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1. 发明申请

WO2010047797A3 SINGLE QUANTUM-DOT-BASED APTAMERIC SENSORS 审中-公开
标题翻译：单个基于量子的APTAMERIC传感器
公开(公告)号：WO2010047797A3
公开(公告)日：2010-06-17
申请号：PCT/US2009005737
申请日：2009-10-21
申请人： UNIV CITY , JOHNSON LAWRENCE W , ZHANG CHUN-YANG
发明人： JOHNSON LAWRENCE W , ZHANG CHUN-YANG
IPC分类号： C12Q1/68 , C12M3/00
CPC分类号： C12Q1/6825 , G01N21/645 , G01N2021/6432 , C12Q2563/107 , C12Q2561/119 , C12Q2525/205
摘要： A signal-off-quantum-dot-based sensor for detecting the presence of a target molecule comprising: an aptamer probe having a nucleotide sequence which specifically interacts with the target molecule by sequence-dependent interaction, wherein the aptamer probe is sandwiched between (a) an oligonucleotide which is immobilized on the surface of a quantum dot (QD), and (b) a fluorophore-labeled oligonucleotide, wherein when the sensor is excited by an energy source: (i) in the absence of specific interaction between the target molecule and the aptamer probe, a baseline signal is emitted, and (ii) in the presence of specific interaction between the target molecule and the aptamer probe, a detection signal is emitted, wherein the baseline signal is greater than the detection signal, whereby the presence of the target molecule is detected.
摘要翻译：一种用于检测靶分子存在的基于信号的量子点的传感器，包括：具有通过序列依赖性相互作用与靶分子特异性相互作用的核苷酸序列的适体探针，其中适体探针夹在（a ）固定在量子点（QD）的表面上的寡核苷酸，和（b）荧光团标记的寡核苷酸，其中当传感器被能量源激发时：（i）在靶之间没有特异性相互作用的情况下分子和适体探针，发射基线信号，和（ii）在目标分子和适体探针之间存在特异性相互作用的情况下，发射检测信号，其中基线信号大于检测信号，由此检测到靶分子的存在。

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