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1. 发明申请

WO0140188A8 CURCUMIN ANALOGUES FOR TREATING CANCER 审中-公开
标题翻译：用于治疗癌症的CURCUMIN ANALOGUES
公开(公告)号：WO0140188A8
公开(公告)日：2003-11-13
申请号：PCT/US0032870
申请日：2000-12-04
申请人： UNIV EMORY , SNYDER JAMES P , DAVIS MATTHEW C , ADAMS BRIAN , SHOJI MAMORU , LIOTTA DENNIS C , FERSTL EVA M , SUNAY USTUN B
发明人： SNYDER JAMES P , DAVIS MATTHEW C , ADAMS BRIAN , SHOJI MAMORU , LIOTTA DENNIS C , FERSTL EVA M , SUNAY USTUN B
IPC分类号： C07D317/54 , A61K31/065 , A61K31/10 , A61K31/121 , A61K31/122 , A61K31/15 , A61K31/351 , A61K31/352 , A61K31/36 , A61K31/404 , A61K31/4439 , A61K31/45 , A61K31/4545 , A61K31/46 , A61P35/00 , A61P43/00 , C07C33/28 , C07C33/48 , C07C43/23 , C07C45/29 , C07C45/62 , C07C45/74 , C07C49/233 , C07C49/235 , C07C49/248 , C07C49/255 , C07C49/697 , C07C49/747 , C07C49/753 , C07C225/22 , C07C235/34 , C07C251/40 , C07C275/24 , C07C317/10 , C07C317/18 , C07C321/20 , C07D209/34 , C07D213/63 , C07D213/68 , C07D295/205 , C07D309/20 , C07D309/22 , C07D309/38 , C07D311/58 , C07D317/50 , C07D401/06 , C07D401/14 , C07D451/02 , C07D451/06
CPC分类号： C07D295/205 , C07C45/292 , C07C45/62 , C07C45/74 , C07C49/233 , C07C49/235 , C07C49/248 , C07C49/255 , C07C49/697 , C07C49/747 , C07C49/753 , C07C225/22 , C07C235/34 , C07C251/40 , C07C275/24 , C07C317/10 , C07C321/20 , C07D209/34 , C07D213/63 , C07D317/50 , C07D451/02
摘要： The present invention is directed to curcumin analogs (I), wherein Y is OH, halogen, or CF3; Z is H, OH, OR1, halogen, or CF3; X1 and X2 are independently C or N; and A is as defined in the application; exhibiting anti-tumor and anti-angiogenic properties, pharmaceutical formulations including such compounds and methods of using such compounds.
摘要翻译：本发明涉及姜黄素类似物（I），其中Y是OH，卤素或CF 3; Z是H，OH，OR 1，卤素或CF 3; X1和X2独立地为C或N; 和A如申请中所定义; 显示抗肿瘤和抗血管生成性质，包括这些化合物的药物制剂和使用这些化合物的方法。

2. 发明申请

WO0140188A9 CURCUMIN ANALOGUES FOR TREATING CANCER 审中-公开
标题翻译：用于治疗癌症的CURCUMIN ANALOGUES
公开(公告)号：WO0140188A9
公开(公告)日：2002-07-25
申请号：PCT/US0032870
申请日：2000-12-04
申请人： UNIV EMORY , SNYDER JAMES P , DAVIS MATTHEW C , ADAMS BRIAN , SHOJI MAMORU , LIOTTA DENNIS C , FERSTL EVA M , SUNAY USTUN B
发明人： SNYDER JAMES P , DAVIS MATTHEW C , ADAMS BRIAN , SHOJI MAMORU , LIOTTA DENNIS C , FERSTL EVA M , SUNAY USTUN B
IPC分类号： C07D317/54 , A61K31/065 , A61K31/10 , A61K31/121 , A61K31/122 , A61K31/15 , A61K31/351 , A61K31/352 , A61K31/36 , A61K31/404 , A61K31/4439 , A61K31/45 , A61K31/4545 , A61K31/46 , A61P35/00 , A61P43/00 , C07C33/28 , C07C33/48 , C07C43/23 , C07C45/29 , C07C45/62 , C07C45/74 , C07C49/233 , C07C49/235 , C07C49/248 , C07C49/255 , C07C49/697 , C07C49/747 , C07C49/753 , C07C225/22 , C07C235/34 , C07C251/40 , C07C275/24 , C07C317/10 , C07C317/18 , C07C321/20 , C07D209/34 , C07D213/63 , C07D213/68 , C07D295/205 , C07D309/20 , C07D309/22 , C07D309/38 , C07D311/58 , C07D317/50 , C07D401/06 , C07D401/14 , C07D451/02 , C07D451/06
CPC分类号： C07D295/205 , C07C45/292 , C07C45/62 , C07C45/74 , C07C49/233 , C07C49/235 , C07C49/248 , C07C49/255 , C07C49/697 , C07C49/747 , C07C49/753 , C07C225/22 , C07C235/34 , C07C251/40 , C07C275/24 , C07C317/10 , C07C321/20 , C07D209/34 , C07D213/63 , C07D317/50 , C07D451/02
摘要： The present invention is directed to curcumin analogs (I), wherein Y is OH, halogen, or CF3; Z is H, OH, OR1, halogen, or CF3; X1 and X2 are independently C or N; and A is as defined in the application; exhibiting anti-tumor and anti-angiogenic properties, pharmaceutical formulations including such compounds and methods of using such compounds.
摘要翻译：本发明涉及姜黄素类似物（I），其中Y是OH，卤素或CF 3; Z是H，OH，OR 1，卤素或CF 3; X1和X2独立地为C或N; 和A如申请中所定义; 显示抗肿瘤和抗血管生成性质，包括这些化合物的药物制剂和使用这些化合物的方法。

3. 发明申请

WO2005025623A2 CYTOTOXIC COMPOUND-PROTEIN CONJUGATES AS SUPPRESSORS OF TUMOR GROWTH AND ANGIOGENESIS 审中-公开
标题翻译：作为肿瘤生长和血管生成抑制因子的细胞毒素化合物 - 蛋白质结合蛋白
公开(公告)号：WO2005025623A2
公开(公告)日：2005-03-24
申请号：PCT/US2004024490
申请日：2004-07-28
申请人： UNIV EMORY , SHOJI MAMORU , SNYDER JAMES P , LIOTTA DENNIS C , SUN AIMING
发明人： SHOJI MAMORU , SNYDER JAMES P , LIOTTA DENNIS C , SUN AIMING
IPC分类号： A61K47/48
CPC分类号： A61K47/6849 , A61K47/642
摘要： Compositions and methods are provided for delivering cytotoxic compounds, such as natural curcumoids and synthetic curcumin analogs, specifically to cancer cells and to blood vessels that nourish solid tumors. The compositions include a cytotoxic drug tethered to a protein, such as factor VIIa, which can bind with high affinity to a receptor, such as tissue factor, expressed on the surface of cancer cells and vascular endothelial cells within the tumor microenvironment. Upon binding, the drug-protein-receptor complex is endocytosed and the drug is subsequently liberated inside the target cell via proteolytic cleavage. The compositions and methods may increase the efficacy of the cytotoxic agets and decrease their side effects by delivering the agents to specific target cells, such as cancer cells, vascular endothelial cells in a tumor, and metastatic foci anywhere in the body, providing the target cells express surface bound tissue factor. Additionally, methods of synthesis of cytotoxic compound-protein conjugates are provided, for example, curcuminoid-tetherlinker-factor VIIa composition, as well as pharmaceutically acceptable compositions and methods for delivering a therapeutically-effective amount of a cytotoxic compound-protein conjugate together with one or more pharmaceutically acceptable carriers (additives) and/or diluents to an animal or human patient.
摘要翻译：提供组合物和方法用于递送细胞毒性化合物，例如天然的姜黄素和合成的姜黄素类似物，特别是癌细胞和滋养实体瘤的血管。组合物包括与诸如因子VIIa结合的蛋白质的细胞毒性药物，其可以高度亲和力结合到在肿瘤微环境中在癌细胞表面和血管内皮细胞表面上的受体，例如组织因子。结合后，药物 - 蛋白 - 受体复合物被内吞，并且药物随后通过蛋白水解切割在靶细胞内释放。组合物和方法可以通过将药物递送到特定靶细胞，例如肿瘤中的癌细胞，血管内皮细胞和体内任何地方的转移灶，来增加细胞毒性作用的功效并降低其副作用，提供靶细胞表达结合组织因子。此外，提供了合成细胞毒性化合物 - 蛋白质缀合物的方法，例如，姜黄素 - tetherlinker-factor VIIa组合物，以及用于将治疗有效量的细胞毒性化合物 - 蛋白质缀合物与一种或更多的药学上可接受的载体（添加剂）和/或稀释剂给动物或人类患者。

4. 发明申请

WO0219332A3 OPTICAL DISC AND PHYSICAL ADDRESS FORMAT 审中-公开
标题翻译：光盘和物理地址格式
公开(公告)号：WO0219332A3
公开(公告)日：2002-10-31
申请号：PCT/JP0107449
申请日：2001-08-29
申请人： MATSUSHITA ELECTRIC IND CO LTD , NAKAMURA ATSUSHI , MINAMINO JUNICHI , FURUMIYA SHIGERU , SHOJI MAMORU , ISHIDA TAKASHI , ISHIBASHI HIROMICHI
发明人： NAKAMURA ATSUSHI , MINAMINO JUNICHI , FURUMIYA SHIGERU , SHOJI MAMORU , ISHIDA TAKASHI , ISHIBASHI HIROMICHI
IPC分类号： G11B7/007 , G11B20/12 , G11B27/19 , G11B27/24 , G11B27/30
CPC分类号： G11B20/00601 , G11B7/0053 , G11B7/24082 , G11B20/10 , G11B20/12 , G11B20/1217 , G11B20/1833 , G11B27/19 , G11B27/24 , G11B27/3027 , G11B2020/1222 , G11B2020/1232 , G11B2020/1239 , G11B2020/1268 , G11B2020/1298 , G11B2220/20 , G11B2220/235 , G11B2220/2537
摘要： An optical disc medium compares a track groove, along which main information is recorded. The track groove is divided into a plurality of blocks. The plurality of blocks each include a plurality of frames. The plurality of frames each include one shape of wobbles indicating sub information, among a plurality of prescribed shapes of wobbles. The plurality of blocks each have address information. The address information is represented by a string of at least one piece of sub information represented by the shape of wobbles of at least one of the plurality of frames.
摘要翻译：光盘介质比较记录主要信息的轨道槽。轨道槽被分成多个块。多个块各自包括多个帧。在多个规定形状的摆动中，多个帧各自包括指示子信息的一种摆动形状。多个块各具有地址信息。地址信息由至少一条由多个帧中的至少一个的摆动形状表示的子信息的字符串表示。

5. 发明申请

WO0154119A3 OPTICAL RECORDING MEDIUM, OPTICAL REPRODUCTION APPARATUS, AND OPTICAL REPRODUCTION METHOD 审中-公开
标题翻译：光学记录介质，光学再现设备和光学再现方法
公开(公告)号：WO0154119A3
公开(公告)日：2002-02-14
申请号：PCT/JP0100422
申请日：2001-01-23
申请人： MATSUSHITA ELECTRIC IND CO LTD , NAKAMURA ATSUSHI , SHOJI MAMORU , ISHIDA TAKASHI , MINAMINO JUNICHI , KOBAYASHI YOSHIHARU , ISHIBASHI HIROMICHI , FURUMIYA SHIGERU
发明人： NAKAMURA ATSUSHI , SHOJI MAMORU , ISHIDA TAKASHI , MINAMINO JUNICHI , KOBAYASHI YOSHIHARU , ISHIBASHI HIROMICHI , FURUMIYA SHIGERU
IPC分类号： G11B7/24 , G11B7/007 , G11B20/12 , G11B27/19 , G11B27/24 , G11B27/30
CPC分类号： G11B27/24 , G11B7/007 , G11B7/00718 , G11B7/00745 , G11B20/1217 , G11B27/3027 , G11B2020/1232 , G11B2020/1267 , G11B2020/1292 , G11B2220/216 , G11B2220/235 , G11B2220/237 , G11B2220/2575
摘要： An optical recording medium comprises a plurality of identifiers (106, 107) in association with address information (108), wherein: each identifier is provided on the optical recording medium; and each identifier comprises at least one of: a first pattern provided on the optical recording medium and representing a first code expressed by one bit; a second pattern provided on the optical recording medium and representing a second code expressed by one bit; and a third pattern provided on the optical recording medium and representing a third code expressed by one bit.
摘要翻译：光记录介质包括与地址信息（108）相关联的多个标识符（106,107），其中：每个标识符设置在光学记录介质上; 并且每个标识符包括以下中的至少一个：设置在所述光学记录介质上并表示由一位表示的第一代码的第一图案; 设置在光学记录介质上并表示由一位表示的第二代码的第二图案; 以及设置在光学记录介质上并表示由一位表示的第三代码的第三图案。

6. 发明申请

WO0225645A3 OPTICAL DISC AND A REPRODUCTION METHOD, REPRODUCTION APPARATUS, AND RECORDING APPARATUS FOR THE SAME 审中-公开
标题翻译：光盘和复制方法，复制装置和记录装置
公开(公告)号：WO0225645A3
公开(公告)日：2002-11-28
申请号：PCT/JP0108267
申请日：2001-09-21
申请人： MATSUSHITA ELECTRIC IND CO LTD , SHOJI MAMORU , NAKAMURA ATSUSHI , ISHIDA TAKASHI , ISHIBASHI HIROMICHI , MIYASHITA HARUMITSU , SENGA HISASHI , TAKAHASHI RIE
发明人： SHOJI MAMORU , NAKAMURA ATSUSHI , ISHIDA TAKASHI , ISHIBASHI HIROMICHI , MIYASHITA HARUMITSU , SENGA HISASHI , TAKAHASHI RIE
IPC分类号： G11B7/005 , G11B7/007 , G11B7/013 , G11B19/12 , G11B20/00 , G11B20/12 , G11B23/28 , G11B23/30
CPC分类号： G11B20/0021 , G11B7/0053 , G11B7/007 , G11B7/24085 , G11B20/00086 , G11B20/00094 , G11B20/00115 , G11B20/00304 , G11B20/00311 , G11B20/00405 , G11B20/00492 , G11B20/00507 , G11B20/00514 , G11B20/00528 , G11B20/00557 , G11B20/00586 , G11B20/00594 , G11B20/00601 , G11B20/00739 , G11B20/1217 , G11B23/284
摘要： An optical disk, and a method and apparatus for reproducing and/or recording data to the disk are provided for preventing illegal copying of authorized disks recording copyrighted digital content. The optical disk 10 has a control area 12 for storing control data, a data area 14 for storing main digital data (content), and an identification area 13 for storing sub-digital data specific to the main digital data. The sub-digital data is recorded as a pit sequence (R1, R3, R5) at a locally phase modulated clock timing. When disk identification data is recorded as the sub-digital data, key information stored to the reproduction apparatus is compared with identification data (sub-digital data) detected from jitter fluctuations in the identification area 13 when content is reproduced from the optical disk 10. If a specific correlation is thus confirmed, the disk is recognized as a legally copied disk and reproduction is enabled. Illegal copies can thus be prevented.
摘要翻译：提供光盘，以及用于再现和/或记录数据到磁盘的方法和装置，用于防止非法拷贝记录受版权保护的数字内容的授权磁盘。光盘10具有用于存储控制数据的控制区域12，用于存储主数字数据（内容）的数据区域14以及用于存储专用于主数字数据的子数字数据的识别区域13。在本地相位调制时钟定时，子数字数据被记录为凹坑序列（R1，R3，R5）。当磁盘识别数据被记录为子数字数据时，将存储到再现装置的密钥信息与从光盘10再现内容时识别区域13中的抖动波动检测到的识别数据（子数字数据）进行比较。如果确定了具体的相关性，则将该盘识别为合法复制的盘并且使能再生。因此可以防止非法副本。

7. 发明申请

WO0235529A3 OPTICAL DISC, RECORDING APPARATUS AND METHOD, AND REPRODUCTION APPARATUS AND METHOD 审中-公开
标题翻译：光盘，记录装置和方法以及再现装置和方法
公开(公告)号：WO0235529A3
公开(公告)日：2002-07-25
申请号：PCT/JP0109430
申请日：2001-10-26
申请人： MATSUSHITA ELECTRIC IND CO LTD , NAGAI TAKAHIRO , ISHIHARA HIDESHI , YUMIBA TAKASHI , TAKAHASHI RIE , SHOJI MAMORU , YAMAGUCHI HIROYUKI , MIYASHITA HARUMITSU
发明人： NAGAI TAKAHIRO , ISHIHARA HIDESHI , YUMIBA TAKASHI , TAKAHASHI RIE , SHOJI MAMORU , YAMAGUCHI HIROYUKI , MIYASHITA HARUMITSU
IPC分类号： G11B7/007 , G11B7/013 , G11B7/24085 , G11B20/00 , G11B27/30 , G11B23/28 , G11B23/36
CPC分类号： G11B20/0021 , G11B7/007 , G11B7/00745 , G11B7/24085 , G11B20/00086 , G11B20/00268 , G11B20/00376 , G11B20/00586 , G11B20/00594 , G11B20/0071 , G11B20/00768 , G11B20/10 , G11B27/3027 , G11B2220/2562
摘要： An optical disc having a plurality of sectors, each of which includes a plurality of frames. Sub information bit value "0" or "1" is assigned to the plurality of frames constituting a sector, excluding the first and last frames. Edge positions are displaced so that leading/lagging errors appear in accordance with a certain rule when data fields of the frames to which sub information bit value "1" is assigned are read. Edge positions are displaced so that leading/lagging errors appear in accordance with a reversed rule of the certain rule when data fields of the frames to which sub information bit value "0" is assigned are read.
摘要翻译：一种具有多个扇区的光盘，每个扇区包括多个帧。副信息比特值“0”或“1”被分配给构成一个扇区的多个帧，不包括第一帧和最后一帧。当读取分配了子信息比特值“1”的帧的数据字段时，边缘位置被移位，从而根据一定规则出现前/后误差。当读取分配有子信息位值“0”的帧的数据字段时，边缘位置被移位，从而根据特定规则的反向规则出现前导/滞后误差。

8. 发明申请

WO03075847A2 NOVEL CURCUMINOID-FACTOR VIIa CONSTRUCTS AS SUPPRESSORS OF TUMOR GROWTH AND ANGIOGENESIS 审中-公开
标题翻译：新型凝血因子VIIa作为肿瘤生长抑制素和血管生成的结构
公开(公告)号：WO03075847A2
公开(公告)日：2003-09-18
申请号：PCT/US0307043
申请日：2003-03-07
申请人： UNIV EMORY
发明人： SHOJI MAMORU , SYNDER JAMES , LIOTTA DENNIS C , SUN AIMING
IPC分类号： A61K31/45 , A61K45/00 , A61K47/42 , A61K47/48 , A61P1/16 , A61P9/00 , A61P11/00 , A61P15/00 , A61P17/00 , A61P19/00 , A61P27/02 , A61P29/00 , A61P35/00 , A61P35/02 , C07D213/63 , C07K14/745 , C12N9/64 , A61K
CPC分类号： C12Y304/21021 , A61K47/64 , A61K47/6425 , C07D213/63 , C12N9/6437
摘要： The fluorinated curcuminoid (3,5-bis-(2-fluorobenzylidene)-piperidin-4-one-acetate is about ten times more effective at arresting the growth of tumor cells than cisplatin. The present invention provides methods to deliver a cytotoxic compound, such as a curcuminoid, specifically to cancer cells and to the vascular endothelial cells that nourish solid tumors. The method involves tethering the drug to a protein such as in factor VIIa that retains high affinity for the surface protein tissue factor. Upon complexation, the resulting heterodimer is endocytosed and the drug is subsequently liberated inside the target cell via proteolytic cleavage. The present invention further provides for the synthesis of novel curcuminoid-tether-linker-factor VIIa compositions and for methods of delivery of effective doses of the novel compositions to target tumor or endothelial cells in a patient.
摘要翻译：氟化姜黄素（3,5-双 - （2-氟亚苄基） - 哌啶-4-酮乙酸酯在阻止肿瘤细胞生长方面比顺铂高约十倍。本发明提供递送细胞毒性化合物的方法，例如姜黄素，特别是癌细胞和滋养实体瘤的血管内皮细胞，该方法涉及将药物系在蛋白质上，例如对表面蛋白组织因子保持高亲和力的因子VIIa，在复合后，产生异二聚体被内吞，并且药物随后通过蛋白水解切割在靶细胞内释放。本发明还提供了新型姜黄素 - 连接子 - 连接因子VIIa组合物的合成和用于将有效剂量的新组合物递送至靶肿瘤或内皮细胞。

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