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1. 发明申请

WO2005074612A9 SENSOR SYSTEM 审中-公开
标题翻译：传感器系统
公开(公告)号：WO2005074612A9
公开(公告)日：2006-04-20
申请号：PCT/US2005003243
申请日：2005-02-03
申请人： UNIV CASE WESTERN RESERVE , ROZAKIS GEORGE , GRATZL MIKLOS , TOHDA KOJI , YANG JIAN
发明人： ROZAKIS GEORGE , GRATZL MIKLOS , TOHDA KOJI , YANG JIAN
IPC分类号： B01D33/19
CPC分类号： B01D33/19
摘要： A sensor probe suited for implanting into the skin of a person includes a sensor body which may be formed from a polymer which includes 2-hydroxyethyl methacrylate (HEMA). A sensing system is supported by the body. The sensing system exhibits a detactable change when the probe is exposed to the analyte in the fluid. The sensing system may include an enzyme capable of catalyzing a reaction of the analyte to form a reaction product and a dye system which absorbs in the infrared region of the spectrum in response to the reaction product.
摘要翻译：适用于植入人体皮肤的传感器探头包括传感器主体，该传感器主体可以由包含甲基丙烯酸2-羟乙酯（HEMA）的聚合物形成。感应系统由身体支撑。当探头暴露于流体中的分析物时，传感系统呈现可分离的变化。感测系统可以包括能够催化分析物反应以形成反应产物的酶和响应于反应产物在光谱的红外区域吸收的染料体系。

2. 发明申请

WO2004034032A3 SLIVER TYPE AUTONOMOUS BIOSENSORS 审中-公开
标题翻译： SLIVER TYPE AUTONOMOUS生物传感器
公开(公告)号：WO2004034032A3
公开(公告)日：2005-03-24
申请号：PCT/US0332367
申请日：2003-10-10
申请人： UNIV CASE WESTERN RESERVE , GRATZL MIKLOS , TOHDA KOJI , YANG JIAN , ROZAKIS GEORGE
发明人： GRATZL MIKLOS , TOHDA KOJI , YANG JIAN , ROZAKIS GEORGE
IPC分类号： A61B5/00 , C12Q1/00 , C12N9/02 , C12N11/16 , C12N11/18 , C12Q1/26 , C12Q1/54
CPC分类号： A61B5/14546 , A61B5/14528 , A61B5/14532 , A61B5/14539 , A61B5/1455 , A61B5/1459 , A61B5/14865 , A61B5/686 , C12Q1/001
摘要： In vivo or in vitro monitoring of chemical and biochemical species (e.g., pH, or glucose levels) in the interstitial fluid of patients or in a sample of a fluid to be analyzed is provided by a probe (10, 70, 210, 270). For in vivo monitoring, the probe is readily inserted by a minimally invasive method. Optical or electrochemical sensing methods are employed to detect a physical or chemical change, such as pH, color, electrical potential, electric current, or the like, which is indicative of the concentration of the species or chemical property to be detected. Visual observation by the patient may be sufficient to monitor certain biochemicals (e.g., glucose) with this approach. A CAP membrane allows high enzyme loadings, and thus enables use of microminiature probes, and/or diagnosis of low levels of the analyte(s), with sufficient signal-to-noise ratio and low background current.
摘要翻译：通过探针（10,70,210,270）提供患者或待分析的流体样品中间质液体中的化学和生物化学物质（例如pH或葡萄糖水平）的体内或体外监测，。对于体内监测，通过微创方法容易地插入探针。使用光学或电化学感测方法来检测物理或化学变化，例如pH，颜色，电势，电流等，其指示要检测的物质或化学性质的浓度。患者的目视观察可能足以用这种方法监测某些生物化学物质（例如葡萄糖）。 CAP膜允许高酶负载，从而使得能够使用微型探针和/或诊断低水平的分析物，具有足够的信噪比和低背景电流。

3. 发明申请

WO2005074612A3 SENSOR SYSTEM 审中-公开
标题翻译：传感器系统
公开(公告)号：WO2005074612A3
公开(公告)日：2006-11-02
申请号：PCT/US2005003243
申请日：2005-02-03
申请人： UNIV CASE WESTERN RESERVE , ROZAKIS GEORGE , GRATZL MIKLOS , TOHDA KOJI , YANG JIAN
发明人： ROZAKIS GEORGE , GRATZL MIKLOS , TOHDA KOJI , YANG JIAN
IPC分类号： G01N33/543 , B01D33/19
CPC分类号： B01D33/19
摘要： A sensor probe suited for implanting into the skin of a person includes a sensor body which may be formed from a polymer which includes 2-hydroxyethyl methacrylate (HEMA). A sensing system is supported by the body. The sensing system exhibits a detactable change when the probe is exposed to the analyte in the fluid. The sensing system may include an enzyme capable of catalyzing a reaction of the analyte to form a reaction product and a dye system which absorbs in the infrared region of the spectrum in response to the reaction product.
摘要翻译：适于植入人的皮肤的传感器探头包括可以由包含甲基丙烯酸2-羟乙酯（HEMA）的聚合物形成的传感器体。感应系统由身体支撑。当探针暴露于流体中的分析物时，感测系统显示可发生的变化。感测系统可以包括能够催化分析物的反应以形成反应产物的酶，以及响应于反应产物在光谱的红外区域吸收的染料体系。

4. 发明申请

WO2004033100A3 DEVICE FOR PRECISE CHEMICAL DELIVERY AND SOLUTION PREPARATION 审中-公开
标题翻译：精密化学品交付和解决方案准备的设备
公开(公告)号：WO2004033100A3
公开(公告)日：2004-06-24
申请号：PCT/US0331971
申请日：2003-10-09
申请人： UNIV CASE WESTERN RESERVE , GRATZL MIKLOS , TOHDA KOJI , ROZAKIS GEORGE
发明人： GRATZL MIKLOS , TOHDA KOJI , ROZAKIS GEORGE
IPC分类号： B01D61/24 , B01D61/28 , B01D69/10 , B01L3/02 , B01L99/00 , G01N35/10
CPC分类号： B01D61/246 , B01D61/28 , B01D69/10 , B01L3/0275 , B01L3/0293 , B01L2300/025 , B01L2300/0681 , B01L2300/18 , G01N2035/1053
摘要： A burette (10, 110, 200) suitable for delivery of a reagent into a target solution (50) employs diffusion for delivering the reagent. The reagent is in the form of a solution, which is combined with a matrix material (22), such as a gel or porous ceramic. A membrane (32) covers a delivery outlet (20) to the burette. In one embodiment, the delivery outlet comprises a plurality of fine bores (36), each one filled with or covered by a membrane (38). Stirring of the burette or target solution is achieved with a stirring means (104, 106). A heating or cooling means (80) heats a tip (16) of the burette.
摘要翻译：适合于将试剂输送到目标溶液（50）中的滴定管（10,110,200）使用用于递送试剂的扩散剂。试剂是溶液的形式，其与基质材料（22）如凝胶或多孔陶瓷组合。膜（32）覆盖到滴定管的输送出口（20）。在一个实施例中，输送出口包括多个细孔（36），每个孔被填充或被膜（38）覆盖。用搅拌装置（104,106）实现滴定管或目标溶液的搅拌。加热或冷却装置（80）加热滴定管的尖端（16）。

5. 发明申请

WO2004034020A3 HYDRODYNAMIC MICROMANIPULATION OF INDIVIDUAL CELLS TO PATTERNED ATTACHEMENT SITES 审中-公开
标题翻译：个体细胞的水动力微观分析
公开(公告)号：WO2004034020A3
公开(公告)日：2006-05-11
申请号：PCT/US0331888
申请日：2003-10-08
申请人： UNIV CASE WESTERN RESERVE , YOSHIDA MAKOTO , TOHDA KOJI , GRATZL MIKLOS
发明人： YOSHIDA MAKOTO , TOHDA KOJI , GRATZL MIKLOS
IPC分类号： C12M1/34 , C12Q1/24 , G01N15/10 , G01N15/14 , G01N33/50
CPC分类号： G01N15/1404 , G01N15/147 , G01N15/1475 , G01N33/5005 , G01N2015/1006 , G01N2015/1075 , G01N2015/1415
摘要： A system for manipulation of a cell (100) includes a platform (33) which defines a surface (50) having a site (60) at which the cell has a higher probability of attachment in a period of time than on an adjacent area (52) of the surface. First and second syringes (10, 12) are selectively actuated to deliver a liquid to first and second tubes (26, 28) respectively. Outlets (29, 29') of the first and second tubes are positioned so as to deliver the liquid to a liquid medium on the platform, thereby creating generally orthogonal fluid flows through the liquid to/from a region of interest (35). Cells located in the liquid medium at the region of interest move at a speed which is much lower than that of the liquid at the tube outlets and along the tube axis, allowing the cell to be manipulated to the site by manual or automated actuation of the syringes. Once on the site, the cell attaches, unwanted cells on the adjacent area can be washed away, allowing electrochemical or other measurements to be performed on an accurately positioned cell or group of cells.
摘要翻译：用于操纵电池（100）的系统包括平台（33），其限定具有位置（60）的表面（50），在该位置处，电池在一段时间内具有比在相邻区域上更高的附着概率（ 52）。第一和第二注射器（10,12）被选择性地致动以将液体分别输送到第一和第二管（26,28）。第一和第二管的出口（29,29'）被定位成将液体输送到平台上的液体介质，从而使大体正交的流体流过/流过感兴趣区域（35）。位于感兴趣区域的液体介质中的细胞以比出口处的液体和管轴线的速度低得多的速度移动，从而允许通过手动或自动致动将细胞操纵到现场注射器。一旦在该部位上，细胞附着，相邻区域上的不想要的细胞就可以被洗掉，从而允许在精确定位的细胞或细胞组上进行电化学或其它测量。

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