专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2001023612A3 DETERMINING MUTATIONS BY SELECTIVE REACTION OF THE 2'-RIBOSE POSITION IN HYBRIDIZED OLIGONUCLEOTIDES 审中-公开
公开(公告)号：WO2001023612A3
公开(公告)日：2001-04-05
申请号：PCT/US2000/026320
申请日：2000-09-25
申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , WEEKS, Kevin , CHAMBERLIN, Stacy, I. , JOHN, Deborah, M.
发明人： WEEKS, Kevin , CHAMBERLIN, Stacy, I. , JOHN, Deborah, M.
IPC分类号： C12Q1/68
摘要： New chemical tagging methods and kits of the present invention utilize the discovery that chemical modification ( e.g. , acylation) of 2'-substituted ribonucleotides or deoxyribonucleotides by reactive compounds ( e.g. , activated esters) is sensitive to the base-paired state of the nucleotide. Perfectly base-paired positions are generally unreactive, while mismatched or unmatched bases are reactive under a wide variety of reaction conditions. The methods of the invention include a method of detecting a mutation in a nucleic acid molecule suspected of containing a mutation. The nucleic acid is hybridized to an oligonucleotide having a sequence complementary to the sequence the nucleic acid would have if a mutation were not present. The oligonucleotide comprises at least one nucleotide with a substitution at the 2'-ribose position. After the oligonucleotide is hybridized to the nucleic acid molecule, the hybridized oligonucleotide is then contacted with a reactive compound comprising a reporter moiety. Detection of the binding of the reporter moiety to the hybridized oligonucleotide indicates a mismatch i.e. , a mutation) in the nucleic acid molecule. The methods and kits of the present invention are useful in detecting point mutations and other defects in nucleic acid sequences. These methods and kits are also useful for detecting single nucleotide polymorphisms (SNPs) and mutations responsible for cancer and other genetic diseases in humans; for quantifying amounts of nucleic acids; and for detecting conformational changes in nucleic acid structures, including those found in the products of in vitro selection experiments i.e. , aptamers).

2. 发明申请

WO2022256382A1 RNA-TARGETING LIGANDS, COMPOSITIONS THEREOF, AND METHODS OF MAKING AND USING THE SAME 审中-公开
公开(公告)号：WO2022256382A1
公开(公告)日：2022-12-08
申请号：PCT/US2022/031736
申请日：2022-06-01
申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
发明人： WEEKS, Kevin , AUBÉ, Jeffrey , LI, Kelin , ZELLER, Meredith
IPC分类号： C07D401/12 , C07D241/12 , A61K31/498
摘要： The disclosure is directed to compounds that bind to a target RNA molecule, such as a TPP riboswitch, compositions comprising the compounds, and methods of making and using the same. The compounds contain two structurally different fragments that allow for binding with the target RNA at two different binding sites thereby producing a higher affinity binding ligand compared to compounds that only bind to a single RNA binding site.

3. 发明申请

WO2021026245A1 RNA-TARGETING LIGANDS, COMPOSITIONS THEREOF, AND METHODS OF MAKING AND USING THE SAME 审中-公开
公开(公告)号：WO2021026245A1
公开(公告)日：2021-02-11
申请号：PCT/US2020/045022
申请日：2020-08-05
申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
发明人： WEEKS, Kevin , AUBÉ, Jeffrey , LI, Kelin , ZELLER, Meredith
IPC分类号： C07D401/12 , A61K31/498 , A61P43/00
摘要： The disclosure is directed to compounds that bind to a target RNA molecule, such as a TPP riboswitch, compositions comprising the compounds, and methods of making and using the same. The compounds contain two structurally different fragments that allow for binding with the target RNA at two different binding sites thereby producing a higher affinity 5 binding ligand compared to compounds that only bind to a single RNA binding site.

4. 发明申请

WO2013016773A1 A MULTI ANGLE ROOF TRUSS TIE-DOWN APPARATUS AND METHOD 审中-公开
标题翻译：多角度倒角装置和方法
公开(公告)号：WO2013016773A1
公开(公告)日：2013-02-07
申请号：PCT/AU2012/000921
申请日：2012-08-06
申请人： WEEKS HOLDINGS PTY LTD , WEEKS, Kevin
发明人： WEEKS, Kevin
IPC分类号： E04C3/02 , E04B1/00 , E04B7/02
CPC分类号： E04B7/045 , E04B1/24 , E04B7/04 , E04B7/063 , E04B2001/2439 , E04B2001/2448 , E04B2001/249 , E04C2003/0482
摘要： The present invention relates to a roof truss tie-down apparatus including a pin and bracket engagement which enables a wall frame to accommodate any style of roof truss at any angle, and a method of constructing such a roof frame.
摘要翻译：屋顶桁架固定装置技术领域本发明涉及一种屋顶桁架固定装置，其包括销和支架接合，其能够使壁架以任何角度适应任何风格的屋顶桁架，以及构造这种屋顶框架的方法。

5. 发明申请

WO2011003143A1 A PREFABRICATED STRUCTURAL BUILDING FRAME AND METHOD OF MAKING THE SAME 审中-公开
标题翻译：一种预制结构建筑框架及其制作方法
公开(公告)号：WO2011003143A1
公开(公告)日：2011-01-13
申请号：PCT/AU2010/000869
申请日：2010-07-07
申请人： WEEKS GROUP PTY LTD , WEEKS, Kevin
发明人： WEEKS, Kevin
IPC分类号： E04C2/22 , E04B1/62
CPC分类号： E04C2/386 , E04B1/08 , E04C2/22 , E04C2/384
摘要： The present invention relates to prefabricated structural building frames and, in particular, to foam-filled exterior wall frames for a building structure such as a house. In a preferred embodiment, each wall frame includes a foam facade on one side of the frame for receiving a finishing material and service cut-outs on the opposed internal side of the frame. The present invention also relates to a method of manufacturing the frames in accordance with building design data.
摘要翻译：本发明涉及预制结构建筑框架，特别涉及用于诸如房屋的建筑结构的泡沫填充的外墙框架。在优选实施例中，每个壁架包括在框架的一侧上的泡沫立面，用于在框架的相对的内侧上接收整理材料和服务切口。本发明还涉及根据建筑物设计数据制造框架的方法。

6. 发明申请

WO2008055292A1 A FLOOR PIER SUPPORT 审中-公开
标题翻译：地板支撑
公开(公告)号：WO2008055292A1
公开(公告)日：2008-05-15
申请号：PCT/AU2007/001680
申请日：2007-11-01
申请人： WEEKS GROUP PTY LTD , WEEKS, Kevin
发明人： WEEKS, Kevin
IPC分类号： E04B5/17 , B66F7/12 , E04C3/00
CPC分类号： E04B5/10 , E02D27/14 , E04B1/003 , E04C3/07 , E04C2003/0452 , E04C2003/0473 , E04F15/02183 , E04F15/02458 , E04F15/02464 , E04F2015/02061
摘要： The present invention relates to a floor pier support and, in particular, to a pier support which allows for in-situ height adjustment of a floor frame mounted thereabove. In particular, the pier support includes a base adapted to be fixed to said surface, a connection member including a first and a second attachment means, the first attachment means used to fix the connection member to a frame element, and the second attachment means being connectable to the base in a configuration which facilitates height adjustment of the frame relative to the base. The pier support of the present invention provides for a strong, robust support for floor frames and is advantageous in that the height of the frame can be easily adjusted at regular intervals post-construction, for maintenance purposes, or for height re-adjustment where for example the ground has subsided over time.
摘要翻译：本发明涉及一种地板墩架支架，特别涉及一种允许现场高度调节安装在其上的地板框架的码头支架。特别地，码头支撑件包括适于固定到所述表面的基部，包括第一和第二附接装置的连接构件，用于将连接构件固定到框架元件的第一附接装置，第二附接装置可以以便于框架相对于基座的高度调节的构造连接到基座。本发明的码头支撑件提供了对于地板框架的坚固的，坚固的支撑，并且有利的是，框架的高度可以容易地在施工后，维护目的或为了高度重新调整而以规则的间隔进行调整，例如，随着时间的推移，地面已经平息下来。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式