专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2007134292A3 TREPROSTINIL ADMINISTRATION USING A METERED DOSE INHALER 审中-公开
标题翻译：使用计量剂量吸入剂进行血小板计数管理
公开(公告)号：WO2007134292A3
公开(公告)日：2008-01-10
申请号：PCT/US2007068884
申请日：2007-05-14
申请人： UNITED THERAPEUTICS CORP , OLSCHEWSKI HORST , ROSCIGNO ROBERT , RUBIN LEWIS J , SCHMEHL THOMAS , SEEGER WERNER , STERRITT CARL , VOSWINCKEL ROBERT
发明人： OLSCHEWSKI HORST , ROSCIGNO ROBERT , RUBIN LEWIS J , SCHMEHL THOMAS , SEEGER WERNER , STERRITT CARL , VOSWINCKEL ROBERT
IPC分类号： A61K31/557 , A61K9/12 , A61K9/72
CPC分类号： A61K31/557 , A61K9/0078 , A61K9/008 , A61K31/192
摘要： Treprostinil can be administered using a metered dose inhaler. Such administration provides a greater degree of autonomy to patients. Also disclosed are kits that include a metered dose inhaler containing a pharmaceutical formulation containing treprostinil.
摘要翻译：曲前列环素可以使用计量吸入器进行给药。这种管理为患者提供更大程度的自主权。还公开了包含含有含有曲前列素的药物制剂的计量吸入器的试剂盒。

2. 发明申请

WO2004046202A2 BIO-DEGRADABLE COLLOID PARTICLES, IN PARTICULAR FOR PULMONARY APPLICATIONS 审中-公开
标题翻译：生物可降解胶体颗粒，特别适用于肺部应用
公开(公告)号：WO2004046202A2
公开(公告)日：2004-06-03
申请号：PCT/DE0303787
申请日：2003-11-14
申请人： TRANSMIT TECHNOLOGIETRANSFER , UNIV GIESSEN JUSTUS LIEBIG , UNIV MARBURG PHILIPPS , SEEGER WERNER , SCHMEHL THOMAS , GESSLER TOBIAS , DAILEY LEA ANN , WITTMAR MATTHIAS
发明人： SEEGER WERNER , SCHMEHL THOMAS , GESSLER TOBIAS , DAILEY LEA ANN , WITTMAR MATTHIAS
IPC分类号： A61K9/00 , A61K9/51 , A61K47/34 , A61K47/48 , C08F2/00 , C08F8/44 , C08F283/06 , C08L51/08 , C08F
CPC分类号： A61K9/5138 , A61K9/0078 , A61K9/5153 , A61K9/5161 , A61K47/34 , C08F8/44 , C08F283/06 , C08L51/08 , C08L2666/02
摘要： The invention relates to a composition consisting of a bio-degradable, water-soluble comb polymer, based on a polyol backbone with side chains that carry amino groups and a stabiliser in the form of at least one negatively charged organic base, which can be a Lewis or Brönsted base, or a corresponding acid of said base, which can be a Lewis or Brönsted acid. There can be an excess or deficiency of the acidic groups of the stabilisers in relation to the primary, secondary or tertiary amino groups of the comb polymers or an excess or deficiency of the basic groups in relation to the quaternary amino groups of the comb polymers, in such a way that the colloid particles have a positive or negative zeta potential. Colloid particles of this type are particularly suitable for the pulmonary application of acidic or negatively charged pharmaceutical active agents.
摘要翻译：本发明涉及基于多元醇骨架轴承具有氨基侧链和作为稳定剂的至少一种带负电荷的有机基，其可以是路易斯酸或布朗斯台德碱，或其相应的酸，路易斯可生物降解的水溶性梳形聚合物的组合物 - 可能是或布朗斯台德酸，其中在过量或不足的稳定剂的酸性基团相对于该主，梳形聚合物的仲或叔氨基的基团存在或存在时，在地下室或相对过量的季氨基的梳形聚合物的碱性基团，从而使胶体颗粒具有正或负的ZetaPotential。这种胶体颗粒特别适用于酸性或负电荷活性药物成分的肺部给药。

3. 发明申请

WO2011000835A3 LIPOSOMES FOR PULMONARY APPLICATION 审中-公开
标题翻译：用于肺部应用的脂质体
公开(公告)号：WO2011000835A3
公开(公告)日：2011-03-03
申请号：PCT/EP2010059216
申请日：2010-06-29
申请人： UNIV GIESSEN JUSTUS LIEBIG , GESSLER TOBIAS , SCHMEHL THOMAS , RIEGER MONIKA
发明人： GESSLER TOBIAS , SCHMEHL THOMAS , RIEGER MONIKA
IPC分类号： A61K9/00 , A61K9/127
CPC分类号： A61K9/127 , A61K9/0078
摘要： The invention relates to liposomes for pulmonary application, advantageously comprising at least one first and at least one second phospholipid, cholesterol, and at least one active substance and/or colorant, wherein the first phospholipid is a phosphatidylcholine, preferably DSPC, and the second phospholipid is a phosphatidylcholine or an ethanolamine, preferably selected from the group DMPC, DPPC, DPPE. It is thereby advantageous if the first and the second phospholipid are present at a molar ratio of 0.5:1 to 10:1, preferably at a ratio of 6:1 to 2:1, in particular preferably at a ratio of 3:1. It is further advantageous if the molar ratio between phospholipids and cholesterol is between 10:1 and 1:1, preferably between 6:1 and 3:1, in particular preferably 4:1. The second phospholipid is further preferably DMPC or DPPE, in particular preferably DPPE. The size of the liposomes is advantageously between 0.05 µm and 5 µm, preferably between 0.2 µm and 2.0 µm, and the median aerodynamic mass diameter of aerosol particles comprising the liposomes is between 1 µm and 6 µm, preferably between 1.5 µm and 5 µm, in particular preferably between 2 µm and 4.5 µm. It is further in particular advantageous if the liposomes comprise an atomization stability of greater than 50%, preferably greater than 75%, in particular preferably greater than 80%, and if the transition temperature is greater than 37 °C, preferably greater than 45 °C, in particular preferably greater than 50 °C.
摘要翻译：为有利地包含至少一个第一和至少一个第二磷脂和胆固醇和至少一种活性物质和/或染料，其中所述第一磷脂是磷脂酰胆碱，优选DSPC，和第二磷脂肺施用本发明的脂质体是磷脂酰胆碱或乙醇胺优选选自DMPC，DPPC，DPPE。有利的是，当第一和在0.5:1的摩尔比的第二磷脂：1〜10：1，优选在6：1的比例为2：1，更优选为3：1的比例存在，也有利的是，如果磷脂和胆固醇10之间的摩尔比：1和1：1之间，优选在6：1和3：1，更优选4：1。应进一步理解，第二种磷脂优选为DMPC或DPPE，更优选为DPPE。有利地，脂质体的大小为0.05微米和5微米之间，优选在0.2微米和2.0微米和含脂质体是1微米和6微米之间的气溶胶颗粒的质量中值空气动力学直径之间，优选为1.5微米之间和5μm，更优选在2μm和4.5μm之间。这也是特别有利的，如果超过50％，优选超过75％，特别优选80％以上的脂质体雾化稳定性，并且当转变温度超过37℃，优选大于45℃，更优选超过50℃

4. 发明申请

WO2010106063A3 COMPOSITE MATERIALS LOADED WITH THERAPEUTIC AND DIAGNOSTIC AGENTS COMPRISING POLYMER NANOPARTICLES AND POLYMER FIBERS 审中-公开
标题翻译：药物和诊断负载的复合材料综合聚合物纳米微粒以及聚合物纤维
公开(公告)号：WO2010106063A3
公开(公告)日：2011-09-29
申请号：PCT/EP2010053381
申请日：2010-03-16
申请人： UNIV GIESSEN JUSTUS LIEBIG , UNIV MARBURG PHILIPPS , TRANSMIT GMBH , SCHMEHL THOMAS , NGUYEN JULIANE , BECK-BROICHSITTER MORITZ , GESSLER TOBIAS , KISSEL THOMAS , THIEME MARCEL
发明人： SCHMEHL THOMAS , NGUYEN JULIANE , BECK-BROICHSITTER MORITZ , GESSLER TOBIAS , KISSEL THOMAS , THIEME MARCEL
IPC分类号： A61K9/51 , A61K9/70
CPC分类号： A61K9/5153 , A61K9/70
摘要： The invention relates to composite materials comprising polymer nanofibers and polymer nanoparticles, wherein at least one of the two polymer materials is loaded with a substance selected from therapeutic and diagnostic agents. Fibers and nanoparticles can comprise identical or different polymers; the polymer materials are, however, biocompatible in every case. Therapeutic and diagnostic agents can be hydrophilic or lipophilic and the two polymer materials likewise. The at least one polymer material and the substance with which said material is loaded are either both hydrophilic or both lipophilic. The polymer nanoparticles of the composite materials have a diameter of 10 nm to 600 nm. The polymer fibers have diameters of 10 nm to 50 µm and lengths of 1 µm to several meters. The invention further relates to a method for producing said composite materials. Polymer nanoparticles can be produced in different ways, such as through controlled precipitation of a polymer solution that optionally comprises a loading substance. The nanoparticles are then mixed with another polymer and a loading substance as applicable, depending on whether particles, fibers or both are to be loaded with substance. The processing of this solution into composites comprising polymer fibers polymer nanoparticles can occur by means of electrospinning, melt spinning, extruding or template process. Composite materials according to the invention are suitable for the production of pharmaceuticals that release therapeutically or diagnostically effective substances slowly and in a controlled manner.
摘要翻译：本发明提供了包含制备的聚合物纳米纤维和纳米颗粒的聚合物复合材料，其特征在于，在治疗和诊断中加载的物质中选择的两种聚合物材料中的至少一种。纤维和纳米颗粒可以由相同或不同的聚合物; 然而，聚合材料是在每种情况下生物相容的。治疗和诊断由此可以是亲水性或亲脂性，以及两种聚合物材料为好。所述至少一种聚合物材料和与它加载的物质，无论是二者均为亲水或亲脂。复合材料的聚合物纳米颗粒的直径为10nm至600nm的。所述聚合物纤维具有从10纳米至50微米的直径和1微米长度可达几米。本发明提供了一种制备所述复合材料的进一步处理。聚合物纳米颗粒可以以各种方式通过聚合物溶液的控制的沉淀来制备，例如，任选地含有负载物质。随后，将纳米颗粒与另一种聚合物混合，并且如果必要的话，装载物质，根据不同的颗粒，纤维，或两者是否将被装载的物质。这种解决方案的处理，以复合材料，其包括聚合物纤维的聚合物纳米颗粒可以，例如，静电纺丝，熔融纺丝，挤出或通过装置发生模板。根据本发明的复合材料是适合于释放治疗或诊断活性物质缓慢和受控的药物中的用途。

5. 发明申请

WO2006122542A3 NON-VIRAL VECTOR SYSTEM FOR TRANSPORTING NUCLEIC ACID INTO THE LUNGS 审中-公开
标题翻译：未经病毒载体系统对于核酸在肺运输
公开(公告)号：WO2006122542A3
公开(公告)日：2007-01-18
申请号：PCT/DE2006000875
申请日：2006-05-20
申请人： TRANSMIT TECHNOLOGIETRANSFER , UNIV GIESSEN JUSTUS LIEBIG , UNIV MARBURG PHILIPPS , KISSEL THOMAS , KLEEMANN ELKE , NEU MICHAEL , GESSLER TOBIAS , SCHMEHL THOMAS
发明人： KISSEL THOMAS , KLEEMANN ELKE , NEU MICHAEL , GESSLER TOBIAS , SCHMEHL THOMAS
IPC分类号： C12N15/63 , A61K38/00 , C08G81/00
CPC分类号： C08G81/00
摘要： The invention relates to a non-viral vector system for transporting nucleic acid, which system is modified on the basis of polyethylene imine (PEI) with polyethylene glycol (PEG) and has a peptide sequence with PTD/CPP functionality. The inventive vector system is used as a gene transfer system in the epithelial cells of the bronchial tubes and alveoles of the lungs. The system is highly stable, protects the DNA in the pulmonary surroundings, has a low zeta potential and little tendency to aggregate in a medium with a high ionic strength. It has low in-vitro and in-vivo cytotoxicity and excellent transfection efficiency. The inventive vector system is used for transfection by inhalation in local pulmonary therapy.
摘要翻译：本发明涉及一种用于用聚乙二醇（PEG）和用具有官能度PTD / CPP的肽序列递送的核酸，其为聚乙烯亚胺（PEI）的基础上修改的非病毒载体系统。该载体系统被用作基因递送系统在支气管和肺泡上皮细胞。它显示很强的稳定性，保护肺区域的DNA具有低ζ电势和聚合在介质中具有大的离子强度低的倾向。此外，它具有在体外和体内的细胞毒性和非常高的转染效率低。根据本发明的载体系统在肺部局部疗法应用于转染通过吸入。

6. 发明申请

WO02094122A3 EQUINE INHALATION MASK 审中-公开
标题翻译：吸入面罩马
公开(公告)号：WO02094122A3
公开(公告)日：2003-05-01
申请号：PCT/DE0201874
申请日：2002-05-23
申请人： TRANSMIT TECHNOLOGIETRANSFER , SCHMEHL THOMAS , GESSLER TOBIAS , FEY KERSTIN
发明人： SCHMEHL THOMAS , GESSLER TOBIAS , FEY KERSTIN
IPC分类号： A61D7/04
CPC分类号： A61D7/04
摘要： The invention relates to an equine inhalation mask, comprising at least one valveless combined inhalation and exhalation conduit, into which inhalant sources comprising respiration control elements and an energy supply that does not require supply lines are interchangeably integrated. A filter system is mounted on the outer end of the inhalation and exhalation conduit facing away from the head of the horse. Said system and the fact that the mask is effectively sealed when on the head of the horse prevent any escape of the aerosol into the environment, thus permitting a reliable inhalation therapy lasting several minutes under normal resting respiratory conditions.
摘要翻译：作为本发明的用于马的吸入面罩提出了一种具有至少一个无阀组合输入/呼气，可拆卸地从过滤系统中的远程集成在内容源与呼吸控制，并提供独立的电源并在其外表，马头端被安装时，与它们一起掩模的任何气雾剂出口在环境中防止马的头部的有效密封，从而实现了安全吸入疗法在正常潮式呼吸几分钟。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式