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1. 发明申请

WO02085376A3 A METHOD FOR DECREASING SUPEROXIDE ANION PRODUCTION AND FOR THE TREATMENT OF DISEASES ASSOCIATED WITH OXIDATIVE STRESS 审中-公开
标题翻译：减少超氧化物阴离子生成和治疗与氧化应激有关的疾病的方法
公开(公告)号：WO02085376A3
公开(公告)日：2003-03-06
申请号：PCT/CA0200568
申请日：2002-04-19
申请人： UNIV MONTREAL , DE CHAMPLAIN JACQUES , WU RONG , EL MIDAOUI ADIL
发明人： DE CHAMPLAIN JACQUES , WU RONG , EL MIDAOUI ADIL
IPC分类号： A61K31/60 , A61K31/616 , A61P3/10 , A61P5/48 , A61P9/08 , A61P9/12 , A61P29/00 , A61K31/18 , A61K31/405
CPC分类号： A61K31/616 , A61K31/60
摘要： The present invention relates to a new method for reducing vascular, cardiac and colonic tissue O2 generation by lowering the NAD(P)H oxidase activity of these tissues in normal and hypertensive subjects using ASA, nimesulide and indomethacin. Although ASA did not show any acute effect in vitro, chronic oral treatment or chronic incubation with ASA significantly lowered the O2 basal or NAD(P)H activated production in aorta and smooth muscle cells from normotensive and hypertensive rats. These effects were dose-dependent and needed more than 3 days to onset in vivo condition. ASA treatment significantly improved the impaired aortic relaxation response to acetylcholine in SHR and significantly attenuated the age-dependent development of hypertension in young SHR. In another model of hypertension and insulin resistance induced by high glucose feeding, which was also found to be associated with a higher production of superoxide anion in tissues from the cardiovascular system, chronic ASA treatment was found to prevent simultaneously the development of hypertension, insulin resistance and the production of superoxide anion. Finally, in another hypertension model induced by the chronic administration of angiotensin II which has the property to activate NAD(P)H oxidase and to enhance the superoxide production in vessels, the concomitant treatment with ASA was also found to simultaneously prevent the development of hypertension and the enhanced superoxide anion production.
摘要翻译：本发明涉及一种通过使用ASA，尼美舒利和吲哚美辛降低正常和高血压受试者中这些组织的NAD（P）H氧化酶活性来减少血管，心脏和结肠组织O 2代的新方法。虽然ASA在体外没有显示任何急性作用，但慢性口服治疗或与ASA的慢性温育显着降低了来自正常血压和高血压大鼠的主动脉和平滑肌细胞中的O2基础或NAD（P）H活化产生。这些作用是剂量依赖性的，需要超过3天的体内发病。 ASA治疗显着改善SHR中乙酰胆碱受损的主动脉松弛反应，并显着减轻年轻SHR中高血压的年龄依赖性发展。在高葡萄糖喂养诱导的高血压和胰岛素抵抗的另一模型中，也发现与心血管系统组织中超氧化物阴离子的产生量相关，慢性ASA治疗可以预防同时发生高血压，胰岛素抵抗并产生超氧阴离子。最后，在慢性给予血管紧张素II诱导的高血压模型中，其具有激活NAD（P）H氧化酶的性质并增强血管中的超氧化物产生，同时也发现ASA伴随治疗同时预防高血压发展并增强超氧阴离子的生成。

2. 发明申请

WO2005058814A2 BIOCIDAL SILOXANE COATING MATERIAL CONTAINING N-HALOGENATED AMINE AND AMIDE FUNCTIONAL GROUPS 审中-公开
标题翻译：含有N-羟基化胺和酰胺官能团的生物硅氧烷涂料
公开(公告)号：WO2005058814A2
公开(公告)日：2005-06-30
申请号：PCT/US2004038558
申请日：2004-11-17
申请人： UNIV AUBURN , WORLEY SHELBY D , CHEN YONGJUN , LIANG JIE , WU RONG , BARNES KEVIN , BROUGHTON ROYALL M , CHO UNCHIN , LEE JAEWOONG
发明人： WORLEY SHELBY D , CHEN YONGJUN , LIANG JIE , WU RONG , BARNES KEVIN , BROUGHTON ROYALL M , CHO UNCHIN , LEE JAEWOONG
IPC分类号： A61K31/785 , C07D20060101 , C07D487/10 , C07F7/02 , C07F7/18 , D06M13/325 , D06M15/643 , D06M16/00 , C07D
CPC分类号： D06M13/325 , C07D487/10 , C07F7/1836 , D06M13/352 , D06M13/355 , D06M13/513 , D06M15/6436 , D06M16/00
摘要： N-halamine compounds which contain hindered amine and amide functional groups. Compounds include structure (TTDD); wherein X, X', and X'' independently are H, CI, or Br, wherein no more than two of X, X', and X'' are H and structure (I) wherein R, R', and R'' are independently alkyl groups containing (1) to (4) carbon atoms or hydrogen, and X and X' are independently H, CI, or Br. Compositions comprising the compounds are also described. The compounds and/or compositions can be used, for example, for the purpose of constructing biocidal coatings and materials. The biocidal activity can inactivate pathogenic microorganisms such as bacteria, fungi, and yeasts, as well as, virus particles, which can cause infectious diseases, and those microorganisms which cause noxious odors and unpleasant coloring, such as mildew.
摘要翻译：含有受阻胺和酰胺官能团的N-卤代胺化合物。化合物包括结构（TTDD）; 其中X，X'和X“独立地为H，Cl或Br，其中X，X'和X”中不超过2个为H，结构（I）其中R，R'和R' 独立地为含有（1） - （4）个碳原子的烷基或氢，X和X'独立地为H，Cl或Br。还描述了包含化合物的组合物。化合物和/或组合物可以用于例如用于构建杀生物剂的涂料和材料的目的。杀生物活性可以灭活细菌，真菌和酵母等致病微生物，以及可能引起传染病的病毒颗粒，以及引起有害气味和不愉快着色如微生物的微生物。

3. 发明申请

WO2011143144A2 AN ELECTROMAGNETIC SHIELDING ADHESIVE TAPE 审中-公开
标题翻译：电磁屏蔽胶带
公开(公告)号：WO2011143144A2
公开(公告)日：2011-11-17
申请号：PCT/US2011035817
申请日：2011-05-10
申请人： 3M INNOVATIVE PROPERTIES CO , ZHANG WEN JIE , WU RONG
发明人： ZHANG WEN JIE , WU RONG
IPC分类号： B32B15/08
CPC分类号： H05K9/0084 , C09J7/28 , C09J7/29 , C09J2201/602
摘要： The invention provides an electromagnetic shielding adhesive tape, comprising: a resin film layer; and an electro-magnetic interference shielding layer with a sandwiched structure, which is laminated with the resin film layer and comprises: a first adhesive layer bonded to one side of the resin film layer; a second adhesive layer; and a conductive metal layer provided between the first adhesive layer and the second adhesive layer.
摘要翻译：本发明提供一种电磁屏蔽胶带，包括：树脂膜层; 以及具有夹层结构的电磁干扰屏蔽层，其与所述树脂膜层层叠，并且包括：粘合到所述树脂膜层的一侧的第一粘合剂层; 第二粘合层; 以及设置在第一粘合剂层和第二粘合剂层之间的导电金属层。

4. 发明申请

WO2006099567A3 BIOCIDAL N-HALAMINE EPOXIDES 审中-公开
标题翻译：生物碱N-硫酸环氧化物
公开(公告)号：WO2006099567A3
公开(公告)日：2007-09-13
申请号：PCT/US2006009628
申请日：2006-03-10
申请人： UNIV AUBURN , WORLEY S D , LIANG JIE , CHEN YONGJUN , BROUGHTON ROYALL M , WANG JIA-WANG , WU RONG , CHO UNCHIN , LEE JAEWOONG , BARNES KEVIN
发明人： WORLEY S D , LIANG JIE , CHEN YONGJUN , BROUGHTON ROYALL M , WANG JIA-WANG , WU RONG , CHO UNCHIN , LEE JAEWOONG , BARNES KEVIN
IPC分类号： C07D233/00 , C07D235/00 , C08G63/44
CPC分类号： A01N65/00 , A01N35/02 , A01N43/50 , A01N43/90 , A01N59/00 , A61Q17/005 , C09D5/14 , C09D5/16 , A01N25/10 , A01N25/34
摘要： N-halaminehydantoinyl epoxide compounds which can be used for the construction of coatings and materials which can be rendered biocidal by exposure to halogen solutions either before or after curing the coating or material are disclosed. The biocidal coatings and materials can then be used to inactivate pathogenic microorganisms such as bacteria, fungi, and yeasts, as well as virus particles, which can cause infectious diseases, and those microorganisms which cause noxious odors and unpleasant coloring such as mildew. The coatings are compatible with a variety of substrates including, but not limited to, cellulose, chitin, chitosan, synthetic fibers, cement grout, latex caulk, acrylic films, polyurethanes, plastics and paints.
摘要翻译：公开了可用于构建涂层和材料的N-卤代乙酰乙酰基环氧化合物，其可以在固化涂层或材料之前或之后通过暴露于卤素溶液而变成杀生物剂。然后可以使用杀生物涂料和材料来灭活病原微生物如细菌，真菌和酵母，以及可能引起传染病的病毒颗粒，以及引起有害气味和令人不快的着色如霉菌的微生物。这些涂层与各种基材相容，包括但不限于纤维素，壳多糖，壳聚糖，合成纤维，水泥浆，乳胶填缝剂，丙烯酸膜，聚氨酯，塑料和油漆。

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