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1. 发明申请

WO2014169007A3 COMBINATION THERAPEUTIC NANOPARTICLES 审中-公开
标题翻译：组合治疗纳米颗粒
公开(公告)号：WO2014169007A3
公开(公告)日：2015-01-08
申请号：PCT/US2014033431
申请日：2014-04-09
申请人： UNIV GEORGIA , DHAR SHANTA , PATHAK RAKESH KUMAR
发明人： DHAR SHANTA , PATHAK RAKESH KUMAR
IPC分类号： A61K9/16 , A61K47/30 , A61K47/48 , A61P35/00
CPC分类号： A61K9/50 , A61K9/5153 , A61K31/222 , A61K31/573 , A61K31/663 , A61K33/24 , A61K47/482 , A61K47/48246 , A61K47/55 , A61K47/593 , A61K47/64 , A61K47/6937 , C07C69/78 , C07J5/0053
摘要： Nanoparticles that include a chemotherapeutic agent and an anti-inflammatory are particularly cytotoxic to prostate cancer cells.
摘要翻译：包括化学治疗剂和抗炎剂的纳米颗粒对前列腺癌细胞特别是细胞毒性。

2. 发明申请

WO2015089389A1 PRODRUG FOR RELEASE OF CISPLATIN AND CYCLOOXYGENASE INHIBITOR 审中-公开
标题翻译：释放CISPLATIN和CYCLOOXYGENASE抑制剂的准则
公开(公告)号：WO2015089389A1
公开(公告)日：2015-06-18
申请号：PCT/US2014069997
申请日：2014-12-12
申请人： UNIV GEORGIA , DHAR SHANTA , PATHAK RAKESH
发明人： DHAR SHANTA , PATHAK RAKESH
IPC分类号： C07F15/00 , A61K31/282 , A61K47/48 , A61P31/00 , A61P35/00
CPC分类号： C07F15/0093 , A61K47/54 , A61K47/546 , A61K47/55 , A61K47/62
摘要： Pt(IV) prodrugs include one or more conjugated cyclooxygenase inhibitor. Reduction of Pt(IV) to Pt(II) can result cisplatin and a cyclooxygenase inhibitor. For proof of concept, a Pt(IV) prodrug that can produce cisplatin and aspirin, Platin-A, was synthesized. Platin-A exhibited excellent anticancer and anti-inflammatory properties, which were better than the combination of free formulation of cisplatin and aspirin.
摘要翻译： Pt（IV）前药包括一种或多种缀合的环氧合酶抑制剂。将Pt（IV）还原成Pt（II）可导致顺铂和环氧合酶抑制剂。为了证明概念，合成了可以产生顺铂和阿司匹林的铂（IV）前药，铂 - A。铂-A显示出优异的抗癌和抗炎性质，其优于顺铂和阿司匹林的游离制剂的组合。

3. 发明申请

WO2015134599A8 PLATINUM(IV) COMPOUNDS AND METHODS OF MAKING AND USING SAME 审中-公开
公开(公告)号：WO2015134599A8
公开(公告)日：2015-11-26
申请号：PCT/US2015018720
申请日：2015-03-04
申请人： UNIV GEORGIA , DHAR SHANTA , PATHAK RAKESH K , POPIK VLADIMIR V , MCNITT CHRISTOPHER D
发明人： DHAR SHANTA , PATHAK RAKESH K , POPIK VLADIMIR V , MCNITT CHRISTOPHER D
IPC分类号： A61K31/282 , C07D225/08 , C07D249/16
CPC分类号： C07F15/0093 , C07D225/08 , C07D249/16 , C07D261/20 , C07D271/12 , C07D487/04 , C07D498/04
摘要： Reactions of 1,3-dipole-functional (e.g., azide-functional) platinum(IV) compounds with cyclic alkynes under conditions effective for a cycloaddition reaction to form a heterocyclic compound are disclosed herein. In certain embodiments, the conditions effective for the cycloaddition reaction to form the heterocyclic compound includes the substantial absence of added catalyst (e.g., copper catalyst).

4. 发明申请

WO2015134599A2 PLATINUM(IV) COMPOUNDS AND METHODS OF MAKING AND USING SAME 审中-公开
标题翻译：铂（IV）化合物及其制备和使用方法
公开(公告)号：WO2015134599A2
公开(公告)日：2015-09-11
申请号：PCT/US2015018720
申请日：2015-03-04
申请人： UNIV GEORGIA , DHAR SHANTA , PATHAK RAKESH K , POPIK VLADIMIR V , MCNITT CHRISTOPHER D
发明人： DHAR SHANTA , PATHAK RAKESH K , POPIK VLADIMIR V , MCNITT CHRISTOPHER D
IPC分类号： C07D491/04 , C07D487/04
CPC分类号： C07F15/0093 , C07D225/08 , C07D249/16 , C07D261/20 , C07D271/12 , C07D487/04 , C07D498/04
摘要： Reactions of 1,3-dipole-functional (e.g., azide-functional) platinum(IV) compounds with cyclic alkynes under conditions effective for a cycloaddition reaction to form a heterocyclic compound are disclosed herein. In certain embodiments, the conditions effective for the cycloaddition reaction to form the heterocyclic compound includes the substantial absence of added catalyst (e.g., copper catalyst).
摘要翻译：本文公开了1,3-偶极官能的（例如叠氮官能的）铂（IV）化合物与环状炔烃在有效进行环加成反应以形成杂环化合物的条件下的反应。在某些实施方案中，有效用于形成杂环化合物的环加成反应的条件包括基本不添加催化剂（例如铜催化剂）。

5. 发明申请

WO2013012628A3 IMMUNE-STIMULATING PHOTOACTIVE HYBRID NANOPARTICLES 审中-公开
标题翻译：免疫刺激光学杂交纳米颗粒
公开(公告)号：WO2013012628A3
公开(公告)日：2013-05-10
申请号：PCT/US2012046171
申请日：2012-07-11
申请人： UNIV GEORGIA , DHAR SHANTA , CHOI JOSHUA , MARRACHE SEAN
发明人： DHAR SHANTA , CHOI JOSHUA , MARRACHE SEAN
IPC分类号： A61K47/48 , A61K9/14 , A61K9/16 , A61K47/30 , A61P35/00
CPC分类号： A61K47/48915 , A61K41/0071
摘要： Provides is a therapeutic technology that combines the phototoxic and immune- stimulating ability of photodynamic therapy with the widespread effectiveness of the immune system to reduce the viability of such as cancer cells and tumors. The nanoparticle compositions of the disclosure combine an immunostimulant with a photosensitizer using a nanoparticle delivery platform. For example, zinc pthalocyanine, which is a long-wavelength absorbing photosensitizer, integrated into a polymeric nanoparticle core made up of poly(D, L-lactic-co-glycolic acid)-b-poly(ethylene glycol) (PLGA-b-PEG). The outside surface of the core can be coated with metallic nanoparticles, which are then modified with CpG- ODN. Metastatic mouse breast carcinoma cells showed significant photocytotoxicity of the hybrid after irradiation with a 660 nm LASER light and this activity was remarkably better than either treatment alone. Treatment of mouse bone marrow derived dendritic cells with the photodynamic therapy-killed 4T1 cell lysate showed that the combination of photodynamic therapy with a synerg istic immunostimulant in a single nanoparticle system resulted in an immune response suitable for the treatment of such as a metastatic cancer.
摘要翻译：提供一种治疗技术，将光动力疗法的光毒性和免疫刺激能力与免疫系统的广泛有效性相结合，以降低癌细胞和肿瘤的生存能力。本公开的纳米颗粒组合物使用纳米颗粒递送平台将免疫刺激剂与光敏剂组合。例如，作为长波长吸收光敏剂的锌酞菁聚合在由聚（D，L-乳酸 - 共 - 乙醇酸）-b-聚（乙二醇）（PLGA-b- PEG）。芯的外表面可以涂覆金属纳米粒子，然后用CpG-ODN进行修饰。转移性小鼠乳腺癌细胞在用660nm激光照射后显示杂合物的显着的光细胞毒性，并且该活性显着优于单独的任一种治疗。用光动力疗法杀死的4T1细胞裂解物处理小鼠骨髓衍生的树突状细胞显示，单一纳米颗粒系统中光动力学治疗与协同免疫刺激剂的组合导致适合于治疗转移性癌症的免疫应答。

6. 发明申请

WO2011084620A3 PARTICLES FOR MULTIPLE AGENT DELIVERY 审中-公开
标题翻译：多种代理商交付的颗粒
公开(公告)号：WO2011084620A3
公开(公告)日：2011-11-17
申请号：PCT/US2010060814
申请日：2010-12-16
申请人： BRIGHAM & WOMENS HOSPITAL , MASSACHUSETTS INST TECHNOLOGY , FAROKHZAD OMID C , KOLISHETTI NAGESH , DHAR SHANTA , LIPPARD STEPHEN J , LANGER ROBERT S
发明人： FAROKHZAD OMID C , KOLISHETTI NAGESH , DHAR SHANTA , LIPPARD STEPHEN J , LANGER ROBERT S
IPC分类号： A61K47/48 , A61K9/20 , A61K9/22 , A61K47/30 , A61P25/28 , A61P35/00
CPC分类号： A61K45/06 , A61K47/593 , A61K47/60 , A61K47/6937
摘要： Delivery compositions are provided that include two or more active agents, wherein at least one active agent is conjugated to a polymer. The delivery compositions allow for controlled release of multiple active agents, including active agents with varying solubility, charge, and/or molecular weight.
摘要翻译：提供包含两种或更多种活性剂的递送组合物，其中至少一种活性剂与聚合物缀合。递送组合物允许控制释放多种活性剂，包括具有不同溶解度，电荷和/或分子量的活性剂。

7. 发明申请

WO2010047765A2 NANOSTRUCTURES FOR DRUG DELIVERY 审中-公开
标题翻译：用于药物递送的纳米结构
公开(公告)号：WO2010047765A2
公开(公告)日：2010-04-29
申请号：PCT/US2009005687
申请日：2009-10-20
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL , LIPPARD STEPHEN J , DHAR SHANTA , FAROKHZAD OMID C , KOLISHETTI NAGESH , GU FRANK X
发明人： LIPPARD STEPHEN J , DHAR SHANTA , FAROKHZAD OMID C , KOLISHETTI NAGESH , GU FRANK X
IPC分类号： A61K9/16 , A61K33/24 , A61P13/08
CPC分类号： A61K9/48 , A61K9/143 , A61K31/555 , A61K33/24 , A61K47/48092 , A61K47/48869 , A61K47/48915 , A61K47/549 , A61K47/6925 , A61K47/6937 , B82Y5/00
摘要： The present invention provides compositions, preparations, formulations, kits, and methods useful for treating subjects having cancer or at risk of developing cancer. Some embodiments of the invention may comprise a composition comprising a plurality of particles comprising a platinum(IV) therapeutically active precursor.
摘要翻译：本发明提供了可用于治疗患有癌症或有癌症发生危险的受试者的组合物，制剂，制剂，试剂盒和方法。本发明的一些实施方案可以包含包含多个包含铂（IV）治疗活性前体的颗粒的组合物。

8. 发明申请

WO2010047765A3 NANOSTRUCTURES FOR DRUG DELIVERY 审中-公开
标题翻译：用于药物递送的纳米结构
公开(公告)号：WO2010047765A3
公开(公告)日：2010-07-22
申请号：PCT/US2009005687
申请日：2009-10-20
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL , LIPPARD STEPHEN J , DHAR SHANTA , FAROKHZAD OMID C , KOLISHETTI NAGESH , GU FRANK X
发明人： LIPPARD STEPHEN J , DHAR SHANTA , FAROKHZAD OMID C , KOLISHETTI NAGESH , GU FRANK X
IPC分类号： A61K9/16 , A61K33/24 , A61P13/08
CPC分类号： A61K9/48 , A61K9/143 , A61K31/555 , A61K33/24 , A61K47/48092 , A61K47/48869 , A61K47/48915 , A61K47/549 , A61K47/6925 , A61K47/6937 , B82Y5/00
摘要： The present invention provides compositions, preparations, formulations, kits, and methods useful for treating subjects having cancer or at risk of developing cancer. Some embodiments of the invention may comprise a composition comprising a plurality of particles comprising a platinum(IV) therapeutically active precursor.
摘要翻译：本发明提供了用于治疗患有癌症或处于癌症风险中的对象的组合物，制剂，制剂，试剂盒和方法。本发明的一些实施方案可以包含含有多个包含铂（IV）治疗活性前体的颗粒的组合物。

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