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1. 发明申请

WO2005032686A2 QUASI-INTERPENETRATING NETWORKS USED AS SEPARATION MEDIA 审中-公开
标题翻译：用于分离介质的准互连网络
公开(公告)号：WO2005032686A2
公开(公告)日：2005-04-14
申请号：PCT/US2004/030068
申请日：2004-09-16
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , CHU, Benjamin , SONG, Liguo , FANG, Dufei , LIANG, Dehai , LIU, Tianbo , WANG, Yanmei , YING, Quicong
发明人： CHU, Benjamin , SONG, Liguo , FANG, Dufei , LIANG, Dehai , LIU, Tianbo , WANG, Yanmei , YING, Quicong
IPC分类号： B01D
CPC分类号： C08L33/24 , C08L2205/02 , C08L2205/04
摘要： The invention relates to a quasi-interpenetrating network of polymer chains, the chains comprising linear polyacrylamide (LPA) chains in the form of a main frame having a weight average molecular weight of approximately 0.05 million to approximately 25 million g/mole, and a radius of gyration of approximately 10 nrn to 350 rim; and polydimethylacrylamide (PDMA) chains prepared by polymerizing PDMA in the presence of the LPA main frame, wherein the LPA and PDMA chains are entangled within one another and interpenetrate one another, and wherein the quasi-interpenetrating network has stifistantially no chemical cross-linking.
摘要翻译：本发明涉及聚合物链的准互穿网络，该链包括主框形式的线性聚丙烯酰胺（LPA）链，其重均分子量为约0.05至约2500万克/摩尔，半径回转约10 nrn至350 rim; 和通过在LPA主要框架存在下聚合PDMA而制备的聚二甲基丙烯酰胺（PDMA）链，其中LPA和PDMA链彼此缠结并相互渗透，并且其中准互穿网络没有化学交联。

2. 发明申请

WO2003024297A3 CELL STORAGE AND DELIVERY SYSTEM 审中-公开
公开(公告)号：WO2003024297A3
公开(公告)日：2003-03-27
申请号：PCT/US2002/026377
申请日：2002-08-20
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
发明人： CHU, Benjamin , HSIAO, Benjamin, S. , HADJIARGYROU, Michael , FANG, Dufei , ZONG, Xinhua , KIM, Kwangsok
IPC分类号： A01N63/00
摘要： Cell storage and delivery systems and methods for storing and delivering viable cells to a mammal are disclosed. The cell storage and delivery systems include a biodegradable and/or bioabsorbable fibrous matrix physically associated with viable cells to contain and release the cells at a controlled rate. The biodegradable and/or bioabsorbable matrix can be formed by electrospinning fibers of biodegradable and/or bioabsorbable fiberizable material. The method include methods for storing viable cells and for delivering viable cells to a mammal using the cell storage and delivery system.

3. 发明申请

WO2003024297A2 CELL STORAGE AND DELIVERY SYSTEM 审中-公开
标题翻译：细胞存储和递送系统
公开(公告)号：WO2003024297A2
公开(公告)日：2003-03-27
申请号：PCT/US2002/026377
申请日：2002-08-20
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
发明人： CHU, Benjamin , HSIAO, Benjamin, S. , HADJIARGYROU, Michael , FANG, Dufei , ZONG, Xinhua , KIM, Kwangsok
IPC分类号： A61B
CPC分类号： G06Q30/02 , A61F2/28 , A61F2/30756 , A61K9/70 , A61K35/32 , C12N5/0068 , C12N2533/40
摘要： Cell storage and delivery systems and methods for storing and delivering viable cells to a mammal are disclosed. The cell storage and delivery systems include a biodegradable and/or bioabsorbable fibrous matrix physically associated with viable cells to contain and release the cells at a controlled rate. The biodegradable and/or bioabsorbable matrix can be formed by electrospinning fibers of biodegradable and/or bioabsorbable fiberizable material. The method include methods for storing viable cells and for delivering viable cells to a mammal using the cell storage and delivery system.
摘要翻译：公开了用于向哺乳动物存储和递送活细胞的细胞储存和递送系统和方法。细胞储存和递送系统包括与活细胞物理相关的可生物降解和/或生物可吸收的纤维基质，以受控的速率含有和释放细胞。可生物降解和/或生物可吸收的基质可以通过静电纺丝的可生物降解和/或生物可吸收的可纤化材料的纤维形成。该方法包括用于存储活细胞并使用细胞储存和递送系统向哺乳动物递送活细胞的方法。

4. 发明申请

WO2002092888A1 APPARATUS AND METHODS FOR ELECTROSPINNING POLYMERIC FIBERS AND MEMBRANES 审中-公开
标题翻译：用于电聚合纤维和膜的装置和方法
公开(公告)号：WO2002092888A1
公开(公告)日：2002-11-21
申请号：PCT/US2002/015507
申请日：2002-05-15
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
发明人： CHU, Benjamin , HSIAO, Benjamin, S. , FANG, Dufei
IPC分类号： D01D5/00
CPC分类号： D01D5/0092 , D04H1/728
摘要： An apparatus and methods for electrospinning polymer fibers and membranes include electrospinning a polymer fiber from a conducting fluid containing the polymer in the presence of a first electric field established between a conducting fluid introduction device (5) and a ground source (9) and modifying the first electric field with a second electric field to form a jet stream of the conducting fluid. The apparatus includes a conducting fluid introduction device (5) containing a plurality of spinnerets (6) for delivering a conducting fluid a ground member (9) positioned adjacent the spinnerets (6), a support member (3) disposed between the spinnerets (6) and the ground member (9) and movable to receive fibers formed from the conducting fluid, and a means (2) for controlling the flow characteristics of conducting fluid from at least one spinneret (6) independently from the flow characteristics of conducting fluid from another spinneret (6).
摘要翻译：用于静电纺丝聚合物纤维和膜的装置和方法包括在存在导电流体引入装置（5）和地源（9）之间建立的第一电场的情况下，从含有聚合物的导电流体静电纺丝聚合物纤维，并修饰具有第二电场的第一电场以形成导电流体的喷射流。该装置包括：导电流体引入装置（5），其包含多个用于输送导电流体的喷丝头（6），位于喷丝板（6）附近定位的接地构件（9）;布置在喷丝头（6）之间的支撑构件）和接地构件（9）并且可移动以接收由导电流体形成的纤维，以及用于独立于导电流体的流动特性独立地控制来自至少一个喷丝头（6）的导电流体的流动特性的装置（2）另一个喷丝头（6）。

5. 发明申请

WO2002092339A1 BIODEGRADABLE AND/OR BIOABSORBABLE FIBROUS ARTICLES AND METHODS FOR USING THE ARTICLES FOR MEDICAL APPLICATIONS 审中-公开
标题翻译：可生物降解和/或生物吸收的纤维制品和用于医疗应用的文章的方法
公开(公告)号：WO2002092339A1
公开(公告)日：2002-11-21
申请号：PCT/US2002/015502
申请日：2002-05-15
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
发明人： CHU, Benjamin , HSIAO, Benjamin, S. , FANG, Dufei , BRATHWAITE, Collin
IPC分类号： B32B27/04
CPC分类号： B32B27/12 , A61K9/0024 , A61K9/70 , A61L27/18 , A61L27/58 , A61L31/06 , A61L31/148 , B32B27/18 , B32B27/28 , B32B27/36 , B32B2250/20 , B32B2262/0276 , B32B2307/7163 , B32B2535/00 , Y10T442/2525 , Y10T442/614 , Y10T442/619 , Y10T442/696 , C08L67/04
摘要： Biodegradable and/or bioabsorbable fibrous articles and methods for using the articles in medical applications are disclosed. The biodegradable and/or bioabsorbable fibrous articles, which are formed by electrospinning fibers of biodegradable and/or bioabsorbable fiberizable material, comprise a composite (or asymmetric composite) of different biodegradable and/or bioabsorbable fibers. Articles having specific medical uses include an adhesion-reducing barrier and a controlled delivery system. The methods include methods for reducing surgical adhesions, controlled delivery of a medicinal agent and providing controlled tissue healing.
摘要翻译：公开了可生物降解和/或生物可吸收的纤维制品以及在医疗应用中使用制品的方法。由可生物降解和/或生物可吸收的可纤化材料的静电纺丝形成的可生物降解的和/或生物可吸收的纤维制品包括不同的可生物降解的和/或生物可吸收的纤维的复合材料（或不对称的复合材料）。具有特定医疗用途的制品包括减粘屏障和受控递送系统。所述方法包括减少手术粘连，药物的受控输送和提供受控组织愈合的方法。

6. 发明申请

WO2006026104A2 CROSSLINKING OF HYALURONAN SOLUTIONS AND NANOFIBROUS MEMBRANES MADE THEREFROM 审中-公开
标题翻译：透明质酸溶液和纳米纤维膜的交联
公开(公告)号：WO2006026104A2
公开(公告)日：2006-03-09
申请号：PCT/US2005/028505
申请日：2005-08-10
申请人： STONY BROOK TECHNOLOGY AND APPLIED RESEARCH , CHU, Benjamin , HSAIO, Benjamin, S. , FANG, Dufei , OKAMOTO, Akio
发明人： CHU, Benjamin , HSAIO, Benjamin, S. , FANG, Dufei , OKAMOTO, Akio
IPC分类号： B32B5/02 , D04H13/00
CPC分类号： D06M11/11 , C08B37/0072 , D01D5/0038 , D01D5/0069 , D01F9/00 , D04H3/03 , D04H3/16 , D06M11/55 , D06M11/64 , D06M11/70 , D06M13/144 , D06M13/188 , D06M13/256 , Y10T442/20 , Y10T442/60 , Y10T442/607
摘要： A method for producing a non-chemically crosslinked hyaluronan is provided which involves contacting a sample of hyaluronan with an acidic solvent/water mixture for a period of time and at a temperature sufficient to effect crosslinking, wherein the acidic solvent/water mixture has a content of a solvent sufficient to prevent dissolution of said hyaluronan and wherein the solvent is miscible with water, and an amount of an acid sufficient to effect crosslinking of the hyaluronan, and the crosslinked, water resistant nonwoven hyaluronan resulting therefrom.
摘要翻译：提供了一种用于生产非化学交联的乙酰透明质酸的方法，其包括将乙酰透明质酸样品与酸性溶剂/水混合物接触一段时间并且温度足以引起交联，其中酸性溶剂/水混合物的溶剂含量足以防止所述乙酰透明质酸的溶解，并且其中所述溶剂可与水混溶，并且足够量的足以引起乙酰透明质酸交联的酸，以及交联的，耐水的非溶剂;编织物由此产生的透明质酸。

7. 发明申请

WO2005033381A2 ELECTRO-BLOWING TECHNOLOGY FOR FABRICATION OF FIBROUS ARTICLES AND ITS APPLICATIONS OF HYALURONAN 审中-公开
标题翻译：电动吹扫技术制造纤维制品及其应用
公开(公告)号：WO2005033381A2
公开(公告)日：2005-04-14
申请号：PCT/US2004/030901
申请日：2004-10-01
申请人： STONYBROOK TECHNOLOGY AND APPLIED RESEARCH , CHU, Benjamin , HSIAO, Benjamin, S. , FANG, Dufei , OKAMOTO, Akio
发明人： CHU, Benjamin , HSIAO, Benjamin, S. , FANG, Dufei , OKAMOTO, Akio
IPC分类号： D01D
CPC分类号： D01D5/0069 , D01F9/00
摘要： A method for electroblowing fibers is provided which involves the steps of forcing a polymer fluid through a spinneret in a first direction towards a collector located a first distance from the spinneret, while simultaneously blowing a gas through an orifice that is substantially concentrically arranged around the spinneret, wherein the gas is blown substantially in the first direction; wherein an electrostatic differential is generated between the spinneret and the collector; and collecting the fibers, and its use in preparing submicron scale fibers of various types, particularly hyaluronan fibers, and the hyaluronan nanofibers thus formed.
摘要翻译：提供了一种用于电喷发光纤的方法，其包括以下步骤：将聚合物流体沿着第一方向通过喷丝板朝向距离喷丝头第一距离的收集器强制，同时将气体吹过基本上同心地布置在喷丝板周围的孔口，其中所述气体基本上在所述第一方向上吹送; 其中在所述喷丝头和所述收集器之间产生静电差异; 并收集纤维，以及其在制备各种类型的亚微米级纤维，特别是透明质酸纤维和由此形成的透明质酸纳米纤维中的用途。

8. 发明申请

WO2007001405A2 HIGH FLUX AND LOW FOULING FILTRATION MEDIA 审中-公开
标题翻译：高通滤波和低滤波滤波介质
公开(公告)号：WO2007001405A2
公开(公告)日：2007-01-04
申请号：PCT/US2005/035738
申请日：2005-10-05
申请人： RESEARCH FOUNDATION OF SUNY , CHU, Benjamin , HSIAO, Benjamin, S. , FANG, Dufei , KIM, Kwang-sok
发明人： CHU, Benjamin , HSIAO, Benjamin, S. , FANG, Dufei , KIM, Kwang-sok
IPC分类号： B01D69/08
CPC分类号： B01D69/12 , B01D65/08 , B01D69/141 , B01D71/08 , B01D2321/168 , B01D2323/38 , B01D2323/39 , B01D2325/022 , Y10T428/249921 , Y10T428/25 , Y10T428/256 , Y10T428/259 , Y10T428/29 , Y10T428/2913 , Y10T428/2915 , Y10T428/2944 , Y10T428/298 , Y10T442/20 , Y10T442/2033 , Y10T442/277 , Y10T442/2861 , Y10T442/2885 , Y10T442/2893 , Y10T442/291 , Y10T442/2918 , Y10T442/659
摘要： Membranes suitable for microfiltration, ultrafiltration (UF) and nanofiltration (NF) filters are provided. Such membranes may include a nanofibrous scaffold, optionally in combination with a non-woven substrate and/or a coating of a polymer and a functionalized nanofiller. Suitable membranes may also include a coating of a polymer and a functionalized nanofiller on a substrate, which can include a non-woven membrane, a nanofibrous scaffold, or both.
摘要翻译：提供适用于微滤，超滤（UF）和纳滤（NF）过滤器的膜。这种膜可以包括纳米纤维支架，任选地与无纺基底和/或聚合物和官能化纳米填料的涂层组合。合适的膜还可以包括在基底上的聚合物和功能化纳米填料的涂层，其可以包括无纺膜，纳米纤维支架或两者。

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