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1. 发明申请

WO2007120675A3 METHOD OF DETECTING GENETIC MUTATIONS 审中-公开
标题翻译：检测遗传突变的方法
公开(公告)号：WO2007120675A3
公开(公告)日：2008-10-09
申请号：PCT/US2007008857
申请日：2007-04-10
申请人： UNIV DUKE , GAO FENG , ZHU JUN
发明人： GAO FENG , ZHU JUN
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6827
摘要： The present invention relates to a method of detecting genetic variants, including genetic variants associated with drug resistance, cancer and genetic dysfunctional diseases.
摘要翻译：本发明涉及一种检测遗传变异体的方法，包括与耐药性，癌症和遗传功能障碍性疾病相关的遗传变异。

2. 发明申请

WO2008118470A3 ACUTE TRANSMITTED HIV ENVELOPE SIGNATURES 审中-公开
标题翻译：急性传播HIV感染信号
公开(公告)号：WO2008118470A3
公开(公告)日：2010-03-11
申请号：PCT/US2008003965
申请日：2008-03-27
申请人： UNIV CALIFORNIA , UNIV DUKE , UNIV ALABAMA , UNIV NORTH CAROLINA , HAYNES BARTON F , KORBER BETTE T , HAHN BEATRICE H , BHATTACHARYA TANMOY , GNANAKARAN GNANA S , GAO FENG , SWANSTROM RON , SHAW GEORGE
发明人： HAYNES BARTON F , KORBER BETTE T , HAHN BEATRICE H , BHATTACHARYA TANMOY , GNANAKARAN GNANA S , GAO FENG , SWANSTROM RON , SHAW GEORGE
IPC分类号： A61K39/21
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , C12N2740/16122 , C12N2740/16134
摘要： The present invention relates, in general, to human immunodeficiency virus (HIV) and, in particular, to a method of inducing an immune response to HIV in a patient and to immunogens suitable for use in such a method. The invention also relates to diagnostic test kits and methods of using same.
摘要翻译：本发明一般涉及人类免疫缺陷病毒（HIV），特别涉及在患者中诱导对HIV的免疫应答的方法以及适用于这种方法的免疫原。本发明还涉及诊断测试试剂盒及其使用方法。

3. 发明申请

WO2008063586A2 MULTICOMPONENT VACCINE 审中-公开
标题翻译：多组分疫苗
公开(公告)号：WO2008063586A2
公开(公告)日：2008-05-29
申请号：PCT/US2007024122
申请日：2007-11-19
申请人： UNIV DUKE , HAYNES BARTON F , SMITH NANCY G , ALAM S MUNIR , GAO FENG , LIAO HUA-XIN
发明人： HAYNES BARTON F , SMITH NANCY G , ALAM S MUNIR , GAO FENG , LIAO HUA-XIN
IPC分类号： A61K48/00
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K39/385 , A61K39/39 , A61K39/39533 , A61K39/3955 , A61K39/42 , A61K2039/5256 , A61K2039/53 , A61K2039/55516 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , A61K2039/6018 , C07K2319/04 , C12N15/86 , C12N2740/16122 , C12N2740/16134 , C12N2760/20243
摘要： The present invention relates, in general, to human immunodeficiency virus (HIV) and, in particular, to a multicomponent vaccine and method of using same to protect against HTV-I infection.
摘要翻译：本发明一般涉及人类免疫缺陷病毒（HIV），并且特别涉及多组分疫苗和使用其来防止HIV-1感染的方法。

4. 发明申请

WO2011139385A3 GENETIC SIGNATURES IN HIV-1 SUBTYPE C ENVELOPE GLYCOPROTEINS 审中-公开
标题翻译： HIV-1亚型C包裹糖蛋白的遗传信号
公开(公告)号：WO2011139385A3
公开(公告)日：2012-06-14
申请号：PCT/US2011000810
申请日：2011-05-09
申请人： UNIV DUKE , LOS ALAMOS NAT SECURITY LLC , MUSONDA ROSEMARY , HAYNES BARTON F , GAO FENG , KORBER BETTE T , MONTEFIORI DAVID
发明人： MUSONDA ROSEMARY , HAYNES BARTON F , GAO FENG , KORBER BETTE T , MONTEFIORI DAVID
IPC分类号： C07K14/155 , A61K39/21 , A61K39/42 , A61P29/00 , A61P31/18 , C12N15/49
CPC分类号： A61K39/42 , A61K39/12 , A61K39/21 , A61K2039/53 , C07K14/005 , C12N2740/16122 , C12N2740/16134
摘要： The present invention relates, in general, to HIV-1 and, in particular, to immunogens that elicit broadly neutralizing antibodies against HIV-1 subtype C envelope glycoproteins, and compositions comprising same. The invention further relates to methods of inducing the production of such antibodies in a subject.
摘要翻译：本发明一般涉及HIV-1，特别是涉及引起针对HIV-1亚型C包膜糖蛋白的广泛中和抗体的免疫原，以及包含其的组合物。本发明还涉及在受试者中诱导产生这种抗体的方法。

5. 发明申请

WO2011126576A2 GENETIC SIGNATURES IN THE ENVELOPE GLYCOPROTEIN OF HIV-1 审中-公开
标题翻译：艾滋病毒1型糖尿病的遗传标志
公开(公告)号：WO2011126576A2
公开(公告)日：2011-10-13
申请号：PCT/US2011000642
申请日：2011-04-11
申请人： UNIV DUKE , LOS ALAMOS NAT SECURITY LLC , HAYNES BARTON F , MONTEFIORI DAVID C , LIAO HUA-XIN , GAO FENG , KORBER BETTE K , GNANAKARAN S , DANIELS MARCUS G , BHATTACHARYA TANMOY , LAPEDES ALAN S
发明人： HAYNES BARTON F , MONTEFIORI DAVID C , LIAO HUA-XIN , GAO FENG , KORBER BETTE K , GNANAKARAN S , DANIELS MARCUS G , BHATTACHARYA TANMOY , LAPEDES ALAN S
IPC分类号： C07K14/155 , A61K39/12 , A61P31/18 , C07K16/10 , C12N15/49
CPC分类号： C07K16/1045 , A61K39/00 , A61K39/12 , A61K39/21 , C07K14/005 , C07K2317/34 , C07K2317/76 , C12N7/00 , C12N2740/16122 , C12N2740/16134 , C12N2760/16023
摘要： The present invention relates, in general, to HIV-1 and, in particular, to immunogens that elicit broadly neutralizing antibodies against HIV-1, and compositions comprising same. The invention further relates to methods of inducing the production of such antibodies in a subject.
摘要翻译：本发明一般涉及HIV-1，特别涉及引发广泛中和抗HIV-1的抗体的免疫原，以及包含其的组合物。本发明还涉及在受试者中诱导产生这种抗体的方法。

6. 发明申请

WO2005028625A2 CONSENSUS/ANCESTRAL IMMUNOGENS 审中-公开
标题翻译：一致/反应原免疫
公开(公告)号：WO2005028625A2
公开(公告)日：2005-03-31
申请号：PCT/US2004030397
申请日：2004-09-17
申请人： UNIV DUKE , HAYNES BARTON F , GAO FENG , KORBER BETTE T , HAHN BEATRICE H , SHAW GEORGE M , KOTHE DENISE , LI YING YING , DECKER JULIE , LIAO HUA-XIN
发明人： HAYNES BARTON F , GAO FENG , KORBER BETTE T , HAHN BEATRICE H , SHAW GEORGE M , KOTHE DENISE , LI YING YING , DECKER JULIE , LIAO HUA-XIN
IPC分类号： A61K39/21 , C07H21/04 , C12N20060101 , C12N5/02 , C12N15/74 , C12N
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/53 , A61K2039/57 , C07K14/005 , C07K16/4225 , C12N2740/15022 , C12N2740/15034 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16322
摘要： The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralizes a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.
摘要翻译：本发明一般涉及免疫原，特别涉及用于诱导中和广谱HIV原发分离株和/或诱导T细胞免疫应答的免疫原的抗体的免疫原。本发明还涉及使用这种免疫原诱导抗HIV抗体的方法，和/或诱导T细胞免疫应答的方法。本发明还涉及编码本发明免疫原的核酸序列。

7. 发明申请

WO2010082066A3 SURFACE CHARACTERISTIC DETERMINING APPARATUS 审中-公开
标题翻译：表面特征测定装置
公开(公告)号：WO2010082066A3
公开(公告)日：2010-10-14
申请号：PCT/GB2010050063
申请日：2010-01-15
申请人： UNIV HUDDERSFIELD , JIANG XIANGQIAN , WANG KAIWEI , GAO FENG , MUHAMEDSALIH HUSSAM
发明人： JIANG XIANGQIAN , WANG KAIWEI , GAO FENG , MUHAMEDSALIH HUSSAM
IPC分类号： G01B9/02 , G01B11/24
CPC分类号： G01B9/02068 , G01B9/02007 , G01B9/02077 , G01B9/02084 , G01B9/0209 , G01B11/2441 , G01B2290/65
摘要： A wavelength selector (5) selects a wavelength of a broadband light source (4). A light director (BS1, BS2) directs light from the wavelength selector along a measurement path towards a region of a sample surface and along a reference path towards a reference surface,such that light reflected by the region of the sample surface and light reflected by the reference surface interfere to produce an interferogram. A controller (20) controls the wavelength selector to change the wavelength selected by the wavelength selector. A recorder (63) records successive images,each image representing the interferogram produced by a respective one of the wavelengths selected by the wavelength selector. A data processor (18, 180) processes the recorded images to produce at least one of a surface profile and a surface height map of at least a part of the sample surface. The reference path may be controlled to compensate for environmental effects such as vibration, thermal effects and air turbulence. The data processor may use a graphics processing unit to enable pixel data to be processed in parallel.
摘要翻译：波长选择器（5）选择宽带光源（4）的波长。光导向器（BS1，BS2）沿着测量路径将来自波长选择器的光引导到样本表面的区域并且沿着参考路径朝向参考表面，使得由样品表面的区域反射的光和由参考表面干涉以产生干涉图。控制器（20）控制波长选择器改变由波长选择器选择的波长。记录器（63）记录连续的图像，每个图像表示由波长选择器选择的相应一个波长产生的干涉图。数据处理器（18,180）处理所记录的图像以产生至少一部分样品表面的表面轮廓和表面高度图中的至少一个。可以控制参考路径以补偿诸如振动，热效应和空气湍流的环境影响。数据处理器可以使用图形处理单元来并行地处理像素数据。

8. 发明申请

WO2008010982A3 THERMALLY IMAGEABLE DIELECTRIC LAYERS, THERMAL TRANSFER DONORS AND RECEIVERS 审中-公开
标题翻译：热成像介电层，热转印供体和接收器
公开(公告)号：WO2008010982A3
公开(公告)日：2008-03-20
申请号：PCT/US2007016118
申请日：2007-07-16
申请人： DU PONT , ANDREWS GERALD DONALD , BAILEY RICHARD KEVIN , BLANCHET GRACIELA BEATRIZ , CASPAR JONATHAN V , CATRON JOHN W , CHESTERFIELD REID JOHN , GAO FENG , GOLDFINGER MARC B , JAYCOX GARY DELMAR , JOHNSON LYNDA KAYE , MALAJOVICH IRINA , MARSHALL WILLIAM J , MCCORD ELIZABETH FORRESTER , MCEWEN CHARLES NEHEMIAH , METH JEFFREY SCOTT , NUNES GEOFFREY , O'NEIL GERARD , SHANNON PAUL J , SHARP KENNETH GEORGE , VISSCHER KARYN B
发明人： ANDREWS GERALD DONALD , BAILEY RICHARD KEVIN , BLANCHET GRACIELA BEATRIZ , CASPAR JONATHAN V , CATRON JOHN W , CHESTERFIELD REID JOHN , GAO FENG , GOLDFINGER MARC B , JAYCOX GARY DELMAR , JOHNSON LYNDA KAYE , MALAJOVICH IRINA , MARSHALL WILLIAM J , MCCORD ELIZABETH FORRESTER , MCEWEN CHARLES NEHEMIAH , METH JEFFREY SCOTT , NUNES GEOFFREY , O'NEIL GERARD , SHANNON PAUL J , SHARP KENNETH GEORGE , VISSCHER KARYN B
IPC分类号： H01G4/14 , B41M5/26 , B41M5/382 , G02F1/1335 , H01L21/02 , H01L23/532 , H01L51/00
CPC分类号： B41M5/395 , B41M5/38214 , B41M5/46 , B41M5/465 , B41M2205/06 , C08J7/123 , H01G4/18 , H01G4/33 , H01L21/312 , H01L51/0035 , H01L51/0043 , Y10S430/106 , Y10T428/24942 , Y10T428/25 , Y10T428/31909 , Y10T428/31928
摘要： The invention is related to thermal imageable dielectric layers and thermal transfer donors and receivers comprising dielectric layers. The thermal transfer donors are useful in making electronic devices by thermal transfer of dielectric layers having excellent resistivity, good transfer properties and good adhesion to a variety of receivers.
摘要翻译：本发明涉及可热成像的电介质层和包含电介质层的热转印供体和接受体。热转印供体用于通过热转印具有优异电阻率，良好转印性能和对各种接收器的良好附着力的介电层来制造电子器件。

9. 发明申请

WO0182987A8 A PREPARATION METHOD FOR A POROUS FRAMEWORK USED IN THE PROSTHESES OF TISSUE AND ORGANS 审中-公开
标题翻译：用于组织和器官遗传的多孔框架的制备方法
公开(公告)号：WO0182987A8
公开(公告)日：2002-03-14
申请号：PCT/IB0100632
申请日：2001-04-17
申请人： CLONETIC TECHNOLOGIES LTD , UNIV TSINGHUA , HU PING , JIANG LINGFEI , GAO FENG
发明人： HU PING , JIANG LINGFEI , GAO FENG
IPC分类号： A61L27/56 , A61L27/58 , A61L27/00 , A61F2/00 , C08J9/28 , C12N11/00
CPC分类号： A61L27/58 , A61L27/56
摘要： The present invention relates to a preparation method for a porous framework used in the prostheses of tissue and organs. First is to select the pore-forming agent into the degradable polymer in the dissolvent, then put the pore-forming agent into the polymer solution. After mixed even, the mixture is put into the mould and then closed in the mould and dried. After dried, the preparation is knocked out of the mould and dried in the vacuum drying oven. Then the dried preparation is dipped into deionized water or weak acid aqueous solution and dried again thereafter. Thus the porous framework of the present invention is prepared. In this invention, frameworks that require mutually-connected pores and different porosity is prepared by modulating the particle diameters of the pore-forming agent and concentration of the solution.
摘要翻译：本发明涉及用于组织和器官假体的多孔骨架的制备方法。首先是将溶剂中的成孔剂选择成可降解聚合物，然后将成孔剂放入聚合物溶液中。混合均匀后，将混合物放入模具中，然后在模具中封闭并干燥。干燥后，将制备物从模具中敲出并在真空干燥炉中干燥。然后将干燥的制剂浸入去离子水或弱酸水溶液中，然后再干燥。因此，制备本发明的多孔骨架。在本发明中，通过调节成孔剂的粒径和溶液的浓度来制备需要相互连通的孔和不同孔隙率的框架。

10. 发明申请

WO2008010981A2 A PROCESS FOR ENHANCING THE RESOLUTION OF A THERMALLY TRANSFERRED PATTERN 审中-公开
标题翻译：一种增强热转印图案分辨率的方法
公开(公告)号：WO2008010981A2
公开(公告)日：2008-01-24
申请号：PCT/US2007016117
申请日：2007-07-16
申请人： DU PONT , ANDREWS GERALD D , BAILEY RICHARD KEVIN , BLANCHET GRACIELA BEATRIZ , CATRON JOHN W , GAO FENG , JAYCOX GARY DELMAR , JOHNSON LYNDA KAYE , KEUSSEYAN ROUPEN LEON , METH JEFFREY SCOTT , PRINCIPE FRANK S , SCHIFFINO RINALDO S , YOHANNAN ROBERT MAR
发明人： ANDREWS GERALD D , BAILEY RICHARD KEVIN , BLANCHET GRACIELA BEATRIZ , CATRON JOHN W , GAO FENG , JAYCOX GARY DELMAR , JOHNSON LYNDA KAYE , KEUSSEYAN ROUPEN LEON , METH JEFFREY SCOTT , PRINCIPE FRANK S , SCHIFFINO RINALDO S , YOHANNAN ROBERT MAR
IPC分类号： G03F7/20 , G03F7/34
CPC分类号： B41M5/38207 , B41M5/38214 , H01L51/0013 , H01L51/0052 , H01L51/0068 , H01L51/052 , H01L51/0545 , H05K3/046 , H05K3/26 , H05K2201/0761 , H05K2203/0191 , H05K2203/0528 , H05K2203/107
摘要： Provided are processes for improving a thermally transferred pattern on an imaged thermal transfer receiver, wherein the imaged thermal transfer receiver comprises a surface having an exposed portion and a non-exposed portion of one or more thermally transferred layer(s), comprising: (a) contacting said surface with an adhesive layer for a contact period to provide a laminate; (b) separating said adhesive layer from the laminate to provide a treated thermal transfer receiver having a surface substantially free of said non-exposed portion of one or more thermally transferred layer(s). The processes are useful in the fabrication of electronic devices including thin film transistors, circuits, electromagnetic interference shields, touchpad sensors and other electronic devices.
摘要翻译：提供了用于改善成像的热转印接收器上的热转印图案的方法，其中成像的热转印接收器包括具有一个或多个热转印层的暴露部分和未曝光部分的表面，包括：（a ）使所述表面与粘合剂层接触接触期以提供层压体; （b）从所述层压体分离所述粘合剂层以提供经处理的热转印接收器，其具有基本上不含一个或多个热转移层的所述未曝光部分的表面。这些方法在制造包括薄膜晶体管，电路，电磁干扰屏蔽，触摸板传感器和其它电子设备的电子器件中是有用的。

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