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1. 发明申请

WO1998025630A1 TRANSALDOLASE-MEDIATED REGULATION OF APOPTOSIS 审中-公开
标题翻译：转录因子介导的病毒调节
公开(公告)号：WO1998025630A1
公开(公告)日：1998-06-18
申请号：PCT/US1997022770
申请日：1997-12-12
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
发明人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , PERL, Andras , BANKI, Katalin
IPC分类号： A61K31/70
CPC分类号： C12N9/1022 , A61K38/00 , C12Y202/01002
摘要： Transaldolase (TAL) plays an important role in regulating the sensitivity of cells to apoptosis. Methods which upregulate TAL gene expression, such as by delivery of exogenous TAL-encoding DNA to a cell, or methods which stimulate TAL enzymatic activity, such as induction of phosphorylation through protein kinase C, promote programmed cell death in response to apoptotic signals. Conversely, inhibition of TAL gene expression, such as by delivery of TAL antisense DNA, or the suppression of TAL enzymatic activity, renders the cell resistant to apoptotic signalling. The present invention provides approaches to the treatment of conditions characterized by enhanced apoptosis, for example, neurodegenerative diseases, demyelinating diseases or HIV disease, or conditions in which apoptosis is inappropriately suppressed, for example cancer, certain virus infections and autoimmunity, by the appropriate up- or down-regulation of TAL expression or TAL enzymatic activity.
摘要翻译：转醛醇酶（TAL）在调节细胞对细胞凋亡的敏感性方面起重要作用。上调TAL基因表达的方法，例如通过将外源性TAL编码DNA递送至细胞，或刺激TAL酶活性的方法，例如通过蛋白激酶C诱导磷酸化，促进响应凋亡信号的程序性细胞死亡。相反，TAL基因表达的抑制，例如通过递送TAL反义DNA或抑制TAL酶活性，使得细胞对凋亡信号传导具有抗性。本发明提供治疗特征在于增强细胞凋亡，例如神经退行性疾病，脱髓鞘疾病或HIV疾病的病症的治疗方法，或通过适当的上调，细胞凋亡被不适当地抑制的病症，例如癌症，某些病毒感染和自身免疫 - 或TAL表达或TAL酶活性的下调。

2. 发明申请

WO1997015830A1 A METHOD FOR DETECTING A MAMMAL'S PRIOR EXPOSURE TO RADIATION OR RADIOMIMETIC CHEMICALS 审中-公开
标题翻译：用于检测母体以前暴露于辐射或放射化学化学品的方法
公开(公告)号：WO1997015830A1
公开(公告)日：1997-05-01
申请号：PCT/US1996016880
申请日：1996-10-21
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
发明人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , GONG, Joseph, K. , GLOMSKI, Chester, A.
IPC分类号： G01N33/53
CPC分类号： G01N33/80 , C07K14/70582 , C07K16/2881 , C12Q1/6876 , G01N33/5014 , G01N33/56966 , G01N33/84 , G01N2333/79 , Y10S436/805 , Y10S436/811 , Y10T436/13
摘要： The present invention is directed to a method for detecting a mammal's prior exposure to radiation or radiometic agents. Labeled antibodies are employed to determine the quantity of transferrin receptors on the red blood cells of the mammal. The quantity of transferrin receptors on the red blood cells of the mammal is correlated to the mammal's prior exposure.
摘要翻译：本发明涉及一种用于检测哺乳动物先前暴露于辐射或辐射剂的方法。标记抗体用于确定哺乳动物红细胞上的转铁蛋白受体的量。哺乳动物红细胞上的转铁蛋白受体的量与哺乳动物的先前接触相关。

3. 发明申请

WO1996040250A3 PLATELET-SPECIFIC CHIMERIC IMMUNOGLOBULIN AND METHODS OF USE THEREFOR 审中-公开
公开(公告)号：WO1996040250A3
公开(公告)日：1996-12-19
申请号：PCT/US1996010216
申请日：1996-06-05
申请人： CENTOCOR, INC. , THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
发明人： CENTOCOR, INC. , THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , COLLER, Barry, S. , KNIGHT, David, M.
IPC分类号： A61K39/395

4. 发明申请

WO1995008985A1 PERFLUOROCARBONS AS ANTI-INFLAMMATORY AGENTS 审中-公开
标题翻译：全氟沙门菌作为抗炎剂
公开(公告)号：WO1995008985A1
公开(公告)日：1995-04-06
申请号：PCT/US1994011092
申请日：1994-09-29
申请人： ALLIANCE PHARMACEUTICAL CORP. , THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
发明人： ALLIANCE PHARMACEUTICAL CORP. , THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , FUHRMAN, Bradley, Phillip , FLAIM, Stephen, F. , HERNAN, Lynn, Joanne , NESTI, Frances, Darey , PAPO, Michele, Cecile , STEINHORN, David, Marc
IPC分类号： A61K09/12
CPC分类号： A61K31/02 , A61K9/007 , A61K9/0073 , A61K33/00 , Y10S514/848 , Y10S514/886 , Y10S514/887 , Y10S514/959 , A61K2300/00
摘要： A method for reducing the inflammatory response in tissue of a patient, by contacting the tissue with an effective, inflammation-reducing amount of a liquid or gaseous fluorocarbon.
摘要翻译：通过使组织与有效的减少炎症的量的液体或气体碳氟化合物接触来减少患者组织中的炎症反应的方法。

5. 发明申请

WO1995006163A1 METHOD FOR REDUCING THERMAL AND LIGHT-INDUCED BRIGHTNESS REVERSION IN LIGNIN-CONTAINING PULPS 审中-公开
标题翻译：降低含有木质素含量的粉末中的热和光诱导亮度反射的方法
公开(公告)号：WO1995006163A1
公开(公告)日：1995-03-02
申请号：PCT/US1994009510
申请日：1994-08-24
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , MINERALS TECHNOLOGIES INC.
发明人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , MINERALS TECHNOLOGIES INC. , FRANCIS, Raymond, C. , EVANS, Daniel, B.
IPC分类号： D21H17/05
CPC分类号： D21C9/1047
摘要： A method and article of manufacture thereof is provided for reducing brightness reversion in bleached lignin-containing pulps or newsprint by the treatment of the bleached lignin-containing pulp or newsprint with 2,5-dihydroxydioxane. In one embodiment, calcium carbonate is added to enhance the activity of 2,5-dihydroxydioxane.
摘要翻译：提供了一种方法和制造方法，用于通过用2,5-二羟基二恶烷处理漂白的含木质素的纸浆或新闻纸来减少含漂白木质素纸浆或新闻纸的亮度回复。在一个实施方案中，加入碳酸钙以增强2,5-二羟基二氧杂环己烷的活性。

6. 发明申请

WO1995000667A1 IMPROVED METHODS FOR DETECTING NUCLEIC ACID SEQUENCES 审中-公开
标题翻译：用于检测核酸序列的改进方法
公开(公告)号：WO1995000667A1
公开(公告)日：1995-01-05
申请号：PCT/US1994006855
申请日：1994-06-16
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
发明人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , LANE, Michael, J. , BENIGHT, Albert, S. , FALDASZ, Brian, D.
IPC分类号： C12Q01/68
CPC分类号： C12Q1/6813 , C12Q2537/155 , C12Q2525/121 , C12Q2521/307
摘要： Improved cycling probe reactions are disclosed.
摘要翻译：公开了改进的循环探针反应。

7. 发明申请

WO1995000666A1 IMPROVED NUCLEIC ACID REACTIONS 审中-公开
标题翻译：改善核酸反应
公开(公告)号：WO1995000666A1
公开(公告)日：1995-01-05
申请号：PCT/US1994006800
申请日：1994-06-16
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
发明人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , LANE, Michael, J. , BENIGHT, Albert, S. , FALDASZ, Brian, D.
IPC分类号： C12Q01/68
CPC分类号： C12Q1/6813 , C12N15/10 , C12Q1/6846 , C12Q2522/101
摘要： A method of promoting a reaction between a duplex-binding ligand and a duplex nucleic acid molecule, the duplex nucleic acid molecule being formed from a first single strand nucleic acid molecule and a second single strand nucleic acid molecule, under conditions wherein the rate of duplex formation would be substantially less in the absence of the duplex-binding ligand.
摘要翻译：一种促进双链体结合配体和双链体核酸分子之间的反应的方法，所述双链体核酸分子由第一单链核酸分子和第二单链核酸分子形成，条件是其中双链体在不存在双链体结合配体的情况下，形成将显着减少。

8. 发明申请

WO1994021856A1 IMPROVED OZONE/PERACID PROCESS FOR DELIGNIFYING A LIGNOCELLULOSIC MATERIAL 审中-公开
标题翻译：改进氧化物质的改进方法
公开(公告)号：WO1994021856A1
公开(公告)日：1994-09-29
申请号：PCT/US1994003447
申请日：1994-03-22
申请人： SOLVAY INTEROX , THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
发明人： SOLVAY INTEROX , THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , FRANCIS, Raymond, C. , ZHANG, Xiao-Zhu , TROUGHTON, Nicholas, A.
IPC分类号： D21C09/153
CPC分类号： D21C9/166 , D21C9/153
摘要： A process for delignifying a lignocellulosic material comprising exposing the material to a mixture of peracid and ozone. Preferred peracids include Caro's acid and peracetic acid. Also disclosed is a kraft pulp delignification mixture comprising in combination: (a) water; (b) a kraft pulp at 1-40 % consistency; (c) a peracid; and (d) from 0.1 to 5.0 % ozone on pulp.
摘要翻译：木质纤维素材料脱木质素的方法，包括将材料暴露于过酸和臭氧的混合物。优选的过酸包括卡罗酸和过乙酸。还公开了一种牛皮纸浆脱木素混合物，其组合包括：（a）水; （b）1-40％稠度的牛皮纸浆; （c）过酸; 和（d）0.1至5.0％的纸浆上的臭氧。

9. 发明申请

WO1998020300A1 LASER MEASUREMENT SYSTEM FOR RAPID CALIBRATION OF MACHINE TOOLS 审中-公开
标题翻译：用于快速校准机床的激光测量系统
公开(公告)号：WO1998020300A1
公开(公告)日：1998-05-14
申请号：PCT/US1997020530
申请日：1997-11-07
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
发明人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , HUANG, Peisen, S.
IPC分类号： G01B09/02
CPC分类号： G01B11/26 , G01B9/02029
摘要： A laser measurement system for rapid calibration of machine tools includes a measurement enhancement device which enables an existing standard single degree of freedom laser interferometry system to simultaneously measure up to four additional degrees of freedom. The device includes a first beamsplitter (56) which splits a laser beam of the existing measurement system, such as return laser beam (58), into a first beam (60) for use by an existing component of the existing interferometry system, and a second beam (62) for use by the measurement enhancement device. The measurement enhancement device also includes a measurement component which simultaneously receives second beam (62) for determination of a measurement value for at least a second degree of freedom in response to second beam (62).
摘要翻译：用于机床快速校准的激光测量系统包括测量增强装置，其使得现有的标准单自由度激光干涉仪系统能够同时测量多达四个附加自由度。该装置包括将现有测量系统的激光束（例如返回激光束（58））分成第一光束（60）以供现有干涉测量系统的现有部件使用的第一分束器（56），以及第二光束（62）供测量增强装置使用。测量增强装置还包括测量部件，其同时接收用于响应于第二光束（62）确定至少第二自由度的测量值的第二光束（62）。

10. 发明申请

WO1998006432A1 OUTER MEMBRANE PROTEIN B1 OF MORAXELLA CATARRHALIS 审中-公开
标题翻译：外膜蛋白B1的MORAXELLA CATARRHALIS
公开(公告)号：WO1998006432A1
公开(公告)日：1998-02-19
申请号：PCT/US1997014596
申请日：1997-08-15
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
发明人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , CAMPAGNARI, Anthony, A.
IPC分类号： A61K39/395
CPC分类号： C07K14/212 , A61K39/00 , C07K16/1217
摘要： An isolated and purified outer membrane protein B1, and peptides formed therefrom, of Moraxella catarrhalis are described. A method for the isolation and purification of outer membrane protein B1 from a bacterial strain that produces B1 protein, e.g. Moraxella catarrhalis, comprises growing the bacteria in culture in iron-depleted medium to enhance the expression of the B1 protein, harvesting the bacteria from the culture, extracting from the harvested bacteria a preparation substantially comprising an outer membrane protein preparation, contacting the outer membrane preparation with an affinity matrix containing immobilized transferrin wherein B1 protein binds to the transferrin, and eluting the bound B1 protein from the transferrin. Disclosed are the uses of the B1 protein as an immunogen for vaccine formulations, and as antigens in diagnostic immunoassays.
摘要翻译：描述了分离和纯化的外膜蛋白B1及其形成的由莫拉氏卡他莫拉菌引起的肽。从产生B1蛋白质的细菌菌株分离和纯化外膜蛋白B1的方法，例如，卡他莫拉菌包括在贫铁培养基中生长培养物中的细菌以增强B1蛋白的表达，从培养物中收获细菌，从收获的细菌中提取基本上包含外膜蛋白制剂的制剂，使外膜制剂其中含有固定化转铁蛋白的亲和基质，其中B1蛋白与转铁蛋白结合，并从转铁蛋白洗脱结合的B1蛋白。公开了B1蛋白作为疫苗制剂的免疫原以及作为诊断性免疫测定中的抗原的用途。

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