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1. 发明申请

WO2015184084A2 SWEAT MONITORING AND CONTROL OF DRUG DELIVERY 审中-公开
标题翻译：药物传递的SWEAT监测和控制
公开(公告)号：WO2015184084A2
公开(公告)日：2015-12-03
申请号：PCT/US2015032866
申请日：2015-05-28
申请人： UNIV CINCINNATI
发明人： HEIKENFELD JASON C
IPC分类号： A61B5/053 , A61B5/00
CPC分类号： A61B5/14517 , A61B5/0531 , A61B5/14546 , A61B5/4266 , A61B5/4839 , A61B5/6804 , A61B5/6831 , A61M37/0015 , A61M2037/0007 , A61M2037/0023 , A61M2230/005 , A61N1/0412 , A61N1/0448 , A61N1/327
摘要： The concentration of an administered compound, such as a drug (D), in an organ or a bodily fluid, such as blood, is determined directly through detecting the drug (D) or its metabolites (DM) in sweat. The concentration may be determined indirectly by administering the drug (D) together with one or more tracer compounds (T, T2) or metabolites thereof (TM, T2M) or by detecting concentrations and trends of other analytes present in the body that react to the presence of the drug (D). By determining tracer concentration in sweat, the concentration of the drug (D) in blood or an organ can be determined. The tracer (T, T2) is a compound selected for ease of detection in sweat, known metabolic and solubility profiles that correspond to those of the drug (D), and safety of use. A smart transdermal delivery patch (300) is used to administer a dosage of drug to a wearer in coordination with at least one sweat sensor (324) reading conveying information about the wearer.
摘要翻译：通过检测出汗液中的药物（D）或其代谢物（DM），可以直接测定给药化合物（例如药物（D））在器官或体液如血液中的浓度。可以通过将药物（D）与一种或多种示踪剂化合物（T，T2）或其代谢物（TM，T2M）一起施用或通过检测存在于身体中的其它分析物的浓度和趋势来间接测定浓度药物的存在（D）。通过测定汗液中的示踪剂浓度，可以确定血液或器官中药物（D）的浓度。示踪剂（T，T2）是选择用于在汗液中易于检测的化合物，已知的与药物（D）的代谢和溶解度特征对应的代谢和溶解度分布以及使用的安全性。使用智能透皮递送贴片（300），以与至少一个读取关于穿着者的传递信息的汗液传感器（324）协调地向使用者施用一定剂量的药物。

2. 发明申请

WO2015184097A3 DEVICES WITH REDUCED SWEAT VOLUMES BETWEEN SENSORS AND SWEAT GLANDS 审中-公开
标题翻译：具有传感器和SWEAT GLANDS之间的减少量的设备
公开(公告)号：WO2015184097A3
公开(公告)日：2016-01-21
申请号：PCT/US2015032893
申请日：2015-05-28
申请人： UNIV CINCINNATI
发明人： HEIKENFELD JASON C
IPC分类号： A61B5/00 , A61B5/05
CPC分类号： A61B10/0064 , A61B5/0531 , A61B5/0537 , A61B5/14521 , A61B5/4266 , A61B5/6833 , A61B2560/0412
摘要： A sweat sensor device (400c) for sensing sweat on the skin (12) includes one or more sweat sensors (420) and a volume-reducing component that provides a volume-reduced pathway (480) for sweat between the one or more sweat sensors (420) and sweat glands in said skin (12) when the device (400c) is positioned on said skin (12). The volume-reducing component may include a volume -reducing material (470) and a pressure-permeated component (460), a sweat dissolvable material (490), a mechanically compliant material (570) for conforming to the skin (12), an adhesive with a vertically anisotropic sweat pathway, and microcapsules (1385) including a barrier material. The presence of a volume-reducing component reduces the sweat volume and decreases the sampling interval.
摘要翻译：一种用于感测皮肤（12）上的汗水的汗液传感器装置（400c）包括一个或多个汗液传感器（420）和减少体积的部件，其为一个或多个汗液传感器之间的汗液提供体积减小的通道（480）当所述装置（400c）位于所述皮肤（12）上时，所述皮肤（420）和所述皮肤（12）中的汗腺。体积减小部件可以包括体积减小材料（470）和压力透过部件（460），汗液可溶材料（490），用于与皮肤（12）一致的机械柔顺材料（570），具有垂直各向异性汗液通道的粘合剂和包含阻挡材料的微胶囊（1385）。降低体积的组件的存在降低了汗量，并减少了采样间隔。

3. 发明申请

WO2008039832A3 LIGHT EMISSIVE SIGNAGE DEVICES BASED ON LIGHTWAVE COUPLING 审中-公开
标题翻译：基于轻型联轴器的轻型发射信号装置
公开(公告)号：WO2008039832A3
公开(公告)日：2009-02-12
申请号：PCT/US2007079509
申请日：2007-09-26
申请人： UNIV CINCINNATI , HEIKENFELD JASON C , STECKL ANDREW J , RUDOLPH JOHN D
发明人： HEIKENFELD JASON C , STECKL ANDREW J , RUDOLPH JOHN D
IPC分类号： F21V7/04 , G02B6/35 , G02B26/02 , G09F9/37
CPC分类号： G02B26/02 , Y10S385/901
摘要： A signage device (180, 180', 190, 199, 200, 200', 208, 209, 242a-f, 250, 260, 270, 280) comprising one or more light sources (185), a waveguide (184, 204, 210, 226, 230, 251, 290, 300, 402) or arrangement of waveguides (184a,b, 204a,b, 262a-c, 271 a-c, 284a-c) and photoluminescent features (182, 182a,b, 200a,b, 254, 266a-c, 291, 301) coupled thereto. In one embodiment, a waveguide (184, 184a,b, 204, 204a,b, 210, 226, 230, 251, 262a-c, 271 a-c, 284a-c, 290, 300, 402) is adapted to receive light of a first wavelength and the photoluminescent features (182, 182a,b, 206a,b, 254, 266a-c, 291, 301) are adapted to emit light of a second wavelength in response to receiving light of the first wavelength.
摘要翻译：包括一个或多个光源（185）的标志装置（180,180'，190,199,200,200'，208,209,242a-f，250,260,270,280），波导（184,204 ，210,226,230,251,290,300,402）或布置波导（184a，b，204a，b，262a-c，271ac，284a-c）和光致发光特征（182,182a，b，200a ，b，254,266a-c，291,301）。在一个实施例中，波导（184,184a，b，204,204a，b，210,226,230,251,262a-c，271ac，284a-c，290,300,402）适于接收第一波长和光致发光特征（182,182a，b，206a，b，254,266a-c，291,301）适于响应于接收到第一波长的光而发射第二波长的光。

4. 发明申请

WO2007022311A3 ELECTROFLUIDIC TEXTILES AND CLEANING IMPLEMENTS USING SUCH ELECTROFLUIDIC TEXTILES 审中-公开
标题翻译：使用这种电子流变纺织品的电子流体纺织品和清洁用具
公开(公告)号：WO2007022311A3
公开(公告)日：2007-08-02
申请号：PCT/US2006032050
申请日：2006-08-17
申请人： UNIV CINCINNATI , HEIKENFELD JASON C
发明人： HEIKENFELD JASON C
IPC分类号： B32B7/00
CPC分类号： B01D35/06 , A47L13/16 , A47L13/20 , A47L13/40 , B32B5/26 , B32B2307/206 , B32B2432/00
摘要： The invention relates to textiles (26, 40, 46, 52, 56), reservoirs (64, 72), or films (12; 14) which may be switchably rendered hydrophilic or hydrophobic for liquid wicking, repelling, moving, holding, absorbing, drying, wetting, dispensing, and other means of electrically manipulation of liquids (16, 20).
摘要翻译：本发明涉及纺织品（26,40,46,52,56），储存器（64,72）或薄膜（12; 14），它们可以可切换地变为亲水或疏水的以用于液体芯吸，排斥，移动，保持，吸收，干燥，润湿，分配和其他液体电操纵手段（16,20）。

5. 发明申请

WO02073708A3 ELECTROLUMINESCENT DISPLAY DEVICE 审中-公开
标题翻译：电致发光显示装置
公开(公告)号：WO02073708A3
公开(公告)日：2002-11-14
申请号：PCT/US0207262
申请日：2002-03-12
申请人： UNIV CINCINNATI , STECKL ANDREW J , HEIKENFELD JASON C
发明人： STECKL ANDREW J , HEIKENFELD JASON C
IPC分类号： H01L33/30 , H01L33/32 , H05B33/10 , H05B33/12 , H05B33/14 , H01L33/00
CPC分类号： H05B33/145 , H01L33/305 , H01L33/32 , H05B33/10 , H05B33/12
摘要： Wide band gap semiconductor materials, such as gallium nitride, doped with rare earth dopants may be used to emit light in alternating current electroluminescent devices (12, 41, 51). The electroluminescent device (51) may have front and rear thin coatings (56, 58) of a dielectric material in turn connected to alternating current electrodes (18, 40). The electroluminescent device (12, 41, 51) may be formed on a glass substrate (16, 30) and then be coated with a rear thick film of dielectric (22, 38, 54). The thick film dielectric (22, 38, 54) can be applied as a gel and heat treated, after coating the semiconductor material, to form a light emitting device.
摘要翻译：宽带隙半导体材料，例如掺杂有稀土掺杂剂的氮化镓，可用于在交流电致发光器件（12,41,51）中发光。电致发光器件（51）可具有介电材料的前和后薄涂层（56,58），其依次连接到交流电极（18,40）。电致发光器件（12,41,51）可以形成在玻璃基底（16,30）上，然后涂覆后电介质厚膜（22,38,54）。厚膜电介质（22,38,54）可以作为凝胶施加并且在涂覆半导体材料之后进行热处理以形成发光器件。

6. 发明申请

WO2016007944A2 COMBINATORIAL SENSING OF SWEAT BIOMARKERS USING POTENTIOMETRIC AND IMPEDANCE MEASUREMENTS 审中-公开
标题翻译：利用电位差法和阻抗法测量甜食生物标记物的组合检测
公开(公告)号：WO2016007944A2
公开(公告)日：2016-01-14
申请号：PCT/US2015040113
申请日：2015-07-13
申请人： UNIV CINCINNATI , US AIR FORCE
发明人： SONNER ZACHARY COLE , HEIKENFELD JASON C , HAGEN JOSHUA A
IPC分类号： A61B5/04
CPC分类号： A61B5/4266 , A61B5/01 , A61B5/0205 , A61B5/02055 , A61B5/02405 , A61B5/0537 , A61B5/08 , A61B5/1118 , A61B5/14517 , A61B5/14539 , A61B5/14546 , A61B5/14552 , A61B5/1468 , A61B5/1477 , A61B5/1486 , A61B5/4519 , A61B5/4866 , A61B5/4875 , A61B5/6833 , A61B5/68335 , A61B5/7275 , A61B10/0064 , A61B2560/0252 , A61B2562/0214 , A61B2562/0219 , A61B2562/242
摘要： A wearable sweat sensor device (1) may include a plurality of sensors (150, 160, 170, 180) capable of measuring a plurality of ion-selective biomarker potentials and a mechanism that analyzes a combination of measurements as a proxy for one or more physiological conditions such as muscle activity, exertion, or tissue damage. A device may include a sensor capable of taking at least one skin impedance measurement along with a plurality of sensors (150, 160, 170, 180) and a mechanism that analyzes a combination of measurements as a proxy for one or more physiological conditions, such as hydration or sweat rate. Because several of said sensors (150, 160, 170, 180) may not be stable when stored if fully exposed to air, the device (1) may include a temporary seal (400) for said sensors (150, 160, 170, 180) that is removable prior to placement and use of said sensors (150, 160, 170, 180).
摘要翻译：可穿戴式汗液传感器装置（1）可以包括能够测量多个离子选择性生物标记物电势的多个传感器（150,160,170,180）以及分析测量的组合作为一个或多个生理状况如肌肉活动，劳累或组织损伤。装置可以包括能够与多个传感器（150,160,170,180）一起进行至少一个皮肤阻抗测量的传感器以及分析作为一个或多个生理状况的代理的测量的组合的机构，例如作为水合作用或出汗率。因为如果完全暴露于空气中时，所述传感器（150,160,170,180）中的若干个在存储时可能不稳定，所述装置（1）可包括用于所述传感器（150,160,170,180）的临时密封件（400）），其在放置和使用所述传感器（150,160,170,180）之前是可移除的。

7. 发明申请

WO2013152087A3 SWEAT SIMULATION, COLLECTION AND SENSING SYSTEMS 审中-公开
标题翻译： SWEAT模拟，收集和感测系统
公开(公告)号：WO2013152087A3
公开(公告)日：2014-01-16
申请号：PCT/US2013035092
申请日：2013-04-03
申请人： UNIV CINCINNATI , US AIR FORCE
发明人： HAGEN JOSHUA A , HEIKENFELD JASON C , PAPAUTSKY IAN , HOU LINLIN , NAIK RAJESH , KELLY-LOUGHNANE NANCY , STONE MORLEY , BUSBEE JOHN , WANG XIAO
IPC分类号： B01L3/00 , A61B10/00
CPC分类号： G01N27/3273 , A61B5/14517 , A61B10/0064 , A61B10/0096 , B01L3/5023 , B01L2200/0621 , B01L2300/022 , B01L2300/023 , B01L2300/0645 , B01L2300/069 , B01L2300/0803 , B01L2300/0864 , B01L2400/0406 , B01L2400/0677 , B01L2400/086 , G01N27/4145
摘要： Biological chemicals, potentially found in blood are measured by collecting sweat and determining the concentration or meaning of the selected chemical in sweat. The sweat can be collected using a time based, interval collector (10) and analyzed using an external device. It can also be collected on a one time basis, using a flexible, chemical capacitor (50), or on a continuous basis using a chemical, field effect transducer 98.
摘要翻译：血液中可能发现的生物化学物质是通过收集汗液并确定所选择的化学物质在汗液中的浓度或含义来测量的。可以使用基于时间的间隔收集器（10）收集汗液，并使用外部设备进行分析。也可以使用柔性的化学电容器（50）或使用化学的场效应传感器98连续地收集一次。

8. 发明申请

WO2006017129A2 DISPLAY CAPABLE ELECTROWETTING LIGHT VALVE 审中-公开
标题翻译：显示电容式电磁阀
公开(公告)号：WO2006017129A2
公开(公告)日：2006-02-16
申请号：PCT/US2005024145
申请日：2005-07-08
申请人： UNIV CINCINNATI , STECKL ANDREW J , HEIKENFELD JASON C
发明人： STECKL ANDREW J , HEIKENFELD JASON C
CPC分类号： G02B26/004 , G02B5/02
摘要： The invention relates to light transmissive, transflective, or reflective flat panel display devices and, more specifically, to light emissive flat panel displays constructed from high performance electrowetting light valve (ELV) devices (10a-g). An array of ELV devices (10a-g) is mounted on or adjacent to a backlight (11), employing a reflector (13) allowing for improved transmission. The backlight (11) may be partially diffusely reflective or translucent as to also allow for creation of a transflective display panel.
摘要翻译：本发明涉及透光，半透反射或反射平板显示装置，更具体地说，涉及由高性能电润湿光阀（EL-V）装置（10a-g）构成的发光平板显示器。 ELV装置阵列（10a-g）安装在背光源（11）上或与背光源（11）相邻，采用允许改进透射的反射器（13）。背光（11）可以是部分地漫反射或半透明的，以便也可以创建透反射显示面板。

9. 发明申请

WO2012091776A3 ELECTROFLUIDIC IMAGING FILM, DEVICES, AND DISPLAYS, AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：电磁成像膜，器件和显示器及其制造和使用方法
公开(公告)号：WO2012091776A3
公开(公告)日：2014-04-03
申请号：PCT/US2011054267
申请日：2011-09-30
申请人： UNIV CINCINNATI , HEIKENFELD JASON C , HAGEDON MATTHEW , DEAN KENNETH A
发明人： HEIKENFELD JASON C , HAGEDON MATTHEW , DEAN KENNETH A
IPC分类号： G02B26/00 , H01J9/00
CPC分类号： G02B26/005 , Y10T29/49117 , Y10T29/49124 , Y10T29/49826
摘要： A device (12-16) and method of making and using the same. The device (12-16) includes first and second substrates (22-26, 32-36) that are spaced to define a fluid space. Polar and non-polar fluids (212-215, 222-225) occupy the fluid space. A first electrode (122- 126), with a dielectric layer (92-96), is positioned on the first substrate (22-26) and electrically coupled to at least one voltage source (522-526), which is configured to supply an electrical bias to the first electrode (122-126). The fluid space includes at least one fluid splitting structure (52-56) that is configured to facilitate the movement of the non-polar fluid (222-225) into a portion of the polar fluid (212-215). Fluid splitting structure assisted movement of the non-polar fluid (222-225) splits the polar fluid (212-215).
摘要翻译：一种装置（12-16）及其制作和使用方法。装置（12-16）包括间隔开以限定流体空间的第一和第二基板（22-26,32-36）。极地和非极性流体（212-215,222-225）占据流体空间。具有电介质层（92-96）的第一电极（122-126）定位在第一衬底（22-26）上并电耦合到至少一个电压源（522-526），其被配置为供应电偏压到第一电极（122-126）。流体空间包括至少一个流体分离结构（52-56），其被构造成便于非极性流体（222-225）移动到极性流体（212-215）的一部分中。非极性流体（222-225）的流体分裂结构辅助运动分离极性流体（212-215）。

10. 发明申请

WO2005114740B1 LIQUID LOGIC STRUCTURES FOR ELECTRONIC DEVICE APPLICATIONS 审中-公开
标题翻译：用于电子设备应用的液体逻辑结构
公开(公告)号：WO2005114740B1
公开(公告)日：2006-02-23
申请号：PCT/US2005017752
申请日：2005-05-20
申请人： UNIV CINCINNATI , STECKL ANDREW J , HEIKENFELD JASON C
发明人： STECKL ANDREW J , HEIKENFELD JASON C
IPC分类号： H01H59/00 , H01L29/66 , H01L29/72
CPC分类号： H01H59/0009 , H01H2029/008
摘要： Electronic devices (10,30,50) utilizing electrically-controlled liquid components to accomplish device switching. Electric fields are used in a device structure to manipulate the position and/or geometrical shape of a conductive fluid or liquid (60,24) using electrowetting. This manipulation regulates the flow of current between electrodes of the device structure, such as the source and drain regions (16,20) of a transistor construction, by bridging a non-conductive channel (15) separating the electrodes (16,20) so that the electrodes (16,20) are electrically coupled.
摘要翻译：电子设备（10,30,50）利用电控液体组件来实现设备切换。电场用于器件结构中以使用电润湿来操纵导电流体或液体（60,24）的位置和/或几何形状。这种操作通过桥接分离电极（16,20）的非导电通道（15）来调节器件结构的电极之间的电流（例如晶体管结构的源极和漏极区域（16,20））的流动，从而电极（16,20）电耦合。

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