛋白质（例如G蛋白偶联受体）的仿生传感器装置，并且可用于含分析物样品的高灵敏度分析。这些传感器可用于确定样品中一种或多种分析物的存在或浓度。本发明还包括制造装置的方法和使用该装置来测定样品的方法。

2. 发明申请

WO2012050646A3 BIOMIMETIC CHEMICAL SENSORS USING NANOELECTRONIC READOUT OF OLFACTORY RECEPTORS 审中-公开
标题翻译：使用纳米电子阅读器的生物化学传感器
公开(公告)号：WO2012050646A3
公开(公告)日：2012-10-04
申请号：PCT/US2011042290
申请日：2011-06-29
申请人： UNIV PENNSYLVANIA , UNIV ILLINOIS , JOHNSON ALAN T JR , GOLDSMITH BRETT R , MITALA JOSEPH J JR , DISCHER BOHDANA , SLIGAR STEPHEN G , BAYBURT TIMOTHY H
发明人： JOHNSON ALAN T JR , GOLDSMITH BRETT R , MITALA JOSEPH J JR , DISCHER BOHDANA , SLIGAR STEPHEN G , BAYBURT TIMOTHY H
IPC分类号： H01L21/00 , G01N27/26 , H01L23/00
CPC分类号： G01N33/6842 , G01N33/5432 , G01N33/54353 , G01N33/5438 , G01N33/554 , G01N33/6872 , G01N2333/726 , G06F19/28
摘要： Biomimetic sensor devices that utilize proteins - such as G-protein coupled receptors - and are useful in high-sensitivity analysis of analyte-containing samples. These sensors may be used to determine the presence or concentration of one or more analytes in a sample. Methods of fabricating the devices include Three-terminal transistor circuits were fabricated from carbon nanotubes grown on oxidized silicon substrates by catalytic chemical vapor deposition, with the heavily doped substrate used as a back gate electrode. Methods of using the devices to assay samples include contacting a sample with a device comprising a transmembrane protein disposed in a lipid, an amphiphile, or both, the device comprising a semiconductor material in electronic communication with the transmembrane protein; and measuring a first electronic characteristic of the device when the device is contacted with the sample.
摘要翻译：利用蛋白质（如G蛋白偶联受体）的生物模拟传感器设备，可用于含分析物样品的高灵敏度分析。这些传感器可用于确定样品中一种或多种分析物的存在或浓度。制造器件的方法包括通过催化化学气相沉积在氧化硅衬底上生长的碳纳米管制造三端晶体管电路，重掺杂衬底用作背栅电极。使用该装置来测定样品的方法包括使样品与包含设置在脂质，两亲物或两者中的跨膜蛋白的装置接触，所述装置包括与跨膜蛋白电子通信的半导体材料; 以及当所述装置与所述样品接触时测量所述装置的第一电子特性。

3. 发明申请

WO2006047684A3 TISSUE FACTOR PHOSPHOLIPID VESICLE PARTICLES AND METHODS OF USE FOR COAGULATION 审中-公开
标题翻译：组织因子磷脂囊泡和凝血使用方法
公开(公告)号：WO2006047684A3
公开(公告)日：2006-07-27
申请号：PCT/US2005038781
申请日：2005-10-27
申请人： UNIV ILLINOIS , MORRISSEY JAMES H , PUREZA VINCENT S , SLIGAR STEPHEN G
发明人： MORRISSEY JAMES H , PUREZA VINCENT S , SLIGAR STEPHEN G
IPC分类号： A61K38/00 , C07K14/00
CPC分类号： C07K14/745 , A61K9/127 , A61K9/5123 , A61K9/5169 , A61K38/363
摘要： Tissue Factor (natural or recombinant truncated) can be incorporated into stable, soluble nanoscale particles so that activity is maintained. These particles can be used as a reagent in prothrombin clotting time assays or they can be used in therapeutic compositions for use in humans or animals. Therapeutic settings can include supplementation in the case of a genetic deficiency, uncontrolled bleeding, surgical incisions or seepage, thrombocytopenia, soft tissue trauma or other trauma, to effect tumor regression or to inhibit tumor growth.
摘要翻译：可将组织因子（天然或重组截短的）并入稳定的可溶性纳米级颗粒中，从而维持活性。这些颗粒可以用作凝血酶原凝结时间测定中的试剂，或者它们可以用于在人或动物中使用的治疗组合物。治疗设置可以包括在遗传缺陷，不受控制的出血，手术切口或渗血，血小板减少症，软组织创伤或其他创伤的情况下补充，以实现肿瘤消退或抑制肿瘤生长。

4. 发明申请

WO2005081743A3 MEMBRANE SCAFFOLD PROTEINS 审中-公开
标题翻译：膜蛋白质蛋白
公开(公告)号：WO2005081743A3
公开(公告)日：2006-05-26
申请号：PCT/US2005001122
申请日：2005-01-13
申请人： UNIV ILLINOIS , SLIGAR STEPHEN G , BAYBURT TMOTHY H , SCHULER MARY A , CIVJAN NATANYA R , GRINKOVA YELENA V , DENISOV ILIA G , GRIMME STEPHEN JAMES
发明人： SLIGAR STEPHEN G , BAYBURT TMOTHY H , SCHULER MARY A , CIVJAN NATANYA R , GRINKOVA YELENA V , DENISOV ILIA G , GRIMME STEPHEN JAMES
IPC分类号： A61K9/14 , C07K14/00 , C07K14/435 , C07K14/47 , C07K14/775
CPC分类号： C07K14/775 , C07K14/47
摘要： The membrane scaffold proteins (MSP) of the present invention assemble with hydrophobic or partially hydrophobic proteins to form soluble nanoscale particles which preserve native structure and function; they are improved over liposomes and detergent micelles, in terms of stability and preservation of biological activity and native conformation. In the presence of phospholipid, MSPs form nanoscopic phospholipid bilayer disks, with the MSP stabilizing the particle at the perimeter of the bilayer domain. The particle bilayer structure allows manipulation of incorporated proteins in solution or on solid supports, including for use with such surface sensitive techniques as scanning probe microscopy or surface plasmon resonance. The nanoscale particles, which are robust in terms of integrity and maintenance of biological activity of incorporated proteins, facilitate pharmaceutical and biological research, structure/function correlations, structure determinations, bioseparations, and drug discovery.
摘要翻译：本发明的膜支架蛋白（MSP）与疏水或部分疏水的蛋白质组合形成可溶性纳米级颗粒，其保留天然结构和功能; 在稳定性和保存生物活性和天然构象方面，它们比脂质体和洗涤剂胶束得到改善。在磷脂的存在下，MSP形成纳米视磷脂双层盘，MSP在双层结构域的周边稳定颗粒。颗粒双层结构允许在溶液或固体载体上操作掺入的蛋白质，包括用于诸如扫描探针显微镜或表面等离振子共振的表面敏感技术。在完整性和维持结合蛋白质的生物活性方面坚固的纳米级颗粒有助于药物和生物学研究，结构/功能相关性，结构测定，生物分离和药物发现。

5. 发明申请

WO0240501A3 MEMBRANE SCAFFOLD PROTEINS 审中-公开
标题翻译：膜支架蛋白
公开(公告)号：WO0240501A3
公开(公告)日：2002-09-26
申请号：PCT/US0143451
申请日：2001-11-20
申请人： UNIV ILLINOIS
发明人： SLIGAR STEPHEN G , BAYBURT TIMOTHY H
IPC分类号： G01N33/50 , C07K14/00 , C07K14/47 , C07K14/705 , C07K19/00 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , G01N33/15 , C07H21/02 , C07H21/04 , C12N15/85 , C12N15/86 , G01N33/53
CPC分类号： C07K14/47
摘要： Membrane proteins are difficult to express in recombinant form, purify, and characterize, at least in part due to their hydrophobic or partially hydrophobic properties. Membrane scaffold proteins (MSP) assemble with target membrane or other hydrophobic or partially hydrophobic proteins or membrane fragments to form soluble nanoscale particles which preserve their native structure and function; they are improved over liposomes and detergent micelles. In the presence of phospholipid, MSPs form nanoscopic phospholipid bilayer disks, with the MSP stabilizing the particle at the perimeter of the bilayer domain. The particle bilayer structure allows manipulation of incorporated proteins in solution or on solid supports, including for use with such surface-sensitive techniques as scanning probe microscopy or surface plasmon resonance. The nanoscale particles facilitate pharmaceutical and biological research, structure/function correlation, structure determination, bioseparation, and drug discovery.
摘要翻译：至少部分由于其疏水或部分疏水性质，膜蛋白难以以重组形式表达，纯化和表征。膜支架蛋白（MSP）与靶膜或其他疏水性或部分疏水性蛋白质或膜片段组装以形成保留其天然结构和功能的可溶性纳米级粒子; 它们比脂质体和洗涤剂胶束有所改进。在存在磷脂的情况下，MSP形成纳米级磷脂双分子层盘，MSP稳定双层区周边的粒子。颗粒双层结构允许在溶液中或在固体载体上操作掺入的蛋白质，包括用于诸如扫描探针显微镜术或表面等离子体共振的表面敏感技术。纳米级颗粒促进了药物和生物学研究，结构/功能关联，结构测定，生物分离和药物发现。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式