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1. 发明申请

WO2008006712A3 PREPARATION OF NANODISPERSIONS 审中-公开
标题翻译：纳米尺度的制备
公开(公告)号：WO2008006712A3
公开(公告)日：2009-02-26
申请号：PCT/EP2007056560
申请日：2007-06-29
申请人： UNILEVER PLC , UNILEVER NV , ANGUS DORIS , DUNCALF DAVID JOHN , ELPHICK ANDREW JAMES , FOSTER ALISON JAYNE , LONG JAMES , RANNARD STEVEN PAUL , WANG DONG
发明人： ANGUS DORIS , DUNCALF DAVID JOHN , ELPHICK ANDREW JAMES , FOSTER ALISON JAYNE , LONG JAMES , RANNARD STEVEN PAUL , WANG DONG
IPC分类号： A61K9/16 , A01N31/16 , A01N37/50 , A01N43/653 , A01N53/00 , A23L27/00
CPC分类号： A61K9/1617 , A01N25/04 , A61K9/10 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/19 , A61K31/167 , A01N43/54 , A01N53/00 , A01N31/16 , A01N37/18
摘要： The invention provides process for making contra-soluble nano-dispersions of at most sparingly-soluble materials in a soluble carrier material comprising the steps of: (i) providing a single phase mixture of: a) a solvent or a mixture of miscible solvents, b) at least one carrier material soluble in solvent (a), said carrier material being also contra-soluble to payload material (c) and solid at ambient temperature, c) at least one a payload material which is soluble in solvent (a), and, (ii) drying the mixture to remove solvent (a) and thereby obtain the carrier material (b) in solid form with payload (c) dispersed therein as nanoparticles.
摘要翻译：本发明提供了在可溶性载体材料中制备至多微溶性材料的可溶性纳米分散体的方法，其包括以下步骤：（i）提供单相混合物：a）溶剂或可混溶溶剂的混合物， b）可溶于溶剂（a）的至少一种载体材料，所述载体材料在环境温度下也可溶于有效载荷材料（c）和固体，c）至少一种可溶于溶剂（a）的有效载荷材料，，和（ii）干燥混合物以除去溶剂（a），从而获得固体形式的载体材料（b），其中有效载荷（c）作为纳米颗粒分散在其中。

2. 发明申请

WO2008006716A3 IMPROVEMENTS RELATING TO PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：关于药物组合物的改进
公开(公告)号：WO2008006716A3
公开(公告)日：2008-03-13
申请号：PCT/EP2007056564
申请日：2007-06-29
申请人： UNILEVER PLC , UNILEVER NV , DUNCALF DAVID JOHN , ELPHICK ANDREW JAMES , FOSTER ALISON JAYNE , LONG JAMES , RANNARD STEVEN PAUL , WANG DONG
发明人： DUNCALF DAVID JOHN , ELPHICK ANDREW JAMES , FOSTER ALISON JAYNE , LONG JAMES , RANNARD STEVEN PAUL , WANG DONG
IPC分类号： A61K9/16 , A23L27/00 , A61K31/496
CPC分类号： A61K9/1617 , A01N25/04 , A61K9/10 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/19 , A61K31/167 , A01N43/54 , A01N53/00 , A01N31/16 , A01N37/18
摘要： A process for the production of a composition comprising a water-insoluble sartan which comprises the steps of: a) providing a mixture comprising: i) a water-insoluble sartan, ii) a water soluble carrier, iii) a solvent for each of the sartan and the carrier, and b) spray-drying the mixture to remove the or each solvent and obtain a substantially solvent-free nano-dispersion of the sartan in the carrier.
摘要翻译：一种制备包含水不溶性沙丁胺的组合物的方法，其包括以下步骤：a）提供混合物，其包括：i）不溶于水的沙坦，ii）水溶性载体，iii）沙坦和载体，以及b）喷雾干燥该混合物以除去或各种溶剂，并获得载体中沙丁烷的基本上无溶剂的纳米分散体。

3. 发明申请

WO2008006713A2 IMPROVEMENTS RELATING TO ANTI-PARASITIC COMPOSITIONS 审中-公开
标题翻译：有关抗菌成分的改进
公开(公告)号：WO2008006713A2
公开(公告)日：2008-01-17
申请号：PCT/EP2007056561
申请日：2007-06-29
申请人： UNILEVER PLC , UNILEVER NV , DUNCALF DAVID JOHN , ESSA ASHA HASSAN , FOSTER ALISON JAYNE , LONG JAMES , RANNARD STEVEN PAUL , WANG DONG
发明人： DUNCALF DAVID JOHN , ESSA ASHA HASSAN , FOSTER ALISON JAYNE , LONG JAMES , RANNARD STEVEN PAUL , WANG DONG
IPC分类号： A61K9/16 , A23L27/00 , A61K31/496
CPC分类号： A61K9/1617 , A01N25/04 , A61K9/10 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/19 , A61K31/167 , A01N43/54 , A01N53/00 , A01N31/16 , A01N37/18
摘要： The present invention relates to nanodisperse antiparasitcs and provides a composition comprising at least one water insoluble anti-parasitic drug and a water-soluble carrier material, wherein the water-insoluble anti-parasitic drug (preferably an Artemisinin-type drug or a quinine type drug) is dispersed through the carrier material in nano-disperse form having a peak diameter of the nano-disperse form below 1000nm. The invention further provides an aqueous dispersion of a water insoluble anti-parasitic drug and a water-soluble carrier material, wherein the anti-parasitic drug is in nano-disperse form having a peak diameter of the nano- disperse form below 1000nm, the invention further subsists in a process for preparing an anti-parasitic composition comprising a water insoluble anti-parasitc agent and a water-soluble carrier, which comprises the steps of either: a) providing an emulsion comprising a solution of the anti-parasitic agent in a water-immiscible solvent for the same, and an aqueous solution of the carrier, or providing a mixture comprising at least one non-aqueous solvent optional water a water-soluble carrier material soluble in the mixture and a water-insoluble anti- parasitic agent soluble in the mixture, and, b) drying the emulsion (preferably by spray drying) to remove water and the water-immiscible solvent to obtain a substantially solvent-free nano-dispersion of the anti-parasitic agent in the carrier.
摘要翻译：本发明涉及纳米分散抗寄生虫剂，并提供包含至少一种水不溶性抗寄生虫药物和水溶性载体材料的组合物，其中所述水不溶性抗寄生虫药物（优选青蒿素型药物或奎宁型药物）以纳米分散形式的峰值直径低于1000nm的纳米分散形式分散在载体材料中。本发明还提供了水不溶性抗寄生虫药物和水溶性载体材料的水性分散体，其中抗寄生虫药物为纳米分散形式，其纳米分散体形式的峰值直径低于1000nm，本发明进一步存在于制备包含水不溶性抗寄生虫剂和水溶性载体的抗寄生物组合物的方法中，其包括以下步骤：a）提供包含抗寄生虫剂溶液的乳液或与提供包含至少一种非水溶剂任选的水的混合物，可溶于该混合物的水溶性载体材料和可溶于水的不溶性抗寄生剂溶液在混合物中，并且b）干燥乳液（优选通过喷雾干燥）以除去水和与水不混溶的溶剂，以获得基本上无溶剂的抗吸附剂的纳米分散体 tic代理在承运人。

4. 发明申请

WO2008006715A3 IMPROVEMENTS RELATING TO PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：与药物组合物有关的改进
公开(公告)号：WO2008006715A3
公开(公告)日：2008-05-08
申请号：PCT/EP2007056563
申请日：2007-06-29
申请人： UNILEVER PLC , UNILEVER NV , DUNCALF DAVID JOHN , FOSTER ALISON JAYNE , LONG JAMES , RANNARD STEVEN PAUL , WANG DONG
发明人： DUNCALF DAVID JOHN , FOSTER ALISON JAYNE , LONG JAMES , RANNARD STEVEN PAUL , WANG DONG
IPC分类号： A61K9/16 , A23L27/00 , A61K31/366
CPC分类号： A61K9/1617 , A01N25/04 , A61K9/10 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/19 , A61K31/167 , A01N43/54 , A01N53/00 , A01N31/16 , A01N37/18
摘要： A process for the production of a composition comprising a water-insoluble statin which comprises the steps of: a) providing a mixture comprising: i) a water-insoluble statin ii) a water soluble carrier, iii) a solvent for each of the statin and the carrier, and b) spray-drying the mixture to remove the or each solvent and obtain a substantially solvent-free nano-dispersion of the statin in the carrier.
摘要翻译：一种生产包含不溶于水的他汀的组合物的方法，该方法包括以下步骤：a）提供一种混合物，该混合物包含：i）不溶于水的他汀类ii）水溶性载体，iii）每种他汀类的溶剂和载体，和b）喷雾干燥混合物以除去该溶剂或每种溶剂，并获得他汀在载体中的基本上无溶剂的纳米分散体。

5. 发明申请

WO2008006714A3 IMPROVEMENTS RELATING TO BIOCIDAL COMPOSITIONS 审中-公开
标题翻译：有关生物组合物的改进
公开(公告)号：WO2008006714A3
公开(公告)日：2008-02-21
申请号：PCT/EP2007056562
申请日：2007-06-29
申请人： UNILEVER PLC , UNILEVER NV , DUNCALF DAVID JOHN , FOSTER ALISON JAYNE , LONG JAMES , RANNARD STEVEN PAUL , WANG DONG
发明人： DUNCALF DAVID JOHN , FOSTER ALISON JAYNE , LONG JAMES , RANNARD STEVEN PAUL , WANG DONG
IPC分类号： A61K9/16 , A01N31/16 , A23L27/00 , A61K31/496 , A61K47/00
CPC分类号： A61K9/1617 , A01N25/04 , A61K9/10 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/19 , A61K31/167 , A01N43/54 , A01N53/00 , A01N31/16 , A01N37/18
摘要： The invention provides a solvent-free biocidal composition of improved efficacy comprising at least one water insoluble biocide (preferably a herbicide) and a water-soluble carrier material, wherein the water-insoluble biocide is dispersed through the carrier material in nano-disperse form having a peak diameter of the nano-disperse form below 1000nm. The invention also provides a process which comprises spray drying a solution of the biocide and a solution of a water- soluble carrier to obtain a solvent free dispersion of the biocide in the carrier, which, when dissolved in water, produces a nano-disperse biocide. The invention also provides an aqueous dispersion of a water insoluble biocide and a water-soluble carrier obtained by the dispersion of the composition of the solvent free composition in water.
摘要翻译：本发明提供具有改进功效的无溶剂杀生物组合物，其包含至少一种水不溶性杀生物剂（优选除草剂）和水溶性载体材料，其中水不溶性杀生物剂以纳米分散体形式分散通过载体材料，在1000nm以下的纳米分散体的峰值直径。本发明还提供了一种方法，其包括喷雾干燥杀生物剂溶液和水溶性载体溶液以获得杀生物剂在载体中的无溶剂分散体，当溶解于水中时，该分散体产生纳米分散杀生物剂。本发明还提供了通过将无溶剂组合物的组合物分散在水中获得的水不溶性杀生物剂和水溶性载体的水分散体。

6. 发明申请

WO2010023066A3 IMPROVEMENTS RELATING TO PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：与药物组合物有关的改进
公开(公告)号：WO2010023066A3
公开(公告)日：2010-08-05
申请号：PCT/EP2009060007
申请日：2009-08-03
申请人： UNILEVER PLC , UNILEVER NV , ANGUS DORIS , DUNCALF DAVID JOHN , FOSTER ALISON JAYNE , RANNARD STEVEN PAUL , WANG DONG
发明人： ANGUS DORIS , DUNCALF DAVID JOHN , FOSTER ALISON JAYNE , RANNARD STEVEN PAUL , WANG DONG
IPC分类号： A61K9/16
CPC分类号： A61K9/1694 , A61K9/1652 , A61K9/5161
摘要： The present invention provides a substantially solvent-free nano-dispersion of an active in a carrier, wherein the carrier comprises an enteric carrier soluble at intestinal pH, but insoluble at stomach pH, and wherein the enteric carrier comprises at least 50% by weight of the nano-dispersion; and processes for the preparation of a substantially solvent-free nano-dispersion of an active in a carrier.
摘要翻译：本发明提供了基本上无溶剂的载体中活性剂的纳米分散体，其中所述载体包含可溶于肠pH的肠溶载体，但在胃pH下不溶，并且其中所述肠载体包含至少50重量％的纳米分散体; 以及用于制备载体中的活性物质的基本上无溶剂的纳米分散体的方法。

7. 发明申请

WO2008007151A3 PROCESSES FOR PREPARING PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：制备药物组合物的过程
公开(公告)号：WO2008007151A3
公开(公告)日：2008-03-06
申请号：PCT/GB2007050408
申请日：2007-07-13
申请人： UNILEVER PLC , DUNCALF DAVID JOHN , RANNARD STEVEN PAUL , LONG JAMES , WANG DONG , ELPHICK ANDREW JAMES , STANIFORTH JOHN , FOSTER ALISON JAYNE
发明人： DUNCALF DAVID JOHN , RANNARD STEVEN PAUL , LONG JAMES , WANG DONG , ELPHICK ANDREW JAMES , STANIFORTH JOHN , FOSTER ALISON JAYNE
IPC分类号： A61K9/16 , A23L27/00 , A61K31/167 , A61K31/192 , A61K31/60
CPC分类号： A61K9/1617 , A01N25/04 , A61K9/10 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/19 , A61K31/167 , A01N43/54 , A01N53/00 , A01N31/16 , A01N37/18
摘要： A process for the production of a composition comprising a water-insoluble triptan which comprises the steps of: a) providing a mixture comprising: i) a water-insoluble triptan, ii) a water soluble carrier, and iii) a solvent for each of the triptan and the carrier, and b) spray-drying the mixture to remove the or each solvent and obtain a substantially solvent-free nano-dispersion of the triptan in the carrier.
摘要翻译：一种生产包含水不溶性曲普坦的组合物的方法，该方法包括以下步骤：a）提供一种混合物，该混合物包含：i）一种水不溶性曲坦，ii）一种水溶性载体，以及iii）曲普坦和载体，和b）喷雾干燥混合物以除去所述或每种溶剂，并且获得载体中的曲普坦的基本上无溶剂的纳米分散体。

8. 发明申请

WO2010020518A3 IMPROVEMENTS RELATING TO NANODISPERSE COMPOSITIONS 审中-公开
标题翻译：有关纳米分散组合物的改进
公开(公告)号：WO2010020518A3
公开(公告)日：2010-10-14
申请号：PCT/EP2009059546
申请日：2009-07-24
申请人： UNILEVER PLC , UNILEVER NV , ANGUS DORIS , DUNCALF DAVID JOHN , FOSTER ALISON JAYNE , RANNARD STEVEN PAUL , WANG DONG
发明人： ANGUS DORIS , DUNCALF DAVID JOHN , FOSTER ALISON JAYNE , RANNARD STEVEN PAUL , WANG DONG
IPC分类号： A61K9/16 , A61K31/00
CPC分类号： A61K9/1694 , A61K9/1623 , A61K9/1635 , B01J2/04
摘要： A process for the production of a soluble composition comprising a water- insoluble active which comprises either the steps of: a) providing a liquid mixture comprising: i) a dissolved water-insoluble active, ii) a dissolved water-soluble carrier, iii) a solvent for each of the active and the carrier, and b) spray-granulating the mixture to remove the, or each, solvent and obtain a substantially solvent-free nano-dispersion of the water-insoluble active in the carrier said water-insoluble active being in nano-particles having a size range of 999-20 nm; or, the steps of: a) providing a substantially solvent-free powder comprising a water-insoluble active dispersed in a water soluble carrier, said water-insoluble active being in nano-particles having a size range of 999-20 nm, and, b) spray-granulating the powder to obtain larger and denser particles. The invention also relates to solvent-free, granular products with a particle size in the range 20 microns to 10mm and a bulk-density of greater than 0.4g/cm3 comprising a water-soluble carrier material, the carrier material having dispersed therein a water-insoluble active, wherein on addition of water the carrier dissolves to form an aqueous dispersion of the active with a peak (z-average) particle size of below 800nm, preferably below 500nm and more preferably below 200nm. The invention also relates to an analogous "reverse" process in which the active is water soluble and the carrier is oil soluble.
摘要翻译：一种生产包含水不溶性活性物质的可溶性组合物的方法，该方法包括以下步骤：a）提供液体混合物，该液体混合物包含：i）溶解的水不溶性活性物质，ii）溶解的水溶性载体，iii）用于活性物质和载体中的每一种的溶剂，和b）喷雾造粒混合物以除去所述溶剂或每种溶剂，并获得所述水不溶性活性物质在所述载体中的基本上无溶剂的纳米分散体，所述水不溶性物质活性纳米颗粒的尺寸范围为999-20nm; 或以下步骤：a）提供基本上无溶剂的粉末，其包含分散在水溶性载体中的水不溶性活性物质，所述水不溶性活性物质为纳米颗粒，其尺寸范围为999-20nm， b）将粉末喷雾造粒以获得更大和更致密的颗粒。本发明还涉及包含水溶性载体材料的无溶剂颗粒产品，其颗粒尺寸为20微米至10毫米，堆密度大于0.4克/厘米3，所述载体材料中分散有水其中在加入水时，载体溶解以形成具有低于800nm，优选低于500nm并且更优选低于200nm的峰（z-平均）粒径的活性物质的含水分散体。本发明还涉及一种类似的“反向”方法，其中活性成分是水溶性的而载体是油溶性的。

9. 发明申请

WO2008007152A2 PREPARATION OF PHARMACEUTICAL FORMULATIONS 审中-公开
标题翻译：药物制剂的制备
公开(公告)号：WO2008007152A2
公开(公告)日：2008-01-17
申请号：PCT/GB2007050409
申请日：2007-07-13
申请人： UNILEVER PLC , DUNCALF DAVID JOHN , RANNARD STEVEN PAUL , LONG JAMES , WANG DONG , ELPHICK ANDREW JAMES , STANIFORTH JOHN , CHAUVIN DANIELE , FOSTER ALISON JAYNE
发明人： DUNCALF DAVID JOHN , RANNARD STEVEN PAUL , LONG JAMES , WANG DONG , ELPHICK ANDREW JAMES , STANIFORTH JOHN , CHAUVIN DANIELE , FOSTER ALISON JAYNE
IPC分类号： A61K9/16 , A23L27/00 , A61K31/167 , A61K31/192 , A61K31/60
CPC分类号： A61K9/1617 , A01N25/04 , A61K9/10 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/19 , A61K31/167 , A01N43/54 , A01N53/00 , A01N31/16 , A01N37/18
摘要： A process for the production of a composition comprising a water-insoluble opioid which comprises the steps of: a) providing a mixture comprising: i) a water-insoluble opioid, ii) a water soluble carrier, and iii) a solvent for each of the opioid and the carrier, and b) spray-drying the mixture to remove the or each solvent and obtain a substantially solvent-free nano-dispersion of the opioid in the carrier.
摘要翻译：一种生产包含水不溶性阿片样物质的组合物的方法，该方法包括以下步骤：a）提供一种混合物，该混合物包含：i）水不溶性阿片样物质，ii）水溶性载体，和iii）阿片样物质和载体，和b）喷雾干燥混合物以除去所述或每种溶剂，并获得载体中的阿片样物质的基本上无溶剂的纳米分散体。

10. 发明申请

WO2011128623A3 IMPROVEMENTS RELATING TO ANTIVIRAL COMPOSITIONS 审中-公开
标题翻译：有关组合物的改进
公开(公告)号：WO2011128623A3
公开(公告)日：2012-05-03
申请号：PCT/GB2011000549
申请日：2011-04-08
申请人： IOTA NANOSOLUTIONS LTD , FOSTER ALISON JAYNE , LONG JAMES , RANNARD STEVEN PAUL , WANG DONG , DUNCALF DAVID JOHN
发明人： FOSTER ALISON JAYNE , LONG JAMES , RANNARD STEVEN PAUL , WANG DONG , DUNCALF DAVID JOHN
IPC分类号： A61K9/51
CPC分类号： A61K9/10 , A61K9/5123 , A61K9/5138 , A61K9/5146 , A61K9/5161 , A61K9/5192 , A61K31/427 , A61K31/4725 , A61K31/513 , A61K31/536 , A61K47/10 , A61K47/32 , A61K47/38
摘要： The present invention provides a composition and an antiviral drug preparation, each comprising at least one water-insoluble antiviral drug and at least one water-soluble carrier material, wherein the water-insoluble antiviral drug is dispersed through the water-soluble carrier material in nano-disperse form. The present invention further provides processes for preparing the compositions and drug preparations, and also aqueous nano-dispersions obtained by combining water and the compositions.
摘要翻译：本发明提供一种组合物和抗病毒药物制剂，每种组合物和抗病毒药物制剂各自包含至少一种水不溶性抗病毒药物和至少一种水溶性载体材料，其中所述水不溶性抗病毒药物通过纳米级的水溶性载体材料分散 - 分散形式。本发明还提供了制备组合物和药物制剂的方法，以及通过将水和组合物组合获得的水性纳米分散体。

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