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1. 发明申请

WO1997027856A1 REMEDIES OR PREVENTIVES FOR AIDS 审中-公开
标题翻译：艾滋病的救济或预防措施
公开(公告)号：WO1997027856A1
公开(公告)日：1997-08-07
申请号：PCT/JP1997000218
申请日：1997-01-30
申请人： SANKYO COMPANY, LIMITED , UBE INDUSTRIES, LTD. , KOMAI, Tomoaki , OHMINE, Toshinori , NISHIGAKI, Takashi , KIMURA, Tomio , KATSUBE, Tetsushi
发明人： SANKYO COMPANY, LIMITED , UBE INDUSTRIES, LTD.
IPC分类号： A61K31/445
CPC分类号： C07D215/56 , A61K31/70 , A61K38/55 , A61K31/47 , A61K2300/00
摘要： Combined use of one or more drugs selected from among quinolonecarboxylic acid-based anti-HIV agents with one or more drugs selected from among reverse transcriptase inhibitors and HIV protease inhibitors for treating or preventing AIDS; and remedies or preventives for AIDS containing as the active ingredient one or more drugs selected from among quinolonecarboxylic acid-based anti-HIV agents together with one or more drugs selected from among reverse transcriptase inhibitors and HIV protease inhibitors.
摘要翻译：将选自喹诺酮类羧基抗HIV剂中的一种或多种药物与选自逆转录酶抑制剂和HIV蛋白酶抑制剂的一种或多种药物联合用于治疗或预防艾滋病; 以及含有作为活性成分的一种或多种选自喹诺酮羧酸类抗HIV药物的一种或多种药物与一种或多种选自逆转录酶抑制剂和HIV蛋白酶抑制剂的药物的补救剂或预防剂。

2. 发明申请

WO1996002512A1 TRIFLUOROMETHYLQUINOLINECARBOXYLIC ACID DERIVATIVE 审中-公开
标题翻译：三氟甲基喹啉羧酸衍生物
公开(公告)号：WO1996002512A1
公开(公告)日：1996-02-01
申请号：PCT/JP1995001123
申请日：1995-06-07
申请人： UBE INDUSTRIES, LTD. , SANKYO COMPANY, LIMITED , KIMURA, Tomio , KATSUBE, Tetsushi , NISHIGAKI, Takashi
发明人： UBE INDUSTRIES, LTD. , SANKYO COMPANY, LIMITED
IPC分类号： C07D215/56
CPC分类号： C07D215/56
摘要： An 8-trifluoromethylquinolinecarboxylic acid derivative represented by general formula (I) or a pharmacologically acceptable salt or ester thereof wherein: R represents lower alkyl, halogenated lower alkyl or cycloalkyl; R represents a phenyl group which may be substituted by R , a five- or six-membered heteroaromatic monocyclic group which may be substituted by R and bears one or two heteroatoms selected from among N, O and S, or a fused heteroaromatic group composed of the above heteroaromatic monocycle and a benzene ring; R represents halogen, lower alkyl, fluorinated lower alkyl, lower alkoxy or lower alkylthio; R represents hydrogen or lower alkyl; and m represents an integer of 2 or 3.
摘要翻译：由通式（I）表示的8-三氟甲基喹啉羧酸衍生物或其药理学上可接受的盐或酯，其中：R 1表示低级烷基，卤代低级烷基或环烷基; R 2表示可以被R 0取代的苯基，可被R 0取代的五元或六元杂芳族单环基团，并带有一个或两个选自N，O的杂原子和 S或由上述杂芳族单环构成的稠合杂芳族基团和苯环; R 0表示卤素，低级烷基，氟代低级烷基，低级烷氧基或低级烷硫基; R 3表示氢或低级烷基; m表示2或3的整数。

3. 发明申请

WO1995019980A1 PYRROLOPYRIDAZINE DERIVATIVE 审中-公开
标题翻译：吡咯烷酮衍生物
公开(公告)号：WO1995019980A1
公开(公告)日：1995-07-27
申请号：PCT/JP1995000038
申请日：1995-01-18
申请人： SANKYO COMPANY, LIMITED , UBE INDUSTRIES, LTD. , KIMURA, Tomio , FUJIHARA, Yoshimi , SHIBAKAWA, Nobuhiko , FUJIWARA, Hiroshi , ITOH, Etsuro , MATSUNOBU, Keiji , TABATA, Keiichi , YASUDA, Hiroshi
发明人： SANKYO COMPANY, LIMITED , UBE INDUSTRIES, LTD.
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： A pyrrolopyridazine derivative represented by general formula (I) and a pharmacologically acceptable salt thereof, wherein R represents C2-C6 alkenyl, halogenated C2-C6 alkenyl, (C6-C10 aryl)-substituted C2-C6 alkenyl, C2-C6 alkynyl, C3-C7 cycloalkyl, (C3-C7 cycloalkyl)-substituted C1-C6 alkyl, (C5-C7 cycloalkenyl)-substituted C1-C6 alkyl or halogenated C1-C6 alkyl; R and R represent each independently hydrogen, C1-C6 alkyl or C6-C10 aryl; R represents hydrogen or C1-C6 alkyl; R represents C6-C10 aryl or five- to ten-membered heteroaryl wherein heteroatom(s) is(are) selected from among nitrogen, oxygen and sulfur atoms; A represents C1-C3 alkylene; X represents imino, oxygen, sulfur or methylene; m represents 0 or 1; and n represents 0 or 1. The derivative has excellent effects of suppressing gastric secretion and protecting gastric mucosa and an excellent antibacterial activity against Helicobacter pylori, thus being useful as a preventive or remedy for ulcerative diseases and the like.
摘要翻译：由通式（I）表示的吡咯并哒嗪衍生物及其药理学可接受的盐，其中R 1表示C 2 -C 6烯基，卤代C 2 -C 6烯基，（C 6 -C 10芳基） - 取代的C 2 -C 6烯基，C 2 -C 6 炔基，C 3 -C 7环烷基，（C 3 -C 7环烷基） - 取代的C 1 -C 6烷基，（C 5 -C 7环烯基） - 取代的C 1 -C 6烷基或卤代C 1 -C 6烷基; R 2和R 3各自独立地表示氢，C 1 -C 6烷基或C 6 -C 10芳基; R 4表示氢或C 1 -C 6烷基; R 5表示C6-C10芳基或五至十元杂芳基，其中杂原子选自氮，氧和硫原子; A表示C1-C3亚烷基; X表示亚氨基，氧，硫或亚甲基; m表示0或1; n表示0或1.该衍生物具有抑制胃分泌和保护胃粘膜的优异效果，对幽门螺杆菌具有优异的抗菌活性，因此可用作溃疡性疾病等的预防或治疗方法。

4. 发明申请

WO1994019345A1 QUINOLINE DERIVATIVE 审中-公开
标题翻译：喹啉衍生物
公开(公告)号：WO1994019345A1
公开(公告)日：1994-09-01
申请号：PCT/JP1994000234
申请日：1994-02-16
申请人： UBE INDUSTRIES, LTD. , KIMURA, Tomio , KAKU, Yoshio , IKUTA, Takashi , FUJIWARA, Hiroshi , UENO, Hitoshi , OKANARI, Eiji
发明人： UBE INDUSTRIES, LTD.
IPC分类号： C07D405/12
CPC分类号： C07D405/12 , C07D405/14
摘要： A compound (quinoline derivative) represented by general formula (I) and having such a potent leucotriene antagonism that it is significantly useful as an antiallergic and an anti-inflammatory.
摘要翻译：由通式（I）表示的化合物（喹啉衍生物），具有如此有效的白三烯拮抗作用，其显着地用作抗过敏和抗炎。

5. 发明申请

WO1994007890A1 PYRIMIDINE COMPOUND 审中-公开
标题翻译：吡嗪化合物
公开(公告)号：WO1994007890A1
公开(公告)日：1994-04-14
申请号：PCT/JP1993001412
申请日：1993-10-01
申请人： UBE INDUSTRIES, LTD. , KIMURA, Tomio , KUROKI, Yoshiaki , FUJIWARA, Hiroshi , ANPEIJI, Shigeharu
发明人： UBE INDUSTRIES, LTD.
IPC分类号： C07D401/12
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14
摘要： A pyrimidine derivative represented by general formula (II) or (III) and a salt thereof, both having selective acetylcholine esterase inhibitor and type A monoamine oxidase inhibitor effects, thus being useful as antidepressant and senile dementia remedy. In said formulae, R1 and R2 represent each H, halogen, amino, nitro, (un)substituted alkyl, alkoxy or alkoxycarbonyl, provided that R1 and R2 may be combined together to represent (un)substituted alkylene; R3 represents aralkyl or heteroaryl-alkyl; R4 represents H or acyl; R5 represents H, OH or alkoxy; R6 represents H, halogen, alkyl or alkoxy; X represents -CH=, -CH=CH-(CH2)p-, -CH2- or -CH2CH2-(CH2)p-; Y represents =CH-(CH2)p-, -CH2-(CH2)p-, single bond or double bond; p represents 0 or 1; and symbol .(OVERSCORE).(OVERSCORE).(OVERSCORE).(OVERSCORE).(OVERSCORE) represents either single or double bond.
摘要翻译：由通式（II）或（III）表示的嘧啶衍生物及其盐均具有选择性乙酰胆碱酯酶抑制剂和A型单胺氧化酶抑制剂作用，因此可用作抗抑郁药和老年痴呆症药物。在所述式中，R 1和R 2表示每个H，卤素，氨基，硝基，（未）取代的烷基，烷氧基或烷氧基羰基，条件是R 1和R 2可以组合在一起代表（未）取代的亚烷基; R3表示芳烷基或杂芳基 - 烷基; R4代表H或酰基; R5表示H，OH或烷氧基; R6表示H，卤素，烷基或烷氧基; X表示-CH =，-CH = CH-（CH 2）p - ， - CH 2 - 或-CH 2 CH 2 - （CH 2）p - Y表示= CH-（CH 2）p - ， - CH 2 - （CH 2）p - 单键或双键; p表示0或1; （OVERSCORE）（OVERSCORE）（OVERSCORE）（OVERSCORE）（OVERSCORE）（OVERSCORE）（OVERSCORE）（OVERSCORE）（OVERSCORE）。

6. 发明申请

WO1998008811A1 CYCLIC AMINE DERIVATIVES 审中-公开
标题翻译：循环胺衍生物
公开(公告)号：WO1998008811A1
公开(公告)日：1998-03-05
申请号：PCT/JP1997002990
申请日：1997-08-28
申请人： SANKYO COMPANY, LIMITED , UBE INDUSTRIES, LTD. , ASAI, Fumitoshi , SUGIDACHI, Atsuhiro , IKEDA, Toshihiko , KOIKE, Hiroyuki , INOUE, Teruhiko , TAKATA, Katsunori , IWAMURA, Ryo , KITA, Jun-ichiro , YONEDA, Kenji
发明人： SANKYO COMPANY, LIMITED , UBE INDUSTRIES, LTD.
IPC分类号： C07D205/04
CPC分类号： C07D213/70 , C07D205/04 , C07D207/08 , C07D207/12 , C07D211/20 , C07D211/54 , C07D451/02 , C07D451/04 , Y02P20/55
摘要： Cyclic amine derivatives represented by general formula (I) or pharmacologically acceptable salts thereof, excellent in the effect of inhibiting platelet aggregation and useful as a preventive or remedy for embolism, thrombosis or arteriosclerosis, wherein R represents optionally substituted phenyl; R represents optionally substituted C1-C8 acyl, optionally substituted benzoyl or C1-C4 alkoxycarbonyl; and R represents optionally fused, substituted three- to seven-membered cyclic saturated amino.
摘要翻译：由通式（I）表示的环胺衍生物或其药理学上可接受的盐，其抑制血小板聚集的效果优异，可用作栓塞，血栓形成或动脉硬化的预防或治疗，其中R 1表示任选取代的苯基; R 2表示任选取代的C 1 -C 8酰基，任选取代的苯甲酰基或C 1 -C 4烷氧基羰基; R 3表示任选稠合的取代的三至七元环饱和的氨基。

7. 发明申请

WO1997049397A1 NOVEL MEDICINAL COMPOSITIONS OF HYDROPYRIDINES 审中-公开
标题翻译：新型药物组合物
公开(公告)号：WO1997049397A1
公开(公告)日：1997-12-31
申请号：PCT/JP1997002173
申请日：1997-06-24
申请人： SANKYO COMPANY, LIMITED , UBE INDUSTRIES, LTD. , ASAI, Fumitoshi , OGAWA, Taketoshi , INOUE, Teruhiko
发明人： SANKYO COMPANY, LIMITED , UBE INDUSTRIES, LTD.
IPC分类号： A61K31/435
CPC分类号： C07D495/04
摘要： Compositions containing as the active ingredient 4,5,6,7-tetrahydrothieno[3,2-c]pyridines represented by the following general formula (I): R -CH(R )-R or pharmacologically acceptable salts thereof which have an excellent effect of inhibiting the progression of arteriosclerosis and a low toxicity and, therefore, are highly useful as remedies or preventives for arteriosclerosis. In said formula, R represents optionally substituted phenyl; R represents H, alkoxycarbonyl or optionally substituted aliphatic acyl; and R represents optionally substituted 4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl.
摘要翻译：含有下列通式（I）表示的活性成分4,5,6,7-四氢噻吩并[3,2-c]吡啶的组合物：R 1 -CH（R 2）-R 3 或其药理学上可接受的盐，其具有抑制动脉硬化进展和低毒性的优异效果，因此作为动脉硬化的补救剂或预防剂是非常有用的。在所述式中，R 1表示任选取代的苯基; R 2表示H，烷氧基羰基或任选取代的脂族酰基; R 3表示任选取代的4,5,6,7-四氢噻吩并[3,2-c]吡啶-5-基。

8. 发明申请

WO1998047985A1 METHOD AND APPARATUS FOR TREATING WASTES BY GASIFICATION 审中-公开
标题翻译：通过气化处理废物的方法和装置
公开(公告)号：WO1998047985A1
公开(公告)日：1998-10-29
申请号：PCT/JP1997003814
申请日：1997-10-22
申请人： EBARA CORPORATION , UBE INDUSTRIES, LTD.
发明人： EBARA CORPORATION , UBE INDUSTRIES, LTD. , FUJIMURA, Hiroyuki , HIRAYAMA, Yoshio , FUJINAMI, Shosaku , TAKANO, Kazuo , IRIE, Masaaki , HIROSE, Tetsuhisa , NAGATO, Shuichi , OSHITA, Takahiro , FUKUDA, Toshio
IPC分类号： C10J03/54
CPC分类号： C10J3/721 , C10G2300/1003 , C10J3/482 , C10J3/54 , C10J3/56 , C10J3/66 , C10J3/84 , C10J2300/0946 , C10J2300/1606 , C10J2300/1693 , C10J2300/1823 , C10J2300/1861 , C10J2300/1884 , C10K1/101 , C10K3/04
摘要： A method and apparatus for treating wastes by two-stage gasification recovers metals or ash content in the wastes in such a state that they can be recycled, and gases containing carbon monoxide (CO) and hydrogen gas (H2) for use as synthesis gas of ammonia (NH3) or production of hydrogen gas. The wastes are gasified in a fluidized-bed reactor (3) at a low temperature. Then, gaseous material and char produced in the fluidized-bed reactor (3) are introduced into the high-temperature combustor (17), and gasified at a high temperature and ash content is converted into molten slag. After water scrubbing and CO conversion reaction, the gas is separated into H2 and residual gas. The residual gas is then supplied to the fluidized-bed reactor (3) as a fluidizing gas.
摘要翻译：用于通过两阶段气化处理废物的方法和装置在可再循环的状态下回收废物中的金属或灰分含量，以及用作一氧化碳（CO）和氢气（H2）的气体，用作合成气氨（NH3）或氢气的生产。废物在低温下在流化床反应器（3）中气化。然后，将在流化床反应器（3）中产生的气态物质和焦炭引入高温燃烧器（17）中，高温气化并将灰分转化成熔渣。水洗涤和CO转化反应后，将气体分离成H2和残留气体。然后将残余气体作为流化气体供给流化床反应器（3）。

9. 发明申请

WO1998007717A1 PROCESS FOR PREPARING 2-(10,11-DIHYDRO-10-OXODIBENZO[b,f]THIEPIN-2-YL)PROPIONIC ACID AND INTERMEDIATES THEREFOR 审中-公开
标题翻译：制备2-（10,11-二氢-10-氧代苯并[b，f]硫蛋白-2-YL）的方法其酸及其中间体
公开(公告)号：WO1998007717A1
公开(公告)日：1998-02-26
申请号：PCT/JP1997002922
申请日：1997-08-22
申请人： NIPPON CHEMIPHAR CO., LTD. , UBE INDUSTRIES, LTD. , YAMAMOTO, Masao , KOBAYASHI, Kunio , HARADA, Katsumasa , NISHINO, Shigeyoshi , SASAKI, Hiroshi
发明人： NIPPON CHEMIPHAR CO., LTD. , UBE INDUSTRIES, LTD.
IPC分类号： C07D337/14
CPC分类号： C07D337/14
摘要： A novel process for preparing zaltoprofen[2-(10,11-dihydro-10-oxodibenzo[b,f]thiepin-2-yl)propionic acid], which, as compared with the conventional processes, has better practicality from an overall viewpoint including availability and handleability of a starting material and profitability, such as the yield. The novel process is characterized by providing 2-(4-amino-3-carboxymethylphenyl)propionic acid or a salt thereof as a starting compound, subjecting the starting compound to, e.g., diazotization reacting the diazotized compound with thiophenol to prepare 2-(3-carboxymethyl-4-phenylthiophenyl)propionic acid or a salt thereof, and then subjecting this product to a ring-closing reaction. Intermediate compounds useful for the preparation of the above compound are also provided.
摘要翻译：制备zaltoprofen [2-（10,11-二氢-10-氧代二苯并[b，f]硫杂-2-基）丙酸]的新方法，与常规方法相比，从整体观点来看具有更好的实用性包括起始材料的可用性和可处理性以及收益率等获利能力。该新方法的特征在于提供2-（4-氨基-3-羧甲基苯基）丙酸或其盐作为起始化合物，使起始化合物例如重氮化使重氮化化合物与苯硫酚反应，制备2-（3 - 羧甲基-4-苯硫基苯基）丙酸或其盐，然后使该产物进行闭环反应。还提供了可用于制备上述化合物的中间体化合物。

10. 发明申请

WO1997038973A1 HYDRAZINE COMPOUNDS, PROCESS FOR THE PREPARATION THEREOF, AND INSECTICIDES FOR AGRICULTURAL AND HORTICULTURAL USE 审中-公开
标题翻译：水合物化合物，其制备方法和农业和农业用途的杀虫剂
公开(公告)号：WO1997038973A1
公开(公告)日：1997-10-23
申请号：PCT/JP1997001282
申请日：1997-04-14
申请人： UBE INDUSTRIES, LTD. , FUKUDA, Shohei , FUKUDA, Yasuhisa , TSUTSUMIUCHI, Kiyoshi , GOKA, Koichi , KUWATA, Takaaki
发明人： UBE INDUSTRIES, LTD.
IPC分类号： C07C309/04
CPC分类号： C07D213/81 , A01N33/26 , A01N41/04 , A01N43/40 , A01N47/24 , A01N47/34 , C07C309/65 , C07C317/28 , C07C323/48 , C07D213/82
摘要： Hydrazine compounds of general formula (1); process for the preparation of the compounds; and insecticides for agricultural and horticultural use containing the compounds as active ingredients: wherein R is substituted or unsubstituted phenyl; R is hydrogen; R is C1-C4 alkyl or C1-C4 haloalkyl; R is hydrogen or C2-C5 alkylcarbonyl; R is hydrogen, C1-C4 haloalkyl, C2-C5 alkoxyalkyl or C1-C4 alkyl; R is C2-C5 alkoxycarbonyl, C2-C5 alkylcarbonyl, benzoyl, pyridylcarbonyl, C1-C4 alkyl, phenyl, hydrogen, phenylcarbamoyl, pyridyl or formyl; X is C1-C4 alkylene or oxygen; and n is 0 to 2, with the proviso that when X is C1-C4 alkylene, n is 0 or 1, while when X is oxygen, n is 2.
摘要翻译：通式（1）的肼化合物; 化合物的制备方法; 和用于农业和园艺用途的杀虫剂，其含有化合物作为活性成分：其中R 1是取代或未取代的苯基; R 2是氢; R 3是C 1 -C 4烷基或C 1 -C 4卤代烷基; R 4是氢或C 2 -C 5烷基羰基; R 5是氢，C 1 -C 4卤代烷基，C 2 -C 5烷氧基烷基或C 1 -C 4烷基; R 6是C 2 -C 5烷氧基羰基，C 2 -C 5烷基羰基，苯甲酰基，吡啶基羰基，C 1 -C 4烷基，苯基，氢，苯基氨基甲酰基，吡啶基或甲酰基。 X是C 1 -C 4亚烷基或氧; n为0〜2，条件是当X为C1-C4亚烷基时，n为0或1，而当X为氧时，n为2。

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