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1. 发明申请

WO2011141942A1 IMPROVED HIGH TEMPERATURE ORC SYSTEM 审中-公开
标题翻译：改进的高温ORC系统
公开(公告)号：WO2011141942A1
公开(公告)日：2011-11-17
申请号：PCT/IT2011/000140
申请日：2011-05-05
申请人： TURBODEN S.R.L. , GAIA, Mario , BINI, Roberto , PIETRA, Claudio
发明人： GAIA, Mario , BINI, Roberto , PIETRA, Claudio
IPC分类号： F01K7/22 , F01K7/40 , F01K25/08
CPC分类号： F01K25/08 , F01K7/22 , F01K7/40
摘要： An ORC (Organic Rankine Cycle) for the conversion of thermal energy into electric energy, comprising at least one heat exchanger unit (41 ) for re - overheating the work fluid by means of the thermovector fluid from the hot source, between the discharge of the first expander (16) and the input of the second expander (116), and a regenerator unit including a first regenerator (1 and at least one second regenerator (117) for regenerating the work fluid in a least two successive stages, in said first regenerator and at least in said second regenerator respectively, with an additional regenerative heat exchange along the flow line connecting the liquid work fluid output of the second regenerator (117) to the liquid work fluid input of the first regenerator (17).
摘要翻译：一种用于将热能转换成电能的ORC（有机朗肯循环），包括至少一个热交换器单元（41），用于通过来自热源的热动液流体在工作流体的再热过程之间，第一膨胀机（16）和第二膨胀机（116）的输入，以及再生器单元，其包括第一再生器（1和至少一个用于在至少两个连续阶段再生工作流体的第二再生器）再生器，并且至少在所述第二再生器中，沿着将第二再生器（117）的液体工作流体输出连接到第一再生器（17）的液体工作流体输入端的流动管线进行额外的再生热交换。

2. 发明申请

WO2012116176A2 ASYMMETRIC UREAS AND MEDICAL USES THEREOF 审中-公开
标题翻译：非对称性尿路及其医疗用途
公开(公告)号：WO2012116176A2
公开(公告)日：2012-08-30
申请号：PCT/US2012/026315
申请日：2012-02-23
申请人： HELSINN HEALTHCARE SA , GARCIA RUBIO, Silvina , PIETRA, Claudio , GIULIANO, Claudio , LI, Zhigang
发明人： GARCIA RUBIO, Silvina , PIETRA, Claudio , GIULIANO, Claudio , LI, Zhigang
IPC分类号： A61K31/4468 , C07D211/58 , A61P3/04 , A61P3/10 , A61P3/00 , A61P9/04 , A61P21/00 , A61P1/16 , A61P11/00 , A61P1/00 , A61P25/30 , A61P3/08 , A61P5/48 , A61P3/06 , A61P9/10 , A61P9/00 , A61P25/00 , A61P9/12 , A61P7/00 , A61P1/04 , A61P25/32 , A61P25/36
CPC分类号： C07D211/58 , A61K31/4468 , A61K31/4525 , A61K31/4545 , A61K31/5375 , C07D211/60 , C07D211/94 , C07D211/96 , C07D401/06 , C07D401/12 , C07D405/12 , C07D413/12
摘要： Disclosed are compounds, compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the ghrelin receptor. The compounds have the general formula (I).
摘要翻译：公开了用于预防和/或治疗由生长素释放肽受体病理生理介导的疾病的化合物，组合物和方法。化合物具有通式（I）。

3. 发明申请

WO2003053429A3 2-INDANYLAMINO DERIVATIVES FOR THE THERAPY OF CHRONIC PAIN 审中-公开
公开(公告)号：WO2003053429A3
公开(公告)日：2003-07-03
申请号：PCT/EP2002/013839
申请日：2002-12-06
申请人： CHIESI FARMACEUTICI S.p.A. , PIETRA, Claudio , VILLETTI, Gino
发明人： PIETRA, Claudio , VILLETTI, Gino
IPC分类号： A61K31/165
摘要： The present invention relates to the use of 2-indanylamino derivatives for the treatment of chronic pain. In particular, the invention relates to the use of 2-(2-indanylamino)-acetamide for the treatment of neuropathic pain, i.e. the pain associated with postherpetic neuralgia, trigeminal neuralgia, diabetic neuropathy and nerve distruction by the human immunodeficiency virus (HIV).

4. 发明申请

WO2015134839A1 P-SUBSTITUTED ASYMMETRIC UREAS AND MEDICAL USES THEREOF 审中-公开
标题翻译： P-取代不对称的尿道及其医疗用途
公开(公告)号：WO2015134839A1
公开(公告)日：2015-09-11
申请号：PCT/US2015/019112
申请日：2015-03-06
申请人： HELSINN HEALTHCARE SA , GIULIANO, Claudio , RUBIO, Silvina, Garcia , DAINA, Antoine , GUAINAZZI, Angelo , PIETRA, Claudio
发明人： GIULIANO, Claudio , RUBIO, Silvina, Garcia , DAINA, Antoine , GUAINAZZI, Angelo , PIETRA, Claudio
IPC分类号： C07D401/06 , C07C275/06 , C07C275/26 , C07D401/12 , C07D211/58 , C07D211/60 , C07D211/94 , C07D211/96 , C07D213/00
CPC分类号： C07F7/0812 , C07D211/58 , C07D211/60 , C07D211/94 , C07D211/96 , C07D213/00 , C07D239/26 , C07D241/12 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Disclosed are compounds, compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the ghrelin receptor. The compounds have the general Formula (I): or pharmaceutically acceptable salts thereof.
摘要翻译：公开了用于预防和/或治疗由生长素释放肽受体病理生理介导的疾病的化合物，组合物和方法。化合物具有通式（I）：或其药学上可接受的盐。

5. 发明申请

WO2012113103A1 ASYMMETRIC UREAS AND MEDICAL USES THEREOF 审中-公开
标题翻译：非对称尿素及其医疗用途
公开(公告)号：WO2012113103A1
公开(公告)日：2012-08-30
申请号：PCT/CN2011/000298
申请日：2011-02-25
申请人： HELSINN HEALTHCARE S.A. , GARCIA RUBIO, Silvina , PIETRA, Claudio , GIULIANO, Claudio , LI, Zhigang
发明人： GARCIA RUBIO, Silvina , PIETRA, Claudio , GIULIANO, Claudio , LI, Zhigang
IPC分类号： C07D211/58 , C07D405/12 , C07D401/12 , C07D401/06 , C07D413/12 , A61K31/4468 , A61K31/4525 , A61K31/4545 , A61K31/5375 , A61P3/04 , A61P3/10 , A61P3/00 , A61P9/00 , A61P25/30 , A61P1/00
CPC分类号： C07D211/58 , A61K31/4468 , A61K31/4525 , A61K31/4545 , A61K31/5375 , C07D211/60 , C07D211/94 , C07D211/96 , C07D401/06 , C07D401/12 , C07D405/12 , C07D413/12
摘要： Disclosed are compounds, compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the ghrelin receptor. The compounds have the general formula (I).
摘要翻译：公开了用于预防和/或治疗由生长素释放肽受体病理生理学介导的疾病的化合物，组合物和方法。该化合物具有通式（I）。

6. 发明申请

WO2013082102A1 SUBSTITUTED 4 - PHENYL - PYRIDINES FOR THE TREATMENT OF NK-1 RECEPTOR RELATED DISEASES 审中-公开
标题翻译：用于治疗NK-1受体相关疾病的4-苯基 - 吡啶
公开(公告)号：WO2013082102A1
公开(公告)日：2013-06-06
申请号：PCT/US2012/066778
申请日：2012-11-28
申请人： HELSINN HEALTHCARE SA , FADINI, Luca , MANINI, Peter , PIETRA, Claudio , GIULIANO, Claudio , LOVATI, Emanuela , CANNELLA, Roberta , VENTURINI, Alessio , STELLA, Valentino, J.
发明人： FADINI, Luca , MANINI, Peter , PIETRA, Claudio , GIULIANO, Claudio , LOVATI, Emanuela , CANNELLA, Roberta , VENTURINI, Alessio , STELLA, Valentino, J.
IPC分类号： C07D401/04 , A61K31/44 , A61P25/00
CPC分类号： C07F9/650952 , A61K31/44 , A61K31/473 , A61K31/496 , A61K31/56 , A61K31/675 , A61K45/06 , C07D213/74 , C07D213/89 , C07D401/04
摘要： Disclosed are compounds, compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the neurokinin (NKj) receptor. The compounds have the general formula (I):
摘要翻译：公开了用于预防和/或治疗由神经激肽（NKj）受体病理生理介导的疾病的化合物，组合物和方法。该化合物具有通式（I）：

7. 发明申请

WO2010119347A1 NETUPITANT FOR USE IN TREATING BLADDER DYSFUNCTION 审中-公开
标题翻译：用于处理刀片功能的联机
公开(公告)号：WO2010119347A1
公开(公告)日：2010-10-21
申请号：PCT/IB2010/001028
申请日：2010-04-08
申请人： HELSINN HEALTHCARE S.A. , PIETRA, Claudio , CANTOREGGI, Sergio , BRAGLIA, Riccardo
发明人： PIETRA, Claudio , CANTOREGGI, Sergio , BRAGLIA, Riccardo
IPC分类号： A61K31/4523 , A61P13/02
CPC分类号： A61K31/4523
摘要： The present invention relates to methods for reducing the frequency of bladder contractions without significantly affecting micturition pressure, comprising administering a pharmaceutical composition comprising a therapeutically effective amount of netupitant, or a pharmaceutically acceptable salt or prodrug thereof. The method can be used to treat bladder dysfunction without significantly increasing residual volume, including urgency, frequency, pollakiuria, nocturia, low deferment time, suboptimal volume threshold, neurogenic bladder, or combinations thereof.
摘要翻译：本发明涉及降低膀胱收缩频率而不显着影响排尿压力的方法，其包括施用包含治疗有效量的中间体或其药学上可接受的盐或前药的药物组合物。该方法可用于治疗膀胱功能障碍，而不显着增加残留量，包括尿频，频率，尿频，夜尿，低延迟时间，次最佳体积阈值，神经源性膀胱或其组合。

8. 发明申请

WO2015092649A1 CONTROL METHOD FOR AN ORGANIC RANKINE CYCLE 审中-公开
标题翻译：有机RANKINE循环的控制方法
公开(公告)号：WO2015092649A1
公开(公告)日：2015-06-25
申请号：PCT/IB2014/066910
申请日：2014-12-15
申请人： TURBODEN S.R.L.
发明人： BINI, Roberto , PIETRA, Claudio , COLOMBO, Davide
IPC分类号： F01K13/02 , F01K25/08
CPC分类号： F01K13/02 , F01K11/02 , F01K25/08
摘要： An embodiment of the present invention is a method of controlling an Organic Rankine Cycle system, the system comprising at least one feed pump (2), at least one heat exchanger (3), an expansion turbine (5) and a condenser (6), the organic Rankine Cycle comprising a feeding phase of an organic working fluid, a heating and vaporization phase of the same working fluid, an expansion and condensation phase of the same working fluid, wherein said method controls an adjusted variable (X), which is a function of an overheating of the organic fluid, by means of a controller (20) that acts by varying a control variable (Y), which is a parameter of the organic fluid in its liquid phase, and wherein the adjusted variable (X) is a temperature difference (∆T) between a current temperature of the organic fluid in vapor phase at the turbine inlet and a temperature threshold (T lim ), under which the expansion phase involves the formation of a liquid phase of the organic fluid.
摘要翻译：本发明的一个实施例是一种控制有机朗肯循环系统的方法，该系统包括至少一个进料泵（2），至少一个热交换器（3），膨胀涡轮机（5）和冷凝器（6），有机朗肯循环，其包括有机工作流体的进料阶段，相同工作流体的加热和蒸发阶段，相同工作流体的膨胀和冷凝阶段，其中所述方法控制调整的变量（X），其为通过改变作为其液相中的有机流体的参数的控制变量（Y）起作用的控制器（20）的有机流体的过热的功能，并且其中调整后的变量（X）是涡轮机入口处的气相中的有机流体的当前温度与膨胀阶段涉及形成有机流体液相的温度阈值（Tlim）之间的温度差（ΔT）。

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