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1. 发明申请

WO2017070578A1 DETECTION AND TREATMENT OF CARIES AND MICROCAVITIES WITH NANOPARTICLES 审中-公开
标题翻译：纳米颗粒检测和治疗龋病及微小病变
公开(公告)号：WO2017070578A1
公开(公告)日：2017-04-27
申请号：PCT/US2016/058274
申请日：2016-10-21
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , POZNAN UNIVERSITY OF MEDICAL SCIENCES
发明人： LAHANN, Joerg , CHANG, Sywe-Ren , CLARKSON, Brian , JONES, Nathan A. , CZAJKA-JAKUBOWSKA, Agata
IPC分类号： A61K49/18 , A61K49/00
CPC分类号： A61K49/0054 , A61K8/0241 , A61K8/21 , A61K8/24 , A61K8/25 , A61K8/55 , A61K8/64 , A61K8/72 , A61K8/732 , A61K8/736 , A61K49/0043 , A61K49/0063 , A61K2800/413 , A61K2800/434 , A61K2800/5426 , A61K2800/654 , A61K2800/81 , A61K2800/92 , A61Q11/00
摘要： Components, for example, nanoparticles for detecting and/or treating one or more active carious lesions or microcavities in teeth of a subject are provided. The component or nanoparticle may comprise a biocompatible and biodegradable polymer {e.g., a starch) bearing at least one cationic region and/or having a net positive charge and thereby capable of associating with one or more active and/or early carious lesions on a tooth in an oral cavity of a subject. The components or nanoparticles are optionally water soluble or dispersible. The components or nanoparticle also comprises an imaging agent {e.g., a fluorophore or dye) bonded to the biocompatible and biodegradable polymer. The component or nanoparticle is thus capable of indicating the presence of one or more active carious lesions when the component or nanoparticle is associated therewith. Oral care compositions comprising such compounds/nanoparticles and methods of making and using the same are also provided.
摘要翻译：提供了用于检测和/或治疗受试者牙齿中的一种或多种活性龋损或微腔的纳米颗粒的组分。组分或纳米颗粒可以包含生物相容且生物可降解的聚合物（例如淀粉），其带有至少一个阳离子区域和/或具有净正电荷，从而能够与牙齿上的一种或多种活性和/或早期龋损相关联在受试者的口腔中。组分或纳米粒子任选地是水溶性的或可分散的。组分或纳米颗粒还包含与生物相容且可生物降解的聚合物结合的成像剂（例如荧光团或染料）。因此，当组分或纳米颗粒与其结合时，组分或纳米颗粒能够指示一种或多种活性龋损的存在。还提供了包含此类化合物/纳米颗粒的口腔护理组合物及其制备和使用方法。

2. 发明申请

WO2021092452A1 THERAPEUTIC PROTEIN-BASED NANOPARTICLES AND METHODS FOR MAKING THE SAME 审中-公开
公开(公告)号：WO2021092452A1
公开(公告)日：2021-05-14
申请号：PCT/US2020/059497
申请日：2020-11-06
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： HABIBI, Nahal , LAHANN, Joerg , RAHMANI, Sahar , GREGORY, Jason V. , QUEVEDO, Daniel F. , PLUMMER, Bradley
IPC分类号： A61K9/00 , A61K9/14 , B05D1/04 , B29C67/00 , C08J3/00 , C12N5/00 , C12N5/02
摘要： Protein-based nanoparticles and methods of forming such protein-based nanoparticles via electrohydrodynamic jetting methods are provided. The nanoparticle may comprise a water- soluble protein having an average molecular weight of ≥ about 8 kDa and ≤ about 700 kDa. In certain variations, the water-soluble protein is cross-linked (e.g., with an optional crosslinking agent) and defines a mesh structure having an average linear mesh size of ≥ about 1 nm to ≤ about 4 nm. Methods of making such nanoparticles may include jetting a liquid comprising the water- soluble protein through a nozzle, followed by exposing the liquid to an electric field sufficient to solidify the liquid and form the protein-based nanoparticles described above.

3. 发明申请

WO2013059294A1 METHODS AND DEVICES FOR DETECTING AND SEPARATING TARGET ANALYTE SPECIES USING ANISOTROPIC MICRO-PARTICLES 审中-公开
标题翻译：使用各向异性微粒检测和分离目标分析物种的方法和装置
公开(公告)号：WO2013059294A1
公开(公告)日：2013-04-25
申请号：PCT/US2012/060578
申请日：2012-10-17
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： LAHANN, Joerg , GRUNZE, Michael
IPC分类号： G01N33/50 , G01N27/26
CPC分类号： G01N33/5432
摘要： The present disclosure provides new methods for detection and/or separation of target species from a fluid composition, particularly for biological target species, like prokaryotic cells, eukaryotic cells, genetic materials, proteins, polypeptides, biomolecules, viruses, saccharides, antigens, and the like. A target species in a fluid composition is contacted with a plurality of anisotropic multi-compartment micro-particles. At least one distinct compartment of each of the anisotropic multi-compartment micro-particles defines an exposed binding surface, which optionally comprises a moiety selected for binding to the target species. Such anisotropic multi-compartment micro-particles are thus employed to detect and/or separate the target species from the fluid composition. Analytical assays, detection and sensor devices, and separation devices may likewise employ such principles for detection, quantification, and/or separation of target species.
摘要翻译：本公开提供了用于从流体组合物，特别是用于生物靶物种如原核细胞，真核细胞，遗传物质，蛋白质，多肽，生物分子，病毒，糖类，抗原的检测和/或分离目标物种的新方法，以及喜欢。流体组合物中的目标物质与多个各向异性多室微粒接触。每个各向异性多室微粒子的至少一个不同的隔室限定暴露的结合表面，其任选地包含选择用于结合靶物种的部分。因此，这种各向异性多室微粒子用于从流体组合物中检测和/或分离靶物种。分析测定，检测和传感器装置以及分离装置同样可以采用这些原理用于靶物种的检测，定量和/或分离。

4. 发明申请

WO2008112560A1 METHODS AND COMPOSITIONS FOR GROWTH OF EMBRYONIC STEM CELLS 审中-公开
标题翻译：胚胎干细胞生长的方法和组合物
公开(公告)号：WO2008112560A1
公开(公告)日：2008-09-18
申请号：PCT/US2008/056252
申请日：2008-03-07
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , SMITH, Gary, D. , LAHANN, Joerg , DING, Jun , NANDIVADA, Himabindu
发明人： SMITH, Gary, D. , LAHANN, Joerg , DING, Jun , NANDIVADA, Himabindu
IPC分类号： C12N5/08 , C12N5/00
CPC分类号： C12N5/0606 , C12N5/00 , C12N2533/30
摘要： The present invention provides methods and compositions for establishing and maintaining growth of undifferentiated stem cells. In particular, the present invention provides synthetic growth matrices for stem cells, wherein said cells are capable of going through multiple passages while remaining in an undifferentiated state.
摘要翻译：本发明提供了用于建立和维持未分化干细胞生长的方法和组合物。特别地，本发明提供了用于干细胞的合成生长基质，其中所述细胞能够在保持未分化状态的同时经过多次传代。

5. 发明申请

WO2023091676A1 BIOFILM-TARGETING NANOPARTICLES TO INCREASE THE ANTICARIES EFFECT OF FLUORIDE 审中-公开
公开(公告)号：WO2023091676A1
公开(公告)日：2023-05-25
申请号：PCT/US2022/050426
申请日：2022-11-18
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： TENUTA, Livia M.A. , LAHANN, Joerg , CHANG, Albert , HABIBI, Nahal
IPC分类号： A61K9/51 , A61K33/16 , A61P1/02 , A61P31/04
摘要： Nanoparticles for treating a tooth in an oral cavity of a subject are provided. The nanoparticle comprises a biocompatible and biodegradable hydrophilic polymer, a matrix-degrading enzyme, and an anticaries active ingredient present in the nanoparticle at greater than or equal to about 20 % by weight. The nanoparticle has a zeta potential between about -10 mV to about +10 mV at a pH of 7. The nanoparticle is capable of selectively accumulating within a biofilm matrix associated with a surface of the tooth in the oral cavity of the subject. Oral care composition and methods of treating a tooth in an oral cavity of a subject with such nanoparticles are also provided.

6. 发明申请

WO2012058464A2 MULTIPHASIC POLYMERIC PARTICLES CAPABLE OF SHAPE-SHIFTING VIA ENVIRONMENTAL STIMULATION 审中-公开
标题翻译：通过环境刺激形成的多相聚合物颗粒
公开(公告)号：WO2012058464A2
公开(公告)日：2012-05-03
申请号：PCT/US2011/058142
申请日：2011-10-27
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , LAHANN, Joerg , YOON, Jaewon , BHASKAR, Srijanani , LEE, Kyungjin
发明人： LAHANN, Joerg , YOON, Jaewon , BHASKAR, Srijanani , LEE, Kyungjin
IPC分类号： A61K9/00 , C08J3/00 , C09K3/00 , G01N33/48 , B01J19/00
CPC分类号： A61K9/14 , A61K9/1647
摘要： Provided herein are methods of making and controlling multiphasic polymeric micro-components capable of shape-shifting. Such a multiphasic micro-component comprises a first phase (that can include a first polymer) and at least one additional phase distinct from said first phase (that can include a second polymer). One or more of the first phase and additional phase comprises a component that is responsive to an external stimulus. Thus, the micro-component exhibits a substantial physical deformation in response to: (i) the presence of the external stimulus or (ii) a change in the external stimulus. Exemplary external stimuli include temperature, pressure, light, pH, ionic strength, hydrophobicity/hydrophilicity, solvent, concentration, a stimulator chemical, sonic energy, electric energy, pressure, magnetic fields, and combinations thereof.
摘要翻译：本文提供了制造和控制能够形状改变的多相聚合物微组分的方法。这样的多相微组分包含第一相（其可包含第一聚合物）和至少一个不同于所述第一相（可包含第二聚合物）的附加相。第一阶段和附加阶段中的一个或多个包括响应于外部刺激的组件。因此，微元件响应于:(一）外部刺激的存在或（二）外部刺激的变化而显示出明显的物理变形。示例性的外部刺激包括温度，压力，光，pH，离子强度，疏水性/亲水性，溶剂，浓度，化学刺激剂，声波能量，电能，压力，磁场及其组合。

7. 发明申请

WO2010057095A2 METHOD FOR MANUFACTURING AN IMPLANTABLE ELECTRONIC DEVICE 审中-公开
标题翻译：用于制造可植入电子器件的方法
公开(公告)号：WO2010057095A2
公开(公告)日：2010-05-20
申请号：PCT/US2009/064591
申请日：2009-11-16
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , SEYMOUR, John , GULARI, Mayachurat, Ning , LAHANN, Joerg , KIPKE, Daryl
发明人： SEYMOUR, John , GULARI, Mayachurat, Ning , LAHANN, Joerg , KIPKE, Daryl
IPC分类号： A61N1/05 , A61N1/36 , H01L21/02
CPC分类号： A61N1/05 , A61N1/0551 , A61N1/375 , H01L23/293 , H01L2924/0002 , H01L2924/3011 , Y10T29/49117 , Y10T29/49156 , H01L2924/00
摘要： A method of manufacturing an implantable electronic device, including: providing a silicon wafer; building a plurality of layers coupled to the wafer including an oxide layer coupled to the silicon wafer; a first reactive parylene layer coupled to the oxide layer, an electrode layer coupled to the first reactive parylene layer, and a second reactive parylene layer, coupled to the electrode layer, that chemically bonds to the first reactive polymer layer, and a second polymer layer coupled to the second reactive parylene layer; coating the plurality of layers with an encapsulation, and modifying the encapsulation and at least one of the plurality of layers to expose an electrode site in the electrode layer.
摘要翻译：一种制造可植入电子器件的方法，包括：提供硅晶片; 构建耦合到所述晶片的多个层，所述多个层包括耦合到所述硅晶片的氧化物层; 耦合到氧化物层的第一反应性聚对二甲苯层，耦合到第一反应性聚对二甲苯层的电极层和耦合到电极层的与第一反应性聚合物层化学键合的第二反应性聚对二甲苯层，以及第二聚合物层耦合到第二反应聚对二甲苯层; 用封装涂覆多个层，并且修改封装和多个层中的至少一个层以暴露电极层中的电极部位。

8. 发明申请

WO2007149310A2 MULTIPHASIC BIOFUNCTIONAL NANO-COMPONENTS AND METHODS FOR USE THEREOF 审中-公开
标题翻译：多功能生物功能纳米组分及其使用方法
公开(公告)号：WO2007149310A2
公开(公告)日：2007-12-27
申请号：PCT/US2007/014028
申请日：2007-06-15
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , LAHANN, Joerg
发明人： LAHANN, Joerg
IPC分类号： A61J3/00
CPC分类号： A61K9/5153 , A61K9/1694 , A61K9/5089 , A61K9/70 , A61K49/1854 , A61K49/1887 , B82Y5/00
摘要： Multiphasic nano-components (MPNs) having at least two phases and at least one active ingredient are provided. The MPNs can be used in various methods for medical diagnostics or with pharmaceutical, personal care, oral care, and/or nutritional compositions, for example, in oral care, hair, or skin products. The MPNs can be designed to have targeted delivery within an organism, while providing controlled release systems or combining incompatible active ingredients. Further, the MPNs can be used as biomedical coatings (such as anti-microbial coatings), or anti-corrosive coatings, bioimaging probes with combined diagnostic and therapeutic use, and fragrance release systems, among others. The MPNs can be formed by electrified jetting of polymers.
摘要翻译：提供具有至少两相和至少一种活性成分的多相纳米组分（MPN）。 MPN可以用于各种医学诊断方法或药物，个人护理，口腔护理和/或营养组合物，例如口腔护理，毛发或皮肤产品中。 MPN可以设计成在生物体内具有靶向递送，同时提供受控释放系统或组合不相容的活性成分。此外，MPN可以用作生物医学涂层（例如抗微生物涂层）或抗腐蚀涂层，具有组合诊断和治疗用途的生物成像探针和香料释放系统等。 MPN可以通过聚合物的电喷射形成。

9. 发明申请

WO2017181108A1 TEMPLATED SYNTHESIS OF SHAPE-CONTROLLED POLYMERIC NANOFIBERS BY CHEMICAL VAPOR DEPOSITION (CVD) IN LIQUID CRYSTALS 审中-公开
标题翻译：化学气相沉积（CVD）法在液晶中模板合成形状控制的聚合物纳米纤维
公开(公告)号：WO2017181108A1
公开(公告)日：2017-10-19
申请号：PCT/US2017/027764
申请日：2017-04-14
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , WISCONSIN ALUMNI RESEARCH FOUNDATION
发明人： BEDOLLA PANTOJA, Marco A. , ABBOTT, Nicholas L. , CHENG, Kenneth , LAHANN, Joerg
IPC分类号： B82Y30/00 , D01F6/00
摘要： Methods are provided for fabricating functional nanostructures (e.g., nanowires/nanofibers) via chemical vapor deposition polymerization of paracyclophanes or substituted paracyclophanes onto and through a structured fluid, such as a film of liquid crystals, on a substrate. A one-step process is provided that does not require the use of any solid templates, nor does it require any volatile solvents, additives or catalysts. The resulting nanowires/nanofibers can be in the form of aligned nanowires/nanofibers arrays supported on any solid material, in the form of nanofibers mats supported on porous materials, or as individual free-standing nanowires/nanofibers. By using chiral liquid crystals, chiral nanofibers can be fabricated. The functional nanowires /nanofibers can contain one or more type of surface reactive groups that allows for post surface chemical modifications on the nanowires/nanofibers. Such nanostructures can be used in a range of different applications, including in biomedical applications.
摘要翻译：提供了通过将对环芳烃或取代的对环芳烃化学气相沉积聚合到基材上并穿过结构流体（例如液晶膜）的功能性纳米结构（例如，纳米线/纳米纤维）的方法。提供一步法，不需要使用任何固体模板，也不需要任何挥发性溶剂，添加剂或催化剂。所得到的纳米线/纳米纤维可以以任何固体材料支撑的排列的纳米线/纳米纤维阵列的形式，以纳米纤维垫的形式支撑在多孔材料上，或者作为独立的自立式纳米线/纳米纤维。通过使用手性液晶，可以制造手性纳米纤维。功能纳米线/纳米纤维可含有一种或多种类型的表面反应性基团，其允许纳米线/纳米纤维上的表面后化学修饰。这种纳米结构可用于各种不同的应用，包括生物医学应用。

10. 发明申请

WO2011159923A2 IMPLANTABLE MICRO-COMPONENT ELECTRODES 审中-公开
标题翻译：可植入的微组件电极
公开(公告)号：WO2011159923A2
公开(公告)日：2011-12-22
申请号：PCT/US2011/040741
申请日：2011-06-16
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , KIPKE, Daryl R. , KOZAI, Takashi Daniel Yoshida , LANGHALS, Nick , LAHANN, Joerg , KOTOV, Nicholas A. , DENG, Xiaopei , PATEL, Paras
发明人： KIPKE, Daryl R. , KOZAI, Takashi Daniel Yoshida , LANGHALS, Nick , LAHANN, Joerg , KOTOV, Nicholas A. , DENG, Xiaopei , PATEL, Paras
IPC分类号： A61B5/0215 , A61B5/0478 , A61N1/05
CPC分类号： A61B5/04001 , A61B5/685 , A61B2562/125 , A61N1/05 , A61N1/0529 , A61N1/0551 , B82Y5/00
摘要： The present disclosure provides robust implantable micro-component electrodes that can be used in a variety of medical devices. The medical device may be a neural probe that can monitor or stimulate neural activity in an organism's brain, spine, nerves, or organs, for example. The micro-component electrode has a small physical profile, with ultra-thin dimensions, while having high strength and flexibility. The micro-electrode has an electrically conductive core material, e.g., carbon. The surface of the core material includes one or more electrically conductive regions coated with an electrically conductive material and one or more non-conductive regions having an electrically non-conductive biocompatible polymeric coating. Implantable devices having such micro-components are capable of implantation in an organism for very long durations.
摘要翻译：本公开提供可用于各种医疗装置的可植入的微型组件电极。医疗装置可以是例如可以监测或刺激生物体的脑，脊柱，神经或器官中的神经活动的神经探针。微组件电极具有小的物理特性，具有超薄的尺寸，同时具有高的强度和柔韧性。微电极具有导电芯材料，例如碳。芯材料的表面包括涂覆有导电材料的一个或多个导电区域和具有不导电的生物相容性聚合物涂层的一个或多个非导电区域。具有这种微组件的可植入装置能够在生物体内植入非常长的持续时间。

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