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    • 3. 发明申请
    • CATHETER WITH INFLATABLE BALLOON ASSEMBLY AND OPTICALLY ACTIVATED X-RAY SOURCE
    • 带有可充气球囊组件和光学激活X射线源的导管
    • WO2006065299A1
    • 2006-06-22
    • PCT/US2005/032849
    • 2005-09-15
    • CARL ZEISS AGDINSMORE, MarkENGEL, Thomas
    • DINSMORE, MarkENGEL, Thomas
    • A61N5/10H01J35/00H01J35/22
    • H01J35/32A61N5/1015H01J35/065H05H6/00
    • An apparatus delivers x-rays to at least a portion of an interior surface of a body cavity. The apparatus includes a flexible catheter, at least one balloon or inflatable element affixed to the catheter, one or more flexible probe assemblies, and an x-ray generator assembly coupled to each probe assembly. The flexible catheter includes one or more interior channels, and each flexible probe assembly is slidably positionable within a respective interior channel of the catheter. Each balloon, when inflated, defines a predetermined surface contour disposed about an interior region of a body cavity. Each flexible probe includes a transmission path for transmitting activating energy. The x-ray generator assembly includes an electron source and a target element. The electron source emits electrons in response to activating optical energy transmitted through the transmission path. The target element generates x-rays in accordance with a desired radiation profile.
    • 一种装置将x射线传送到体腔的内表面的至少一部分。 该装置包括柔性导管,固定到导管上的至少一个气囊或可膨胀元件,一个或多个柔性探针组件以及耦合到每个探针组件的x射线发生器组件。 柔性导管包括一个或多个内部通道,并且每个柔性探针组件可滑动地定位在导管的相应内部通道内。 当充气时,每个气囊限定围绕体腔的内部区域设置的预定表面轮廓。 每个柔性探针包括用于传送激活能量的传输路径。 x射线发生器组件包括电子源和靶元件。 电子源响应于通过传输路径传输的光能而发射电子。 目标元件根据期望的辐射轮廓产生X射线。
    • 4. 发明申请
    • CONTROLLER FOR ARRAY OF MINIATURE RADIATION SOURCES
    • 微型辐射源阵列控制器
    • WO2003061763A1
    • 2003-07-31
    • PCT/US2003/001987
    • 2003-01-22
    • PHOTOELECTRON CORPORATIONTHOMSON, EuanDINSMORE, Mark
    • THOMSON, EuanDINSMORE, Mark
    • A61N5/10
    • A61N5/1001
    • A controller (140) is provided for selectively and independently control each of a plurality of therapeutic radiation sources (20i) arranged along an array. The controller (140) is operable to selectively generate therapeutic radiation at selected time intervals and at selected intensities. The controller (140) includes intensity control circuitry (142) for controlling the intensity of the therapeutic radiation generated by each therapeutic radiation source (20i). The controller (140) also includes duration control circuitry (144) for controlling the duration of the therapeutic radiation generated by each therapeutic radiation source (20i). The controller (140) may also include a mechanical introducer (95) for inserting the array into a treatment region, and for withdrawing the array from the treatment region.
    • 提供控制器(140),用于选择性且独立地控制沿阵列布置的多个治疗辐射源(20i)中的每一个。 控制器(140)可操作以选择性地以选定的时间间隔和选定的强度产生治疗辐射。 控制器(140)包括用于控制由每个治疗辐射源(20i)产生的治疗辐射的强度的强度控制电路(142)。 控制器(140)还包括用于控制由每个治疗辐射源(20i)产生的治疗辐射持续时间的持续时间控制电路(144)。 控制器(140)还可以包括用于将阵列插入治疗区域并将阵列从治疗区域中取出的机械导引器(95)。
    • 5. 发明申请
    • THERMALLY MODULATED FIELD EMISSION CATHODE AND BEAM CURRENT MEASUREMENT TECHNIQUE
    • 热调制场辐射阴极和光束电流测量技术
    • WO2004066335A2
    • 2004-08-05
    • PCT/US2004/000974
    • 2004-01-15
    • CARL-ZEISS-STIFTUNG, d/b/a CARL ZEISS, OBERKOCHEN, GERMANYDINSMORE, Mark
    • DINSMORE, Mark
    • H01J
    • B82Y10/00H01J35/32H01J2235/062H05G1/46
    • An x-ray source includes a carbon nanotube FE (field emission) cathode that is heated with laser light propagated down a fiber optic cable. The resulting two-terminal x-ray tube allows for independent control of tube voltage and tube current. Control of the tube voltage is typically achieved using a control electrode, whereas the field emission tube current is controlled by thermal modulation. A technique is provided for accurately measuring beam current in the x-ray source. The method includes activating the cathode and adjusting the laser intensity, until a desired dose of output x-ray radiation is attained, then measuring the total x-ray tube current. The cathode is then turned off, so that the electron beam is turned off. The total x-ray tube current is measured again. The cathode is turned on again, immediately thereafter. The difference between the two values of the total x-ray tube current gives the correct x-ray tube beam current.
    • x射线源包括用光纤传播的激光加热的碳纳米管FE(场发射)阴极。 所得到的两端X射线管允许独立控制管电压和管电流。 通常使用控制电极来实现管电压的控制,而通过热调制控制场发射管电流。 提供了一种用于精确测量x射线源中的束电流的技术。 该方法包括激活阴极并调节激光强度,直到达到所需剂量的输出x射线辐射,然后测量总X射线管电流。 然后关闭阴极,使电子束关闭。 再次测量总X射线管电流。 之后立即再次打开阴极。 总X射线管电流的两个值之间的差异给出了正确的X射线管束电流。
    • 6. 发明申请
    • ARRAY OF MINIATURE RADIATION SOURCES
    • 微型辐射源阵列
    • WO2003065401A1
    • 2003-08-07
    • PCT/US2003/001990
    • 2003-01-22
    • PHOTOELECTRON CORPORATIONTHOMSON, EuanDINSMORE, Mark
    • THOMSON, EuanDINSMORE, Mark
    • H01J35/00
    • A61N5/1001A61N5/1007A61N5/1014A61N2005/1012
    • A system (10) for delivering therapeutic radiation, such as x-rays, to a treatment region includes a plurality of individually controllable therapeutic radiation sources(20) . The therapeutic radiation sources are selectively and moveably disposed along one or more axes, or upon a two-dimensional surface, or within a three-dimensional volume, so as to form a one-dimensional or a multi-dimensional array. Each therapeutic radiation source includes an electron source (50) for emitting electrons, and an associated target element (60) adapted to emit therapeutic radiation in response to incident electrons. In one embodiment, each therapeutic radiation source is coupled to a distal end of an associated optical delivery structure, which is adapted to direct a beam of optical radiation to impinge upon a surface of the electron source so as to cause emission of electrons therefrom.
    • 用于将诸如x射线的治疗辐射传送到治疗区域的系统(10)包括多个单独可控的治疗辐射源(20)。 治疗性辐射源沿着一个或多个轴,或二维表面或三维体积内选择性地和可移动地设置,以便形成一维或多维阵列。 每个治疗辐射源包括用于发射电子的电子源(50)和适于响应入射电子发射治疗辐射的相关联的目标元件(60)。 在一个实施例中,每个治疗辐射源耦合到相关联的光学传递结构的远端,其适于引导光束射束撞击电子源的表面,从而引起电子的发射。
    • 7. 发明申请
    • OPTICALLY DRIVEN THERAPEUTIC RADIATION SOURCE
    • 光学驱动治疗辐射源
    • WO2002102459A1
    • 2002-12-27
    • PCT/US2002/019416
    • 2002-06-19
    • PHOTOELECTRON CORPORATIONDINSMORE, Mark
    • DINSMORE, Mark
    • A61N5/10
    • A61N5/1001A61N2005/1022G21K1/06H01J35/06H01J35/32H01J2235/164
    • A miniaturized, optically driven therapeutic radiation source (100) includes a laser-heated thermionic cathode (122). A fiber optic cable (113) directs a light beam from an optical source (104) to impinge upon a surface of the thermionic cathode (122), heating the surface to a temperature sufficient to cause thermionic emission of electrons. The target element (128) emits therapeutic radiation, such as x-rays, in response to incident accelerated electrons from the electron beam. In one embodiment, the electron source (122) and the target element (128) are disposed within a capsule (130) which defines a substantially evacuated region. The inner surface of the capsule is coated with a semiconductor coating, so that a uniform voltage gradient is maintained within the evacuated capsule. In another embodiment, the thermionic cathode (300) is formed of a spiral-shaped conductive element (310) having a plurality of spaced-apart turns. Interstitial spacing between adjacent turns essentially eliminates heat transfer across the spacin.
    • 小型化,光学驱动的治疗辐射源(100)包括激光加热的热离子阴极(122)。 光纤电缆(113)引导来自光源(104)的光束照射到热离子阴极(122)的表面上,将表面加热到足以引起电子的热离子发射的温度。 目标元件(128)响应于来自电子束的入射加速电子而发射诸如x射线的治疗辐射。 在一个实施例中,电子源(122)和目标元件(128)设置在限定基本抽真空区域的胶囊(130)内。 胶囊的内表面涂覆有半导体涂层,使得在抽空的胶囊内保持均匀的电压梯度。 在另一个实施例中,热离子阴极(300)由具有多个间隔开的匝的螺旋形导电元件(310)形成。 相邻圈之间的间隙间隔基本上消除了跨越空间的热传递。
    • 8. 发明申请
    • X-RAY SOURCE FOR MATERIALS ANALYSIS SYSTEMs
    • 材料分析系统的X射线源
    • WO2002103743A1
    • 2002-12-27
    • PCT/US2002/019235
    • 2002-06-18
    • PHOTOELECTRON CORPORATIONDINSMORE, Mark
    • DINSMORE, Mark
    • H01J35/06
    • H01J35/32H01J35/06
    • A miniaturized, increased efficiency x-ray source for materials analysis includes a laser source, an optical delivery structure, a laser-driven thermionic cathode (108), an anode (122), and a target from the laser source and directs the beam onto a surface of the themionic cathode. The surfaces electrons form an electron beam along a beam path. The target element (110) is disposed in the beam path, and emits x-rays in response to incident accelerated electrons from the thermionic cathode. The target element includes an inclined surface that forms an angle of inclination (113) of about 40 degrees with respect to the electon beam path, so that x-rays are emitted from the target substantially at an angle of about 45 degrees with respect to the electron beam path.
    • 用于材料分析的小型化,增加的效率的x射线源包括激光源,光学传递结构,激光驱动的热离子阴极(108),阳极(122)和来自激光源的靶,并将光束引导到 阴离子的表面。 表面电子沿光束路径形成电子束。 目标元件(110)设置在光束路径中,并且响应于来自热离子阴极的入射加速电子发射X射线。 目标元件包括相对于电子束路径形成大约40度的倾斜角(113)的倾斜表面,使得x射线相对于基本上以大约45度的角度从目标射出 电子束路径。