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1. 发明申请

WO2009067177A2 BONE MORPHOGENIC PROTEIN BINDING PEPTIDE 审中-公开
标题翻译：骨形态发生蛋白结合肽
公开(公告)号：WO2009067177A2
公开(公告)日：2009-05-28
申请号：PCT/US2008/012833
申请日：2008-11-14
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , MURRAY, Samuel, S. , MURRAY, Elsa, J. , WANG, Jeffrey, C. , BEHNAM, Keyvan
发明人： MURRAY, Samuel, S. , MURRAY, Elsa, J. , WANG, Jeffrey, C. , BEHNAM, Keyvan
IPC分类号： C07K7/00 , C07H21/00 , A61K35/12 , A61P19/00
CPC分类号： A61L27/227 , A61K35/28 , A61K38/12 , A61K38/1841 , A61K38/1875 , A61L27/3821 , A61L27/3834 , A61L27/54 , A61L2400/18 , A61L2430/02 , C07K7/08 , C07K14/51 , C12N5/0668 , C12N2501/15 , C12N2501/155 , A61K2300/00
摘要： A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2, as do endogenous forms of BBP, and sequence conservation between species results in a variety of useful BBP compositions. BBP increases the over-all osteogenic activity of rhBMP- 2, increases the rate at which rhBMP-2 induces bone formation, and BBP induces calcification alone. Compositions and substrates including BBP, and methods of using BBP are useful in therapeutic, diagnostic and clinical applications requiring calcification and osteogenesis.
摘要翻译：命名为BMP结合肽（BBP）的环化肽是如同内源形式的BBP一样热亲和结合rhBMP-2的合成肽，以及物种之间的序列保守性导致多种有用的BBP组合物。 BBP增加rhBMP-2的全部成骨活性，增加rhBMP-2诱导骨形成的速率，并且BBP单独诱导钙化。包括BBP的组合物和底物以及使用BBP的方法可用于需要钙化和骨生成的治疗，诊断和临床应用。

2. 发明申请

WO2008079400A2 SURGICAL APPLICATIONS FOR BMP BINDING PROTEIN 审中-公开
标题翻译： BMP结合蛋白的外科应用
公开(公告)号：WO2008079400A2
公开(公告)日：2008-07-03
申请号：PCT/US2007/026315
申请日：2007-12-26
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , DEPARTMENT OF VETERANS AFFAIRS , MURRAY, Samuel, S. , MURRAY, Elsa, J. , BEHNAM, Keyvan , WANG, Jeffrey, C.
发明人： MURRAY, Samuel, S. , MURRAY, Elsa, J. , BEHNAM, Keyvan , WANG, Jeffrey, C.
IPC分类号： A61K38/10
CPC分类号： A61K38/10 , A61K38/1841 , A61K38/1875 , C07K14/51 , A61K2300/00
摘要： The present invention relates to the clinical application of BBP, alone or in combination with other growth factors, for use in bone healing applications, such as spinal surgery. Additional applications include use in orthopedic implantable prostheses and implantation into other surgical sites (e.g., surgical reconstruction, regional osteopenia, etc.) where bone is desired.
摘要翻译：本发明涉及BBP的单独使用或与其它生长因子组合用于骨愈合应用如脊柱外科手术中的临床应用。另外的应用包括在矫形植入式假体中使用并植入其中需要骨骼的其它手术部位（例如手术重建，区域性骨量减少等）。

3. 发明申请

WO2014071265A1 MULTI-LAYER CAST SYSTEMS AND METHODS 审中-公开
标题翻译：多层铸件系统和方法
公开(公告)号：WO2014071265A1
公开(公告)日：2014-05-08
申请号：PCT/US2013/068180
申请日：2013-11-02
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , WU, Benjamin, M. , REED, Stephanie
发明人： WU, Benjamin, M. , REED, Stephanie , WANG, Jeffrey, C. , LOUGHRAN, Emily, W.
IPC分类号： A61F5/01 , A41D13/08 , A61F13/02
CPC分类号： A61F5/05841 , A61F5/01 , A61F13/041 , A61F13/046 , A61F2240/00 , A61L15/12
摘要： A multi-layer cast for immobilizing a body member of a patient includes a hydrophobic sleeve having a shape configured to be applied over the body member and substantially conform to the shape of the body member, and a moldable layer configured to be positioned around said sleeve and hardened to conform to the shape of said body member adjacent said sleeve is presented. The hydrophobic sleeve includes fibers configured to wick moisture outward away from the body member, and the moldable layer includes a network of pores that extend through the moldable layer such that the pores are configured to contact the hydrophobic sleeve to promote flow of moisture from the hydrophobic sleeve outward through the moldable layer. An external removable wrap may also be detachably disposed around the moldable layer for additional support and moisture wicking.
摘要翻译：用于固定患者的身体构件的多层铸件包括具有被配置为施加在主体构件上并且基本上符合本体构件的形状的形状的疏水套管，以及构造成围绕所述套筒定位的可模制层并且被硬化以符合邻近所述套筒的所述本体构件的形状。疏水套管包括被配置为将湿气向外远离本体构件的纤维，并且可模塑层包括延伸穿过可模制层的孔网，使得孔构造成接触疏水套管以促进水分从疏水性通过可成型层向外套。外部可去除的包装也可以可拆卸地设置在可模制层周围以用于额外的支撑和湿气芯吸。

4. 发明申请

WO2002072201A1 TRANSCUTANEOUS SPINE TRAUMA AND DISORDERS TREATMENT USING ULTRASONICALLY INDUCED CONFINED HEAT ZONE 审中-公开
标题翻译：使用超声波诱导的限制性热带的TRANSCUTANEOUS SPINE TRAUMA AND DISORDERS TREATMENT
公开(公告)号：WO2002072201A1
公开(公告)日：2002-09-19
申请号：PCT/US2002/007073
申请日：2002-03-07
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： BAR-COHEN, Yoseph , KABO, J. Michael , KWONG-FU, Helenann , LEE, Paul, L. , WANG, Jeffrey, C. , MAL, Ajit, K.
IPC分类号： A61N7/02
CPC分类号： A61N7/02 , A61B2017/00261
摘要： A method of heating a tissue using pulsed focused ultrasonic waves, and an apparatus for carrying out the method. The method comprises depositing an amount of ultrasound energy sufficient to heat the selected site without adversely damaging other parts of the tissue. The apparatus comprises an ultrasonic source for producing pulsed ultrasonic waves, a lens for focusing the ultrasonic waves, and a controller for controlling wave frequency and transmission parameters of the ultrasonic waves. The method and apparatus can be used to treat spine or other joint disorders associated with lax ligamentous tissues, i.e., soft tissue disruption.
摘要翻译：使用脉冲聚焦超声波加热组织的方法，以及用于执行该方法的装置。该方法包括沉积一定量的超声能量以足以加热所选择的部位而不会不利地损坏组织的其它部分。该装置包括用于产生脉冲超声波的超声波源，用于聚焦超声波的透镜，以及用于控制超声波的波频和传输参数的控制器。该方法和装置可用于治疗与松弛韧带组织相关的脊柱或其它关节疾病，即软组织破裂。

5. 发明申请

WO2005062902A2 STATIC & DYNAMIC CERVICAL PLATES AND CERVICAL PLATE CONSTRUCTS 审中-公开
标题翻译：静，动态宫颈板和宫颈板结构
公开(公告)号：WO2005062902A2
公开(公告)日：2005-07-14
申请号：PCT/US2004/043172
申请日：2004-12-22
申请人： LIFE SPINE, LLC , BUTLER, Michael, S. , WANG, Jeffrey, C.
发明人： BUTLER, Michael, S. , WANG, Jeffrey, C.
IPC分类号： A61B17/56 , A61B17/58 , A61B17/70 , A61B17/80
CPC分类号： A61B17/8047 , A61B17/7059 , A61B17/8023 , A61B17/8042
摘要： A cervical bone plate includes a graft window that allows access to and/or visualization of a bone graft area of the cervical spine after attachment of the present cervical plate to the vertebrae. The window is preferably, but not necessarily, sized for maximum exposure of the graft area and/or the vertebral body without compromising plate strength, particularly with respect to federal standards for such devices. The window is centrally positioned on the plate and is sized to provide alignment of the plate onto the vertebrae at the base of the vertebra fastener or screw holes of the plate. In a dynamic form of this cervical bone plate, the graft window expands and contracts with respective expansion and contraction of the dynamic plate after attachment to the vertebrae (i.e. "dynamizes"). In another form, a threecomponent dynamic bone plate is configured such that a middle component accepts an identical end component at both ends of the middle component. The end component is a 180° interchangeable part. The middle component and the end component have cooperating configurations and complementarily configured grooves that allow sliding movement between the middle component and the end components. A two-pillar construction provides a central window.
摘要翻译：颈椎骨板包括移植物窗口，该移植物窗口允许在将当前颈盘附接到椎骨后接近和/或可视化颈椎的骨移植物区域。该窗口优选但不是必须地确定尺寸，以使得移植物区域和/或椎体的最大暴露不会影响板强度，特别是关于这种设备的联邦标准。窗口位于板的中心位置，其大小设置为将板对准椎骨紧固件底部或板的螺钉孔处的椎骨。在该颈椎骨板的动态形式中，移植窗在附着于椎骨后（即“动态化”）随着动态板的相应膨胀和收缩而膨胀和收缩。在另一种形式中，构造一个三sh组件动态骨板，使得中间组件在中间组件的两端接受相同的端部组件。最终组件是180°; 可互换的部分。中间部件和端部部件具有配合结构和互补配置的凹槽，其允许中间部件和端部部件之间的滑动运动。双柱结构提供了一个中央窗口。

6. 发明申请

WO2003101319A2 LAMINOPLASTY DEVICES AND METHODS 审中-公开
标题翻译： LAMINOPLASTY设备和方法
公开(公告)号：WO2003101319A2
公开(公告)日：2003-12-11
申请号：PCT/US2003/016795
申请日：2003-05-29
申请人： SDGI HOLDINGS, INC. , MARIK, Gregory, C. , NULL, William, B. , WEAKLEY, Robert, W. , HELLER, John, G. , WANG, Jeffrey, C.
发明人： MARIK, Gregory, C. , NULL, William, B. , WEAKLEY, Robert, W. , HELLER, John, G. , WANG, Jeffrey, C.
IPC分类号： A61B17/70
CPC分类号： A61B17/7059 , A61B17/7071
摘要： Laminoplasty plates are engageable to at least one portion of a divided lamina to maintain a desired spacing relative to the spinal canal. The laminoplasty plates include a spacer portion having a first end and a second end that spans a gap formed by at least one of a divided lamina portion. The laminoplasty plates can include a lamina engagement portion at one end for engagement with the divided lamina portion.
摘要翻译：椎板成形术板可接合至分裂片的至少一部分以保持相对于椎管的期望间隔。椎板成形术板包括间隔部分（810），该间隔部分具有第一端部和第二端部，该第二端部跨越由分割的片部分中的至少一个形成的间隙。椎板成形术板可包括在一端的椎板接合部分（815），用于与分开的椎板部分接合。

7. 发明申请

WO2003101319A3 LAMINOPLASTY DEVICES AND METHODS 审中-公开
公开(公告)号：WO2003101319A3
公开(公告)日：2003-12-11
申请号：PCT/US2003/016795
申请日：2003-05-29
申请人： SDGI HOLDINGS, INC. , MARIK, Gregory, C. , NULL, William, B. , WEAKLEY, Robert, W. , HELLER, John, G. , WANG, Jeffrey, C.
发明人： MARIK, Gregory, C. , NULL, William, B. , WEAKLEY, Robert, W. , HELLER, John, G. , WANG, Jeffrey, C.
IPC分类号： A61B17/70
摘要： Laminoplasty plates are engageable to at least one portion of a divided lamina to maintain a desired spacing relative to the spinal canal. The laminoplasty plates include a spacer portion (810) having a first end and a second end that spans a gap formed by at least one of a divided lamina portion. The laminoplasty plates can include a lamina engagement portion (815) at one end for engagement with the divided lamina portion.

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